Clinical trials: Retina
Age-Related Macular Degeneration
A Clinical Trial to Explore Safety and Efficacy of Different Doses of Pegaptanib Sodium, Compared to Sham, in Patients With Wet AMD.
The purpose of this study is to compare the ability of different doses of pegaptanib sodium to safely and effectively minimize fluid leakage within the eye, thereby stabilizing or impriving vision in patients with wet AMD when…
- Trial name
- NCT00321997
- Testing
- Pegaptanib sodium
- Volunteers
- 540 people
- Sponsor
- Eyetech Pharmaceuticals
Varices; Cord
Outcome of Sub-inguinal Varicocelectomy on Normal Semen in Patients Complaining of Orchilagia With Normal Semen
varicoclelectomy is done for subfertiltiy and varicocele induced orchialgia. The effect of varicocelectomy on semen analysis is controversial. Many articles report favorable outcomes and others do not.
- Trial name
- NCT03835143
- Testing
- subinguinal varicocelectomy
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Thalassemia
The Role of OCTA in Patients Affected by Beta Thalassemia
To investigate, using optical coherence tomography angiography (OCTA), the retinal and choriocapillaris vascular features in patients affected by Beta Thalassemia.
- Trial name
- NCT04582110
- Testing
- Optical coherence tomography angiography
- Where
- Italy
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Federico II University
Rhegmatogenous Retinal Detachment
Early Prevention Strategies of Severe Proliferative Vitreoretinopathy Base on Precision Diagnosis of Single Cell Sequencingvitreoretinopathy
Study of initiating proliferative vitreoretinopathy (PVR)cell subtype (PVR initiating cells (PVR-IC) in RPE cells of rhegmatogenous retinal detachment (RRD) patients; to prove the percentage of PVR-IC decides the risk of serious…
- Trial name
- NCT04520789
- Testing
- RPE cell collection and single cell heterogeneity study, Postoperative intervention, Conventional Surgery for Retinal Detachment
- Volunteers
- 60 people
- Sponsor
- Shanghai 10th People's Hospital
Macular Degeneration
A Long-Term Monitoring Study of the IMT-002 Patients
This is a 5-year study of patients implanted with the Implantable Miniature Telescope (IMT by Dr. Isaac Lipshitz) under Protocol IMT-002.
- Trial name
- NCT00976235
- Testing
- IMT - Implantable Miniature Telescope
- Where
- 28 sites in United States
- Volunteers
- 129 people
- Sponsor
- VisionCare, Inc.
Vitrectomy
Vitrectomy for Branch Retinal Vein Occlusion
To evaluate the long term outcomes of pars plana vitrectomy (PPV), with and without internal limiting membrane (ILM) peeling, in eyes with persistent macular edema secondary to branch retinal vein occlusion (BRVO).
- Trial name
- NCT00685490
- Testing
- Vitrectomy w/o ILM peeling for macular edema with BRVO
- Where
- Japan
- Volunteers
- 70 people
- Sponsor
- Shinjo Ophthalmologic Institute
Epiretinal Membrane
Fundus Autofluorescence After Vitrectomy for Epiretinal Membrane
Fundus autofluorescence (FAF) at the macula originates from hyperfluorescence from retinal pigment epithelium (RPE) and blockage of hyperfluorescence by macular pigment.
- Trial name
- NCT02628158
- Testing
- Vitrectomy with internal limiting membrane removal
- Where
- Japan
- Volunteers
- 91 people
- Sponsor
- Kyorin University
Hypertension
Target Organ Damage and Polymorphisms Vav-2 and Vav-3 in Hypertensive Subjects
Objectives: To analyze the influence on the presence of target organ damage renal, cardiac and vascular of peripheral and central blood pressure, retinal vessels caliber, oxidative stress and polymorphisms of genes VAV-2-3 in…
- Trial name
- LOD-HTA (NCT02022618)
- Where
- Spain
- Volunteers
- 454 people
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Age Related Macular Degeneration, Diabetic Retinopathy
Oral Acetazolamide, Brimonidine Tartarate, and Anterior Chamber Paracentesis for Ocular Hypertension Control After Intravitreal Bevacizumab
The purpose of this study is to evaluate the effects of anterior chamber paracentesis, brimonidine and oral acetazolamide to reduce intra-ocular pressure variations after intravitreal bevacizumab injection.
- Trial name
- NCT00864838
- Testing
- Acetazolamide, Brimonidine tartarate, Anterior chamber paracentesis
- Volunteers
- 56 people
- Sponsor
- University of Sao Paulo
Giant Cell Arteritis (GCA), Ischemic Optic Neuropathy
Orbital Vascular Inflammation in Ischemic Optic Neuropathy and Giant Cell Arteritis
Giant cell arteritis (GCA) is an inflammation of the blood vessels. A dangerous complication is sudden vision loss due to insufficient blood supply to the optic nerve.
- Conditions
- Giant Cell Arteritis (GCA), Ischemic Optic Neuropathy, NAION - Non-Arteritic Ischemic Optic Neuropathy
- Trial name
- VISION-GCA (NCT07206238)
- Testing
- Positron Emission Tomography / Magnetic Resonance Imaging
- Where
- Denmark
- Volunteers
- 122 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Type 1 Diabetes Mellitus With Artificial Pancreas Device
OCT and OCT-A Deep Learning in Diabetic Patients Wiht Artificial Pancreas Device
This study evaluates the ability of deep learning to improve the knowledge about structural and vascular retinal changes in diabetic patients undergoing artificial pancreas device, using optical coherence tomography angiography.
- Trial name
- NCT05809843
- Testing
- hybrid artificial pancreas systems (CSII)
- Where
- Italy
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Federico II University
Macular Hole
Air Tamponade in Macular Hole Surgery
Macular hole is a hole formation which takes place in the center of the retina. Such a hole needs surgical steps in order to close. Closure of the macular hole will lead to a substantially improvement of vision in most cases.
- Trial name
- NCT01680068
- Testing
- Pars plana vitrectomy and postoperative air tamponade
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Helse Stavanger HF
Diabetic Macular Edema, Macular Edema Due to Diabetes Mellitus
OCT and OCT-Angiography Biomarkers of Treatment Response to Dexamethasone Implant in Macular Edema Due to Retinal Vascular Diseases - DME and RVO
The purpose of this pilot study is to evaluate different imaging parameters in patients with previously treatment-naive DME and ME due to RVO before and after treatment with dexamethasone implant, in order to find specific…
- Conditions
- Diabetic Macular Edema, Macular Edema Due to Diabetes Mellitus, Retinal Vein Occlusion
- Trial name
- NCT06332690
- Testing
- dexamethasone implant
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Multimedica
Macular Holes
Postoperative Positioning After Surgery for Macular Holes
Idiopathic macular holes are an important cause of visual loss. Macular holes can be treated by surgically removing the vitreous gel and injecting intraocular gas.
- Trial name
- NCT01974310
- Testing
- Vitrectomy & Intraocular gas fill, Postoperative face-down positioning
- Where
- Denmark
- Volunteers
- 68 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Retinal Vein Occlusion
Radial Optic Neurotomy in Central Retinal Vein Occlusion : a Randomized Trial
Natural evolution of severe central retinal vein occlusion with low visual acuity is very poor. A randomized clinical trial will compare troxerutin and platelet anti-aggregating agents (drug treatment) versus surgery and drug…
- Trial name
- OVCR (NCT00379223)
- Testing
- vitrectomy with radial optic neurotomy
- Where
- France
- Volunteers
- 7 people
- Sponsor
- University Hospital, Bordeaux
Cytomegalovirus Retinitis, HIV Infections
A Randomized, Controlled Study of Intravenous Ganciclovir Therapy for Peripheral Cytomegalovirus Retinitis in Patients With AIDS
To provide information about the usefulness and safety of giving injections of ganciclovir (DHPG) for treating peripheral cytomegalovirus (CMV) retinitis.
- Trial name
- NCT00000688
- Testing
- Ganciclovir
- Where
- 22 sites in United States
- Volunteers
- 180 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Macular Holes, Microperymetry
The Application of M-charts and Microperimetry for the Assessment of Visual Function in Patients After Vitrectomy Due to the Full Thickness Macular Hole.
To examine the relationship between morphological and functional results in eyes after vitrectomy due to the full thickness macular hole (FTMH).
- Conditions
- Macular Holes, Microperymetry, Vitrectomy, M-charts
- Trial name
- NCT03701542
- Testing
- Microperymetry, M-charts
- Volunteers
- 22 people
- Sponsor
- Medical University of Lublin
Age-related Macular Degeneration
A Safety and Efficacy Study of Carbidopa-levodopa in Patients With Macular Degeneration
From 3 large patient databases, patients diagnosed with AMD who have never taken levodopa(L-DOPA) containing medications have a mean age of diagnosis at 71 years.
- Trial name
- NCT02873351
- Testing
- carbidopa-levodopa 25-100 mg
- Where
- United States
- Sponsor
- Snyder, Robert W., M.D., Ph.D., P.C.
Diabetic Retinopathy
A Study of PER-001 in Participants With Diabetic Retinopathy
This is a Phase 2a, randomized, single-masked (participant), sham controlled clinical study.
- Trial name
- NCT06003751
- Testing
- PER-001 Intravitreal Implant - Low Dose, PER-001 Intravitreal Implant - High Dose
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Perfuse Therapeutics, Inc.
"Wet" Age-Related Macular Degeneration
A Safety and Efficacy Study of Squalamine Lactate for Injection (MSI-1256F) for "Wet" Age-Related Macular Degeneration
Age-Related Macular Degeneration (AMD) is a degenerative eye disease of the retina that causes a progressive loss of central vision. AMD is the leading cause of blindness among adults age 50 or older in the Western world.
- Trial name
- NCT00139282
- Testing
- Squalamine Lactate
- Where
- 29 sites in United States
- Sponsor
- Genaera Corporation
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