Clinical trials: Retina
Macular Degeneration, Geographic Atrophy
GOLDEN STUDY: A Study to Assess Safety and Efficacy of Multiple Doses of IONIS-FB-LRx in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (AMD)
Evaluate the effect of IONIS-FB-LRx on the rate of change of the area of geographic atrophy (GA) secondary to age-related macular degeneration (AMD) measured by fundus autofluorescence (FAF).
- Trial name
- NCT03815825
- Testing
- IONIS-FB-LRx
- Where
- 88 sites in United States, Australia and 7 more
- Volunteers
- 332 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Macular Holes
Extent of ILM Removal and Its Impact on Outcomes of MH Surgery
Eligible patients who were scheduled for surgery for idiopathic macular hole (MH) were equally randomized to small extent group or large extent group depending on the extent of internal limiting membrane (ILM) to be removed.
- Trial name
- NCT02010138
- Testing
- small-extent peeling, large-extent peeling
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Samsung Medical Center
Neovascular (Wet) Age-Related Macular Degeneration, Retinal Vein Occlusion
Study of the SCD411 Prefilled Syringe for Treating Adults With Wet Age-Related Macular Degeneration, Retinal Vein Occlusion, Diabetic Macular Edema, or Diabetic Retinopathy
This is a single-arm, multicenter study to evaluate clinical usability of a pre-filled syringe containing SCD411 in adult patients with neovascular Wet Age-Related Macular Degeneration (AMD), Retinal Vein Occlusion (RVO)…
- Conditions
- Neovascular (Wet) Age-Related Macular Degeneration, Retinal Vein Occlusion, Diabetic Macular Edema, Diabetic Retinopathy
- Trial name
- NCT07501052
- Testing
- SCD411 0.05mL (2mg)
- Where
- 4 sites in United States
- Volunteers
- 33 people
- Sponsor
- Sam Chun Dang Pharm. Co. Ltd.
Premature Birth of Newborn, Retinopathy of Prematurity (ROP)
A Multicenter and Prospective Study of Screening Retinopathy of Prematurity in China
The purpose of the study is to explore the current incidence rate of retinopathy of prematurity (ROP) in China and to explore more appropriate screening criteria for ROP.
- Conditions
- Premature Birth of Newborn, Retinopathy of Prematurity (ROP), Low Birthweight Infant
- Trial name
- SChiROP (NCT06729333)
- Where
- China
- Volunteers
- 4,841 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Pseudoexfoliation Syndrome
The Correlation Between Pupil Size and Retinal Nerve Fibers Changes in Pseudoexfoliation Syndrome.
To study the possible correlation between pupillary diameter before and after dilation with intraocular pressure, lens stability and glaucomatous damage (represented by optic disc changes using cup to disc ratio and OCT changes…
- Trial name
- NCT06588816
- Testing
- optical coherence tomography
- Volunteers
- 33 people
- Sponsor
- Assiut University
AMD, Age- Related Macular Degeneration
Study of the Effects of Supplements on Eye Disease in Participants From the Age-Related Eye Disease Study
Background: The Age-Related Eye Disease 2 Study (AREDS2) looked at two eye diseases. These were age-related macular degeneration (AMD) and cataracts.
- Trial name
- NCT01915238
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- National Eye Institute (NEI)
Macular Hole
Objective Evaluation of Postoperative Positioning in Macular Hole Surgery
The macular hole formation takes place in the centre of the retina. A closure of the macular hole is believed to take place if the central retinal area is kept dry in the postoperative period.
- Trial name
- NCT02295943
- Testing
- Positioning measuring device
- Where
- 4 sites in Norway
- Volunteers
- 205 people
- Sponsor
- Helse Stavanger HF
Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor
Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Bone marrow transplantation may allow doctors to give higher doses of chemotherapy and kill more tumor cells.
- Conditions
- Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Head and Neck Cancer, Kidney Cancer
- Trial name
- NCT00002515
- Testing
- filgrastim, carboplatin, thiotepa
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Age Related Macular Degeneration
Association of MPOD Values With Blue Light.
This study aims to investigate in healthy adults 18-65 years of age the association of electronic device blue light exposure and macular pigment optical density (MPOD) considering usual dietary intake of lutein and zeaxanthin…
- Trial name
- AMPBL19 (NCT04779398)
- Where
- Australia
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Age-Related Macular Degeneration
Study of Safety and Efficacy of Brolucizumab 6 mg Dosed Every 4 Weeks Compared to Aflibercept 2 mg Dosed Every 4 Weeks in Patients With Retinal Fluid Despite Frequent Anti-VEGF Injections
This clinical study was designed to compare the safety and efficacy of brolucizumab 6 mg dosed every 4 weeks to aflibercept 2 mg dosed every 4 weeks in those neovascular age-related macular degeneration (nAMD) patients with…
- Trial name
- MERLIN (NCT03710564)
- Testing
- Brolucizumab, Aflibercept
- Where
- 61 sites in United States, Puerto Rico
- Volunteers
- 535 people
- Sponsor
- Novartis Pharmaceuticals
Sickle Cell Anemia, Retinopathy
Ranibizumab for Neovascularization in Sickle Cell Retinopathy
The purpose of this study is to determine the ocular and non-ocular safety of a single dose of ranibizumab in treating neovascularization secondary to sickle cell retinopathy.
- Trial name
- NCT00618644
- Testing
- Ranibizumab
- Where
- United States
- Sponsor
- Kresge Eye Institute
Type 2 Diabetes Mellitus, Non-Proliferative Diabetic Retinopathy
Blood-retinal Barrier Imaging and Neuropsychiatric Sequela in Type 2 Diabetes Mellitus
In Type 2 Diabetes mellitus patients we will: 1. quantify vasculopathy and blood-retinal barrier (BRB) leakage 2. measure blood-brain barrier (BBB) permeability and neuroanatomical changes 3.
- Conditions
- Type 2 Diabetes Mellitus, Non-Proliferative Diabetic Retinopathy, Diabetic Macular Edema
- Trial name
- NCT01107132
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Soroka University Medical Center
Age-related Macular Degeneration (AMD)
Real-world Evaluation of Prevalence of Ocular Adverse Events in Patients With Neovascular (Wet) Age-related Macular Degeneration (AMD) Who Received Anti-vascular Endothelial Growth Factor (VEGF) Agents (Komodo Health)
This was the cross-sectional study to assess the period prevalence of IOI in patients with wet AMD who were treated with anti- VEGF agents (excluding brolucizumab) over a one-year period in 2019.
- Trial name
- NCT05146687
- Testing
- Aflibercept, Ranibizumab, Bevacizumab
- Where
- United States
- Volunteers
- 369,600 people
- Sponsor
- Novartis Pharmaceuticals
Non-arteritic Anterior Ischemic Optic Neuropathy
Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)
Clinical trial.gov Brief summary : Non-arteritic anterior ischemic optic neuropathy (NAION) is an optic neuropathy due to acute or subacute ischemic event of anterior optic nerve axons retrolaminar part that was vascularized by…
- Trial name
- NAION (NCT03046693)
- Testing
- Group A Citicoline 1000 mg oral tablet
- Where
- Indonesia
- Volunteers
- 38 people
- Sponsor
- Valen Chia
Glaucoma, Myopia
Efficacy of Retinal Nerve Fiber Layer (RNFL) / Retinal Thickness Ratio by Cirrus OCT Utilizing Spectral -Domain Technology as a Diagnostic Predictor of Glaucoma
Glaucoma is presumed to be an axonal disease which starts at the lamina cribrosa. This assumption has led to the monitoring of the retinal nerve fiber layer thickness for the diagnosis and monitoring of progression of glaucoma.
- Trial name
- NCT00772993
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Diabetes Mellitus
Assess Screening for Diabetic Retinopathy Using Retinal Camera in Family Medicine Clinic
The long-term goal for this study is to improve compliance of screening for diabetic retinopathy among subjects with diabetes. Researchers are also doing this research to determine the ability of appropriately trained family…
- Trial name
- NCT03828890
- Testing
- Screening eye exam using Optos technology
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Macular Holes
Observation of Recovery of Foveal Cone Microstructures After Macular Hole Surgery
The objective is to determine whether a recovery of the microstructures of the foveal photoreceptors after macular hole (MH) closure is correlated with the best-corrected visual acuity (BCVA) is determined.
- Trial name
- NCT01306487
- Testing
- Vitrectomy
- Where
- Japan
- Volunteers
- 58 people
- Sponsor
- Kyorin University
Uveitis, Scleritis
Causes of Visual Loss in Retinal Disease
This is a study of visual outcomes in retinal disease that seeks to identify the causes of visual loss. This data will be used to predict which patients are at risk of losing vision and how they can be better treated.
- Trial name
- NCT01613963
- Testing
- Immunosuppressive Agents
- Where
- 2 sites in United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Macular Hole, Myopia
Efficacy and Safety of Myopic Macular Hole Closure Surgery Without Endotamponade Agent
Macular hole (MH) is a common condition that affects approximately 1.6/1000 elderly Chinese population. The prevalence is expected to be even higher in individuals with high myopia (HM), an established risk factor for MH.
- Trial name
- NCT07129798
- Testing
- ILM flap with no endotamponade technique
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Neovascular (Wet) AMD
Clinical Study to Compare Efficacy and Safety of AVT06 and EU-Eylea (ALVOEYE)
This is a randomized, double-masked, parallel-group, multicenter, therapeutic equivalence study evaluating the efficacy, safety, and immunogenicity of AVT06 compared with Eylea in subjects with neovascular (wet) AMD.
- Trial name
- ALVOEYE (NCT05155293)
- Testing
- AVT06 (proposed aflibercept biosimilar), Eylea® (Aflibercept)
- Where
- 6 sites in Czechia, Georgia and 3 more
- Volunteers
- 413 people
- Sponsor
- Alvotech Swiss AG
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