Clinical trials: Retina Detachment
Proliferative Vitreoretinopathy
The GUARD Trial - Part 1: A Phase 3 Clinical Trial for Prevention of Proliferative Vitreoretinopathy
The GUARD Trial is a multi-center, randomized, controlled, adaptive Phase 3 clinical trial of repeated intravitreal injections of ADX-2191 versus standard-of-care for the prevention of proliferative vitreoretinopathy.
- Trial name
- NCT04136366
- Testing
- ADX-2191 (intravitreal methotrexate 0.8%), Standard surgical care procedure
- Where
- 23 sites in United States
- Volunteers
- 106 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Retinal Detachment
Comparison High-density Silicone Oils in Retinal Detachment
The purpose of the study is to compare the safety, intraocular adverse effects and the anatomic and functional outcome with two endotamponade silicone oil after a 3-month in complex inferior retinal re-detachments.
- Trial name
- NCT00403702
- Testing
- Oxane HD [oil-RMN3-mixture], Densiron [(F6H8)
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Rhegmatogenous Retinal Detachment
Retinal Detachment - Demographic and Clinical Survey
Background: Rhegmatogenous retinal detachment is an ophthalmic emergency that, without surgical repair, often leads to blindness. The incidence is about 1/10000/year.
- Trial name
- NCT01845571
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Medical University of Vienna
Rhegmatogenous Retinal Detachment
Treatment of Retinal Detachment in People Who Have Not Had Cataract Surgery With Vitrectomy vs Vitrectomy and Cataract Removal
Background and study aims The retina is the layer at the back of the eye that allows us to see. Sometimes, it can detach from the wall of the eye, causing a condition called rhegmatogenous retinal detachment (RRD), which leads to…
- Trial name
- COMBAT (NCT06997874)
- Testing
- Phacovitrectomy, Vitrectomy
- Where
- 30 sites in United Kingdom
- Volunteers
- 276 people
- Sponsor
- Queen's University, Belfast
Rhegmatogenous Retinal Detachment
Effect of Silicon Oil on Retinal Electrical Functions Using Multifocal Electroretinogram
Retinal detachment is one of the leading causes for permanent vision loss.Incidence of Rheugmatogenous Retinal Detachment (RRD) about 10.5 people per 100,000 population pars plana vitrectomy is the most popular and effective…
- Trial name
- SO/RRD/mfERG (NCT07609628)
- Testing
- Multi focal electroretinogram
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Minia University
Dry Age-related Macular Degeneration, Detachment of the Posterior Hyaloid
Posterior Macular Adhesion: A Potential Risk Factor for Non-exudative Age Related Macular Degeneration (AMD) to Develop Exudative AMD
Choroidal neovascularisation in age related macular degeneration is one of the major causes of legal blindness in the western world existing in two major occurences, the dry and the wet form.The etiology of age related macular…
- Trial name
- PAM (NCT00926861)
- Testing
- ultrasound, OCT
- Where
- Austria
- Volunteers
- 320 people
- Sponsor
- The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
Wet Macular Degeneration
Efficacy of Fixed Monthly Dosing of Ranibizumab in Neovascular Age-related Macular Degeneration
The objective of this pilot study is to evaluate the efficacy of intensive fixed monthly dosing of intravitreal Lucentis® (Ranibizumab) for the treatment of SRF and PED in neovascular AMD which is persistent to anti-VEGF…
- Trial name
- NCT02944227
- Testing
- Lucentis
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Retinal Detachment, Metamorphopsia
Retinal Displacement Rates in Pneumatic Retinopexy Versus Pars Plana Vitrectomy For Primary Retinal Detachment
Patients may experience metamorphopsia, or image distortion, after having vitrectomy to repair their rhegmatogenous retinal detachments (RRDs) especially those with a detached macula.
- Trial name
- REVEAL (NCT04158622)
- Testing
- PnR + laser/cryotherapy, PPV + laser/cryotherapy
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto
Retinal Disease
Perfluorooctyl Bromide Which Empowers the Liquid to Flat the Detached Retina and Displace the Underneath Fluids Anteriorly
Perfluorohexyloctaneis Essential for Repositioning Giant Retinal Breaks and Can be Used for Removal of Subretinal Fluid as Well as Stabilization of the Retina to Offset
- Trial name
- NCT05699096
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- EL Romany Ophthalmics Factory
Retinal Detachment, Vitreoretinopathy Proliferative
Eye Injections of Bevacizumab for Lowering Risk of Scar Tissue in the Retina and Repeated Retinal Detachment.
The purpose of this study is to examine the effects of a drug called bevacizumab (Avastin) on the rates of recurrent retinal detachment and scar tissue formation.
- Trial name
- NCT01860586
- Testing
- Bevacizumab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Wills Eye
Retinal Detachment
Clinical Characteristics and Surgical Outcomes of the Fellow Eye in Bilateral Retinal Detachments
To assess the clinical features and the surgical outcomes of RD repair surgery of the fellow eye in bilateral retinal detachments
- Trial name
- NCT06292572
- Testing
- Retinal Detachment Surgery
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Central Hospital, Nancy, France
Retinal Detachment
23 Gauge and 20 Gauge Vitrectomy for Rhegmatogenous Retinal Detachments
This study is a comparison (23 gauge vs 20 gauge instrumentation) of surgical instrumentation for retinal detachment repair.
- Trial name
- NCT01716507
- Testing
- Retinal Detachment repair
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Wills Eye
Proliferative Vitreoretinopathy, Retinal Detachment
The Silicone Study
To compare, through a randomized, multicenter surgical trial, the postoperative tamponade effectiveness of intraocular silicone oil with that of an intraocular long-acting gas (initially sulfur hexafluoride [SF 6 ], later…
- Trial name
- NCT00000140
- Testing
- Perfluoropropane, Sulfur Hexafluoride, Silicone Oil
- Sponsor
- National Eye Institute (NEI)
Retinal Vein Occlusion, Posterior Vitreous Detachment
Posterior Vitreous Detachment (PVD) Assessment During Dual Retinal Vein Occlusion (RVO) Lucentis Evaluations
This is a study of subjects with retinal vein occlusion (RVO) specifically looking at the difference in outcomes between patients with posterior vitreous detachment (PVD) and those without PVD.
- Trial name
- PADDLE (NCT00831350)
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Barnes Retina Institute
Conjunctivitis, Glaucoma
Feasibility Study and Preliminary Application Study on Iris OCTA
All participants will underwent imaging using the OCTA system (Zeiss) with the anterior segment optical adaptor lens. The main outcomes are iris blood flow density and vascular density.
- Conditions
- Conjunctivitis, Glaucoma, Myopia, Diabetic Retinopathy
- Trial name
- NCT03631108
- Testing
- OCTA (ZEISS)
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Retina Detachment
Pneumatic Retinopexy for Severe Bullous Retinal Detachment
To compare the efficacy and safety outcomes of scleral buckling (SB) and drainage-injection-pneumoretinopexy (DIP), a modified pneumatic retinopexy technique, in which, before injecting the gas, the drainage of the subretinal…
- Trial name
- NCT04139746
- Testing
- Scleral Buckling, Drainage-Injection-Pneumoretinopexy
- Where
- Italy
- Volunteers
- 58 people
- Sponsor
- Università degli Studi di Brescia
Retina--Diseases, Retinal Detachment
Evaluation of Discomfort Associated With Scleral Depression During Retina Examinations
Scleral depression is an important technique used to examine the peripheral retina but often causes patient discomfort. The goal of this study was to compare levels of discomfort during scleral depression with a Schocket scleral…
- Conditions
- Retina--Diseases, Retinal Detachment, Retinal Degeneration
- Trial name
- DEPRESS (NCT04115917)
- Testing
- Schocket scleral depressor, Cotton tipped applicator
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation
Retinal Detachment
Adaptive Optics in PVR
The purpose of this study is to investigate the loss of retinal cells following retinal detachment surgery using an imaging device called an adaptive optics camera. The retina is a thin layer which lines the back of the eye.
- Trial name
- NCT03551574
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Ophthalmopathy
Evaluating Medium-chain Triglycerides as a Temporary Intraocular Tamponading Agent for Retinal Detachment
Background : Surgery is needed in order to flatten and position a detached retina onto the choroid, to allow sealing of the tears and to prevent or reverse vision loss.
- Trial name
- MCT (NCT03855462)
- Testing
- MCT oil injection
- Where
- 2 sites in France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Toulouse
Optic Disc Structural Anomaly, Maculopathy
Surgical Management of Optic Disc Pit Maculaopathy
To evaluate the anatomical and functional results of pars plana vitrectomy (PPV) combined with internal limiting membrane (ILM) peeling, endolaser photocoagulation and gas tamponade in management of optic disc pit (ODP)…
- Trial name
- NCT03185936
- Testing
- pars plana vitrectomy with internal limiting membrane (ILM) peeling
- Volunteers
- 9 people
- Sponsor
- Minia University