Clinical trials: Retina Detachment
Intravitreal Bevacizumab Injection, Pars Plana Vitrectomy
Preoperative Injection of Bevacizumab Prior to Vitreoretinal Surgery in Diabetic Tractional Retinal Detachment
Vitreoretinal surgery for epiretinal proliferation tractional retinal detachment associated with proliferative diabetic retinopathy (PDR) is often complicated by hemorrhage from fibrovascular tissue.
- Conditions
- Intravitreal Bevacizumab Injection, Pars Plana Vitrectomy, Tractional Retinal Detachment, Diabetic Retinopathy
- Trial name
- NCT00548197
- Testing
- Bevacizumab
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Iran University of Medical Sciences
Pigment Epithelial Detachment
Aflibercept in Patients With Pigment Epithelial Detachments (PED)
Uncontrolled single site non randomized non interventional study to determine the safety and efficacy of intravitreal injections of Aflibercept in patients with recent vision loss due to retinal pigment epithelial detachment…
- Trial name
- NCT03370380
- Testing
- Aflibercept
- Where
- Germany
- Volunteers
- 18 people
- Sponsor
- University Hospital Muenster
Retinal Detachment, Macular Pucker
Zeiss RESIGHT Disposable Lenses Evaluation Study
To evaluate the intra-operative efficacy of a new intra-operative viewing device.
- Conditions
- Retinal Detachment, Macular Pucker, Macular Holes, Vitreomacular Traction
- Trial name
- RESIGHT (NCT05860985)
- Testing
- ZEISS disposable
- Where
- Belgium
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Retinal Detachment
Use of Ocular Point of Care Ultrasound in Diagnosing Retinal Detachment in the Emergency Department
The study is collecting data along with other academic institutions regarding the accuracy of ocular ultrasound in diagnosing retinal detachment.
- Trial name
- RDOcularUS (NCT03106025)
- Testing
- Ultrasound, Ophthalmology Assessment
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Loma Linda University
Retinal Detachment
Adaptive Optics in PVR
The purpose of this study is to investigate the loss of retinal cells following retinal detachment surgery using an imaging device called an adaptive optics camera. The retina is a thin layer which lines the back of the eye.
- Trial name
- NCT03551574
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Retinal Detachment
Flexibility, Efficacy, and Safety of a Foldable Capsular Vitreous Body in the Treatment of Severe Retinal Detachment
The purpose of this study is to determine the feasibility, primary safety and efficacy of foldable capsular vitreous body (FCVB) in the treatment of retinal detachment, based on the multi-center clinical trial.
- Trial name
- NCT01261533
- Testing
- foldable capsular vitreous body(FCVB)
- Where
- 9 sites in China
- Volunteers
- 122 people
- Sponsor
- GuangZhou WeiShiBo Biotechnology Co., ltd
Retinal Detachment
Duration of Silicone Oil Tamponade on Foveal and Parafoveal Thickness in Rhegmatogenous Retinal Detachment
Our study observes and analyses the influence of the duration of tamponade with silicone oil on the foveal and parafoveal thickness.
- Trial name
- siliconeoil (NCT05817630)
- Testing
- Silicone oil Tamponade for Retinal Detachment
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- Dar El Oyoun Hospital
Retinal Detachment
Clinical Investigation of the Safety and Effectiveness of the ABV-1701 Ocular Endotamponade (OE)
A Prospective Multi-Site Open Label Randomized Controlled Clinical Investigation of the Safety and Effectiveness of the ABV-1701 Ocular Endotamponade (OE)
- Trial name
- NCT05414747
- Testing
- ABV-1701, SF6 Gas
- Where
- 4 sites in Australia, Thailand
- Volunteers
- 40 people
- Sponsor
- BioFirst Corporation
Exudative Retinal Detachment and Uveal Melanoma
Dexamethasone Implant for Retinal Detachment in Uveal Melanoma
This is an investigator-initiated Phase I study of a single dose of an intravitreally-administered dexamethasone implant (Ozurdex™) in subjects with uveal melanomas (UM) and exudative retinal detachments (ERD: build-up of fluid…
- Trial name
- NCT04082962
- Testing
- Dexamethasone intravitreal implant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Ivana K. Kim
Rhegmatogenous Retinal Detachment
Foldable Capsular Scleral Buckling Versus Vitrectomy in Medium-complex Rhegmatogenous Retinal Detachment Treatment
The objective of the study is to evaluate: 1. Safety and efficacy of a novel foldable capsular scleral buckle (FCSB) in scleral buckling for primary rhegmatogenous retinal detachment (RRD) of medium complexity. 2.
- Trial name
- FCSB (NCT06610786)
- Testing
- foldable capsular scleral buckling, vitrectomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Proliferative Vitreoretinopathy
The GUARD Trial - Part 1: A Phase 3 Clinical Trial for Prevention of Proliferative Vitreoretinopathy
The GUARD Trial is a multi-center, randomized, controlled, adaptive Phase 3 clinical trial of repeated intravitreal injections of ADX-2191 versus standard-of-care for the prevention of proliferative vitreoretinopathy.
- Trial name
- NCT04136366
- Testing
- ADX-2191 (intravitreal methotrexate 0.8%), Standard surgical care procedure
- Where
- 23 sites in United States
- Volunteers
- 106 people
- Sponsor
- Aldeyra Therapeutics, Inc.
Rhegmatogenous Retinal Detachment, High-risk for Proliferative Vitreoretinopathy (PVR)
Prophylactic Intravitreal 5-Fluorouracil and Heparin to Prevent PVR in High-risk Patients With Retinal Detachment.
This study investigates the effectiveness of a simple treatment to prevent proliferative vitreoretinopathy (PVR). Intraoperative intravitreal 5-fluorouracil (5-FU) and low molecular weight heparin (LMWH) is used as a prophylactic…
- Trial name
- PRIVENT (NCT02834559)
- Testing
- 5-fluorouracil and low molecular weight heparin
- Where
- 13 sites in Germany
- Volunteers
- 326 people
- Sponsor
- Universitätsklinikum Köln
Epiretinal Membrane Surgery
Post-surgical Functional Results in Patients With Epiretinal Membrane Undergoing Controlled Macular Detachment
This study aims to evaluate postsurgical functional changes in patients with advanced epiretinal membrane (ERM) (stages 3 and 4) by integrating a controlled macular detachment with a balanced salt solution to the conventional ERM…
- Trial name
- DMER25 (NCT07095907)
- Testing
- Pars plana vitrectomy with epiretinal membrane peeling and controlled macular detachment
- Where
- Mexico
- Volunteers
- 36 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Diabetic Retinopathy
Intravitreal Bevacizumab for Management of Active Progressive Proliferative Diabetic Retinopathy (PDR)
To evaluate the effect of intravitreal bevacizumab on the course of diabetic retinopathy in cases with the signs of active progressive PDR
- Trial name
- NCT00370721
- Testing
- bevacizumab
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Stress Disorders, Post-Traumatic, Retinal Detachment
Diagnosis of Posttraumatic Stress Disorder Following Primary Rhegmatogenous Retinal Detachment
To investigate the prevalence of posttraumatic stress disorder (PTSD) in patients that underwent surgery for primary rhegmatogenous retinal detachment (RRD) and to determine variables associated with the disorder.
- Trial name
- NCT01233908
- Where
- Israel
- Volunteers
- 547 people
- Sponsor
- Sheba Medical Center
Age Related Macular Degeneration, Pigment Epithelial Detachment
On-label tReatment With Intravitreal Aflibercept injectiOn for Patients With Persistent Pigment epitheliaL Detachments in Neovascular Age Related Macular Degeneration (AMD)
The purpose of this study is to evaluate the efficacy and safety of intravitreal aflibercept injection in a population of neovascular AMD patients that have been previously treated with 2.0 mg ranibizumab for persistent PEDs.
- Trial name
- ROLL (NCT01670162)
- Testing
- Aflibercept
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Tennessee Retina
Macular Hole Retinal Detachment, Myopic Traction Maculopathy
Vitrectomy and Scleral Shortening for Macular Hole Retinal Detachment or Myopic Traction Maculopathy
The medical records of 16 eyes of 16 patients with macular hole retinal detachment or myopic traction maculopathy who received viterctomy including internal limiting membrane peeling and scleral shorting surgery were reviewed.
- Trial name
- NCT02528045
- Testing
- Vitrectomy with scleral shortening
- Where
- Japan
- Volunteers
- 16 people
- Sponsor
- Kyorin University
Vitreomacular Traction
A Study to Compare Multiple Doses Intravitreal Microplasmin for Treatment of Patients With Vitreomacular Traction (MIVI-IIt)
A multicenter study to compare multiple doses of intravitreal microplasmin for non-surgical PVD induction for treatment of patients with vitreomacular traction.
- Trial name
- NCT00435539
- Testing
- ocriplasmin
- Where
- 4 sites in Belgium, Germany
- Volunteers
- 60 people
- Sponsor
- ThromboGenics
Retinal Detachment Rhegmatogenous
Use of Preoperative Gas in Eyes With Macula-off Rhegmatogenous Retinal Detachment (RRD)
The purpose of this study is to evaluate whether a preoperative intraocular gas injection improves visual outcomes in patients with a macula-off rhegmatogenous retinal detachment (RRD).
- Trial name
- NCT07855770
- Testing
- Intravitreal 100% C3F8 Injection, Pars plana vitrectomy or pars plana vitrectomy with scleral buckle
- Where
- 2 sites in United States
- Volunteers
- 190 people
- Sponsor
- Wills Eye
Posterior Vitreous Detachment, Diabetic Retinopathy
Annular Array Ultrasound in Ophthalmology
The objective of this research is to improve the care of ocular disease and disorders, in particular the changes in the eye associated with diabetes, by providing clinicians with dramatically improved ultrasonic images of the…
- Trial name
- NCT01415037
- Testing
- annular array ultrasound exam
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Columbia University