Clinical trials: Retinal Degeneration
Macular Degeneration, Retinal Degeneration
Pistachios and Neural Macular Pigment
Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss as people age. Studies have shown that lutein and zeaxanthin, nutrients found in green leafy vegetables and egg yolks, can help protect…
- Conditions
- Macular Degeneration, Retinal Degeneration, Retinal Diseases, Eye Diseases
- Trial name
- NCT05283941
- Testing
- Pistachio Group
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tufts University
Age-Related (Dry) Macular Degeneration
Ocular Proteomics Testing In Chronic Atrophy
Study to evaluate the safety of routine diagnostic anterior chamber paracentesis (ACP) for proteomic profiling in patients with geographic atrophy (GA)
- Trial name
- OPTICA (NCT07298291)
- Testing
- AC Tap (anterior chamber paracenthesis)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- ClinOmicsAI
Parkinson Disease, Diabetes Mellitus, Type 1
Biological Sample Collection for Research and Biobanking
The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to study different conditions and diseases by using cells from the body (such as skin or blood cells).
- Conditions
- Parkinson Disease, Diabetes Mellitus, Type 1, Macular Degeneration, ALS
- Trial name
- NCT04270604
- Testing
- Biological sample collection
- Where
- United States
- Volunteers
- 1,279 people, healthy volunteers welcome
- Sponsor
- New York Stem Cell Foundation Research Institute
Age-Related Macular Degeneration
First-in-Human Study of LHA510 in Elderly Subjects and Patients With Age-Related Macular Degeneration
The purpose of this first-in-human study is to assess the local ocular and systemic safety and tolerability of LHA510 eye drops when administered at various concentrations and dosing frequencies.
- Trial name
- NCT02076919
- Testing
- LHA510 Ophthalmic Suspension, LHA510 Vehicle
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Alcon Research
Age-Related Macular Degeneration, Geographic Atrophy
Evaluation of the Precision of the Microperimetry Function of the Spectral OCT/SLO
To conduct a precision study to assess the microperimetry function of the Spectral OCT/SLO. The study will assess variability across measurements taken by three different operator-device configuration across clinical sites…
- Conditions
- Age-Related Macular Degeneration, Geographic Atrophy, Diabetic Retinopathy, Macular Edema
- Trial name
- NCT01692938
- Where
- 3 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Optos, PLC
Pigmentary Retinopathy
Impact of Visual Field Restriction on Visual Exploration
To communicate with the observer and guide his gaze on the canvas, painters have developed different stylistic processes that artists, in the manner of scientists, have acquired on the functioning of human visual perception.
- Trial name
- REVE (NCT04360291)
- Testing
- Eye tracker
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Retinal Vein Occlusion (RVO), Macular Edema
Ozurdex Implant for Macular Edema After Treatment Failure With Anti-VEGF
To determine if Ozurdex implant can offer an effective treatment for macular edema associated with retinal vein occlusion when treatment with intravitreal Avastin, Lucentis, or Eylea have not demonstrated a significant response.
- Trial name
- NCT01946399
- Testing
- Ozurdex implant
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Retina Research Institute, LLC
Intravitreal Injection, Ocular Rinse
The Effect of Ocular Rinse Volume on Surface Irritation After Intravitreal Injections
This is the first randomized controlled trial looking into post-injection rinse volume of standard ophthalmic eyewash and its affect on patient comfort up to 72 hours after injections.
- Conditions
- Intravitreal Injection, Ocular Rinse, Age-Related Macular Degeneration, Diabetic Macular Edema
- Trial name
- NCT05615805
- Testing
- OSDI questionnaire, SPEEDII questionnaire
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Retinal Dystrophies, Color Vision Defects
Natural History Study of Inherited Retinal Diseases
This prospective, observational investigation seeks to delineate the interplay between chromatic vision deficits and both functional visual outcomes and anatomical retinal biomarkers in individuals affected by Inherited Retinal…
- Conditions
- Retinal Dystrophies, Color Vision Defects, Vision Disorders, Macular Degeneration
- Trial name
- MojiLVCDT (NCT07085533)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Augelux Therapeutics
Macular Edema, Cystoid, Uveitis
Vascular Endothelial Growth Factor (VEGF) in Uveitis
This study will look for the presence in blood of a substance called vascular endothelial growth factor (VEGF) in patients with uveitis (eye inflammation).
- Trial name
- NCT00001738
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Age-Related Macular Degeneration
Feasibility Study of a Remote Behavioral Dietary Intervention in Patients With Early to Intermediate AMD: Glucose Lowering for Vision Extension
The primary goal of the study is to test dietary intervention at glycemic control and carotenoid levels in participants with intermediate age-related macular degeneration.
- Trial name
- GLOVE (NCT07605468)
- Testing
- Low glycemic Mediterranean diet behavioral modification
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Stanford University
Retinitis Pigmentosa
Safety and Efficacy of the Alpha AMS Subretinal Implant
The aim of this single-centre study is to assess the safety and efficacy of the Retina Implant Alpha AMS (Retina Implant AG, Reutlingen, Germany) in participants with severe visual impairment secondary to outer retinal…
- Trial name
- OX-RI (NCT02720640)
- Testing
- Implant 'on' vs implant 'off'
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Visual Impairment
Post-market Evaluation of OdySight App to Monitor Near Visual Acuity at Home (TIL002)
OdySight is a mobile application allowing self-testing of visual parameters including near visual acuity and communication of the data to an online dashboard to patient's doctors.
- Trial name
- TIL002 (NCT05510479)
- Testing
- Software as medical device
- Where
- 3 sites in France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Tilak Healthcare
Age Related Macular Degeneration
Life Style and Food Habits Questionnaire in the Portuguese Population Aged 55 or More
The study population will be selected from the "Epidemiological study on the prevalence of Age related Macular Degeneration in Portugal" (Protocol N.
- Trial name
- NCT01715870
- Testing
- Life style and food habits questionnaire
- Where
- Portugal
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Age Related Cognitive Decline, Age Related Macular Degeneration
Walnuts and Healthy Aging
This will be a systematic investigation of the role of walnuts in preventing or slowing age related cognitive decline and age related macular degeneration.
- Trial name
- WAHA (NCT01634841)
- Testing
- Walnuts, habitual diet
- Where
- 2 sites in United States, Spain
- Volunteers
- 708 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Age Related Macular Degeneration
Effect of Oral Curcumin Supplementation in Dry Age-related Macular Degeneration (AMD) Patients
Nutrition plays an important role in preventing progression of dry age related macular degeneration (AMD), a disease of aging that leads to drusen deposits in the macula causing significant decrease in vision.
- Trial name
- NCT04590196
- Testing
- Longvida curcumin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Dry AMD, Diabetic Retinopathy (DR)
Microperimetry Changes in Retinal Function in Macular Disorders
The purpose of this study is to measure precisely how sensitive the central part of the retina - the light-sensitive film at the back of the eye, is to light.
- Trial name
- MAIAStud (NCT07170683)
- Testing
- MAIA Microperimetry, Microperimetry, Visual Acuity Measurement (logMAR)
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Macular Edema
Use of Diagnostic Dye to Identify Areas of Leakeage,in the Retina, Prior to Receiving Focal Laser Treatment
The use of Indocyanine green diagnostic dye will identify areas of vascular leakage which will provide more effective laser treatment by targeting these specific areas.
- Trial name
- NCT01792141
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Retina Institute of Hawaii
Age-Related Macular Degeneration
The Role of Complement Factor H Polymorphism in the Regulation of Choroidal Vascular Tone in Young Healthy Subjects
Age related macular degeneration (AMD) is a multifactorial disease with a strong genetic component. Given that it is known that impaired regulation of choroidal vascular tone is present in patients with AMD, the current study…
- Trial name
- NCT02102880
- Testing
- the polymerase chain reaction (PCR)
- Where
- Austria
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Mitochondrial Diseases, Mitochondrial Respiratory Chain Deficiencies
A Phase Ia/Ib, SAD and MAD Study of of KL1333 in Healthy Subjects and Patients With Primary Mitochondrial Disease
This will be a double blind, randomised, placebo controlled, single and multiple oral dose study conducted in 3 parts: Part A, Part B and Part C.
- Conditions
- Mitochondrial Diseases, Mitochondrial Respiratory Chain Deficiencies, MELAS Syndrome, Mitochondrial Myopathies
- Trial name
- NCT03888716
- Testing
- KL1333
- Where
- 2 sites in United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Abliva AB