Clinical trials: Retinal Disease, Electroretinogram
Age Related Macular Degeneration
Treatment of AMD With Rheohemapheresis /RHF/
In this research rheohemapheresis will be used for the treatment of patients with high-risk dry form of age-related macular degeneration.
- Trial name
- TARHF (NCT01943396)
- Testing
- rheohemapheresis
- Where
- Czechia
- Volunteers
- 36 people
- Sponsor
- University Hospital Hradec Kralove
Electroretinography
The Electroretinogram in Healthy and Glucose Intolerant Young Men
The purpose is to investigate the electroretinogram (ERG) in young, healthy men in the normoglycaemic and hyperglycaemic state before and after intervention with corticosteroids treatment, high calorie diet and exercise restraint.
- Trial name
- NCT01140932
- Testing
- Prednisolone, Lifestyle change
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Central Serous Chorioretinopathy
Comparison of Multifocal Electroretinogram Assessment in Chronic Central Serous Chorioretinopathy (CSC) Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy
This study is a comparison of multifocal electroretinogram assessment between the laser treatment group and the photodynamic therapy group in chronic central serous chorioretinopathy.
- Trial name
- NCT00803517
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Samsung Medical Center
Macular Degeneration
The Effect of Intravitreal Avastin on the Retina Measured by Electroretinogram
To evaluate the scotopic and photopic ERG responses before and after one month of intravitreal avastin injection in patients with choroidal neovascularization.
- Trial name
- NCT00478530
- Testing
- ELECTRORETINOGRAM
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Retinal Detachment
Correlation Between OCT and mFERG Findings With VA After Vitrectomy Surgery for Retinal Detachment
Correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity after vitrectomy surgery for Retinal detachment.
- Trial name
- NCT05993208
- Testing
- optical coherence tomography,multifocal electroretinogram. VA measurment
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- New Valley University
Retinitis Pigmentosa
Cone Rescue in Retinitis Pigmentosa by the Treatment of Lycium Barbarum
Objectives: To study the immediate effect and the persistent effect of Lycium barbarum (LB) treatment on retinal functions, especially the cone function, and retinal structure in patients with retinitis pigmentosa (RP) Design…
- Trial name
- NCT02244996
- Testing
- Lycium Barbarum
- Where
- Hong Kong
- Volunteers
- 50 people
- Sponsor
- The Hong Kong Polytechnic University
Diabetic Retinopathy
Performance of the Electroretinogram, Performed and Interpreted by an Advanced Practice Nurse, in the Screening for Diabetic Retinopathy.
Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus and the leading cause of preventable blindness in working-age individuals. Early screening for DR is a public health issue.
- Trial name
- ERGDIAB (NCT06782997)
- Testing
- Electroretinogram
- Where
- France
- Volunteers
- 270 people
- Sponsor
- CHU de Reims
Retinal Degeneration, Retinitis Pigmentosa
Stem Cells Therapy in Degenerative Diseases of the Retina
The purpose of this study is to test the safety and effectiveness of an autologous bone marrow-derived stem/progenitor cells administered intravitreously in the subjects with degenerative diseases of the retina.
- Conditions
- Retinal Degeneration, Retinitis Pigmentosa, Age Related Macular Degeneration, Stargardt Disease 1
- Trial name
- NCT03772938
- Testing
- Stem/progenitor cells transplantation
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Pomeranian Medical University Szczecin
Primary Open Angle Glaucoma
Electroretinogram and Retinal Vascular Changes After Cataract Surgery
To compare electrophysiological and Optical coherence tomography angiography of optic disc and macula changes after uneventful phacoemulsification between normal and cataractus patients with primary open angle glaucoma.
- Trial name
- NCT05871034
- Testing
- phacoemulsification
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Hydroxychloroquine Retinopathy
Novel ERG for Detection of Hydroxychloroquine Retinopathy
The purpose of the study is to investigate novel electroretinography (ERG) devices in the detection of hydroxychloroquine retinopathy.
- Trial name
- NCT06035887
- Testing
- Hand-Held Full-Field Skin-Electrode Electroretinography (Device to be evaluated), Trolley-Mounted Multifocal Skin-Electrode Electroretinography (Device to be evaluated), Spectral-Domain Optical Coherence Tomography (Standard of Care test)
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- King's College Hospital NHS Trust
Retinitis Pigmentosa
Biomarkers in Retinitis Pigmentosa
The objective of this study is to discover biomarkers that demonstrate a correlation between the severity of retinitis pigmentosa (RP) and the thickness of the retinal pigment epithelium (RPE).
- Trial name
- RPMARKER (NCT06306690)
- Testing
- OCT, OCT angiography, flicker ERG and Ultra Wide Field retinography and autofluorescence.
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Smith-Lemli-Opitz Syndrome, Cone-Rod Dystrophy
Cholesterol and Antioxidant Treatment in Patients With Smith-Lemli-Opitz Syndrome (SLOS)
Patients with biochemically confirmed SLOS are being treated with cholesterol supplementation and antioxidant medication. They are carefully monitored with visits to clinic, laboratory testing including cholesterol and…
- Conditions
- Smith-Lemli-Opitz Syndrome, Cone-Rod Dystrophy, Hearing Loss
- Trial name
- NCT01773278
- Testing
- Antioxidants, Cholesterol
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Parkinson Disease, Healthy Adult Participants
Brain Dopamine Biomarker
This study is being conducted at the Morsani College of Medicine to determine whether signals recorded from the eyes and brain can be used as a noninvasive way to monitor dopamine function.
- Trial name
- B3-4D (NCT07748715)
- Testing
- Levadopa/Carbidopa eyedrops, Levodopa/Carbidopa (Sinemet)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Glaucoma, Homocysteinemia
Effect of Vitamin Supplementation in Glaucoma Patients
The impact of targeted vitamin supplementation on retinal venous pressure (RVP) and steady state pattern ERG (SSpERG) in patients with RVP 15mmHg or more above intra-ocular pressure (IOP) and serum homocystein 12µmol/l or more…
- Conditions
- Glaucoma, Homocysteinemia, Elevated Retinal Venous Pressure, Abnormal Steady State Pattern Electroretinography
- Trial name
- NCT05080153
- Testing
- Ocufolin forte
- Where
- Belgium
- Volunteers
- 26 people
- Sponsor
- Devogelaere Vision
Age-Related Macular Degeneration, Retinal Function
Ranibizumab Short- and Log-term Effects on Retinal Function in wAMD
Multifocal-electroretinoram (ERG) and microperimetry are objective criteria to asses retinal function. No information besides visual acuity exist for the development of retinal function during the course of wet AMD during therapy…
- Trial name
- LucERG (NCT01269151)
- Testing
- Lucentis (Ranibizumab)
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Luebeck
PTSD, Posttraumatic Stress Disorder
Biomarkers in the Retina for Prognosticating Mental Health Treatments
Title: ERG as a potential biomarker of SSRI-responsive PTSD: A pilot study Posttraumatic stress disorder (PTSD) affects many individuals who experience a traumatic event.
- Trial name
- BRIGHT (NCT06363968)
- Testing
- RETeval
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Puget Sound Health Care System
Major Depressive Disorder
Study of Electrophysiological Markers of Antidepressants in Major Depressive Disorder
Major depressive disorder (MDD) is a frequent and particularly disabling disorder. The efficacy of current antidepressants is limited, with 50-60% of patients not achieving a sufficient response to treatment.
- Trial name
- MESANTIDEP (NCT06532604)
- Testing
- Electroretinography (ERG)
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Centre Psychothérapique de Nancy
Proliferative Diabetic Retinopathy, Diabetic Retinopathy
Single Session vs Multiple-Session Panretinal Photocoagulation for Treatment of Proliferative Diabetic Retinopathy
Proliferative diabetic retinopathy (PDR) is the leading cause for blindness in working-age adults. The current gold standard treatment for PDR is panretinal photocoagulation (PRP).
- Conditions
- Proliferative Diabetic Retinopathy, Diabetic Retinopathy, Diabetic Retinopathy Visually Threatening, Diabetic Macular Edema
- Trial name
- SMART-PRP (NCT06549023)
- Testing
- Single-session panretinal PRP (SS-PRP), Multiple-session panretinal PRP (MS-PRP)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Primary Open Angle Glaucoma, Ocular Hypertension
Effect of Epigallocatechin-Gallate on Inner Retinal Function in Ocular Hypertension and Early Glaucoma
The present study attempts to evaluate the potential beneficial effects of a flavonoid, the epigallocatechingallate, on retinal ganglion cell function, evaluated by pattern electroretinogram, in subjects with ocular hypertension…
- Trial name
- NCT00476138
- Testing
- Epigallocatechin-gallate
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Catholic University of the Sacred Heart
Retinal Diseases
Effect of Levodopa on Human Multifocal Electroretinogram
It is known that dopamine is a functional neuromodulator at several levels of the visual system. Dopamine seems to be involved in the organization of the ganglion cell and the bipolar cell receptive fields and modulation of…
- Trial name
- NCT00812760
- Testing
- levodopa
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna