Clinical trials: Retinal Disorder
Retinal Artery Occlusion
Long-term Clinical Outcomes After Retinal Artery Occlusion
Retinal artery occlusion (RAO) is a rare but vision-threatening vascular disorder that is commonly caused by embolic events originating from the heart or carotid arteries.
- Trial name
- CVO-RAO (NCT07482228)
- Testing
- retinal artery occlusion
- Where
- South Korea
- Volunteers
- 15,000 people
- Sponsor
- Chonnam National University Hospital
Diabetic Retinopathy
Pharmacological Intervention in Diabetic Retinopathy
The purpose of this study is to determine if diabetic retinopathy can be treated with prostaglandin analogues, prostaglandin synthesis inhibitors or carbonic anhydrases inhibitors.
- Trial name
- XAVOT (NCT00619034)
- Testing
- Latanoprost, diclofenac and dorzolamide (eyedrops), Diclofenac, Dorzolamide
- Where
- Denmark
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Age Related Macular Degeneration
Correlation Between Visual Field Defects on FORESEE HOME and on Optical Coherence Tomography in Choroidal Neovascularization Subjects
The FORESEE HOME is used in the recent years to detect Age-related Macular Degeneration (AMD) lesions. The device is capable of differentiation as to stages of AMD and early detection of changes including choroidal…
- Trial name
- NCT00884637
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Notal Vision Ltd.
Retinoschisis, Macular Detachment
Effects of Macular Buckle Versus Vitrectomy on Macular Schisis and Macular Detachment in Highly Myopic Eyes
Macular schisis associated with macular detachment is a one of the complications of high myopia. There is controversy in the primary treatment for this situation.
- Conditions
- Retinoschisis, Macular Detachment, High Myopia
- Trial name
- NCT03023800
- Testing
- Macular buckling, Vitrectomy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sun Yat-sen University
Retinitis Pigmentosa Syndrome
Evaluation of the Visual Field on the Ground
Retinopathy pigmentosa (which affects about 40,000 patients in France) leads to destruction of the peripheral retina. This condition, often familial, frequently affects young patients.
- Trial name
- ECVS (NCT03989622)
- Testing
- evaluation of the visual field on the ground
- Sponsor
- University Hospital, Limoges
Diabetic Macular Edema
NSAID Phase II for Non-central Involved Diabetic Macular Edema (DME)
This study is being conducted to assess the effects of topical nonsteroidal anti-inflammatories (NSAIDs) on macular retinal volume compared with placebo in eyes with non-central diabetic macular edema (DME).
- Trial name
- NCT01331005
- Testing
- nepafenac 0.1% drops, Nepafenac Vehicle
- Where
- 32 sites in United States
- Volunteers
- 125 people
- Sponsor
- Jaeb Center for Health Research
Central Serous Chorioretinopathy
High-dose Antioxidants for Central Serous Chorioretinopathy
Central serous chorioretinopathy (CSC) is the serous neurosensory detachment that usually involves the macular area. It is common in patients between 30-50 years old and effects male more often than female with the ratio of 5-10.
- Trial name
- NCT00963131
- Testing
- antioxidants tablets
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Prince of Songkla University
Dry Age Related Macular Degeneration
The Safety and Tolerability of Sub-retinal Transplantation of SCNT-hES-RPE Cells in Patients With Advanced Dry AMD
To evaluate the safety and tolerability of human somatic cell nuclear transfer embryonic stem cell derived retinal pigmented epithelial(SCNT-hES-RPE) cellular therapy in patients with advanced dry AMD
- Trial name
- NCT03305029
- Testing
- SCNT-hES-RPE Cells
- Where
- South Korea
- Volunteers
- 3 people
- Sponsor
- CHA University
Eye Diseases, Macular Degeneration
Study Evaluating the Safety, Pharmacokinetics and Pharmacodynamics of OPT-302 With or Without Lucentis™ in Patients With Wet AMD
The purpose of this first-in-human study is to evaluate the safety, pharmacokinetics (PK) and pharmacodynamics of OPT-302 administered as monthly intravitreal injections for 3 months with and without Lucentis™ in patients with…
- Conditions
- Eye Diseases, Macular Degeneration, Retinal Diseases, Retinal Degeneration
- Trial name
- NCT02543229
- Testing
- OPT-302, Lucentis™
- Where
- 14 sites in United States
- Volunteers
- 51 people
- Sponsor
- Opthea Limited
Cataract, Epiretinal Membrane
Combined 25-gauge Vitrectomy and Cataract Surgery With Toric Intraocular Lens With Idiopathic Epiretinal Membrane.
Toric intraocular lens (IOL) is now widely used for the cataract surgery with preoperative corneal astigmatism. Symptomatic epiretinal membrane (ERM) is often treated with 25-gauge transconjunctival sutureless vitrectomy…
- Conditions
- Cataract, Epiretinal Membrane, Corneal Astigmatism
- Trial name
- NCT02328157
- Testing
- Vitrectomy with cataract surgery and toric IOL, Vitrectomy with cataract surgery and common IOL
- Where
- Japan
- Volunteers
- 30 people
- Sponsor
- Kagawa University
Retinitis Pigmentosa
A First-in-human, Proof of Concept Study of CPK850 in Patients With RLBP1 Retinitis Pigmentosa
The purpose of this first-in-human study is to explore the maximum tolerated dose (MTD) of CPK850 as determined by the single ascending dose ranging portion of the study.
- Trial name
- NCT03374657
- Testing
- CPK850
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Retinopathy (DR), Macular Edema (ME)
Video Intervention to Improve Understanding of Diabetic Retinopathy at Zuckerberg San Francisco General Hospital and Trauma Center
The study will evaluate whether videos can improve understanding of diabetic eye disease, and follow-up rates in the eye clinic.
- Trial name
- NCT07519707
- Testing
- Animated Videos
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, San Francisco
Training Group, Sensitivity
Developing and Testing a Low Cost Opportunistic Glaucoma Screening Model by Non-physician Graders in Vietnam
This study aims to develop a training course for screening glaucoma using fundus images obtained during diabetic retinopathy screening by non-physician graders.
- Trial name
- NCT05151757
- Testing
- A standard image training set
- Where
- Vietnam
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Macular Edema
Macular Thickness and Visual Acuity in Diabetic Hypertensive Patients
In this study, measurements of central macular thickness using optical coherence tomography along with examination of visual acuity by Snellen's chart in diabetic hypertensive patients will be done .
- Trial name
- NCT05209971
- Volunteers
- 100 people
- Sponsor
- Sohag University
Retinitis Pigmentosa, Dry Age-related Macular Degeneration
CB-PRP in Retinitis Pigmentosa and Dry Age-related Macular Degeneration
The study will provides the enrollment of patients with genetic retinal dystrophies with primary rod impairment and dry age-related macular degeneration (Geographic type) A subretinal injection of umbilical cord blood…
- Trial name
- SiCord (NCT04636853)
- Testing
- Subretinal injection of umbilical cord blood platelet-rich plasma (CB-PRP)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Retinal Artery Occlusion, Retinal Vein Occlusion
Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning
Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury.
- Trial name
- NCT02898480
- Testing
- Remote ischemic conditioning
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Retinal Vein Occlusion
Open Label Study to Assess the Efficacy and Safety of AKB-9778 in Subjects With Macular Edema Due to RVO
Phase 2a open-label study to assess the efficacy and safety of subcutaneous 15mg AKB-9778 administered twice daily for 84 days in subjects with macular edema due to RVO.
- Trial name
- NCT02387788
- Testing
- AKB-9778
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Aerpio Therapeutics
Diabetic Retinopathy
Multicenter Diagnostic Clinical Performance Study For Automated Detection of Diabetic Retinopathy
This study is a retrospective study to assess the efficacy and accuracy of the EyeCheckup software in screening for diabetic retinopathy in healthcare settings.
- Trial name
- NCT05471986
- Testing
- Color Fundus Photography/Non-Mydriatic Opthalmic Cameras
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Ural Telekomunikasyon Sanayi Ticaret Anonim Sirketi
Angioid Streaks
Ranibizumab Therapy for Choroidal Neovascularization (CNV) Asociated With Angioid Streaks
The purpose of this study is to determine whether injections of ranibizumab into the eye are safe and well tolerated when given to subjects in multiple doses.
- Trial name
- NCT01015495
- Testing
- ranibizumab
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Proliferative Vitreoretinopathy
"Comparing Methotrexate Usage Techniques to Prevent Proliferative Vitreoretinopaty After Retinal Detachment Vitrectomy"
This clinical trial, involving participants with rhegmatogenous retinal detachment, aims to compare Methotrexate Usage Techniques in preventing Proliferative Vitreoretinopathy (PVR) after vitrectomy.
- Trial name
- NCT06289205
- Testing
- Methotrexate
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- University of Health Sciences Lahore
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