Clinical trials: Retinal Disorder
Age-Related Macular Degeneration
Natural History of Geographic Atrophy Associated With Age-Related Macular Degeneration
Background: Age-related macular degeneration (AMD) affects the macula in the eye. This is the central part of the retina. It is needed for sharp, clear vision and activities like reading and driving.
- Trial name
- NCT02941263
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Eye Institute (NEI)
Retinal Degeneration
Quality of Life Measures in Patients With Retinal Degeneration
Inherited retinal degeneration (IRD) is a major cause of blindness and partial loss of vision cases in the UK and starts at an early age.
- Trial name
- NCT02814435
- Testing
- Questionnaire, Computerised contrast sensitivity function test
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Carcinoid, Neuroendocrine
Safety Study of Seneca Valley Virus in Patients With Solid Tumors With Neuroendocrine Features
The primary purpose of the study is to determine if Seneca Valley Virus may be administered safely to patients with certain types of advanced cancer.
- Trial name
- NCT00314925
- Testing
- Seneca Valley Virus (biological agent)
- Where
- 10 sites in United States
- Volunteers
- 60 people
- Sponsor
- Neotropix
Diabetic Retinopathy Grading
Smartphone-based Ophthalmoscopy
A subset of 120 diabetic patients underwent dilated examination and smartphone ophthalmoscopy. The smartphone was equipped with a compact add-on that filtered and delivered the smartphone's LED light coaxially to the camera…
- Trial name
- NCT02177747
- Testing
- Ophthalmoscopy conducted using a smartphone equipped with a compact addon, Smartphone
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Università degli Studi di Brescia
Retinoblastoma
Intra-arterial Chemotherapy(Chemosurgery) for Retinoblastoma
Conventional treatments of retinoblastoma involves laser photocoagulation, cryotherapy (freezing of the tumor), plaque radiotherapy,external beam radiotherapy, and intravenous chemotherapy.
- Trial name
- Chemosurgery (NCT00901238)
- Testing
- Intra-arterial Chemotherapy
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Weill Medical College of Cornell University
Diabetes Complications
Retinal Microvasculature by Optical Coherence Tomography Angiography During Integrating Physical Activity in Diabetic Subjects.
Diabetic retinopathy is a common condition of diabetes and can lead to blindness, making it one of the most feared complications of diabetes.
- Trial name
- OCTACTIPH (NCT05645068)
- Testing
- Optical Coherence Tomography Angiography, multidisciplinary care program
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse
Air or Gas Embolism, Carbon Monoxide Poisoning
Hyperbaric Oxygen Therapy Registry
The purpose of the Hyperbaric Oxygen Therapy Registry (HBOTR) is to provide real world patient outcome and side effect information from electronic health records submitted to a specialty specific hyperbaric registry as part of…
- Conditions
- Air or Gas Embolism, Carbon Monoxide Poisoning, Clostridial Myositis and Myonecrosis (Gas Gangrene), Crush Injury, Compartment Syndrome & Other Acute Traumatic Ischemias
- Trial name
- HBOTR (NCT02483650)
- Volunteers
- 5,000 people
- Sponsor
- U.S. Wound Registry
Age-related Macular Degeneration
A Study of Ranibizumab Administered Monthly or on an As-needed Basis in Patients With Subfoveal Neovascular Age-related Macular Degeneration (HARBOR)
This is a Phase III, multicenter, randomized, double-masked, dose-comparison study of the efficacy and safety of ranibizumab injection administered intravitreally to patients with choroidal neovascularization (CNV) secondary to…
- Trial name
- HARBOR (NCT00891735)
- Testing
- Ranibizumab
- Where
- 99 sites in United States
- Volunteers
- 1,097 people
- Sponsor
- Genentech, Inc.
Congenital Cataract
Relationship of Retinal and Visual Cortex Structure and Visual Acuity After Congenital Cataract Surgery
To evaluate the influence of the visual acuity after congenital surgery on the retinal and visual cortex structure.
- Trial name
- NCT04976608
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Wenzhou Medical University
Wet Macular Degeneration
Brolucizumab vs. Aflibercept for Retinal Angiomatous Proliferation
This is a prospective randomised study comparing two intravitreal antiVEGF drugs - brolucizumab and aflibercept - in the treatment of retinal angiomatous proliferation (RAP).
- Trial name
- BEY-RAP (NCT04698850)
- Testing
- Aflibercept 40 MG/ML [Eylea], Brolucizumab-Dbll 120 MG/ML [Beovu], Ranibizumab 6 MG/ML [Lucentis]
- Where
- Czechia
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Macular Edema, Central Retinal Vein Occlusion
Comparison of Initial Ozurdex (Dexamethasone Implant) to Avastin (Bevacizumab) for Treatment of Macular Edema Caused by Central Retinal Vein Occlusion (CRVO)
The purpose of this study is to compare visual improvement and total number of intraocular injections in eyes with macular edema following central retinal vein occlusion (CRVO)after initial treatment with Ozurdex (dexamethasone…
- Trial name
- NCT01231633
- Testing
- Ozurdex, Avastin
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- Long Island Vitreoretinal Consultants
Epiretinal Membrane, Macular Pucker
Intraoperative Analysis of the Central Retina in ERF
Changes in the retinal anatomy that occur in epiretinal fibrosis have not been sufficiently studied. It is possible that epiretinal fibrosis leads not only to traction dislocation of the macula, but also to ILM anatomical…
- Trial name
- NCT04802915
- Testing
- Intraoperative ERM and ILM staining with their assessment and removal
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- The S.N. Fyodorov Eye Microsurgery State Institution
Cardiac Catheterization, Retina
Clinical Significance of Retinal Emboli During Diagnostic and Therapeutic Cardiac Catheterization
Retinal emboli is a common phenomenon in cardiac catheterization. In this study the investigators evaluate the incidence of retinal emboli post diagnostic and therapeutic cardiac catheterization over 300 patients.
- Conditions
- Cardiac Catheterization, Retina, Embolism
- Trial name
- NCT01157338
- Testing
- diagnostic cardiac catheterization, therapeutic cardiac catheterization
- Where
- Iran
- Volunteers
- 300 people
- Sponsor
- Shiraz University of Medical Sciences
Age-Related Macular Degeneration
Brain Connectivity in Age-Related Macular Degeneration
This study is to determine how cognitive deficits (e.g.,verbal fluency deficit) in patients with Age-Related Macular Degeneration (AMD) relate to specific aspects of brain and function.
- Trial name
- NCT01996215
- Where
- United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Duke University
Purtscher Retinopathy, Pancreatic Cancer
An Unusual Association Between Pancreatic Cancer and Purtscher-like Retinopathy
AN UNUSUAL ASSOCIATION BETWEEN PANCREATIC CANCER AND PURTSCHER-LIKE RETINOPATHY
- Trial name
- NCT05350384
- Testing
- Methylprednisolone
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- University of Catania
Epiretinal Membrane
Quantification of Metamorphopsia in Patients With Epiretinal Membranes
Aim of this study is to examine metamorphopsia before and 3 months after vitrectomy with membrane peeling among patients with idiopathic epiretinal membranes.
- Trial name
- NCT05138315
- Testing
- Metamorphopsia quantification
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Retinopathy of Prematurity (ROP)
Analyzing Retinal Microanatomy in Retinopathy of Prematurity to Improve Care
Retinopathy of prematurity (ROP) is a disorder of development of the retina and its vasculature that can impact vision in vulnerable preterm neonates for a lifetime.
- Trial name
- (BabySTEPS3) (NCT07738874)
- Testing
- Ultra-widefield Optical Coherence Tomography (UWF-OCT), Wide-field ophthalmic imaging system
- Where
- 2 sites in United States
- Volunteers
- 175 people
- Sponsor
- Duke University
Macular Edema, Diabetic Mellitus
A Phase 3 Study To Compare The Efficacy And Safety Of 0.3 MG Pegaptanib Sodium To Sham Injections In Subjects With Diabetic Macular Edema
The purpose of the study to assess the efficacy of pegaptanib sodium 0.3 mg comparing sham injection and to confirm safety of pegaptanib sodium 0.3 mg in subjects with diabetic macular edema.
- Conditions
- Macular Edema, Diabetic Mellitus, Retinal Disease
- Trial name
- NCT01100307
- Testing
- pegaptanib sodium
- Where
- 43 sites in Japan
- Volunteers
- 243 people
- Sponsor
- Pfizer
Branch Retinal Vein Occlusion
Evaluation of Macugen Treatment of Macular Edema Due to Branch Retinal Vein Occlusion
The purpose of this study is to evaluate the effect of intravitreal injections of Macugen every 6 weeks for the treatment of macular edema secondary to branch retinal vein occlusion (BRVO).
- Trial name
- NCT00406107
- Testing
- pegaptanib sodium (Macugen)
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Palmetto Retina Center, LLC
Macular Degeneration Advanced, Macular Degeneration, Senile
Visual Rehabilitation Through Acoustic Biofeedback With Retimax Vision Trainer in Patients With Advanced Age-related Macular Degeneration
At present there are no real therapies able to improve visual performance in patients with age-related macular degeneration, atrophic type.
- Conditions
- Macular Degeneration Advanced, Macular Degeneration, Senile, Macular Degeneration, Dry, Macular Scar
- Trial name
- NCT04084587
- Testing
- Retimax Vision Trainer
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- University of Modena and Reggio Emilia