Clinical trials: Retinal Disorder
Macular Edema
Comparison of the Effects of Bevacizumab Before vs After Pattern Panretinal Photocoagulation
Compare the effect of an intravitreal injection of bevacizumab previous or posterior of panretinal laser photocoagulation (PRLP) with a pattern laser; to prevent and reduce diabetic macular edema (DME) in patients with…
- Trial name
- NCT00804206
- Testing
- bevacizumab
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- Asociación para Evitar la Ceguera en México
Stargardt Disease
Phase 1/2 Open-Label Dose-Escalation Study to Evaluate Safety of a Single Intravitreal Injection of RTx-021 in Patients With Stargardt Disease
A Phase 1/2, open-label, non-randomized, dose-escalation study, where a minimum of 9 and a maximum of 18 eligible patients with Stargardt Disease will be enrolled sequentially in up to 3 dose cohorts of RTx-021.
- Trial name
- AURORA (NCT07439887)
- Testing
- RTx-021
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Ray Therapeutics, Inc.
Infant, Premature, Leukomalacia, Periventricular
Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants
Periventricular leukomalacia (PVL) is one of the most common brain injuries that occur in preterm infants. Inflammation, hypoxia-ischemia, free oxygen radical formation and excitotoxicity are all known pathogenic mechanisms that…
- Conditions
- Infant, Premature, Leukomalacia, Periventricular, Intraventricular Hemorrhage, Retinopathy of Prematurity
- Trial name
- NCT00910234
- Testing
- recombinant human erythropoietin (rhEpo), Normal saline
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- China Medical University Hospital
Macular Edema, Diabetic Retinopathy
Effectiveness of Oral Acetazolamide, Brimonidine Tartarate, and Anterior Chamber Paracentesis in Intraocular Pressure (IOP) After Bevacizumab
Purpose: To evaluate the effects of anterior chamber paracentesis, brimonidine and oral acetazolamide to reduce intra-ocular pressure (IOP) variations after intravitreal bevacizumab injection (IVBV).
- Conditions
- Macular Edema, Diabetic Retinopathy, Macular Degeneration
- Trial name
- NCT00804921
- Testing
- bevacizumab, anterior chamber paracentesis, acetazolamide
- Where
- Brazil
- Sponsor
- University of Sao Paulo
Radiation Retinopathy, Macular Edema
Intravitreal Aflibercept Injection for Radiation Retinopathy
The purpose of this study is to assess the safety of intravitreal aflibercept injection - in the treatment of macular edema associated with retinopathy secondary to previous radiation therapy.
- Trial name
- NCT01579760
- Testing
- Aflibercept every 2 months, Aflibercept monthly
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Washington University School of Medicine
Wet Macular Degeneration, Wet Age-related Macular Degeneration
Ziv-aflibercept Efficacy in Better Regulating AMD
This is a randomized, open-label, interventional, controlled study to determine the effects of Zaltrap on Neovascularized Wet Macular Degeneration as compared to the control anti-vascular endothelial growth factor ("anti-VEGF")…
- Trial name
- ZEBRA (NCT03423823)
- Testing
- Ziv-Aflibercept 25 MG/ML [Zaltrap], Ranibizumab
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Kapil Kapoor
Central Retinal Vein Occlusion
Assessing the Efficacy and Safety of Brolucizumab Versus Aflibercept in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion
The purpose of this study was to evaluate the efficacy and safety of brolucizumab in treatment of patients with macular edema (ME) secondary to central retinal vein occlusion (CRVO).
- Trial name
- RAVEN (NCT03810313)
- Testing
- Brolucizumab 6 mg, Aflibercept 2 mg
- Where
- 120 sites in United States, Australia and 18 more
- Volunteers
- 493 people
- Sponsor
- Novartis Pharmaceuticals
Non Proliferative Diabetic Retinopathy
Pars-plana Vitrectomy vs Panretinal Photocoagulation for Severe NPDR
It is estimated that there are about 600 million diabetes mellitus (DM) patients all over the world until 2040，and almost 50% of whom have some degree of diabetic retinopathy (DR) at any given time.
- Trial name
- NCT04103671
- Testing
- Prompt panretinal photocoagulation, 25G Pars-plana vitrectomy
- Where
- China
- Volunteers
- 272 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Pediatric Retinoblastoma, Retinoblastoma
Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients
The purpose of this study is to see if there is a difference between the development of the brain (neurodevelopment) in children who have been treated for retinoblastoma with multiple anesthetic exposures, compared with brain…
- Trial name
- NCT03546387
- Testing
- Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V), California Verbal Learning Test, Children's Version, Beery Developmental Test of Visual Motor Integration, 6th edition
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Retinal Imaging, Cardiovascular Biomarker
High Resolution Imaging of Retinal Vessels as a Biomarker of Cardiovascular Disease in Patients With Renal Insufficiency - RI
The objectives are to better understand, in the dialysis patient, the relationships between microvascular morphometry and cardiovascular events, survival, arterial hypertension, the pathology responsible for renal failure, the…
- Conditions
- Retinal Imaging, Cardiovascular Biomarker, Renal Insufficiency
- Trial name
- IRIR (NCT04116814)
- Testing
- wall-to-lumen ratio measurement
- Where
- France
- Volunteers
- 83 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Retinal Detachment
Evaluation of Neuroprotective Effect of Minocycline
This process appears as a incredible and progressive event that will not stop till reattachment of RPE and neurosensory retina happened .
- Trial name
- minocyclin &RD (NCT01297816)
- Testing
- Minocycline
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Epiretinal Membrane
Evolution of EIFL Following PPV
Various classification systems have been described for epiretinal membrane (ERM). One of them is a new OCT-based staging scheme based on displacement and reorganization of inner retinal layers called ectopic inner retinal layers…
- Trial name
- NCT06040216
- Testing
- optical coherence tomography
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Kocaeli University
Diabetic Proliferative Retinopathy, Vascular Vein Oclussion
Multifocal Electrophysiologic Findings After Intravitreal Bevacizumab(Avastin)Treatment
Purpose: Determine the short-term safety of intravitreal bevacizumab by multifocal electroretinography (mf-ERG). Methods: 120 eyes with choroidal neovascularization, proliferative diabetic retinopathy and retinal vein occlusion…
- Conditions
- Diabetic Proliferative Retinopathy, Vascular Vein Oclussion, Choroidal Neovascularization
- Trial name
- NCT00417833
- Testing
- Intravitreal Bevacizumab
- Sponsor
- Asociación para Evitar la Ceguera en México
Geographic Atrophy
Intravitreal Injections of Sirolimus in the Treatment of Geographic Atrophy
This study will seek to enroll 50 persons who have central or non-central geographic atrophy (GA) associated with age-related macular degeneration (AMD). GA in treated eye must be between 0.75 disk areas (DA) and 8 DA.
- Trial name
- Sirolimus (NCT01675947)
- Testing
- Sirolimus, Lidocaine
- Where
- 13 sites in United States
- Volunteers
- 52 people
- Sponsor
- National Eye Institute (NEI)
Canthaxanthin Retinopathy
Canthaxanthin Retinopathy: A Long-term Observation
Canthaxanthine is a naturally occurring carotenoid that has been a popular over-the-counter oral artificial tanning agent in Europe, Canada, and Australia since 1979.
- Trial name
- NCT01128062
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- University of Cologne
Twin Pregnancy, Antepartum Condition or Complication, Retinal Vascular
Comparison of Posterior Ocular Changes Between Singleton Pregnancy and Multifetal Pregnancy.
It has been known that a pregnant women undergoes significant anatomical and physiological changes that mainly caused by hormonal and hematologic changes during pregnancy.
- Conditions
- Twin Pregnancy, Antepartum Condition or Complication, Retinal Vascular, Choroidal Effusion
- Trial name
- NCT04773561
- Testing
- Corneal tomography, optical coherence tomography and optical coherence tomography angiography
- Where
- Thailand
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Central Serous Chorioretinopathy
Intravitreal Bevacizumab for the Treatment of Central Serous Chorioretinopathy
Central serous chorioretinopathy (CSC) has been known since it was first described by Von Graefe and termed "idiopathic detachment of the macula" in 1866, is a well-characterized disorder leading to serous neurosensory elevation…
- Trial name
- NCT00418431
- Testing
- Intravitreal injection of Bevacizumab
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Diabetic Macular Edema of Both Eyes (Diagnosis), Diabetic Retinopathy Visually Threatening
Shanghai Cohort Study of Diabetic Eye Disease
To describe the design, methodology and baseline characteristics of the Shanghai Cohort study of Diabetic Eye disease (SCODE) study, a community-based study to determine the prevalence and impact of diabetic eye disease…
- Trial name
- SCODE (NCT03665090)
- Testing
- Diabetic eye disease screening
- Volunteers
- 8,000 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Central Serous Choroidopathy
Micropulse 577nm Laser vs Traditional Laser Treatment in Central Serous Chorioretinopathy
The purpose of this study is to observe whether micropulse laser (MPL) is noninferiority to traditional laser therapy in central serous chorioretinopathy.
- Trial name
- NCT02735213
- Testing
- 577-MPL, TLT
- Where
- China
- Volunteers
- 88 people
- Sponsor
- The Eye Hospital of Wenzhou Medical University
Radiation Retinopathy
High Dose Intravitreal Ranibizumab for Recalcitrant Radiation Retinopathy
This study investigates the use of a high dose anti-VEGF agent for the treatment of radiation retinopathy in those patients who have recalcitrant disease.
- Trial name
- NCT01334879
- Testing
- ranibizumab 2.0 mg
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The New York Eye Cancer Center
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