Clinical trials: Retinal Disorder
Cystoid Macular Edema,, Retinal Thickening
Bromfenac BID Plus Prednisolone Acetate BID Versus Bromfenac BID Plus Prednisolone QID for the Prevention of Cystoid Macular Edema and Retinal Thickening
The objective of this study is to determine if twice-daily dosing of prednisolone (Pred Forte) is as effective as four-times-daily dosing of prednisolone for the prevention of retinal thickening and cystoid macular edema (CME)…
- Trial name
- NCT00469781
- Testing
- 2. Xibrom (Bromfenac), 1. Pred Forte
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Center For Excellence In Eye Care
Age Related Macular Degeneration
Visual Function Tests in Age-related Macular Degeneration
The goal of this study is to assess a battery of visual function tests in subjects with non-exudative age-related macular degeneration
- Trial name
- NCT03275753
- Testing
- Visual Function Tests
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- ORA, Inc.
Age-related Macular Degeneration (AMD)
Efficacy and Safety of Brolucizumab 6mg in a Treat and Extend Regimen in Patients With Neovascular Age-Related Macular Degeneration (nAMD) With Prior Anti-VEGF Exposure (PEREGRINE)
The purpose of this study is to assess whether switching nAMD patients from aflibercept to brolucizumab would permit extension of treatment intervals while maintaining treatment efficacy, thereby alleviating the treatment burden…
- Trial name
- PEREGRINE (NCT04697953)
- Testing
- brolucizumab
- Sponsor
- Novartis Pharmaceuticals
Geographic Atrophy
Safety and Tolerability Study of RO7171009 in Participants With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)
This Phase 1, open-label, multicenter study will investigate the safety and tolerability of RO7171009 following single and multiple intravitreal (ITV) administrations in patients with GA secondary to AMD.
- Trial name
- NCT03295877
- Testing
- RO7171009
- Where
- 13 sites in United States
- Volunteers
- 28 people
- Sponsor
- Genentech, Inc.
Rhegmatogenous Retinal Detachment With Grade C Proliferative Vitreoretinopathy
Comparison of Visual Outcomes of Pars Plana Vitrectomy With and Without Injection Clexane for Rhegmatogenous Retinal Detachment Proliferative Vitreoretinopathy
This interventional prospective study was conducted in the Department of Ophthalmology at Lahore General Hospital, Lahore. The study included 60 male and female patients aged 18-65 years who had rhegmatogenous retinal detachment…
- Trial name
- NCT07787377
- Testing
- Enoxaparin Sodium, Pars Plana Vitrectomy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Lahore General Hospital
Central Visual Impairment, Peripherical Visual Impairment
A Study of Taste- and Olfactory-Evoked Potentials in Patients With Visual Impairment: Taste, Smell, and Vision
Visual impairment, whether central or peripheral, may influence the plasticity of other sensory modalities, such as taste and smell.
- Conditions
- Central Visual Impairment, Peripherical Visual Impairment, Macular Retinal Dystrophy, Peripherical Macular Dystrophy
- Trial name
- GOUSTAVIS (NCT07707219)
- Testing
- Taste and smell evaluation, Recording of evoked potentials (EP)
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Retina; Change, Intraocular Pressure
Changes After Suprachoroidal Injection.
Changes after suprachoroidal injection are analyzed for statistical analysis.
- Conditions
- Retina; Change, Intraocular Pressure, Cataract, Macular Edema
- Trial name
- NCT05288192
- Testing
- Suprachoroidal triamcinolone acetonide (SCTA) injection
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Eye Diseases
Study for Collection of Aflibercept Data in Routine Practice
The French CODEX study is designed as a national database to describe, in routine medical practice, functional and anatomical responses to intravitreal Aflibercept injection, in a large population of anti-VGEF-naïve patients…
- Trial name
- CODEX (NCT02811692)
- Testing
- Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
- Where
- France
- Volunteers
- 425 people
- Sponsor
- Bayer
Retinoblastoma
Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma
Retinoblastoma (RB) is the most common intraocular tumor of childhood. Recurrent or refractory disease following therapy most often occurs due to persistence of vitreous disease and/or retinal reactivation of the main tumor mass.
- Trial name
- NCT02792036
- Testing
- Carboplatin, Maxitrol®, Focal Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- St. Jude Children's Research Hospital
Stargardt Disease
Non-interventional Long Term Follow-up Study of Participants Previously Enrolled in the STARLIGHT Study
The current study is a non-interventional long-term safety follow-up of the subjects who completed STARLIGHT, in accordance with FDA guidance on recipients of human gene therapy products.
- Trial name
- SUSTAIN (NCT06048185)
- Testing
- Gene Therapy Product-MCO-010
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Nanoscope Therapeutics Inc.
Retinal Vein Occlusion
Vascular Endothelial Growth Factor (VEGF) Levels in Retinal Vein Occlusion (RVO) During Anti-VEGF Treatment
The purpose of this study is to treat patients with retinal vein occlusion with standard of care anti-vascular endothelial growth factor therapy and to correlate levels of vascular endothelial growth factor in the anterior…
- Trial name
- NCT04707625
- Testing
- Aflibercept Ophthalmic
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Wake Forest University Health Sciences
Age-Related Macular Degeneration
Assessment of Macular Edema Using HRT Technique
Age Related Macular Degeneration (ARMD) is the most common cause of irreversible blindness in people of age 50 or older in the western populations. ARMD has two forms, the wet and the dry forms.
- Trial name
- NCT00627718
- Testing
- HRT screening for macula edema
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Macular Edema, Branch Retinal Vein Occlusion
Development of Intravitreal Ranibizumab by Determining the Pathogenesis of Macular Edema With Retinal Vein Occlusion
The purpose of this study is to evaluate the efficacy of intravitreal ranibizumab by determining the pathogenesis of macular edema, which cause a direct effect on visual function.
- Conditions
- Macular Edema, Branch Retinal Vein Occlusion, Central Retinal Vein Occlusion
- Trial name
- NCT02169648
- Testing
- ranibizumab
- Where
- 2 sites in Japan
- Volunteers
- 100 people
- Sponsor
- Tokyo Medical University
Age-Related Macular Degeneration, Choroidal Neovascularization
Value of Genetic Counseling and Testing for Patients Who Would Like to Know More About Their Personal Risk of AMD
The goals of this study are: To assess the impact of genetic testing based on how it alters behaviors, to assess the utility of serum biomarker measurement in combination with genetic testing, to assess the utility of genetic…
- Conditions
- Age-Related Macular Degeneration, Choroidal Neovascularization, Genetic Counseling
- Trial name
- NCT03024424
- Testing
- Early disclosure, Late disclosure
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Utah
Age-Related Macular Degeneration, Wet Age-Related Macular Degeneration
Safety & Tolerability of the IRay System in Subjects With Exudative Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD)
The purpose of this study is to evaluate the safety and clinical feasibility of the IRay System for the treatment of wet age-related macular degeneration (AMD).
- Conditions
- Age-Related Macular Degeneration, Wet Age-Related Macular Degeneration, Macular Degeneration, Eye Diseases
- Trial name
- NCT01217762
- Testing
- IRay
- Where
- Mexico
- Volunteers
- 62 people
- Sponsor
- Oraya Therapeutics, Inc.
Diabetic Retinopathy, Sickle Cell Trait
Diabetic Retinopathy and Sickle Trait
To more clearly ascertain the relationship between ocular manifestations of sickle cell disease and diabetes, specifically; whether the presence of sickle cell trait exacerbates the disease progression of diabetic retinopathy.
- Trial name
- NCT00720317
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Medical University of South Carolina
Macular Holes
Position Related Changes in Macular Hole Morphology Before and After Surgery
Macular hole is a full thickness retinal defect in the very centre of the retina that gives the sharpest vision. The condition causes a substantial deterioration of visual acuity, and operative measures are necessary in order to…
- Trial name
- NCT04676217
- Testing
- Postoperative positioning advice
- Where
- 2 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Helse Stavanger HF
Diabetes Mellitus, Glaucoma
Smartphone Screening for Eye Diseases
To validate new screening instruments for eye disease, increase eye care access in underserved communities, and provide a scientifically implemented method to set up programs for eye disease screening.
- Conditions
- Diabetes Mellitus, Glaucoma, Age Related Macular Degeneration, ROP
- Trial name
- NCT03076697
- Testing
- Fundus photography
- Volunteers
- 472 people
- Sponsor
- University of Michigan
Macular Degeneration, Neovascularization, Pathologic
Branch Vein Occlusion Study
To determine whether scatter argon laser photocoagulation can prevent the development of neovascularization. To determine whether peripheral scatter argon laser photocoagulation can prevent vitreous hemorrhage.
- Conditions
- Macular Degeneration, Neovascularization, Pathologic, Vitreous Hemorrhage
- Trial name
- NCT00000162
- Testing
- Macular Argon Laser Photocoagulation, Peripheral Scatter Argon Laser Photocoagulation, Scatter Argon Laser Photocoagulation
- Sponsor
- National Eye Institute (NEI)
Retinoblastoma, Retinoblastoma Bilateral
Retinoblastoma Patient Clinical Database and Tissue Repository
Retinoblastoma (RB) is a primary eye cancer that forms in the back of the eye of infants and toddlers. Traditionally, RB is diagnosed without a biopsy; tumor can only be studied once an eye has been surgically removed.
- Conditions
- Retinoblastoma, Retinoblastoma Bilateral, Retinoblastoma Unilateral
- Trial name
- NCT04959097
- Where
- 9 sites in United States, Canada
- Volunteers
- 800 people
- Sponsor
- Children's Hospital Los Angeles
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