Clinical trials: Retinal Disorders
Type I Diabetes
Measurement of Total Retinal Blood Flow in Patients With Diabetes and Healthy Subjects
The prevalence of diabetes and diabetes-associated complications is still increasing. Several major long-term complications of diabetes such as cardiovascular disease, chronic renal failure, diabetic retinopathy and others relate…
- Trial name
- NCT01843114
- Testing
- FDOCT, Dynamic Vessel Analyzer
- Where
- Austria
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
MEK Inhibitor-Associated Serous Retinopathy
Investigation of Potential Retinal Toxicity Associated With Hair Dye Products Containing pPD Type Aromatic Amines
Hair dye products could induce minimal forms of MEKAR retinopathies (Mitogen-activated Extracellular signal-regulated Kinase - inhibitors associated retinopathies).
- Trial name
- CAPITOX (NCT04222387)
- Testing
- OCT-B scan
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Hydroxychloroquine Retinopathy
Novel ERG for Detection of Hydroxychloroquine Retinopathy
The purpose of the study is to investigate novel electroretinography (ERG) devices in the detection of hydroxychloroquine retinopathy.
- Trial name
- NCT06035887
- Testing
- Hand-Held Full-Field Skin-Electrode Electroretinography (Device to be evaluated), Trolley-Mounted Multifocal Skin-Electrode Electroretinography (Device to be evaluated), Spectral-Domain Optical Coherence Tomography (Standard of Care test)
- Where
- United Kingdom
- Volunteers
- 140 people
- Sponsor
- King's College Hospital NHS Trust
Glaucoma
Retinal Nerve Fibres Layers Thickness Study in Glaucomatous Patients
In this study the investigators are going to study the retinal nerve fibers layers (RNFL) modification of two groups of patients, one taking no drugs, the other taking forskolin, rutin and vitamins B1 and B2.
- Trial name
- NCT01254006
- Testing
- forskolin, rutin and vitamins B1 and B2
- Where
- Italy
- Sponsor
- University of Roma La Sapienza
Diabetic Retinopathy
A Study That Tests BI 1467335 in Patients With Diabetic Eye Disease (Diabetic Retinopathy). It Looks at the Way BI 1467335 is Taken up, the Effects it Has, and How Well it is Tolerated.
The main objective is to evaluate ocular and systemic safety and tolerability of BI 1467335 as well as whether BI 1467335 monotherapy has a potential to improve retinal lesions in patients with moderately severe Non-proliferative…
- Trial name
- ROBIN (NCT03238963)
- Testing
- BI 1467335
- Where
- 35 sites in United States, Austria and 6 more
- Volunteers
- 79 people
- Sponsor
- Boehringer Ingelheim
Usher Syndrome, Type 1B
Study of Subretinally Injected AAVB-081 in Patients With Usher Syndrome Type IB (USH1B) Retinitis Pigmentosa
The purpose of the 081-101 study is to evaluate the safety and tolerability of a single subretinal injection of AAVB-081 in USH1B patients with retinitis pigmentosa due to a mutation in the MYO7A gene.
- Trial name
- NCT06591793
- Testing
- AAVB-081
- Where
- 3 sites in Italy, United Kingdom
- Volunteers
- 15 people
- Sponsor
- AAVantgarde Bio Srl
Retinitis Pigmentosa (RP), Age Related Macular Degeneration
Evaluating a New Peptide Therapy for Retinal Diseases: AMD, Diabetic Retinopathy, and Dystrophies
Summary of the Study This clinical trial evaluates a novel peptide-based therapy for treating retinal dystrophies, age-related macular degeneration (AMD), and diabetic retinopathy (DR).
- Conditions
- Retinitis Pigmentosa (RP), Age Related Macular Degeneration, Diabetic Retinopathy
- Trial name
- Retino (NCT06787482)
- Testing
- ACE Retino
- Where
- 2 sites in Egypt
- Volunteers
- 100 people
- Sponsor
- Ace Cells Lab Limited
Retinopathy of Prematurity, Myopia
Prematurity and Ophthalmological Changes
Ophthalmological differences in school-aged children with and without a history of retinopathy of prematurity
- Trial name
- NCT06452524
- Testing
- axial length (AU) and anterior chamber depth (ACD), optical coherence tomography (OCT)
- Where
- Turkey (Türkiye)
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Diabetic Macular Edema
Intravitreal Aflibercept InjectiOn in Vitrectomized Eyes for Treatment of Diabetic Macular Edema
This a non-interventional retrospective study on the efficiency and the tolerance of intravitreal injections of Aflibercept on vitrectomized eyes in the diabetic macular oedema
- Trial name
- MODEVA (NCT02874859)
- Where
- 8 sites in France
- Volunteers
- 49 people
- Sponsor
- Lille Catholic University
Age-related Macular Degeneration (AMD)
Intervention Trial in Early Age-related Macular Degeneration
The purpose of the I-TEAM project is to assess whether there is a change in visual function and status of the retina after a year of intervention in subjects with early signs of Age-related Macular Degeneration.
- Trial name
- I-TEAM (NCT01694680)
- Testing
- Lutein-enriched-egg beverage (NWT-02)
- Where
- 4 sites in United States, Germany and 2 more
- Volunteers
- 120 people
- Sponsor
- Newtricious R&D BV
Retinoblastoma
Can Pretreatment MRI be Used to Predict Intra-arterial Chemotherapy Response in Retinoblastoma?
Retinoblastoma is the most frequent intraocular tumor in children and represents 6% of all pediatric cancers before the age of 5 years-old. The outcome is now excellent with 95 to 97% of 5-years survival rate.
- Trial name
- PREDIR (NCT03267459)
- Testing
- Dynamic contrast-enhanced MRI
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Diabetes Mellitus, Diabetic Retinopathy
A Study to Evaluate THR-317 and Ranibizumab Combination Treatment for Diabetic Macular Oedema (DME)
This study is conducted to evaluate the safety of intravitreal THR-317 administered in combination with ranibizumab, and to assess the efficacy of the combination treatment in improving best-corrected visual acuity (BCVA) and…
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Macular Edema
- Trial name
- NCT03499223
- Testing
- Ranibizumab 0.5mg, THR-317 8mg
- Where
- 37 sites in Belgium, France and 5 more
- Volunteers
- 70 people
- Sponsor
- Oxurion
Diabetes Mellitus, Type 2
A Trial on Ophthalmologist-delivered Health Education on Top of Routine Community Care
Diabetic retinopathy affects over one third of all people with diabetes and is one of the leading causes of vision loss. The management of diabetes and its complications should include screening for diabetic retinopathy.
- Trial name
- NCT04490941
- Testing
- Ophthalmologist-delivered health education, Usual care
- Where
- China
- Volunteers
- 652 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Retinal Detachment
Comparison of Air and Expansile Gas in Pneumatic Retinopexy
The objective of the study is to evaluate the results of using air versus expansile gas (perfluoropropane) in the treatment of rhegmatogenous retinal detachment by pneumatic retinopexy, comparing the retinal reattachment rate and…
- Trial name
- NCT00120445
- Testing
- air, expansile gas
- Where
- Thailand
- Volunteers
- 126 people
- Sponsor
- Khon Kaen University
Macular Dystrophy
Correlation Between OCT and Mf-ERG Findings With BCVA in Patients With Macular Dystrophy
Correlation between optical coherence tomography and multifocal electroretinogram findings with visual acuity in patients with macular dystrophy.
- Trial name
- NCT07171541
- Testing
- OCT ,mFERG,VA test
- Volunteers
- 30 people
- Sponsor
- New Valley University
Retinal Disease
Intravitreal Bevasizumab VS Sham Treatment in Acute BRVO: A Randomized Clinical Trial
In this study we intend to evaluate the outcome of intravitreal avastin on improving the visual acuity and macular edema and late complications of BRVO like NVD and NVE
- Trial name
- NCT00370851
- Testing
- Avastin (Bevacizumab)
- Where
- Iran
- Volunteers
- 82 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Age-Related Macular Degeneration, Geographic Atrophy
Subthreshold Laser Treatment for Reticular Pseudodrusen and Geographic Atrophy Secondary to AMD
To evaluate the effectiveness of subthreshold laser treatment on retinal sensitivity in patients with reticular pseudodrusen and incipient Geographic Atrophy (GA) secondary to Age-Related Macular Degeneration (AMD).
- Conditions
- Age-Related Macular Degeneration, Geographic Atrophy, Reticular Pseudodrusen
- Trial name
- NCT02800356
- Testing
- Subthreshold 577 nm yellow wavelength laser photo-coagulator
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Ospedale San Raffaele
Subfoveal Choroidal Thickness, Intravitreal
Subfoveal Choroidal Thickness and Visual Acuity After Intravitreal Injection of Ranibizumab in Diabetic Retinopathy
The aim of this study is to compare subfoveal choroidal thickness (SFCT) and the visual status before and after intravitreal injection of ranibizumab in diabetic macular edema (DME) with the use of 3D-OCT by enhanced depth…
- Conditions
- Subfoveal Choroidal Thickness, Intravitreal, Ranibizumab, Visual Acuity
- Trial name
- NCT06173245
- Testing
- Intravitreal injection of ranibizumab
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Egyptian Biomedical Research Network
Age Related Macular Degeneration
Superoxide Dismutase (SOD) as Antioxidant Treatment OF Age Related Macular Degeneration (ARMD)
INTRODUCTION: Acting directly on the anti-radical enzyme chain, the superoxide dismutase (SOD), a major enzyme of the anti-oxidant system, provides an alternative of the antioxidants treatment in ARMD.
- Trial name
- NCT00800995
- Testing
- SOD
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Centre de Recherche en Nutrition Humaine Rhone-Alpe
Retinitis Pigmentosa
Phase III Efficacy and Safety Clinical Study of UF-021 for Treatment of Retinitis Pigmentosa
This study is a multicenter trial performed in Japan, consisting of a comparative study period and a continuous administration period.
- Trial name
- NCT01786395
- Testing
- UF-021
- Where
- 34 sites in Japan
- Volunteers
- 202 people
- Sponsor
- R-Tech Ueno, Ltd.
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