Clinical trials: Retinal Disorders
Age Related Macular Degeneration
Correlation Between Visual Field Defects on FORESEE HOME and on Optical Coherence Tomography in Choroidal Neovascularization Subjects
The FORESEE HOME is used in the recent years to detect Age-related Macular Degeneration (AMD) lesions. The device is capable of differentiation as to stages of AMD and early detection of changes including choroidal…
- Trial name
- NCT00884637
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Notal Vision Ltd.
Retinitis Pigmentosa
Long-term Safety of UC-MSC Transplantation in Patients With Retinitis Pigmentosa
The study will perform to follow-up UC-MSCs and CM transplantation. 18 patients will be called back to be examined after 5 years of UC-MSC and/or CM transplantation.
- Trial name
- NCT05786287
- Testing
- Conditioned Medium (CM), Umbilical Cord Mesenchymal Stem Cell (UC-MSC)
- Where
- 2 sites in Indonesia
- Volunteers
- 18 people
- Sponsor
- PT. Prodia Stem Cell Indonesia
Retinal Vein Occlusion, Macular Edema
Post Market Surveillance of OZURDEX® for Branch Retinal Vein Occlusion (BRVO) and Central Retinal Vein Occlusion (CRVO)
This multicenter observational study will assess the efficacy and tolerability of OZURDEX® in clinical practice, and will assess the time at which patients are considered for retreatment.
- Trial name
- NCT01568021
- Testing
- No Intervention
- Where
- 3 sites in Denmark, Norway and 1 more
- Volunteers
- 100 people
- Sponsor
- Allergan
Choroidal NeoVascularization, Age-Related Macular Degeneration
Does Vascular Endothelial Growth Factor (VEGF) or Complement Factor H Gene Polymorphism Play a Role in the Treatment Success With VEGF Inhibitors in Patients With Choroidal NeoVascularization (CNV)?
Age related macular degeneration (AMD) is a multifactorial disease with a strong genetic component. Most importantly a genetic polymorphism in the gene encoding for the complement factor H (CFH) has been recently identified which…
- Trial name
- NCT00813514
- Testing
- VEGF genotyping
- Where
- Austria
- Sponsor
- Medical University of Vienna
Optic Neuritis
Effect of Vitamin D on Retinal Changes in Patient With Optic Neuritis by Optic Coherence Tomography
This study examines the effect of vitamin D on Retinal changes in patient with optic Neuritis.
- Trial name
- NCT01465893
- Testing
- Vitamin D, Vitamin D withheld
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Isfahan University of Medical Sciences
ALS, Amyotrophic Lateral Sclerosis
NYSCF Scientific Discovery Biobank
The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate diverse disease research using cells from the body (such as skin or blood cells) to make stem cells and other types of cells…
- Conditions
- ALS, Amyotrophic Lateral Sclerosis, Alzheimer Disease, Alzheimer Disease, Early Onset
- Trial name
- NCT06203106
- Testing
- Biological Sample Collection
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- New York Stem Cell Foundation Research Institute
Diabetic Retinopathy, Neurotrophic Keratitis
An Investigator-Initiated Study to Assess the Association of Diabetic Retinopathy Severity Scale (DRSS) With Level of Decreased Corneal Sensitivity
Evaluate the association between level of decreased corneal sensitivity and diabetic retinopathy severity scale
- Trial name
- Assess (NCT05566717)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medical Center Ophthalmology Associates
Coat's Disease
Treatment of Congenital Telangiectasia (Coat's Disease) With Open-label Anecortave Acetate (15mg.)
Congenital Telangiectasia or Coat's disease is an uncommon disorder that involves the growth of blood vessels of the macula. These blood vessels msy extend beneth the retina to produce an area of sub-retinal…
- Trial name
- NCT00211315
- Testing
- anecortave acetate
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Manhattan Eye, Ear & Throat Hospital
Macular Degeneration
Ocular Safety Of Patients Receiving Macugen For Neovascular Age Related Macular Degeneration
The study will provide additional safety data for specific safety events in persons receiving intravitreal injections. The Committee for Medicinal Products for Human Use (CHMP) is interested in obtaining additional safety…
- Trial name
- NCT00460408
- Testing
- Macugen
- Where
- 68 sites in Belgium, Cyprus and 11 more
- Volunteers
- 501 people
- Sponsor
- Pfizer
Age Related Macular Degeneration
PDT Study for Exudative AMD With PCV
The purpose of this study is to evaluate and conduct an exploratory comparison of the efficacy and safety of indocyanine green angiography (ICGA) guided photodynamic therapy (PDT) and fluorescein angiography (FA) guided PDT for…
- Trial name
- NCT00331435
- Testing
- Ocular photodynamic therapy with verteporfin
- Where
- 17 sites in Japan
- Volunteers
- 113 people
- Sponsor
- Ophthalmic PDT Study Group
Retinitis Pigmentosa
Evoked Retinal Response
Retinitis pigmentosa (RP) is the name given to a group of inherited eye diseases that affect the retina (the light-sensitive part of the eye).
- Trial name
- NCT01415453
- Testing
- Ultrasound Stimulus
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Columbia University
Proliferative Diabetic Retinopathy
The Individually Marked Panretinal lasEr phoTokoagUlation for Proliferative Diabetic Retinopathy Study - DETECT
The purpose of this study is to determine the threshold level of proliferative diabetic retinopathy progression and regression after standard panretinal photocoagulation.
- Trial name
- IMPETUS-D (NCT02157350)
- Testing
- Panretinal laser photocoagulation
- Where
- Denmark
- Volunteers
- 65 people
- Sponsor
- Odense University Hospital
Diabetic Retinopathy, Macular Oedema
Ranibizumab Treatment of Diabetic Macular Oedema With Bimonthly Monitoring After a Phase of Initial Treatment
This study evaluates a new investigational treatment regimen of three consecutive monthly doses of ranibizumab followed by an as-needed treatment regimen, with monthly follow-up for the first three months then two-monthly…
- Trial name
- RELIGHT (NCT01257815)
- Testing
- Ranibizumab
- Where
- 15 sites in United Kingdom
- Volunteers
- 111 people
- Sponsor
- Novartis Pharmaceuticals
Retinoblastoma
Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma
The primary objective of this protocol is to evaluate the response rate of bilateral disease participants who have at least one eye with advanced intra-ocular retinoblastoma (stratum B) using upfront therapy with chemotherapy…
- Trial name
- NCT01783535
- Testing
- vincristine, topotecan, filgrastim
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- St. Jude Children's Research Hospital
Macular Hole
Outcomes of Macular Hole Surgery With Inverted Flap With vs Without Post op Posturing With SF6 in Macular Hole More Than 400 Micrometres
This study evaluated the outcomes of surgery for large full-thickness macular holes measuring more than 400 micrometres using the inverted internal limiting membrane flap technique with sulphur hexafluoride (SF6) gas tamponade.
- Trial name
- NCT07787390
- Testing
- Macular Hole Surgery With Inverted Internal Limiting Membrane Flap and SF6 Gas Tamponade, Face-Down Postoperative Positioning, No Face-Down Postoperative Positioning
- Where
- Pakistan
- Volunteers
- 52 people
- Sponsor
- Lahore General Hospital
Age-Related Maculopathies
Enhancement of Macular Pigment Density by Oral Lutein Supplementation
The primary objective of EMPOLS is an increase in macular pigment density (MPD) and contrast sensitivity (CS) after six months supplementation of oral non-compound ester Lutein 10 mg daily, contained in VitaluxPlus®.
- Trial name
- EMPOLS (NCT00563979)
- Testing
- VitaluxPlus®, Omega 3
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cognitive Change
Yoga Training and Retinal Vasculature With Parkinson's Disease
This study will compare the impact of a novel high-speed, cued yoga program to a standard yoga program on retinal microvasculature, cognition and neuromuscular function in persons with Parkinson's disease.
- Trial name
- NCT06194227
- Testing
- High-speed, Cognitive Challenge Yoga, Traditional Yoga
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Miami
Age Related Macular Degeneration
Patient's Feelings After Receiving a Diagnosis of Age-related Macular Degeneration
Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population of the industrialized world. AMD is a progressive degenerative disease affecting the central area of the retina, responsible for…
- Trial name
- PANDA (NCT03035461)
- Where
- France
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Wet Macular Degeneration
Real Life of Aflibercept in France in Patients Refractory to Ranibizumab: Observational Study in Wet AMD
The aim of the TITAN study is to describe the clinical practices of a cohort of patients with wAMD refractory to ranibizumab (persistence of intra-retinal and/or subretinal fluid) who switch to aflibercept after less than 12…
- Trial name
- TITAN (NCT02321241)
- Testing
- Aflibercept (EYLEA, BAY-86-5321)
- Where
- France
- Volunteers
- 236 people
- Sponsor
- Bayer
Retinoblastoma
Carboplatin Plus Vincristine in Treating Children With Retinoblastoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002794
- Testing
- carboplatin, vincristine sulfate
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- St. Jude Children's Research Hospital
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