Clinical trials: Retinal Disorders
Coat's Disease
Treatment of Congenital Telangiectasia (Coat's Disease) With Open-label Anecortave Acetate (15mg.)
Congenital Telangiectasia or Coat's disease is an uncommon disorder that involves the growth of blood vessels of the macula. These blood vessels msy extend beneth the retina to produce an area of sub-retinal…
- Trial name
- NCT00211315
- Testing
- anecortave acetate
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Manhattan Eye, Ear & Throat Hospital
Uveitis, Anterior, Cystoid Macular Edema
Blood-aqueous Barrier Changes After the Use of Timolol and Prostaglandin Analogues Fixed Combination in Pseudophakic Patients With POAG
Glaucoma, a progressive optic disc neuropathy causing visual field reduction, is the second leading cause of world blindness. The treatment of glaucoma is mainly based in reducing intraocular pressure (IOP) with topical…
- Trial name
- NCT01978015
- Testing
- travoprost and timolol maleate fixed combination, latanoprost and maleate timolol fixed combination, bimatoprost and timolol maleate fixed combination
- Where
- Brazil
- Volunteers
- 69 people
- Sponsor
- University of Campinas, Brazil
Diabetic Retinopathy
Automated Screening of Diabetic Retinopathy Using a Smartphone-based Camera
The prevalence of diabetic retinopathy (DR) in the UK is on the rise. Within 20 years of diabetes diagnosis, nearly all people with type 1 and almost two thirds of people with type 2 diabetes (60%) have some degree of DR.
- Trial name
- NCT04732208
- Testing
- Colour fundus photography
- Where
- United Kingdom
- Volunteers
- 410 people
- Sponsor
- Tameside General Hospital
Diabetic Retinopathy
The Diabetic Retinopathy Screening, Prevention and Control Program
The greatest harm of diabetes is various acute and chronic complications, especially diabetic retinopathy(DR), leading to extremely high rates of disability and blindness.
- Trial name
- NCT04240652
- Where
- 2 sites in China
- Volunteers
- 500,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Non-proliferative Diabetic Retinopathy
A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 in Non-proliferative Diabetic Retinopathy (NPDR)
This Phase 3 Study will evaluate the efficacy and safety of KSI-301 in participants with moderately severe to severe non-proliferative diabetic retinopathy (NPDR).
- Trial name
- GLOW (NCT05066230)
- Testing
- KSI-301
- Where
- 61 sites in United States, Czechia and 5 more
- Volunteers
- 253 people
- Sponsor
- Kodiak Sciences Inc
Solid Tumors With PTCH1 Loss-of-function Mutations
A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations
This study employs a 2-stage design that aims to evaluate the efficacy and safety of ENV- 101, a potent Hedgehog (Hh) pathway inhibitor, in patients with refractory advanced solid tumors characterized by loss of function (LOF)…
- Trial name
- NCT05199584
- Testing
- ENV-101 (taladegib)
- Where
- 16 sites in United States
- Volunteers
- 20 people
- Sponsor
- Endeavor Biomedicines, Inc.
Retinopathy of Prematurity, Pain
Acupuncture for Preterm Infants Requiring Eye-exam
The purpose is to investigate whether non-invasive acupuncture - NIA (i.e. acupuncture without needles) will help reduce pain for babies in the Neonatal Intensive Care Unit (NICU) during their routine weekly eye-exam for…
- Conditions
- Retinopathy of Prematurity, Pain, Acupuncture, Premature Infant
- Trial name
- MAGNIFIC-ROP (NCT03650621)
- Testing
- Magnetic acupuncture, stickers (magnets removed)
- Where
- 3 sites in Australia, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Retinoblastoma, Secondary Primary Malignancies After Retinoblastoma
New Strategies to Detect Cancers in Carriers of Mutations in RB1
Rationale: Individuals with a cancer predisposition due to a mutation in the paradigm tumor suppressor gene RB1, have a high risk to develop the childhood cancer retinoblastoma (Rb).
- Trial name
- NIRBTEST (NCT04164134)
- Testing
- blood draw
- Where
- 3 sites in France, Germany and 1 more
- Volunteers
- 378 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Diabetic Retinopathy Visually Threatening
Internal Limiting Membrane Peeling in Proliferative Diabetic Retinopathy
Subject/Participant Groups: Study Group: Subjects undergo internal limiting membrane (ILM) peeling during vitrectomy for the indication of tractional retinal detachment Control Group: Subjects do not undergo ILM peeling during…
- Trial name
- NCT04380064
- Testing
- ILM Peeling, No ILM Peeling
- Where
- Mexico
- Volunteers
- 200 people
- Sponsor
- Rush Eye Associates
Primary Open Angle Glaucoma
The Effects of Visior on Ocular Hemodynamics
To determine the relationship between the affects of viewing commercially available content through the VISIOR video goggles and ocular blood flow in glaucoma patients and healthy subjects.
- Trial name
- NCT02959593
- Testing
- VISIOR video goggles
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Visior Technologies Ltd.
Diabetic Retinopathy
Screening for Diabetic RETINopathy Using a Non-mydriatic Retinograph Funduscope in Occupational MEDicine
Diabetic retinopathy is a complication of diabetes that can affect vision. Early detection and appropriate management can help prevent or delay vision loss.
- Trial name
- RETINOMED (NCT07828821)
- Testing
- Non-mydriatic retinography, Self-administered questionnaire
- Where
- France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Clermont-Ferrand
Retinitis Pigmentosa, Choroideremia
Study of a Suprachoroidal Retinal Prosthesis
This study is a proof of principal, to evaluate a safety and efficacy of a prototype suprachoroidal retinal implant.
- Trial name
- NCT03406416
- Testing
- 44Ch Bionic Eye Device
- Where
- Australia
- Volunteers
- 4 people
- Sponsor
- Mobius Medical Pty Ltd.
Age-Related Macular Degeneration, Nonexudative Age-related Macular Degeneration
Transpalpebral Microcurrent Stimulation for the Improvement of Visual Acuity in Patients With Macular Degeneration
The goal of this clinical trial is to evaluate the effectiveness of transpalpebral microcurrent stimulation as a therapy for dry age-related macular degeneration.
- Trial name
- NCT05703867
- Testing
- Active microcurrent therapy
- Volunteers
- 404 people
- Sponsor
- Jarding, John, OD
Glaucoma
Effect of Alphagan on Retinal Blood Flow Autoregulation and Motion Detection in Patients With Normal Pressure Glaucoma
The investigators have completed a study in which the investigators examined the response of the retinal circulation to changes in posture from sitting to lying down in patients with Normal Tension Glaucoma (NTG).
- Trial name
- NCT01105065
- Testing
- brimonidine 0.15%
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Rhegmatogenous Retinal Detachment, Hypotony Ocular
Ocular Hypotony and Refractive Predictability in RRD Surgery
This study evaluates how preoperative ocular hypotony (Goldmann IOP ≤ 7 mmHg) affects refractive predictability, axial length measurements, and visual outcomes in patients undergoing combined phacovitrectomy with silicone oil for…
- Trial name
- HYP-RRD (NCT07283614)
- Testing
- Combined Phacovitrectomy with Intraocular Lens Implantation and Silicone Oil Tamponade, Silicone Oil Removal
- Where
- Kazakhstan
- Volunteers
- 45 people
- Sponsor
- Kazakh Eye Research Institute
Diabetic Retinopathy
A Study That Uses Data From Routine Eye Examinations of Patients Participating in Studies FIDELIO-DKD and FIGARO-DKD to Explore Whether Finerenone Can Delay the Progression of a Diabetes Complication That Affects the Eyes (Diabetic Retinopathy ,DR)
Diabetic retinopathy (DR) is a diabetes complication caused by damage to the small blood vessels inside the retina at the back of the eye. Diabetic retinopathy may cause mild vision problems or eventually blindness.
- Trial name
- ReFineDR (NCT04477707)
- Testing
- Finerenone (BAY94-8862)
- Where
- 62 sites in United States, Argentina and 13 more
- Volunteers
- 206 people
- Sponsor
- Bayer
Glaucoma, Open-angle, Primary Open Angle Glaucoma (POAG)
Nicotinamide for Retinal Protection in Primary Open-Angle Glaucoma (NADIR Trial)
The goal of this clinical trial is to learn whether a high-dose vitamin B3 supplement called nicotinamide can protect retinal nerve cells in adults with primary open-angle glaucoma (POAG) who are already receiving standard…
- Trial name
- NADIR (NCT07808333)
- Testing
- Nicotinamide, Standard Glaucoma Therapy
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- University of Chicago
Diabete Mellitus, Cognitive Impairment
Predicting the Risk of Diabetic Neurodegenerative Disorders by Artificial Intelligence Tools Based on Retinal Imaging
Diabetic Retinopathy (DR) is the most frequent complication of diabetes, and its presence and severity are related to the appearance of both micro and macrovascular events.
- Trial name
- NCT06541834
- Testing
- Retinal imaging
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Ospedale San Raffaele
Exudative Age-Related Macular Degeneration
Efficacy and Safety Study of ESBA1008 Versus EYLEA®
The purpose of this study is to compare the efficacy and safety of ESBA1008 versus EYLEA® in the treatment of exudative age-related macular degeneration.
- Trial name
- NCT01796964
- Testing
- ESBA1008 solution, Aflibercept
- Volunteers
- 173 people
- Sponsor
- Alcon Research
Subfoveal Choroidal Neovascularization, Age-Related Maculopathy
Safety and Efficacy of Dexamethasone as Adjunctive Therapy to Ranibizumab in Subjects With Choroidal Neovascularization and Age-Related Macular Degeneration
This study will evaluate the safety and efficacy of dexamethasone (OZURDEX®) as adjunctive therapy to ranibizumab (LUCENTIS®) compared with ranibizumab alone in the treatment of patients with choroidal neovascularization…
- Trial name
- NCT01122511
- Testing
- 700 ug dexamethasone, ranibizumab
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Allergan
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