Clinical trials: Retinal Disorders
Retinal Disease
SteRilizing Eye SoLution to ImprovE Patient ComFort (RELIEF)
This is a randomized, double-masked study to evaluate the tolerability and safety of IRX-101 versus 5% povidone-iodine (PI) in subjects receiving intravitreal anti-VEGF injections.
- Trial name
- RELIEF (NCT05747430)
- Testing
- IRX-101, Providone-Iodine
- Where
- 7 sites in United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- iRenix Medical, Inc.
Low Vision, Age Related Macular Degeneration
Eye Movement Rehabilitation in Low Vision Patients
Approximately 217 million people worldwide currently suffer from low vision, which impacts a broad range of activities of daily living and is associated with depression and increased mortality.
- Trial name
- NCT04929756
- Testing
- Visual Feedback
- Where
- 2 sites in United States
- Volunteers
- 106 people
- Sponsor
- Northeastern University
Retinal Vein Occlusion, Vascular Occlusive Disease
Intravitreal Aflibercept for Macular Edema Due to Central Retinal Vein Occlusion
Central retinal vein occlusion (CRVO) is a common retinal vascular disorder, occurring when there is a blockage to the main blood vessel that transports blood away from the retina.
- Trial name
- INTRAMED-CRVO (NCT06416241)
- Testing
- EYLEA 2 MG in 0.05 ML Injection
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Athens
Macular Holes, Retinal Detachment
Efficacy of Exercise Program for Facedown Posture-related Pain After Retinal Surgery
The purpose of this study is to evaluate the effects of a structured exercise program on musculoskeletal pain of patients in face-down posture after retinal surgery.
- Trial name
- NCT04535622
- Testing
- A structured exercise
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Samsung Medical Center
Retinal Vein Occlusion
Ranibizumab in Patients With Branch Retinal Vein Occlusion
In a recent study we could show that the early retinal venous vasoconstriction after grid photocoagulation in branch retinal vein occlusion (BRVO) is closely correlated to the visual outcome after three months.
- Trial name
- NCT01027481
- Testing
- Lucentis
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Diabetic Macular Edema (DME), Retinal Vein Occlusion (RVO)
Effectiveness of Intravitreal Injection of Aflibercept 8 mg in Resistant Diabetic Macular Edema, Retinal Vein Occlusion and Myopic Choroidal Neovascularisation Patients
Generally, DM is caused by insufficient insulin secretion in the body; however, the other biological mechanisms remain unclear. Long-term illness in patients with DM damages various organs in the body, such as the eyes, kidneys…
- Conditions
- Diabetic Macular Edema (DME), Retinal Vein Occlusion (RVO), Myopic Choroidal Neovascularisation
- Trial name
- NCT06879301
- Testing
- Intravitreal injection of aflibercept 8 mg
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tanta University
Artificial Intelligence, Retinal Diseases
Artificial Intelligence for Detecting Retinal Diseases
The objective of this study is to apply an artificial intelligence algorithm to diagnose multi retinal diseases from fundus photography.
- Trial name
- NCT04678375
- Testing
- Retinal diseases diagnosed by artificial intelligence algorithm
- Where
- China
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Beijing Tongren Hospital
Geographic Atrophy
Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration
This is a 24-month, Phase III, multicenter, randomized, double-masked, sham-injection controlled study to assess the efficacy and safety of multiple IVT injections of APL-2 in subjects with GA secondary to AMD.
- Trial name
- NCT03525600
- Testing
- APL-2
- Where
- 141 sites in United States, Argentina and 13 more
- Volunteers
- 621 people
- Sponsor
- Apellis Pharmaceuticals, Inc.
Susac Syndrome
Investigation of Biomarkers in Susac Syndrome
Susac Syndrome is a rare disease and the establishment of the diagnosis is often difficult. The aim of this investigation is to identify relevant biomarkers and to elucidate the pathogenesis of Susac syndrome
- Trial name
- NCT01273792
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Chorioretinitis
Antiangiogenic Therapy of Choroidal Neovascularisation Associated With Central Chorioretinitis
The purpose of this study is to determine the effectiveness of antiangiogenic therapy to choroidal neovascularization secondary to central chorioretinitis.
- Trial name
- COAST_UAcCNV (NCT04245072)
- Testing
- Intravitreal injection, Fluorescent angiography, Visometry
- Where
- 3 sites in Ukraine
- Volunteers
- 100 people
- Sponsor
- The Filatov Institute of Eye Diseases and Tissue Therapy
Age-related Macular Degeneration
Metabolomics: A Novel Tool for Investigating the Pathogenesis of Age-related Macular Degeneration
The global aim of this project is to expand the knowledge on the multifactorial pathogenesis of AMD. In addition to age, the multifactorial pathogenesis of AMD includes environmental and genetic risk factors.
- Trial name
- AMDMetab (NCT04241536)
- Testing
- Blood draw and urine collection
- Where
- Portugal
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Diabetic Retinopathy, Diabetic Macular Edema
Efficacy of Dorzolamide as an Adjuvant After Focal Photocoagulation in Clinically Significant Macular Edema
Photocoagulation is the standard treatment in the focal EMCS, disrupts vascular leakage and allows the pigment epithelium remove the intraretinal fluid is effective in reducing the incidence of visual loss but can reduce contrast…
- Trial name
- NCT02227745
- Testing
- Dorzolamide hydrochloride (2%)
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Hospital Juarez de Mexico
Diabetic Retinopathy
Study of Effectiveness of Telemedicine in Identifying Diabetic Retinopathy Cases
The aim of this study is to compare the effectiveness of identifying diabetic retinopathy using tele-medicine based Digital Retinal Imaging in Diabetes Clinics with that of the conventional referral system.
- Trial name
- DRTM (NCT02085681)
- Testing
- Tele-medicine, Conventional referral
- Where
- India
- Volunteers
- 801 people
- Sponsor
- Aravind Eye Care System
Age Related Macular Degeneration
Comparison Between Foresee Home and Optical Coherence Tomography (OCT) Visual Field Defects in Patients With Choroidal Neovascularization (CNV)
The Foresee Home is used in the recent years to detect age-related macular degeneration (AMD) lesions. The device is capable of differentiation as to stages of AMD and early detection of changes including choroidal…
- Trial name
- NCT01073592
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Notal Vision Ltd.
Diabetes Mellitus, Type 2
Skin and Retina Microvascular Endothelial Function in Healthy, Insulin Resistant and Type 2 Diabetic Subjects
The purpose of this study is to investigate microvascular endothelial function in the retina of lean, obese, and type 2 diabetic subjects and to compare microvascular endothelial function in the retina with several other…
- Trial name
- NCT01241370
- Where
- Germany
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- ELAB-Logistics
Diabetic Macular Edema
Bevacizumab Versus Combined Bevacizumab and Triamcinolone for Refractory Diabetic Macular Edema; a Randomized Clinical Trial
The purpose of this study is to compare the efficacy and safety of intravitreal injection of bevacizumab alone versus bevacizumab combined with triamcinolone for treatment of refractory diabetic macular edema.
- Trial name
- NCT00370422
- Testing
- Triamcinolone, Bevacizumab
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Polypoidal Choroidal Vasculopathy (PCV), Age Related Macular Degeneration
Efficacy and Durability of a Personalized Treat-and-extend Regimen of Faricimab for Treatment-naive Polypoidal Choroidal Vasculopathy
To evaluate the Efficacy of a personalized treat-and-extend regimen of faricimab for treatment-naive polypoidal choroidal vasculopathy
- Trial name
- HANGANG (NCT07461441)
- Testing
- Faricimab Injection [Vabysmo]
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Yeungnam University College of Medicine
Autoimmune Disease
Rituximab for Autoimmune Retinopathy
Background: Autoimmune retinopathy (AIR) is an inflammatory condition in which the patient s own immune system is attacking his or her eyes and causing vision loss.
- Trial name
- NCT01086631
- Testing
- Rituximab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Retinopathy
PASCAL Laser Platform Produces Less Pain Responses Compared To Conventional Laser System
The aim of this study is to compare the severity of expressed pain scores in patients with PDR who underwent either PASCAL or conventional laser and to assess the association between patient characteristics and severity of pain.
- Trial name
- NCT02645383
- Testing
- PASCAL laser, Conventional laser
- Volunteers
- 30 people
- Sponsor
- Kocatepe University
Cataract, Retina Detachment
Different Hemostasis According to the Anesthetic Agents
We investigated the hemostatic differences according to the main anesthetic agents by analyzing rotational thromboelastometry (ROTEM) under the hypothesis that propofol-based anesthesia would impair postoperative coagulability…
- Conditions
- Cataract, Retina Detachment, Pterygium, Keratitis
- Trial name
- NCT02151305
- Testing
- Propofol, remifentanil, Sevoflurane
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Seoul National University Bundang Hospital
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