Clinical trials: Retinal Disorders
Age Related Macular Degeneration
Study for Recalcitrant Age Related Macular Degeneration
50 Patients with recalcitrant exudative age-related macular degeneration with a history of retinal or subretinal fluid after multiple intravitreal injections with ranibizumab 0.5mg and subsequently treated with ranibizumab 2.0mg…
- Trial name
- TURF (NCT01543568)
- Testing
- aflibercept 2.0 mg
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- David M. Brown, M.D.
Age-related Macular Degeneration
Head Mounted Eye Tracking Aide for Loss of Central Vision (HETALCEV)
A device has been developed that has eye trackers integrated within the Head Mounted Display (HMD) and can remap text and images around the scotoma in real time to prevent information loss from a central scotoma.
- Trial name
- HETALCEV (NCT02829606)
- Testing
- small scotoma using Head Mounted Display No re-mapping, Large scotoma using Head Mounted Display PLUS re-mapping
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
A Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products
The VOYAGER study is a primary data collection, non-interventional, prospective, multinational, multicenter study. It is designed to collect real-world, long-term data to explore long-term effectiveness, safety, clinical…
- Conditions
- Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion, Branch Retinal Vein Occlusion
- Trial name
- VOYAGER (NCT05476926)
- Testing
- Faricimab, Port Delivery System with Ranibizumab
- Where
- 299 sites in United States, Argentina and 27 more
- Volunteers
- 6,000 people
- Sponsor
- Hoffmann-La Roche
Glaucoma, Macular Degeneration
BCI and Evaluation of Visual and Task Performance in Subjects With Eye Diseases
The purpose of this research study is to better understand the impact of visual impairment caused by different eye diseases on the ability to perform daily activities and compare it to that in patients without eye diseases.
- Conditions
- Glaucoma, Macular Degeneration, Glaucoma Suspect, Optic Neuropathy
- Trial name
- NCT03318549
- Testing
- Visual Performance tests, Brain-computer interface
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Miami
Inflammation
Intravitreal Ketorolac for Chronic Uveitis: A Investigational Safety Study
Intraocular delivery of ketorolac will be an effective means to treat inflammation and macular edema and prevent structural complications and vision loss in patients with uveitis who are unable to tolerate corticosteroids due to…
- Trial name
- INCITE (NCT01164085)
- Testing
- Intravitreal Ketorolac
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Vanderbilt University
Stress Disorders, Post-Traumatic, Retinal Detachment
Diagnosis of Posttraumatic Stress Disorder Following Primary Rhegmatogenous Retinal Detachment
To investigate the prevalence of posttraumatic stress disorder (PTSD) in patients that underwent surgery for primary rhegmatogenous retinal detachment (RRD) and to determine variables associated with the disorder.
- Trial name
- NCT01233908
- Where
- Israel
- Volunteers
- 547 people
- Sponsor
- Sheba Medical Center
Central Serous Retinopathy (CSR), Sub-Threshold Laser
Treatment of Recurrent and Multifocal Central Serous Chorioretinopathy
The goal of this clinical trial is to learn if subthreshold micropulse laser is a safe, effective, and painless treatment for multifocal and recurrent central serous chorioretinopathy (CSCR) in adults.
- Trial name
- NCT07889518
- Testing
- 577 nm Subthreshold Micropulse Laser
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Benha University
Retinitis Pigmentosa
In Depth Observational Clinical Trial Of Retinitis Pigmentosa Patients
Typically, clinical research participation favors a specific demographic group, and little research exists on how trial attributes affect participation.
- Trial name
- NCT05849987
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Retinitis Pigmentosa
A Study of Encapsulated Cell Technology (ECT) Implant for Patients With Late Stage Retinitis Pigmentosa
The purpose of this study is to look at the safety and effectiveness of CNTF implants on vision in persons with retinitis pigmentosa, Usher type II \& III, and Choroideremia.
- Trial name
- NCT00447993
- Testing
- Low Dose NT-501, High Dose NT-501
- Where
- 11 sites in United States
- Volunteers
- 67 people
- Sponsor
- Neurotech Pharmaceuticals
Macular Edema, Retinal Vein Occlusion
Functional and Anatomical Outcomes of Dexamethasone Intra-vitreal Implant in Patients with Resistant Macular Edema Secondary to Retinal Vein Occlusion After Intravitreal Anti-VEGF Injection
Retinal vein occlusion (RVO) is one of the most common causes of vision loss due to retinal vascular disease. Incidence of RVO has been raised in the last years due to increased coexisting systemic vascular risk factors as…
- Trial name
- NCT05003258
- Testing
- Intravitreal injection of Dexamethasone implant
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Assiut University
ADHD
A Novel Device for the Management of ADHD
This is a 2-months study, where eligible ADHD adult participants will be provided with personalized VIZO glasses.
- Trial name
- NCT05777785
- Testing
- VIZO Glasses
- Where
- Israel
- Volunteers
- 108 people
- Sponsor
- VIZO Specs Ltd
Stargardt Disease
ABCA4-associated Disease in Childhood and Adolescence - a Phenotype Study
Retrospective chart review study to elucidate the phenotype and genotype of children with ABCA4-associated Stargardt disease.
- Trial name
- NCT06377150
- Where
- Germany
- Volunteers
- 39 people
- Sponsor
- University Hospital Tuebingen
Retinal Vein Occlusion
Efficacy and Safety of Ranibizumab in Japanese Patients With Retinal Vein Occlusion
The purpose of this study is to provide efficacy and safety data of 3 consecutive monthly intravitreal injections with 0.5 mg ranibizumab in Japanese patients with visual impairment due to macular edema secondary to retinal vein…
- Trial name
- RVO in Japan (NCT01377597)
- Testing
- ranibizumab
- Where
- 8 sites in Japan
- Volunteers
- 47 people
- Sponsor
- Novartis Pharmaceuticals
Macular Disease
Effect of Vascular Endothelial Growth Factor Blockers on Aqueous Humor Dynamics
The objective of this research is to determine the effects of anti-VEGF drugs (bevacizumab, ranibizumab or aflibercept) on aqueous humor dynamics (AHD) in patients with retinal vascular disease.
- Trial name
- NCT01994174
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- University of Nebraska
X-Linked Retinitis Pigmentosa
A Study Comparing Two Doses of AGTC-501 in Male Participants With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (DAWN)
This Phase 2 study is a non-randomized, open-label, study of the safety of AGTC-501 in participants with XLRP who have previously been treated with a full-length AAV vector-based gene therapy targeting RPGR protein.
- Trial name
- NCT06275620
- Testing
- AGTC-501 (high dose and standard corticosteroid regimen), AGTC-501 (low dose and standard corticosteroid regimen), AGTC-501 (high dose and modified corticosteroid regimen)
- Where
- 7 sites in United States
- Volunteers
- 24 people
- Sponsor
- Beacon Therapeutics
Macular Holes
Treatment of Challenging Macular Holes Using Plasma Rich in Growth Factors
Aim of the Study:To report the structural and visual outcomes of plasma rich in growth factors in closure of challenging macular holes
- Trial name
- NCT06115005
- Testing
- Plasma rich in growth factors ( PRGF )
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Minia University
Age-Related Macular Degeneration
A Phase I/II Safety Study of DE-120 Injectable Solution for Age-related Macular Degeneration
The purpose of this study is to assess the safety, tolerability, bioactivity and pharmacokinetics of three concentrations of DE-120 after a single intravitreal injection in subjects with late stage exudative age-related macular…
- Trial name
- NCT02022501
- Testing
- DE-120
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- Santen Inc.
Macular Degeneration
Genetics in Non-response to Anti-VEGF Treatment in Exudative AMD
To assess genetic features and intraocular cytokine profiles of non-responders to anti-VEGF treatment of exudative age-related macular degeneration. Also to assess necessity and frequency of pro re nate medical re-treatment.
- Trial name
- RESPONSE (NCT01213667)
- Testing
- Ranibizumab
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- University of Cologne
Exudative Age-Related Macular Degeneration
Evaluation of AL-78898A in Exudative Age-Related Macular Degeneration
The primary purpose of this study was to demonstrate a biological effect of AL-78898A, as measured by change (reduction) in central subfield (CSF) retinal thickness 4 weeks after a single intravitreal injection, as compared to…
- Trial name
- RACE (NCT01157065)
- Testing
- AL-78898A, Ranibizumab
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Alcon Research
Age-Related Macular Degeneration
Safety and Clinical Effectiveness of Intravitreal Bevacizumab (Lumiere®) in Patients With Wet Age-related Macular Degeneration (Wet AMD)
The purpose of this clinical trial is to evaluate the safety and clinical effectiveness of intravitreal bevacizumab (Lumiere®) in the single-dose form, for the treatment of patients with wet AMD.
- Trial name
- NCT03668054
- Testing
- Bevacizumab (Lumiere®)
- Where
- 3 sites in Argentina
- Volunteers
- 22 people
- Sponsor
- Laboratorio Elea Phoenix S.A.
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