Clinical trials: Retinal Disorders
Neovascular Age-Related Macular Degeneration (NVAMD), Branch Retinal Vein Occlusion (BRVO)
A Dose-masked Study of Intravitreal Remigromig (EYE103) in Participants With NVAMD or Macular Edema Following BRVO
EYE-RES-104 is a randomized, dose-masked study of intravitreal remigromig (EYE103) in participants with neovascular age-related macular degeneration (NVAMD) or macular edema following branch retinal vein occlusion (BRVO).
- Trial name
- Super Tuscan (NCT07205887)
- Testing
- Remigromig, Aflibercept 2.0 mg
- Where
- 55 sites in United States
- Volunteers
- 160 people
- Sponsor
- EyeBiotech Ltd.
Central Retinal Artery Occlusion, Visual Field
Changes of Visual Field Defects After IAT for CRAO
Central retinal artery occlusion (CRAO) is an ophthalmic emergency which leads to devastating visual function defects and poor prognosis.
- Conditions
- Central Retinal Artery Occlusion, Visual Field, Intra-arterial Thrombolysis
- Trial name
- NCT05739487
- Testing
- selective intra-arterial thrombolysis
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Age-related Macular Degeneration (ARMD), Choroidal Neovascularization
Long Term Efficacy of Faricimab Using a Treat and Extend Regimen for Type 3 Macular Neovascularization
Type 3 macular neovascularization (MNV) is a subtype of neovascular age-related macular degeneration accounting for 10-20% of cases, notable for high rates of bilateral involvement and risk of profound vision loss, particularly…
- Conditions
- Age-related Macular Degeneration (ARMD), Choroidal Neovascularization, Anti-vascular Endothelial Growth Factor
- Trial name
- NCT07187804
- Testing
- Intravitreal faricimab injection
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Kim's Eye Hospital
Retinal Disease
Pilot Study for the Evaluation of Finasteride in the Treatment of Chronic Central Serous Chorioretinopathy
Central serous chorioretinopathy (CSC) is a retinal disorder characterized by an accumulation of serous fluid under the retina. Although acute CSC tends to spontaneously resolve on its own with minimal sequelae, chronic CSC tends…
- Trial name
- NCT00837252
- Testing
- Finasteride
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Eye Institute (NEI)
Retinal Detachment, Vitrectomy
Comparative Study of 1000 Centistoke Versus 5000 Centistoke Silicone Oil for Repair of Complex Retinal Detachments
The purpose of this study is to assess the retinal redetachment rates with 1000 centistoke versus 5000 centistoke silicone oil tamponade for repair of complex retinal detachments.
- Conditions
- Retinal Detachment, Vitrectomy, Proliferative Vitreoretinopathy, Diabetic Retinopathy
- Trial name
- NCT01255293
- Testing
- 1000 centistoke silicone oil, 5000 centistoke silicone oil
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mid Atlantic Retina
Pigment Epithelial Detachment
iSONEP to Treat Persistent Pigment Epithelial Detachment (PED) in Subjects With Exudative Age-Related Macular Degeneration (AMD) or Polypoidal Choroidal Vasculopathy (PCV)
LT1009-Oph-002 is a Phase 1b study designed to evaluate the safety and potential efficacy of iSONEP following one, two or three injections of iSONEP, as needed, for the treatment of Pigment Epithelial Detachment (PED) secondary…
- Trial name
- PED (NCT01334255)
- Testing
- iSONEP (sonepcizumab/LT1009)
- Where
- 5 sites in United States
- Volunteers
- 12 people
- Sponsor
- Lpath, Inc.
Geographic Atrophy
Pterygopalatine Ganglion Stimulation for the Treatment of Geographic Atrophy
The goal of this clinical trial is to evaluate the feasibility and safety of pterygopalatine ganglion (PPG) stimulation in adults with geographic atrophy (GA) secondary to age-related macular degeneration (AMD).
- Trial name
- NCT07570355
- Testing
- Pterygopalatine ganglion stimulation
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Glaucoma Eye, Macular Degeneration
Retinal Oxygenation Estimation Trial With Mantis Photonics Hyperspectral Camera
An explorative study of the Mantis Photonics hyperspectral camera for retinal imaging and estimation of retinal oxygenation. Primary objective: To evaluate the performance of the hyperspectral camera for non-invasive retinal…
- Conditions
- Glaucoma Eye, Macular Degeneration, Macula Abnormality, Retinal Detachment
- Trial name
- NCT05566626
- Testing
- Hyperspectral retinal image, Mydriacyl Ophthalmic Product
- Where
- Sweden
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mantis Photonics AB
Macular Edema, Central Retinal Vein Occlusion
Comparison of Initial Ozurdex (Dexamethasone Implant) to Avastin (Bevacizumab) for Treatment of Macular Edema Caused by Central Retinal Vein Occlusion (CRVO)
The purpose of this study is to compare visual improvement and total number of intraocular injections in eyes with macular edema following central retinal vein occlusion (CRVO)after initial treatment with Ozurdex (dexamethasone…
- Trial name
- NCT01231633
- Testing
- Ozurdex, Avastin
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- Long Island Vitreoretinal Consultants
Retinal Vascular Disease
Swept-Source Optical Coherence Tomography for Noninvasive Retinal Vascular Imaging
This is a clinical pilot study to assess the feasibility of using a swept-source optical coherence tomography (SSOCT) system to perform noninvasive imaging of the retinal vasculature in patients with existing microvascular…
- Trial name
- SWEPT (NCT01834196)
- Testing
- Swept-Source Optical Coherence Tomography
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Duke University
Age Related Macular Degeneration, Exudative Age-Related Macular Degeneration
Real-Life Clinical Outcomes of Aflibercept Biosimilar MY-1701P in the Treatment of Exudative Age-Related Macular Degeneration
In this study, patients receiving Eylea treatment will be treated with Yesafili, a biosimilar molecule, and routine examination results will be noted.
- Conditions
- Age Related Macular Degeneration, Exudative Age-Related Macular Degeneration, Anti Vascular Endothelial Growth Factor
- Trial name
- NCT07235527
- Testing
- Aflibercept biosimilar (MY-1701P)
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Saglik Bilimleri Universitesi
Age-Related Macular Degeneration
Progression of Early Atrophic Lesions
Early atrophic age-related macular degeneration (AMD) represents an important time window in the course of so far untreatable atrophic AMD, as patients typically experience only some degree of visual dysfunction, while being at…
- Trial name
- NCT05959005
- Testing
- No intervention
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- University of Utah
Central Serous Chorioretinopathy
Micropulse Diode Laser Treatment for Chronic Central Serous Chorioretinopathy
The aim of this study was to evaluate safety and therapeutic response to micropulse diode 810nm laser treatment in patients with chronic central serous chorioretinopathy.
- Trial name
- NCT01327170
- Testing
- Subthreshold diode micropulse laser
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- Federal University of São Paulo
Macular Degeneration
Long-Term Use Of Pegaptanib In Patients For Subfoveal Choroidal Neovascularization Secondary To Age-Related Macular Degeneration
The objective of this surveillance is to collect information about 1) adverse drug reaction not expected from the LPD (unknown adverse drug reaction), 2) the incidence of adverse drug reactions in this surveillance, and 3)…
- Trial name
- NCT00845273
- Testing
- Pegaptanib sodium
- Volunteers
- 3,538 people
- Sponsor
- Pfizer
X-linked Retinoschisis, XLRS
Clinical Evaluation of Patients With X-linked Retinoschisis
The purpose of this study is to evaluate subjects with X-linked retinoschisis in a clinical setting to collect data on disease progression.
- Trial name
- NCT02331173
- Testing
- Dorzolamide 2% TID or brinzolamide 1% TID
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- Beacon Therapeutics
Diabetes Mellitus, Diabetic Retinopathy
Evaluation of Early Retinal Nerve Injury in Type 2 Diabetes Patients Without Diabetic Retinopathy
The object of this study is to investigate the damage to the retinal nerve fiber layer (RNFL) and ganglion cell complex layer (GCL+) in diabetic patients without retinal microangioma as detected by fundus fluorescein angiography…
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Nerve Injury
- Trial name
- NCT03970161
- Testing
- routine ophthalmic examination
- Where
- China
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Age-Related Macular Degeneration
AMD and Validation Rod-Meditated Dark Adaptation With Everyday Task Performance
The goal is to conduct a cross-sectional, single timepoint study on older adults with early and intermediate AMD, and with subretinal drusenoid deposits (SDD), and those in normal health, establishing an association between dark…
- Trial name
- NCT06619405
- Testing
- Streetlab VR
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Duke University
Macular Edema, Diabetic Retinopathy
Combined Triple Therapy in Diabetic Retinopathy (DRP)
The aim of this pilot study was to investigate the effects of an intravitreal combination therapy using triamcinolone and bevacizumab in patients with macular edema due to diabetic retinopathy.
- Trial name
- NCT00806169
- Testing
- triamcinolone and bevacizumab
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Age-Related Macular Degeneration
Genetic Polymorphisms in Ranibizumab Treatment in Wet Age-Related Macular Degeneration (AMD)
Genetic factors of an individual patient may have an impact on Ranibizumab (Lucentis) treatment outcome in patients with Wet Age-Related Macular Degeneration (AMD).
- Trial name
- NCT01676506
- Testing
- Ranibizumab, Ranibizumab Injection
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- Russian Academy of Medical Sciences
Diabetes, Diabetic Retinopathy
Improve Timely Referral Flow and Compliance of Diabetic Retinopathy Patients
An effective referral system helps to ensure a close relationship between all levels of the health system and ensures clients receive optimum care at the appropriate level and at affordable cost, and hospital facilities are used…
- Trial name
- NCT04834648
- Testing
- Structured Counseling
- Where
- Nepal
- Volunteers
- 150 people
- Sponsor
- Seva Foundation
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