Clinical trials: Retinal Hemorrhage
Vision-Threatening Retinal Lesions, Urgent Referral Retinal Findings
Artificial Intelligence-Assisted Lesion-Based Urgent Referral Triage of Ultra-Widefield Retinal Images
his study evaluates the clinical utility of an artificial intelligence (AI)-assisted lesion-based urgent referral triage system for ultra-widefield (UWF) retinal images.
- Conditions
- Vision-Threatening Retinal Lesions, Urgent Referral Retinal Findings, Retinal Detachment, Pre-retinal Hemorrhage
- Trial name
- ALERT-UWF (NCT07643129)
- Testing
- AI-Assisted UWF Lesion-Based Triage System, Unassisted Interpretation
- Where
- China
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Xiamen Ophthalmology Center Affiliated to Xiamen University
Cataract, Vitreous Hemorrhage
Surgical Procedure Efficiency Evaluation stuDy
The purpose of this real-world evidence study is to compare surgical procedure times for UNITY® VCS and CONSTELLATION® Vision System.
- Conditions
- Cataract, Vitreous Hemorrhage, Retinal Detachment, Macular Pucker
- Trial name
- NCT07228091
- Testing
- UNITY VCS, CONSTELLATION
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Alcon Research
Spontaneous Vitreous Hemorrhage, Retinal Break
Early VItrectomy in DENse Spontaneous Vitreous HEmorrhage
The aim of the protocol is to compare the ocular outcomes after spontaneous vitreous hemorrhage treated with an early vitrectomy versus ultrasound monitoring with late vitrectomy.
- Conditions
- Spontaneous Vitreous Hemorrhage, Retinal Break, Retinal Detachment
- Trial name
- EVIDENSE (NCT04676256)
- Testing
- Early vitrectomy
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Epiretinal Membrane, Macular Hole
UNITY VCS Vitreoretinal Surgery
This purpose of this study is to compare the safety and effectiveness of two eye surgery systems-UNITY VCS and CONSTELLATION-in treating adults with vitreoretinal diseases or disorders.
- Conditions
- Epiretinal Membrane, Macular Hole, Visually Significant Vitreous Floater, Vitreomacular Traction
- Trial name
- NCT07054281
- Testing
- UNITY Vitreoretinal Cataract System (VCS), CONSTELLATION Vision System, Vitreoretinal ophthalmic surgery
- Where
- 8 sites in United States
- Sponsor
- Alcon Research
Diabetic Vitreous Hemorrhage, Tractional Retinal Detachment
Assessment of Retinal Vascular Changes With and Without ILM Peeling in Diabetic Vitrectomy Using OCT-A.
Tractional retinal detachment (TRD) that involves the macula and non-clearing vitreous hemorrhage are the main causes of permanent vision loss in patients with diabetic retinopathy and requires prompt surgical intervention.
- Trial name
- NCT05739539
- Testing
- optical coherence tomography angiography, spectral domain optical coherence tomography
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Kasr El Aini Hospital
Vascular Retinopathy of Left Eye (Disorder), Vascular Retinopathy of Right Eye (Disorder)
Intraoperative Application of Fluorescein Sodium Angiography in Vascular Retinopathy
The study used a new surgical technique: intraoperative fluorescence imaging,In the 1980s, some scholars proposed the concept of intraoperative fluorescein angiography.During vitrectomy, intraoperative fluorescein angiography…
- Conditions
- Vascular Retinopathy of Left Eye (Disorder), Vascular Retinopathy of Right Eye (Disorder), Diabetic Retinopathy, Retinal Vein Occlusion
- Trial name
- NCT06343961
- Testing
- Intraoperative Fluorescein Angiography
- Volunteers
- 80 people
- Sponsor
- Jie Zhong
Abnormal Vitreous Humor Morphology, Abnormal Choroid Morphology
Accuracy of the Red Reflex Test in the Pediatric Population
This study is designed to investigate the sensitivity and specificity of the Red Reflex Test (RRT), with and without dilation, for early detection of ocular abnormalities in children and newborns.
- Conditions
- Abnormal Vitreous Humor Morphology, Abnormal Choroid Morphology, Optic Nerve Diseases, Retinal Disease
- Trial name
- NCT04125043
- Testing
- Direct ophthalmoscope
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Retinal Hemorrhage, Bilateral, Retinal Hemorrhage, Left Eye
Retinal Imaging Study of Children That Might be at Risk of Having Retinal Hemorrhages
This is a clinical trial in which we will learn about the retinal findings in three clinical groups of children, who might be at risk of having retinal hemorrhages (RH).
- Conditions
- Retinal Hemorrhage, Bilateral, Retinal Hemorrhage, Left Eye, Retinal Hemorrhage, Right Eye
- Trial name
- RISC (NCT05576285)
- Testing
- ophthalmoscopy and fundus photography through dilated pupills
- Where
- Sweden
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Vitrectomy, Epiretinal Membrane
Performance Comparison of the 25 Gauge 20,000cpm HYPERVIT Dual Blade vs. 10,000cpm ULTRAVIT Vitrectomy Cutter
This prospective randomised controlled trial will be conducted to investigate that increasing the vitrectomy cutting rate from 10,000 cut/min to 20,000 cut/min will result more efficiency and shorter core vitrectomy time, and it…
- Conditions
- Vitrectomy, Epiretinal Membrane, Macular Hole, Vitreous Hemorrhage
- Trial name
- NCT05710458
- Testing
- 25 gauge 20,000 cpm Hypervit Dual Blade, 25 gauge 10,000 cpm Ultravit Vitrectomy Cutter
- Where
- Hong Kong
- Volunteers
- 72 people
- Sponsor
- The University of Hong Kong
Macular Disease, Rhegmatogenous Retinal Detachment
Combined Vitrectomy and Femtosecond Laser-assisted Cataract Surgery
Based on the progress of cataract surgery, intraocular lens development, vitreoretinal surgery and anesthesia technology in recent years, the purpose of this study is to develop a new type of more accurate and minimally invasive…
- Conditions
- Macular Disease, Rhegmatogenous Retinal Detachment, Epiretinal Membrane, Cataract
- Trial name
- NCT05588037
- Testing
- FLACS +PPV+IOL + air, FLACS +PPV+IOL + epiretinal membrane peeling + Ozurdex, FLACS + PPV+IOL + internal limiting membrane peeling + air
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Aier School of Ophthalmology, Central South University
Proliferative Diabetic Retinopathy, Vitreous Hemorrhage
Cryoapplication Versus Anti-VEGF Before Diabetic Vitrectomy
Pars-plana vitrectomy (PPV) is the cornerstone of surgical treatment for eyes with complicated proliferative diabetic retinopathy. Anti-VEGF intravitreal injection before PPV has shown a good effect on surgical outcomes.
- Conditions
- Proliferative Diabetic Retinopathy, Vitreous Hemorrhage, Tractional Retinal Detachment
- Trial name
- NCT05514925
- Testing
- Bevacizumab Injection [Avastin], Peripheral Retinal Cryoapplication
- Where
- Tunisia
- Volunteers
- 60 people
- Sponsor
- Khairallah Moncef
Uveitis, Conjunctivitis
Ocular Manifestations in Rheumatic Diseases
This is a search strategy for determining the prevalence of ocular complications in inflammatory rheumatic diseases for the purposes of a meta analysis.
- Conditions
- Uveitis, Conjunctivitis, Keratoconjunctivitis Sicca, Xerophthalmia
- Trial name
- NCT03753893
- Testing
- No intervention used
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Vitrectomy, Retinal Detachment
Pars Plana Vitrectomy With 25-gauge 20000 Cpm, Bevel-tip Cutter
Report efficiency and clinical outcomes using 25-gauge, bevel-tip, 20000 cut per minute vitrectomy probe among eyes with various vitreo-retinal diseases
- Conditions
- Vitrectomy, Retinal Detachment, Vitreous Hemorrhage, Macular Holes
- Trial name
- HYPE (NCT04404296)
- Testing
- 25-gauge, bevel-tip, 20000 cut per minute pars plana vitrectomy
- Where
- Philippines
- Volunteers
- 50 people
- Sponsor
- Peregrine Eye and Laser Institute
Vitreous Hemorrhage, Macula Hole
Performance, Safety and Efficiency Comparison Between 10,000 and 5,000 Cuts Per Minute Vitrectomy Using a 25G Cutter - A Prospective Randomized Controlled Study
As technology advances, vitrectomy cutters are smaller and cut rates have become faster. In this prospective study, the vitrectomy efficiency and safety between 5,000 cuts per minute with 10,000 cuts per minute are compared
- Conditions
- Vitreous Hemorrhage, Macula Hole, Epiretinal Membrane, Retinal Detachment
- Trial name
- NCT04859556
- Testing
- Alcon 25Gauge, 10,000 cuts per minute Ultravit cutter, Alcon 25Gauge, 5,000 cuts per minute Ultravit cutter
- Where
- Hong Kong
- Volunteers
- 52 people
- Sponsor
- The University of Hong Kong
Retinal Detachment, Refractive Errors
Refractive Changes Following Vitrectomy
We aimed o compare the refractive changes associated with pars plana vitrectomy with or without intraocular gas tamponade in pseudophakic eyes.
- Conditions
- Retinal Detachment, Refractive Errors, Vitreous Hemorrhage, Epiretinal Membrane
- Trial name
- NCT04712786
- Testing
- pars plana vitrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Bursa Retina Eye Hospital
Exudative Macular Degeneration, Retinal Hemorrhage
Intravitreal tPA and C3F8 for the Treatment of Submacular Haemorrhage as a Complication of Neovascular AMD
This study will recruit patients who have recently had a submacular haemorrhage (bleed under the part of the retina responsible for detailed vision), as a complication of wet age-related macular degeneration (wet AMD).
- Trial name
- TAPAS (NCT01835067)
- Testing
- Ranibizumab, C3F8 Gas, tPA
- Where
- 5 sites in United Kingdom
- Volunteers
- 55 people
- Sponsor
- King's College Hospital NHS Trust
Epiretinal Membrane, Retinal Hemorrhage
Robotic Retinal Dissection Device Trial
The purpose of the study is to determine whether use of a robotic system improves the precision and therefore safety of high precision steps in retinal surgery.
- Trial name
- R2D2 (NCT03052881)
- Testing
- Robot assisted surgery
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Macular Holes, Intraocular Lens Opacification
Oral Sedation in Vitreoretinal Surgery
The purpose of this study is to compare the efficacy of oral sedation to intravenous sedation with anesthesiology support and monitoring.
- Conditions
- Macular Holes, Intraocular Lens Opacification, Vitrectomy, Vitreous Hemorrhage
- Trial name
- NCT04346095
- Testing
- Oral Sedatives with or Without Analgesia, Intravenous Sedatives with or Without Analgesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Rocky Vista University, LLC
Glaucoma, Macular Pucker
Prospective Retinal and Optic Nerve Vitrectomy Evaluation (PROVE) Study
Since the introduction of vitrectomy in 1971, this procedure has become the third most frequently performed ophthalmic surgery. Approximately 225,000 vitrectomies are performed annually in the United States and indications…
- Conditions
- Glaucoma, Macular Pucker, Macula Hole, Vitreomacular Traction
- Trial name
- PROVE (NCT01162356)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Vitreous Hemorrhage, Proliferative Diabetic Retinopathy
Intravitreal Ranibizumab for Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy (N)
This study is being conducted to determine if intravitreal injections of ranibizumab decrease the proportion of eyes in which vitrectomy is performed compared with saline injections in eyes presenting with vitreous hemorrhage…
- Trial name
- N (NCT00996437)
- Testing
- Ranibizumab, Saline
- Where
- 67 sites in United States
- Volunteers
- 261 people
- Sponsor
- Jaeb Center for Health Research