Clinical trials: Retinal Neovascularization
Vision-Threatening Retinal Lesions, Urgent Referral Retinal Findings
Artificial Intelligence-Assisted Lesion-Based Urgent Referral Triage of Ultra-Widefield Retinal Images
his study evaluates the clinical utility of an artificial intelligence (AI)-assisted lesion-based urgent referral triage system for ultra-widefield (UWF) retinal images.
- Conditions
- Vision-Threatening Retinal Lesions, Urgent Referral Retinal Findings, Retinal Detachment, Pre-retinal Hemorrhage
- Trial name
- ALERT-UWF (NCT07643129)
- Testing
- AI-Assisted UWF Lesion-Based Triage System, Unassisted Interpretation
- Where
- China
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Xiamen Ophthalmology Center Affiliated to Xiamen University
Amyotrophic Lateral Sclerosis
Analysis of Capillary Retinal and Papillary Vascularization in Patients With Amyotrophic Lateral Sclerosis - CAPISLA
Amyotrophic Lateral Sclerosis, or Charcot's disease, is a neurodegenerative disease affecting motor neurons. The disease affects between 5 and 10 people per 100,000 in the world, nearly 7,000 patients are affected in France.
- Trial name
- CAPISLA (NCT04686110)
- Testing
- angiographic optical coherence tomography
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Diabetic Retinopathy, Myopia
OCTA Metrics Repeatability and Reproducibility in Different Disorders
Retinal imaging is a corner stone in diagnosis of most retinal disorders. Standard imaging techniques e.g. fluorescein angiography and color fundus photography have a lot of limitations including limited resolution, invasive…
- Conditions
- Diabetic Retinopathy, Myopia, Choroidal Neovascularization, Healthy
- Trial name
- NCT04488887
- Testing
- Optical coherence tomography angiography
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tanta University
Conjunctivitis, Glaucoma
Feasibility Study and Preliminary Application Study on Iris OCTA
All participants will underwent imaging using the OCTA system (Zeiss) with the anterior segment optical adaptor lens. The main outcomes are iris blood flow density and vascular density.
- Conditions
- Conjunctivitis, Glaucoma, Myopia, Diabetic Retinopathy
- Trial name
- NCT03631108
- Testing
- OCTA (ZEISS)
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Macular Degeneration
A Safety Study in Healthy Volunteers to Evaluate Safety, How Fast the Drug is Absorbed, and the Side Effects of the Drug in Humans
This study is to evaluate the safety, absorption rate and side effects associated with the study drug. Healthy volunteers will be given a single dose of the drug in Part 1.
- Trial name
- NCT01051700
- Testing
- GW786034
- Where
- 3 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Uveitis, Diabetic Retinopathy
Biomarkers of Common Eye Diseases
To identify biomarkers of common eye diseases based on single-cell sequencing technologies using PBMC samples. These diseases include uveitis, diabetic retinopathy, age-related macular degeneration and polypoid choroidal…
- Conditions
- Uveitis, Diabetic Retinopathy, Age-related Macular Degeneration, Polypoidal Choroidal Vasculopathy
- Trial name
- NCT04101604
- Testing
- Collection of blood samples
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Age Related Macular Degeneration
Short-term Clinical Effects of Intravitreal Aflibercept Injection 2.0mg as a Predictor of Long-term Results
This is an open label study to evaluate 2.0 mg intravitreal aflibercept injection administered in subject who have active choroidal neovascularization due to Age Related Macular Degeneration (AMD).
- Trial name
- NCT01657669
- Testing
- Intravitreal Aflibercept injection
- Where
- 3 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Retina Research Institute, LLC
Choroidal Neovascularization, Age Related Macular Degeneration
SD-OCT-guided Intravitreal Ranibizumab Treatment in Choroidal Neovascularization Due to Myopia
This investigator initiated pilot study is designed to investigate the efficacy and safety of SD-OCT-guided intravitreal ranibizumab treatment in choroidal neovascularization (CNV) due to myopia.
- Trial name
- NCT03409250
- Testing
- Ranibizumab, Lucentis
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vista Klinik
Angioid Streaks
Ranibizumab Therapy for Choroidal Neovascularization (CNV) Asociated With Angioid Streaks
The purpose of this study is to determine whether injections of ranibizumab into the eye are safe and well tolerated when given to subjects in multiple doses.
- Trial name
- NCT01015495
- Testing
- ranibizumab
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Retinal Vein Occlusion, Retinal Vein Thrombosis
Atorvastatin for the Treatment of Retinal Vein Occlusion
The ATORVO study is designed to determine whether atorvastatin (Lipitor) can improve vision, when compared to placebo
- Conditions
- Retinal Vein Occlusion, Retinal Vein Thrombosis, Central Retinal Vein Occlusion, Branch Retinal Vein Occlusion
- Trial name
- ATORVO (NCT00517257)
- Testing
- Atorvastatin
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Age-Related Macular Degeneration, Choroidal Neovascularization
Value of Genetic Counseling and Testing for Patients Who Would Like to Know More About Their Personal Risk of AMD
The goals of this study are: To assess the impact of genetic testing based on how it alters behaviors, to assess the utility of serum biomarker measurement in combination with genetic testing, to assess the utility of genetic…
- Conditions
- Age-Related Macular Degeneration, Choroidal Neovascularization, Genetic Counseling
- Trial name
- NCT03024424
- Testing
- Early disclosure, Late disclosure
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Utah
Tabagism
Impact of Nicotine on Retinal Vascularization
The main hypothesis is the nicotine is associated with a modification of retinal micro-vascularization. Patients will be recruited during their ophthalmologic consultation at the Rothschild Foundation, an OCT-A will be realized…
- Trial name
- TABARET (NCT03964623)
- Testing
- OCT-A (Optical Coherence Tomography)
- Where
- France
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Glaucoma, Retinal Vein Occlusion
Study of the Retinal Vascularization by Laser Doppler Velocimetry Coupled With an Adaptive Optics Camera ( AO-LDV)
The difficulty to measure blood flow in humans is connected with the necessity of using not invasive, reliable and reproducible techniques.
- Trial name
- AO-LDV (NCT03525132)
- Testing
- Laser Doppler Velocimetry + Optic Adaptative Camera
- Where
- France
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Retinal Vascular Disorder, Sport Injury
Analysis of the Variation of the Retinal Vascularization After a Prolonged Effort
The cardiovascular parameters of prolonged physical exercice have been studied, but very little data is available about the retinal vascularization.
- Trial name
- MARETINE (NCT03864380)
- Testing
- Color retinography, OCT-A, Blood pressure measurement
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Macular Degeneration, Choroidal Neovascularization
Evaluation of Dosing Interval of Higher Doses of Ranibizumab
Evaluation of Dosing Interval of Higher Doses of Ranibizumab for patients with wet age-related macular degeneration (AMD).
- Trial name
- BGB/IST (NCT00533520)
- Testing
- ranibizumab
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Brandon G. Busbee, MD
Venous Retinal Branch Occlusion, Central Retinal Vein Occlusion
Impact of Lucentis on Psychological Morbidity in Patients With Retinal Vein Occlusion
This is a prospective, single-center, non-randomized clinical study on the impact of intravitreally administered ranibizumab (Lucentis) treatment on vision-related functioning and emotional well-being in subjects with central or…
- Conditions
- Venous Retinal Branch Occlusion, Central Retinal Vein Occlusion, Retinal Vein Occlusion, Depression
- Trial name
- NCT01011374
- Testing
- ranibizumab (Lucentis)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Retina Associates of Cleveland, Inc
Subfoveal Choroidal Neovascularization
Comparative Study With Photodynamic Therapy And Triamcinolone Versus Photodynamic Therapy, Triamcinolone And Ranibizumab In Patients With Subfoveal Choroidal Neovascularization
The purpose of this study is to compare the efficacy of photodynamic therapy with verteporfin (PDT) and IVTA vs triple therapy (TT) in patients with subfoveal choroidal neovascularization (CNV) secondary to age-related macular…
- Trial name
- NCT00930189
- Testing
- intravitreal injection of ranibizumab, intravitreal injection of triamcinolone, photodynamic therapy
- Where
- Mexico
- Volunteers
- healthy volunteers welcome
- Sponsor
- Asociación para Evitar la Ceguera en México
Wet Macular Degeneration
Intravitreal Ranibizumab and TA Combination Therapy vs. Ranibizumab Monotherapy in Polypoidal Choroidal Vasculopathy
The purpose of this study is to evaluate the effects and safety of ranibizumab therapy combined with TA versus ranibizumab monotherapy in patients with polypoidal choroidal vasculopathy (PCV).
- Trial name
- RANTA (NCT02806752)
- Testing
- Triamcinolone Acetonide, Ranibizumab
- Where
- 7 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Aier School of Ophthalmology, Central South University
Central Retinal Vein Occlusion With Macular Edema
Use of Ziv Aflibercept in Different Retinal Diseases
A prospective interventional case series study was conducted on 20 eyes of 20 patients with active myopic choroidal neovascularisation (CNV) ,20 eyes with resistant diabetic macular edema and 15 eyes with non ischaemic central…
- Trial name
- NCT04290195
- Testing
- Ziv-Aflibercept 25 MG/ML [Zaltrap]
- Where
- Egypt
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Amin El Sayed Nawar
Age-Related Macular Degeneration
Genetic Study of Age-Related Macular Degeneration
This study will examine skin and blood cells for genetic changes related to the development of age-related macular degeneration, an eye disease that can significantly impair the ability to read, drive, and carry out daily…
- Trial name
- NCT00357578
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)