Clinical trials: Retinal Nerve Fiber Layer Thickness
Glaucoma
Retinal Nerve Fibres Layers Thickness Study in Glaucomatous Patients
In this study the investigators are going to study the retinal nerve fibers layers (RNFL) modification of two groups of patients, one taking no drugs, the other taking forskolin, rutin and vitamins B1 and B2.
- Trial name
- NCT01254006
- Testing
- forskolin, rutin and vitamins B1 and B2
- Where
- Italy
- Sponsor
- University of Roma La Sapienza
Obstructive Sleep Apnea, Hypopnea Syndrome
Retinal Nerve Fiber Layer Thickness Measurements in Patients With Sleep Apnea Syndrome
The purpose of this study was to measure the retinal nerve fiber layer (RNFL) thickness in eyes of Obstructive Sleep Apnea/hypopnea syndrome (OSAHS) using optical coherence tomography (OCT), and assess whether it is decreased.
- Conditions
- Obstructive Sleep Apnea, Hypopnea Syndrome, Glaucoma
- Trial name
- NCT01188291
- Where
- Israel
- Volunteers
- 166 people
- Sponsor
- Carmel Medical Center
Retinal Disease
Changes in Retinal Nerve Fiber Layer Thickness Detected by OCT in Diabetic Retinopathy After Panretinal Photocoagulation
Panretinal photocoagulation reduces the risk of visual loss by 50% in patients with diabetic retinopathy. It is recognized that laser expansion into the retina may be associated with photoreceptor loss, retinal pigment epithelial…
- Trial name
- NCT03786146
- Volunteers
- 30 people
- Sponsor
- Assiut University
Alzheimer Disease
Retinal Nerve Fiber Layer Thickness and Cerebrospinal Fluid Aβ/Tau
To test the hypothesis that retinal nerve fiber layer (RNFL) thickness is correlated with Aβ and Tau concentration of cerebrospinal fluid (CSF) in an older population.
- Trial name
- NCT03447613
- Testing
- surgery
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Shanghai 10th People's Hospital
Dry Eye Disease, Retinal Nerve Fiber Layer
Dry Eye Disease and Retinal Nerve Fiber Layer Thickness in Chronic Smokers
This study aimed to examine the impact of long-term smoking on dry eye parameters and retinal nerve fiber layer thickness in individuals who are chronic smokers.
- Conditions
- Dry Eye Disease, Retinal Nerve Fiber Layer, Chronic Smoking
- Trial name
- NCT07028736
- Testing
- Dry eye assessment
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Multiple Sclerosis, Optic Neuritis
Neuroprotection and Repair in Optic Neuritis
The primary aim of this open-label pilot trial is to estimate the treatment effect of 100 mg of oral minocycline twice daily for 90 days, initiated within 30 days of onset of ON, on functional and structural optic nerve recovery…
- Trial name
- Mino in ON (NCT01073813)
- Testing
- Minocycline
- Volunteers
- 6 people
- Sponsor
- University of Calgary
Glaucoma
Normative Database of the Retinal Nerve Fiber Layer Thickness Measured by the Cirrus HD OCT in Asians
The normal range of retinal nerve fiber layer thickness might be different between Asians and Caucasians. However, the recently developed imaging device such as the Cirrus HD OCT includes only the Caucasian data.
- Trial name
- NCT00744705
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Glaucoma, Myopia
Corrected Measurement of the Retinal Nerve Fiber Layer Thickness by Optic Disc Configuration With the Cirrus HD OCT
Because the measurement of the retinal nerve fiber layer thickness is very sensitive to the position of measurement, it may be incorrect in patients with the tilted disc.
- Trial name
- NCT00741130
- Where
- South Korea
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Parkinson Disease
Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease: A Meta-analysis
Optical coherence tomography (OCT) is a non-invasive retinal imaging technology that can provide high-resolution cross-sectional images of the peripapillary retinal nerve fiber layer (RNFL) and measure its thickness.
- Trial name
- NCT01928212
- Testing
- Optical coherence tomography
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yifan Feng
Glaucoma
The Effectiveness Of Home-Based Circuit Training On Eye Pressure And Eye Nerve Structures In Patients With Glaucoma
The goal of this randomised control trial is to learn about the effect of home based circuit training on patients with primary glaucoma. The main questions to answer are: 1.
- Trial name
- NCT07733388
- Testing
- Home-Based Circuit Training
- Where
- Malaysia
- Volunteers
- 60 people
- Sponsor
- Universiti Sains Malaysia
Alzheimer's Disease
Measurement of Retinal Nerve Fiber Layer Thickness - a Biomarker for the Early Detection of Alzheimer's Disease?
The purpose of this study is to determine whether by measuring changes in the thickness of the retinal nerve fibre layer (the photosensitive layer at the back of the eye) you could predict if someone would develop Alzheimer's…
- Trial name
- SCI-OCT (NCT02051244)
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center
Primary Glaucoma
The Effect Of Tropical Fruits In Patients With Primary Glaucoma
To evaluate the effect of regular tropical fruits intake in primary glaucoma patients. Methodology : Research Design Randomized controlled trial Study Duration February 2024-June 2025 Study Location 1.
- Trial name
- NCT06071494
- Testing
- Tropical fruits
- Where
- Malaysia
- Volunteers
- 104 people
- Sponsor
- Universiti Sains Malaysia
Primary Lung Tuberculosis
Early Retinal Nerve Fiber Layer Change of Ethambutol Optic Neuropathy by Optical Coherence Tomography
Ethambutol is widely used as first-line drug, but has serious side effect of optic neuropathy. As previously reported, incidence of ethambutol optic neuropathy is about 1~2%, there was considerable screening efforts and medical…
- Trial name
- NCT01866579
- Where
- South Korea
- Volunteers
- 49 people
- Sponsor
- Yonsei University
Adverse Effect of Oral Contraceptives, Subsequent Encounter
The Effect of Oral Contraceptive Pills On Eyes
The investigators aimed to evaluate the effect of oral contraceptive pills(OCP) on macula, retinal nerve fiber layer and choroid thickness by using Optical Coherence Tomography (OCT).
- Trial name
- NCT02841202
- Testing
- oral contraceptive pills
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
PCOS
Eye Evaluation in Patients With PCOS
To evaluate the macular, retinal nerve fiber layer (RNFL) and choroidal thickness alterations by using spectral-domain optical coherence tomography (SD-OCT) in polycystic ovary syndrome (PCOS) and to compare them with healthy…
- Trial name
- NCT01950832
- Testing
- Investigating clinically normal patients with optic coherence tomography
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Gökhan Açmaz
Diabetic Retinopathy
Effect of the Adjunctive IVB Before PRP
This study is to investigate the effect of adjunctive intravitreal bevacizumab (IVB) before panretinal photocoagulation (PRP) compared with only PRP on central macular thickness and retinal nerve fiber layer thickness in patients…
- Trial name
- IVB (NCT01504724)
- Testing
- bevacizumab
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Kyungpook National University Hospital
Multiple Sclerosis
Studying the Effects of Copaxone on Retinal Health Using Optical Tomography Over 24 Months
This is a prospective, observational, single-blinded, longitudinal, 24-month OCT study of the evolution of axonal loss, as evidenced by loss of RNFLT and TMV, in RRMS patients treated with GA and in healthy controls.
- Trial name
- GAO (NCT02017808)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University at Buffalo
Glaucoma, Myopia
Efficacy of Retinal Nerve Fiber Layer (RNFL) / Retinal Thickness Ratio by Cirrus OCT Utilizing Spectral -Domain Technology as a Diagnostic Predictor of Glaucoma
Glaucoma is presumed to be an axonal disease which starts at the lamina cribrosa. This assumption has led to the monitoring of the retinal nerve fiber layer thickness for the diagnosis and monitoring of progression of glaucoma.
- Trial name
- NCT00772993
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Glaucoma
Retinal Nerve Fiber Layer Thickness Analysis With Cirrus HD OCT Versus Stratus Optical Coherence Tomography (OCT)
The Cirrus HD OCT, a new spectral domain optical coherence tomography (OCT), has better resolution than the previous time domain Stratus OCT.
- Trial name
- NCT00766389
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Primary Open Angle Glaucoma
Structure Function Correlation in Primary Open Angle Glaucoma
Glaucoma is an optic neuropathy characterised by progressive degeneration of retinal ganglion cells and axons that leads to nerve fibre loss, optic disc cupping, and consecutive glaucomatous visual field defects.
- Trial name
- STR_FN (NCT02028572)
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Vasan Eye Care Hospital