Clinical trials: Retinal Vascular Disorder
Susac Syndrome
Physiotherapy Approach for Susac Syndrome
Susac's syndrome is a rare autoimmune disorder characterised by a triad of encephalopathy (brain dysfunction), branch retinal artery occlusion (loss of vision) and sensorineural hearing loss.
- Trial name
- NCT06349603
- Where
- Bosnia and Herzegovina
- Volunteers
- 1 people
- Sponsor
- Rehabilitation Centre Zivot
Diabetic Macular Edema
A Comparison of Standard Laser With Micropulse Laser for the Treatment of Diabetic Macular Oedema.
DIAMONDS is a Randomised Controlled Clinical Trial that is being carried out in the UK to determine the clinical effectiveness and cost-effectiveness of micropulse laser, compared with standard laser, for the treatment of…
- Trial name
- DIAMONDS (NCT03690050)
- Testing
- Diode 577 nm subthreshold micropulse laser, Standard threshold laser (532 nm laser)
- Where
- 14 sites in United Kingdom
- Volunteers
- 266 people
- Sponsor
- Belfast Health and Social Care Trust
Retinal Vasculitis, Behcet Syndrome
Evaluation of Macular Vascular Changes in Behcet's Disease Using Optical Coherence Tomography Angiography
Behcet's disease is an important cause of retinal vasculitis and vision loss in Egypt. Fluorescein angiography is the standard method of diagnosis of retinal vasculitis.
- Trial name
- NCT03264391
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Retinal Vein Occlusion
Continuing Assessment of Patients Treated With ranibizUmab for REtinal Vein Occlusion (CAPTURE)
This research is being done to assess the long term prognosis of patients treated with ranibizumab for edema due to retinal vein occlusion.
- Trial name
- CAPTURE (NCT01875770)
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Johns Hopkins University
Type2 Diabetes, Diabetic Retinopathy
Tangningtongluo Tablet in the Treatment of Non-proliferative Diabetic Retinopathy
This trial is planned to collect relevant clinical data to evaluate the prevention efficacy and safety of Tangningtongluo tablets on the non-proliferation period of diabetic retinopathy.
- Trial name
- NCT05007262
- Testing
- Tangningtongluo tablets, Calcium dobesilate capsules
- Where
- 13 sites in China
- Volunteers
- 240 people
- Sponsor
- Guizhou Bailing Group Pharmaceutical Co Ltd
Diabetic Retinopathy
OCT Biomarkers for Diabetic Retinopathy
Diabetic retinopathy (DR) is caused by changes in the blood vessels of the retina associated with long-term Type 1 or Type 2 diabetes mellitus. DR is a leading cause of blindness in the United States.
- Trial name
- NCT02330042
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Diabetic Retinopathy, Diabetic Eye Problems
Detection and Classification of Diabetic Retinopathy From Posterior Pole Images With A Deep Learning Model
The duration of diabetes is directly related to eye complications. Diabetic retinopathy affects 80 percent of those who have had diabetes for 20 years or more.
- Conditions
- Diabetic Retinopathy, Diabetic Eye Problems, Diabetic Macular Edema
- Trial name
- NCT04805541
- Testing
- Color Fundus Photography, Mydriatic Agent, EyeCheckup - AI Based DR Screening
- Where
- Turkey (Türkiye)
- Volunteers
- 900 people
- Sponsor
- Ural Telekomunikasyon Sanayi Ticaret Anonim Sirketi
Arteriosclerosis
Evaluation of the Capacity of a Camera to Identify Signs of Arteriosclerosis in Retinal Arterioles
Arteriosclerosis is a degenerative and dysmetabolic disease of the arterial walls. It is known to be the principal cause of coronary artery disease (CAD).
- Trial name
- NCT02849405
- Testing
- MHRC: Metabolic Hyperspectral Retinal Camera
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jean-Claude Tardif
Diabetic Macular Edema
Multiple Dose Safety and Efficacy of LKA651 in Patients With Diabetic Macular Edema
The primary objectives of this study were to evaluate the safety and efficacy of LKA651 in patients with macular edema from diabetic macular edema (DME),
- Trial name
- NCT03927690
- Testing
- LKA651, Lucentis
- Where
- 22 sites in United States, Germany and 3 more
- Volunteers
- 91 people
- Sponsor
- Novartis Pharmaceuticals
Retinal Vein Occlusion, Macular Edema
Retrospective Study in Patients Receiving Two or More OZURDEX® Injections for Retinal Vein Occlusion (RVO)
This is a retrospective data collection study to evaluate the efficacy, safety, and re-injection interval of OZURDEX® in the treatment of macular edema due to RVO. Following informed consent, there were no patient study visits.
- Trial name
- NCT01411696
- Testing
- dexamethasone intravitreal implant 0.7 mg
- Where
- United States
- Volunteers
- 289 people
- Sponsor
- Allergan
Central Retinal Vein Occlusion
The ROVO Study: Radial Optic Neurotomy for CVO
The ROVO study is a prospective, placebocontrolled and randomised study designed to evaluate the effect of radial optic neurotomy in central vein occlusion, versus triamcinolone acetonide.
- Trial name
- NCT00532142
- Testing
- Intravitreal Triamcinolone, Radial Optic Neurotomy
- Where
- Austria
- Sponsor
- Rudolf Foundation Clinic
Diabetic Retinopathy, Lasers
Pattern Scanning Laser Pan-retinal Photocoagulation in Proliferative Diabetic Retinopathy
A randomized study to assess the safety and efficacy of single-session pan-retinal photocoagulation (PRP) using Pattern Scan Laser (PASCAL) in proliferative diabetic retinopathy (PDR) - 1,700 shots vs 2,500 shots
- Conditions
- Diabetic Retinopathy, Lasers, Treatment Outcome
- Trial name
- NCT02816073
- Testing
- Pan-retinal photocoagulation using pattern scanning laser
- Volunteers
- 17 people
- Sponsor
- United Christian Hospital
Infant, Premature, Leukomalacia, Periventricular
Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants
Periventricular leukomalacia (PVL) is one of the most common brain injuries that occur in preterm infants. Inflammation, hypoxia-ischemia, free oxygen radical formation and excitotoxicity are all known pathogenic mechanisms that…
- Conditions
- Infant, Premature, Leukomalacia, Periventricular, Intraventricular Hemorrhage, Retinopathy of Prematurity
- Trial name
- NCT00910234
- Testing
- recombinant human erythropoietin (rhEpo), Normal saline
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- China Medical University Hospital
Neovascular Glaucoma
Clinical Characteristics of Neovascular Glaucoma
The goal of this observational study is to explore the clinical characteristics of patients with neovascular glaucoma (NVG), and to analyze the relationship between NVG and various underlying diseases, ocular conditions…
- Trial name
- NCT07177807
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Diabetic Retinopathy, Diabetic Macular Edema
Treatment of Diabetic Macular Edema: Triamcinolone Injections Vs. Laser Photocoagulation
This study will compare the side effects of two treatments for diabetic macular edema, in which blood vessels in the retina (tissue that lines the back of the eye) become leaky and the retina and macula (the center part of the…
- Conditions
- Diabetic Retinopathy, Diabetic Macular Edema, DME
- Trial name
- NCT00105404
- Testing
- Triamcinolone Acetonide
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Macular Edema, Diabetic Retinopathy
Intravitreal Ranibizumab or Aflibercept After Bevacizumab in Diabetic Macular Edema
PURPOSE: To evaluate the efficacy of switching from bevacizumab to ranibizumab (Lucentis; Genentech, South San Francisco, CA) or aflibercept (Eylea; Regeneron, Tarrytown, NY) in eyes with diabetic macular edema (DME) nonresponders…
- Trial name
- SWITCH (NCT04018833)
- Testing
- Ranibizumab 0.5 MG/0.05 ML Intraocular Solution [LUCENTIS], Aflibercept 40 MG/ML Intraocular Solution [EYLEA]
- Volunteers
- 40 people
- Sponsor
- Bernardete Pessoa MD
Diabetic Retinopathy, Macular Edema
Dosing Study of Ranibizumab for Diabetic Retinal and Macular Edema
This study is to see whether treating diabetic retinal swelling with ranibizumab injections into the eye monthly is better than treating diabetic retinal swelling with ranibizumab injections into the eye less frequently.
- Trial name
- NCT01476449
- Testing
- Ranibizumab
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Retina Vitreous Associates of Florida
Erectile Dysfunction
Fundus Oculi and Erectile Dysfunction
The purpose of this study is to evaluate the correlation between fundus oculi's vascularization in patients with erectile dysfunction and not, and, in the same patients, before and after using drugs for ED.
- Trial name
- NCT02845765
- Testing
- Dynamic Vessel Analyzer (DVA), Phosphodiesterase type 5 Inhibitor (PDE5I)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ospedale San Raffaele
Retinal Vascular Disorder, Macular Degeneration
Ocular Imaging Study Using Advanced OCT
The purpose of this study is to evaluate this AngioScan angiography software on patients with various retinal vascular disorders.
- Trial name
- NCT02827071
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of California, Los Angeles
Macular Degeneration
Vascular Endothelial Growth Factor VEGF Trap-Eye:Investigation of Efficacy and Safety in Wet Age-Related Macular Degeneration(AMD)
This study is a phase 3, double-masked, randomized, study of the efficacy and safety of VEGF Trap-Eye in patients with neovascular age-related macular degeneration.
- Trial name
- VIEW1 (NCT00509795)
- Testing
- ranibizumab, aflibercept injection (VEGF Trap-Eye, BAY86-5321)
- Where
- 188 sites in United States, Canada
- Volunteers
- 1,217 people
- Sponsor
- Regeneron Pharmaceuticals
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