Clinical trials: Retinal Vascular Disorder
Retinopathy of Prematurity
Oral Propranolol Versus Placebo for Early Stages of Retinopathy of Prematurity: A Randomized and Prospective Study
In premature infants, propranolol (Prop) treatment might suppress continuing neo-vascularization (NV) and decelerate the progression of retinopathy of prematurity (ROP) towards its severe stages (III-V), thus avoiding the need of…
- Trial name
- NCT01238471
- Testing
- propranolol, sucrose 5%
- Where
- 4 sites in Israel
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus
Age-Related Macular Degeneration, Diabetic Macular Edema
Evaluation of Therapeutic Efficacy of Faricimab for Clinical AMD, DME, and RVO Patients
The goal of this clinical trial is to learn if drug Faricimab works to treat nAMD, DME or RVO in adults. It will also learn about the safety of drug Faricimab.
- Conditions
- Age-Related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- NCT06572553
- Testing
- Faricimab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Central Retinal Artery Occlusion
Study of Arterial Recanalization of the Central Retinal Artery Occlusions
Central retinal artery occlusions (CRAO) are the equivalent of an ischemic stroke (IS) at the retinal level. They share the same risk factors and common pathology.
- Trial name
- RECANAL (NCT03049514)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Choroidal Neovascularization, Age-Related Maculopathy
Safety and Efficacy of a New Therapy as Adjunctive Therapy to Anti-vascular Endothelial Growth Factor (Anti-VEGF) in Subjects With Wet Age-Related Macular Degeneration (AMD)
The study will evaluate the safety and efficacy of the intravitreal dexamethasone implant as adjunctive therapy to Anti-VEGF treatment in the study eye of treatment naïve subjects with choroidal neovascularization secondary to…
- Trial name
- NCT00775411
- Testing
- dexamethasone, ranibizumab
- Where
- 3 sites in United States, Australia and 1 more
- Volunteers
- 44 people
- Sponsor
- Allergan
Diabetic Retinopathy
A Study of BI 765128 in Patients With an Eye Condition Called Diabetic Macular Ischemia Who Have Received Laser Treatment
This study is open to adults with diabetic macular ischemia who have received laser treatment. The main purpose of this study is to find out whether people with diabetic macular ischemia can tolerate a medicine called BI 765128.
- Trial name
- PARTRIDGE (NCT04919499)
- Testing
- BI 765128
- Where
- 25 sites in United States, Australia and 4 more
- Volunteers
- 46 people
- Sponsor
- Boehringer Ingelheim
Diabetic Retinopathy, Diabetic Macular Edema
OphtAI Diagnostic Performance Validation for Automated Screening of Eye Diseases
Evolucare OphtAI is a medical device offering automated, artificial intelligence powered, screening capabilities for Diabetic Retinopathy, Diabetic Macular Edema, Glaucoma, ARM and AMD, whose performances will by tested through…
- Conditions
- Diabetic Retinopathy, Diabetic Macular Edema, Age-Related Macular Degeneration, Age-related Maculopathy
- Trial name
- OPHTAI-EVAL (NCT05752045)
- Testing
- Eye Fundus Double Capture for Eye Diseases Screening with OphtAI Medical Device
- Where
- 12 sites in France
- Volunteers
- 1,389 people
- Sponsor
- Evolucare Technologies
Diabetic Retinopathy, DR
Impact of Diabetes Mellitus on Retinal Microvasculature in Patients Without Clinical Retinopathy Using Optical Coherence Tomography Angiography
the aim of this study is to assess the impact of duration of DM on OCTA parameters in diabetic patients without clinical Diabetic retinopathy.
- Trial name
- NCT06457295
- Testing
- optical coherence tomography angiography
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sohag University
Branch Retinal Vein Occlusion
Evaluation of Macugen Treatment of Macular Edema Due to Branch Retinal Vein Occlusion
The purpose of this study is to evaluate the effect of intravitreal injections of Macugen every 6 weeks for the treatment of macular edema secondary to branch retinal vein occlusion (BRVO).
- Trial name
- NCT00406107
- Testing
- pegaptanib sodium (Macugen)
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Palmetto Retina Center, LLC
Stroke, Risk Reduction
CHM Teabag Decrease Stroke Risk Among Hong Kong Elderly
This stepped wedge cluster randomized controlled trial aims to examine the efficacy and safety of CHM teabag in decreasing stroke risk by machine-learning-based retinal image analysis in elderly population.
- Conditions
- Stroke, Risk Reduction, Elderly
- Trial name
- NCT05801575
- Testing
- Chinese Herbal Medicine (CHM) teabag
- Where
- China
- Volunteers
- 912 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Macula Edema, Retinal Vein Occlusion
Near-Infrared Light Photobiomodulation Treatment for Retinal Vein Occlusion Macular Oedema
This pilot study aims to establish that treatment with near infrared light (NIR) reduces cystic macular oedema in patients with a retinal vein occlusion.
- Trial name
- NIRVO (NCT04847869)
- Testing
- Ellex Integre NIR laser
- Where
- Australia
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Diabetic Retinopathy
The Efficacy of Intravitreal Aflibercept Injection in Improvement of Retinal Nonperfusion in Diabetic Retinopathy
Retinal nonperfusion drives vision-threatening complications such as pathological neovascularization, which can lead to neovascular glaucoma, vitreous hemorrhage, or tractional retinal detachments and macular edema in diabetic…
- Trial name
- NCT03006081
- Testing
- Intravitreal Aflibercept injection
- Where
- South Korea
- Volunteers
- 38 people
- Sponsor
- Asan Medical Center
Glaucoma, Suspect, Diabetic Retinopathy
Eye Health Intervention Study in Upper Manhattan
Individuals living in Upper Manhattan have limited access to eye care, high vision impairment rates, and poor ocular health outcomes.
- Conditions
- Glaucoma, Suspect, Diabetic Retinopathy, Cataract, Refractive Errors
- Trial name
- EYES-UM (NCT06112431)
- Testing
- Intervention, Usual Care
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Diabetic Retinopathy, Diabetic Macular Edema
Conjunctival Flora Patterns After Serial Intravitreal Injections in Diabetic Patients
The aim of this study is to investigate the conjunctival bacterial flora and antibiotic resistance patterns following serial intravitreal injections of anti-VEGF in diabetic patients, using a povidone-iodine preparation without…
- Trial name
- NCT02337972
- Testing
- povidone-iodine 4%
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Central Retinal Vein Occlusion
Central Retinal Vein Occlusion (CRVO) Treatment With Bevacizumab and Dexamethasone or Bevacizumab Only.
The purpose of this study is to determine whether Bevacizumab (Avastin) in combination with Dexamethasone (Ozurdex) will be effective in reducing if not eliminating the macular edema associated with the disease, central retinal…
- Trial name
- NCT04601701
- Testing
- Bevacizumab Ophthalmic and Intravitreal Dexamethasone., Bevacizumab Ophthalmic.
- Where
- China
- Volunteers
- 100 people
- Sponsor
- He Eye Hospital
Diabetes Mellitus, Diabetic Retinopathy
Macular Involvement in Diabetic Retinopathy Evaluated With Swept-Source OCT
This study evaluates micro-vascular changes in patients with diabetes. Results of diseased retinas will be compared to healthy controls.
- Trial name
- NCT03765112
- Testing
- Optical coherence tomography angiography
- Where
- Canada
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Proliferative Diabetic Retinopathy
Intravitreal Ranibizumab For Persistent New Vessels In Diabetic Retinopathy(Inipe Study)
To evaluate the fluorescein angiographic and visual acuity effects of a single intravitreal injection of ranibizumab for the management of persistent new vessels associated with diabetic retinopathy.
- Trial name
- INIPE (NCT00993525)
- Testing
- Intravitreal injection of ranibizumab
- Volunteers
- 22 people
- Sponsor
- University of Sao Paulo
Diabetic Retinopathy
Trientine Hydrochloride for the Prevention of Macular Edema Associated With Pan-retinal Photocoagulation for Severe Non-proliferative and Proliferative Diabetic Retinopathy
To evaluate the effects of Trientine Hydrochloride in prevention of post-laser (pan-retinal photocoagulation) macular edema in the eyes for subjects with diabetic retinopathy.
- Trial name
- NCT01213888
- Testing
- Trientine Hydrochloride
- Where
- Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Retinal Disease
Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A)
Comparison of OCTA to conventional imaging modalities for the diagnosis of eye diseases
- Trial name
- NCT02811536
- Testing
- optical coherence tomography angiography
- Where
- Switzerland
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetic Retinopathy, Diabetes Mellitus
Leveraging Artificial Intelligence to Prevent Vision Loss From Diabetes
This pragmatic clinical trial is being conducted to test the effectiveness of AI-BRIDGE (Artificial Intelligence-Based point of caRe, Incorporating Diagnosis, SchedulinG, and Education), in improving screening and follow-up eye…
- Trial name
- NCT06763952
- Testing
- AI-BRIDGE, Educational Materials
- Where
- United States
- Volunteers
- 6,900 people
- Sponsor
- University of Wisconsin, Madison
Uveitis, Anterior, Adalimumab
The Efficacy and Safety of Adalimumab in Non-infectious Anterior Pediatric Uveitis With Peripheral Vascular Leakage
Children with anterior uveitis are prone to suffer from chronic recurrent course of intraocular inflammation and adverse effects of glucocorticosteroids (GCs) /immunomodulatory treatment (IMT) agents.
- Trial name
- NCT05015335
- Testing
- Adalimumab, Methotrexate
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking Union Medical College Hospital
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