Clinical trials: Retinal Vessels
Retinal Vascular
Physiologic Change of Posterior Ocular Segment During Pregnancy
Women's physiology changes markedly during normal pregnancy. The most distinct alterations occur in the hormonal and cardiovascular systems. There is a dramatic increase in both estrogen and progesterone.
- Trial name
- NCT04731415
- Testing
- Optical coherence tomography and optical coherence tomography angiography (Optovue®)
- Where
- Thailand
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Khon Kaen University
Diabetes Mellitus
Study on Tear Proteins in Diabetic Retinopathy of Type 2 Diabetics
Diabetes mellitus is becoming a global epidemic. There is a need to devise a non invasive method for detection of diabetes and its related complication.
- Trial name
- NCT00698698
- Where
- Pakistan
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Ischemic Stroke
Correlation Between the Changes of Retinal Structure and Function and Ischemic Stroke
Ischemic stroke is the most common type of stroke, accounting for 60%-80% of all types of strokes, and is one of the leading global causes of death and severe disability.
- Trial name
- NCT05281887
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Guangdong Provincial People's Hospital
Cardiovascular Risk Factor
Automatic Image Analyzer to Assess Retinal Vessel Caliber
The objective of this work is the development and validation (reliability and validity) of the Automatic image analyzer to assess it retinal vessel caliber (ALTAIR) platform to analyze and validate its utility in different…
- Trial name
- ALTAIR (NCT02087605)
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Metabolomics; Retinopathy; Etiology
Study on the Pathogenesis of Retinal Vascular Diseases Based on Body Fluid Metabolomics
Through the analysis of metabolites in body fluids (intraocular fluid, plasma) of patients with retinal vascular diseases (retinal vein occlusion, diabetic retinopathy), the possible pathogenesis of retinal vein occlusion was…
- Trial name
- NCT06408571
- Testing
- etiology
- Where
- China
- Volunteers
- 3,900 people, healthy volunteers welcome
- Sponsor
- Zhongnan Hospital
Retinal Vein Occlusion (RVO), Macular Edema
Ozurdex Implant for Macular Edema After Treatment Failure With Anti-VEGF
To determine if Ozurdex implant can offer an effective treatment for macular edema associated with retinal vein occlusion when treatment with intravitreal Avastin, Lucentis, or Eylea have not demonstrated a significant response.
- Trial name
- NCT01946399
- Testing
- Ozurdex implant
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Retina Research Institute, LLC
Diabetic Retinopathy
OCT Biomarkers for Diabetic Retinopathy
Diabetic retinopathy (DR) is caused by changes in the blood vessels of the retina associated with long-term Type 1 or Type 2 diabetes mellitus. DR is a leading cause of blindness in the United States.
- Trial name
- NCT02330042
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Multiple Sclerosis, Dry Eye Syndromes
Clinical Applications of Advanced Ophthalmic Imaging
The purpose of this study is to determine the clinical application of advanced ophthalmic imaging devices such as optical coherence tomography (OCT), retinal function imager (RFI), slit-lamp biomicroscopy (SLB), PERG in diseased…
- Conditions
- Multiple Sclerosis, Dry Eye Syndromes, Diabetic Retinopathy, Presbyopia
- Trial name
- NCT03135327
- Testing
- Ocufolin
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Miami
Primary Open Angle Glaucoma
Electroretinogram and Retinal Vascular Changes After Cataract Surgery
To compare electrophysiological and Optical coherence tomography angiography of optic disc and macula changes after uneventful phacoemulsification between normal and cataractus patients with primary open angle glaucoma.
- Trial name
- NCT05871034
- Testing
- phacoemulsification
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Arteriosclerosis
Evaluation of the Capacity of a Camera to Identify Signs of Arteriosclerosis in Retinal Arterioles
Arteriosclerosis is a degenerative and dysmetabolic disease of the arterial walls. It is known to be the principal cause of coronary artery disease (CAD).
- Trial name
- NCT02849405
- Testing
- MHRC: Metabolic Hyperspectral Retinal Camera
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jean-Claude Tardif
Diabetic Retinopathy
Trientine Hydrochloride for the Prevention of Macular Edema Associated With Pan-retinal Photocoagulation for Severe Non-proliferative and Proliferative Diabetic Retinopathy
To evaluate the effects of Trientine Hydrochloride in prevention of post-laser (pan-retinal photocoagulation) macular edema in the eyes for subjects with diabetic retinopathy.
- Trial name
- NCT01213888
- Testing
- Trientine Hydrochloride
- Where
- Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cardiovascular Disease, Childhood Obesity
Exercise and Arterial Modulation in Youth
The project is designed as a large scale, cross-sectional study. The aim of the study is to investigate the association of micro- and macrovascular function with physical fitness and body composition in primary school children.
- Conditions
- Cardiovascular Disease, Childhood Obesity, Hypertension, Endothelial Dysfunction
- Trial name
- ExAMIN YOUTH (NCT02853747)
- Testing
- Physical Activity, 20-meter shuttle run
- Where
- Switzerland
- Volunteers
- 337 people, healthy volunteers welcome
- Sponsor
- University of Basel
Diabetic Retinopathy
Validation of the Artificial Intelligence Subsystem of the DDART Medical Device for the Automated Detection of Lesions Compatible With Diabetic Retinopathy in a Random Sample of Retinal Fundus Photographs
To validate the artificial intelligence subsystem of the DDART medical device for the automated detection of lesions compatible with diabetic retinopathy in a random sample of retinal fundus photographs.
- Trial name
- NCT07758582
- Testing
- Color retinal fundus photograph
- Where
- Greece
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Diabetes Mellitus, Type 2 Diabetes
The Hong Kong Diabetes Biobank
Asia is in the midst of an epidemic of diabetes. Epidemiological figures suggest that there are more than 110 million people affected by diabetes in China, with a significant proportion of young adults already affected.
- Conditions
- Diabetes Mellitus, Type 2 Diabetes, Type 1 Diabetes, Diabetic Nephropathies
- Trial name
- HKDB (NCT05282680)
- Testing
- prospective observational study
- Where
- Hong Kong
- Volunteers
- 48,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Diabetic Retinopathy, Age-Related Macular Degeneration (AMD)
Genetics and Markers of Degenerative and Inflammatory Eye Diseases
This study will identify genes that are associated with inflammation or degeneration of the retina (membrane lining the back of the eye that relays vision signals to the brain).
- Conditions
- Diabetic Retinopathy, Age-Related Macular Degeneration (AMD), Uveitis
- Trial name
- NCT00647439
- Where
- United States
- Volunteers
- 609 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Retinal Vein Occlusion
Intravitreal Ranibizumab Treatment of Central Retinal Vein Occlusion With Macular Edema
The purpose of this study is to examine the effects of Lucentis for active Central Retinal Vein Occlusion with Macular Edema
- Trial name
- NCT00403039
- Testing
- Ranibizumab (Lucentis )
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Vitreous -Retina- Macula Consultants of New York
Retinal Vascular, Retina
Normative Data Collection Study of the Zilia Ocular for the Measurement of Oxygen Saturation in the Retina
Mainstream oximetry devices use two-wavelength systems to photograph the retina and estimate the oxygen saturation levels in the retinal vessels by comparing light absorption in the blood of the vessels at the selected…
- Trial name
- NCT04408677
- Testing
- Zilia Ocular
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Zilia Inc.
Diabetes Mellitus, Diabetic Retinopathy
Macular Involvement in Diabetic Retinopathy Evaluated With Swept-Source OCT
This study evaluates micro-vascular changes in patients with diabetes. Results of diseased retinas will be compared to healthy controls.
- Trial name
- NCT03765112
- Testing
- Optical coherence tomography angiography
- Where
- Canada
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Diabetes Mellitus, Diabetic Retinopathy
Is Community Based Monitoring of Diabetic Maculopathy and Pre-proliferative Diabetic Retinopathy Safe?
To assess a pathway using opticians based in their practices and a 'virtual' review by a consultant ophthalmologist, based in the hospital to assess suspected diabetic maculopathy.
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Diabetic Maculopathy
- Trial name
- FARSight-DM (NCT06955611)
- Testing
- Community based optometry with Virtual Review, Usual Care
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hywel Dda Health Board
Macular Degeneration
Study Of The Repeat Dosing Of Ketoconazole On The Pharmacokinetics Of A Single Dose Of Pazopanib (GW786034) Eye Drops
This is a two-period study to evaluate the effect of repeat oral dosing of ketoconazole on the pharmacokinetics of single dose pazopanib administered as an eye drop
- Trial name
- NCT00659555
- Testing
- pazopanib eye drops, Ketoconozole tablets
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline