Clinical trials: Retinoblastoma
Pediatric Retinoblastoma, Retinoblastoma
Determining Whether Multiple Anesthesia Exposures Affect Cognitive Function for Retinoblastoma Patients
The purpose of this study is to see if there is a difference between the development of the brain (neurodevelopment) in children who have been treated for retinoblastoma with multiple anesthetic exposures, compared with brain…
- Trial name
- NCT03546387
- Testing
- Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V), California Verbal Learning Test, Children's Version, Beery Developmental Test of Visual Motor Integration, 6th edition
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Retinoblastoma
Deep Learning in Retinoblastoma Detection and Monitoring.
Retinoblastoma is the most common eye cancer of childhood. Eye-preserving therapies require routine monitoring of retinoblastoma regression and recurrence to guide corresponding treatment.
- Trial name
- NCT05308043
- Testing
- Deep learning algorism
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Tongren Hospital
Retinoblastoma
Treatment of Intraocular Retinoblastoma
This study compares the effects of balloon technology and microcatheter technology on the eye protection rate of neuroblastoma
- Trial name
- NCT05028270
- Testing
- Balloon technology;Microcatheter technology
- Volunteers
- 1,600 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Retinoblastoma
A Clinical Study on the Efficacy and Safety of VEC Intravenous Chemotherapy Combined With Conbercept Intravitreal Injection in the Treatment of Retinoblastoma
This prospective, multi-center, open single-arm Phase II clinical trial is designed to investigate the efficacy and safety of intravenous chemotherapy combined with Conbercept intravitreal injection in the treatment of…
- Trial name
- NCT04990271
- Testing
- Conbercept ophthalmic injection
- Where
- 5 sites in China
- Volunteers
- 92 people
- Sponsor
- Chengdu Kanghong Biotech Co., Ltd.
Phase 1b, Open Label
A Phase 1b, Open-Label Study Of REC-617, A Selective CDK7 Inhibitor, In Patients With Metastatic Or Unresectable RB1-Negative Leiomyosarcoma After Prior Systemic Therapy
To learn if the study drug REC-617 can help to control LMS. The safety of REC-617 will also be studied.
- Conditions
- Phase 1b, Open Label, REC-617, RB1-Negative
- Trial name
- NCT07633756
- Testing
- REC617
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Retinoblastoma, Refractory
Targeting NUDT21 siRNA Drugs for Patients With Refractory Retinoblastoma
Retinoblastoma (RB) is the most common intraocular malignancy in children, accounting for approximately 11% of all cancers diagnosed in children under the age of one.
- Trial name
- NCT06424301
- Testing
- Targeting NUDT21 siRNA drugs
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Retinoblastoma, IAC
RCT of Ballon Technique VS Selective Ophthalmic Artery Infusion For the Retinoblastoma Patients
Retinoblastoma is the most common intraocular tumor in children..IAC--Targeted Treatment for Intraocular Retinoblastoma,Is minimally invasive procedure that infuse chemotherapy select into the ophthalmic artery, its can…
- Conditions
- Retinoblastoma, IAC, Selective Ophthalmic Artery Infusion, Ballon Technique
- Trial name
- NCT03439397
- Testing
- Ballon Technique, SOAI
- Volunteers
- 496 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Retinoblastoma
Intra-arterial Chemotherapy for Children With Retinoblastoma
Retinoblastoma is a cancer of the eye that occurs exclusively in children. The treatment for retinoblastoma may include surgery, chemotherapy, radiation and local treatments to the eye such as freezing (cryotherapy) and local…
- Trial name
- NCT00906113
- Testing
- Intra-arterial injection of melphalan, Injection of melphalan into the ophthalmic artery
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Hadassah Medical Organization
Brain and Central Nervous System Tumors, Intraocular Melanoma
Monoclonal Antibody Therapy in Treating Patients With Leptomeningeal Cancer
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Conditions
- Brain and Central Nervous System Tumors, Intraocular Melanoma, Lung Cancer, Melanoma (Skin)
- Trial name
- NCT00003022
- Testing
- iodine I 131 monoclonal antibody 3F8
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Retinoblastoma
Photodynamic Therapy With Visudyne for Human Retinoblastoma: A Preliminary Study
To study the effectiveness and safety profiles of photodynamic therapy (PDT) for the treatment of human retinoblastoma.
- Trial name
- NCT04429139
- Testing
- photodynamic therapy
- Where
- China
- Volunteers
- 8 people
- Sponsor
- Sun Yat-sen University
Retinoblastoma
A Study of the Effectiveness of a Local Injection of Chemotherapy for Retinoblastoma
Over the past 15 years, intravenous chemotherapy has become the most popular conservative (eye-saving) method for retinoblastoma treatment because it is often effective and usually safe.
- Trial name
- IAC-RB (NCT00857519)
- Testing
- Melphalan, Carboplatin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wills Eye
Non-small Cell Lung Cancer
Cyclin Dependent Kinase (CDK)4/6 Inhibitor, PD0332991 in Advanced Non-small Cell Lung Cancer NSCLC.
The purpose of this study is to determine the efficacy and the toxicities of the study drug PD0332991 in the treatment of patients with Stage IV non-small cell lung cancer with wildtype retinoblastoma protein (RB) and inactivated…
- Trial name
- NCT01291017
- Testing
- PD0332991
- Where
- 2 sites in United States
- Volunteers
- 19 people
- Sponsor
- University of Florida
Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma
Enzalutamide With Ribociclib in Treating Patients With Metastatic Castrate-Resistant, Chemotherapy Naive Prostate Cancer That Retains Retinoblastoma Expression
This phase Ib/II trial studies the safety, side effects, best dose, and effectiveness of ribociclib when given with enzalutamide in treating patients with castrate-resistant prostate cancer that has spread from the primary site…
- Conditions
- Castration-Resistant Prostate Carcinoma, Metastatic Prostate Carcinoma, Prostate Carcinoma Metastatic in the Bone, Stage IV Prostate Cancer AJCC v7
- Trial name
- NCT02555189
- Testing
- Enzalutamide, Ribociclib, Laboratory Biomarker Analysis
- Where
- 4 sites in United States
- Volunteers
- 52 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Retinoblastoma
Photoscreening for Retinoblastoma
Retinoblastoma is the most common pediatric eye malignancy and manifests between 1 and 5 years of age. The tumor is most often diagnosed by leukocoria ( white reflex in the pupil).
- Trial name
- NCT04344652
- Testing
- Photoscreening -
- Volunteers
- healthy volunteers welcome
- Sponsor
- Phoenix Children's Hospital
Retinoblastoma
Intravitreal Carboplatin for the Treatment of Participants With Recurrent or Refractory Intraocular Retinoblastoma
Retinoblastoma (RB) is the most common intraocular tumor of childhood. Recurrent or refractory disease following therapy most often occurs due to persistence of vitreous disease and/or retinal reactivation of the main tumor mass.
- Trial name
- NCT02792036
- Testing
- Carboplatin, Maxitrol®, Focal Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- St. Jude Children's Research Hospital
Retinoblastoma
Quality of Life in Children Cured of Retinoblastoma
The aim of the study is to assess the quality of life of children who have been cured of retinoblastoma - a malignant eye tumor. The study is questionnaire-based, and uses standardized quality of life assessment tools.
- Trial name
- NCT00278031
- Where
- Israel
- Volunteers
- 35 people
- Sponsor
- Hadassah Medical Organization
Retinoblastoma, Retinoblastoma Bilateral
Retinoblastoma Patient Clinical Database and Tissue Repository
Retinoblastoma (RB) is a primary eye cancer that forms in the back of the eye of infants and toddlers. Traditionally, RB is diagnosed without a biopsy; tumor can only be studied once an eye has been surgically removed.
- Conditions
- Retinoblastoma, Retinoblastoma Bilateral, Retinoblastoma Unilateral
- Trial name
- NCT04959097
- Where
- 9 sites in United States, Canada
- Volunteers
- 800 people
- Sponsor
- Children's Hospital Los Angeles
Retinoblastoma, Retinal Neoplasms
Chemotherapy Treatment for Children With Intraocular Germ-Line Retinoblastoma
Retinoblastoma is an unusual cancer of early childhood involving tumor is both eyes or, in certain circumstances, one eye only. This condition is the result of an abnormal gene which makes both retinas (the back of the eye)…
- Trial name
- NCT00179920
- Testing
- Carboplatin, VP-16, Local Surgery
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Retinoblastoma, Retinoblastoma Bilateral
Autonomic Reflexes During Intra-arterial Chemotherapy for Retinoblastoma
Prospective observational study in patients undergoing intra-arterial ophthalmic artery chemotherapy for the treatment of retinoblastoma.
- Conditions
- Retinoblastoma, Retinoblastoma Bilateral, Chemotherapy Effect
- Trial name
- NCT04451304
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Federal University of São Paulo
Hemodynamic Instability
Topical Anesthesia and Intra-arterial Chemotherapy for Retinoblastoma
The objective of this study is to use local topical anesthesia to numb the sensory input, captured by branches of the Trigeminal nerve found on the skin in and around the eye, to decrease a hemodynamic reflex seen during…
- Trial name
- TOPIAC (NCT02955524)
- Testing
- Tetracaine 0.5%, Lidocaine hydrochloride ophthalmic gel 3.5%
- Sponsor
- University of Miami