Clinical trials: Retinopathy, Diabetic
Diabetic Retinopathy, Type 2 Diabetes Mellitus
The Relationship Between Advanced Glycation Endproducts and Diabetes
The overall purpose of this COMIRB application is to perform a cross-sectional pilot study to aid in the design of a prospective epidemiologic study for an NIH grant application.
- Trial name
- NCT02662010
- Where
- United States
- Volunteers
- 157 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetic Retinopathy
Expansion of Integrated AI Solution for Diabetic Retinopathy Screening in Thailand
Efficiency and effectiveness of real-world diabetic retinopathy screening by artificial intelligent (AI) are limited. Investigators will implement AI for diabetic retinopathy screening in 13 health districts in Thailand and…
- Trial name
- NCT05527535
- Testing
- Diabetic retinopathy screening by artificial intelligence, Diabetic retinopathy screening by healthcare personnel
- Volunteers
- 34,500 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Diabetic Retinopathy
Video-based Patient Education Intervention for Diabetic Eye Screening in Latinx Communities
An online survey (n=1,500) and 4 focus groups will be conducted with Latinx patients with diabetes (n=20) to obtain preliminary data regarding whether and how patient and clinician video testimonial interventions (n=6) increase…
- Trial name
- NCT06257082
- Testing
- Online Survey
- Where
- United States
- Volunteers
- 1,526 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Moderately Severe to Severe NPDR
A Study of Keluo Xin Capsule Compare to Placebo in Terms of Efficacy and Safety in Patients With Diabetic Retinopathy
This is a study aiming to assess the efficacy and safety of Keluo Xin capsule in patients with moderately severe to severe nonproliferative diabetic retinopathy (NPDR).
- Trial name
- NCT03258242
- Testing
- Keluo Xin capsule
- Volunteers
- 198 people
- Sponsor
- Chengdu Kanghong Pharmaceutical Co., Ltd.
Diabetic Retinopathy
PST/Laser v. Laser Alone for CSME
Prospective randomized clinical trial comparing Laser Alone v. Laser and posterior sub-tenon injection of triamcinolone acetonide for primary and refractory clinically significant macular edema.
- Trial name
- NCT00229918
- Testing
- triamcinolone acetonide
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Edward Hines Jr. VA Hospital
Vitreous Hemorrhage, Proliferative Diabetic Retinopathy
Intravitreal Bevacizumab for Proliferative Diabetic Retinopathy
To evaluate the efficacy of intravitreal bevacizumab injections for treatment of proliferative diabetic retinopathy (PDR) with new dense vitreous hemorrhage (VH) after previous full panretinal photocoagulation (PRP).
- Trial name
- NCT01724385
- Testing
- intravitreal injection of bevacizumab
- Where
- Thailand
- Volunteers
- 18 people
- Sponsor
- Khon Kaen University
Diabetic Retinopathy
Non-proliferative Diabetic Retinopathy Treated With Runcaciguat
This Phase 2 study is conducted to investigate the safety and efficacy of runcaciguat in the treatment of diabetic retinopathy. To assess efficacy, the retinal morphology will be investigated by 7-field color fundus photography…
- Trial name
- NEON-NPDR (NCT04722991)
- Testing
- Runcaciguat (BAY1101042)
- Where
- 55 sites in United States, Bulgaria and 12 more
- Volunteers
- 109 people
- Sponsor
- Bayer
Diabetic Retinopathy
Green Laser Photocoagulation Study in Proliferative Diabetic Retinopathy
To Demonstrate that indigenous green laser produces similar treatment effect on the retina when compared with already available green laser.
- Trial name
- NCT00355680
- Testing
- Green Laser (Aurolas, Aurolab), Green Laser (Iridex)
- Where
- India
- Volunteers
- 24 people
- Sponsor
- Aurolab
Diabetic Retinopathy, Macular Traction Retinal Detachment
Intravenous Tranexamic Acid in Diabetic Macular TRD Surgeries
The goal of this observational study is to learn about safety and results of peroperative and intraoperative intravenous Tranexamic acid for diabetic macular tractional detachment eye surgeries .
- Trial name
- TXA-DMTRD (NCT06560073)
- Where
- India
- Volunteers
- 102 people
- Sponsor
- Ahalia Foundation Eye Hospital
Descriptor
Place of Glycation in Diabetic Retinopathy
1. Definition: Diabetic retinopathy is a microangiopathic complication of diabetes diabetes mellitus. Its pathophysiology includes glycation and intracellular hypoxia.
- Trial name
- NCT05364723
- Volunteers
- 1,000 people
- Sponsor
- Mohammed VI University Hospital
Diabetic Retinopathy, Vitreous Hemorrhage Due to Diabetes Mellitus
Pre-operative Vabysmo in Patients With Non-clearing Vitreous Hemorrhage Secondary to Proliferative Diabetic Retinopathy
In this phase IV, randomized, double-masked, sham-controlled study the investigators hope to determine the efficacy in peri-operative faricimab (Vabysmo) compared to sham in limiting complications from pars plana vitrectomy for…
- Trial name
- NCT06191094
- Testing
- Faricimab Injection
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Proliferative Diabetic Retinopathy
OCT and OCT-A Afer Diabetic Vitrectomy in PDR
Detection of any structural or vascular changes at the macula after Pars Plana Vitrectomy ( PPV ) in cases with complicated proliferative diabetic retinopathy ( PDR )
- Trial name
- NCT05938491
- Testing
- OCT and OCT-A
- Volunteers
- 30 people
- Sponsor
- Assiut University
Diabetic Retinopathy
Intravitreal Bevacizumab for Proliferative Diabetic Retinopathy
Recently, intravitreal bevacizumab (Avastin) injection has gained popularity as a potential treatment of intraocular neovascularization (CNV) associated with age related macular degeneration and diabetic retinopathy.
- Trial name
- NCT00423059
- Testing
- bevacizumab
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Yonsei University
Visual Acuity Reduced Transiently, Macular Edema, Cystoid
Influence of Diabetes Control on Treatment of Diabetic Macular Edema With Ranibizumab
The aim of the prospective randomized study is to investigate whether a intensified diabetic control program leads to better final visual acuity and less frequent diabetic ocular complications in patients with diabetic…
- Trial name
- DORO (NCT02665689)
- Testing
- ranibizumab
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- Prof. Dr. Antonia M. Joussen
Proliferative Diabetic Retinopathy
Intravitreal Injection of Ranibizumab Versus Sham Before Vitrectomy in Patients With Proliferative Diabetic Retinopathy
Certain percent of the eyes with proliferative diabetic retinopathymay require pars plana vitrectomy (PPV) due to vitreous haemorrhage, proliferative membrane, and tractional retinal detachment.
- Trial name
- NCT02857491
- Testing
- ranibizumab, pars plana vitrectomy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sun Yat-sen University
Eye Diseases, Retinitis Pigmentosa
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Exosomes for NAION
This trial will study the safety and efficacy of intranasal delivery of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of non-arteritic ischemic optic neuropathy
- Conditions
- Eye Diseases, Retinitis Pigmentosa, Diabetic Retinopathy, Macular Degeneration
- Trial name
- NCT05147701
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Diabetic Retinopathy, Diabetes Complications
Study Evaluating Efficacy and Safety of PF-04523655 Versus Laser in Subjects With Diabetic Macular Edema
To evaluate the effectiveness of study drug in improving visual acuity compared to laser treatment in the patients with diabetic macular edema
- Trial name
- DEGAS (NCT00701181)
- Testing
- Laser Treatment, PF-04523655 high, PF-04523655 middle
- Where
- 53 sites in United States, Denmark and 6 more
- Volunteers
- 184 people
- Sponsor
- Quark Pharmaceuticals
Proliferative Diabetic Retinopathy
Propranolol for Diabetic Retinopathy
This study is investigating if the oral beta antagonist propranolol can induce regression of retinal neovascularization associated with proliferative diabetic retinopathy.
- Trial name
- NCT01535495
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Wisconsin, Madison
Diabetic Retinopathy, NPDR - Non Proliferative Diabetic Retinopathy
A Study to Evaluate the Efficacy and Safety of Orally Administered VX-01
The goal of this clinical trial is to evaluate the efficacy, safety, pharmacokinetics (PK) and pharmacodynamics (PD) of VX-01 as stand-alone treatment for Diabetic Retinopathy of Non-Proliferative Type (NPDR).
- Trial name
- NCT06770933
- Testing
- VX-01
- Where
- 27 sites in United States, Australia and 3 more
- Volunteers
- 100 people
- Sponsor
- Vantage Biosciences Ltd
Proliferative Diabetic Retinopathy
PASCAL Laser Versus ETDRS Laser Associated With Intravitreal Ranibizumab (IVR) Versus Only IVR for Proliferative Diabetic Retinopathy
Objectives: Primary objective: To evaluate the effects on retinal morphophysiology of full scatter single target panretinal photocoagulation (PRP) versus full scatter multiple target panretinal photocoagulation (both combined…
- Trial name
- NCT02005432
- Testing
- Intravitreal Ranibizumabe, panfotocoagulation (PASCAL), panfotocoagulation (PRP) single shoot (ETDRS)
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo
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