Clinical trials: Retinopathy, Diabetic
Diabetic Retinopathy, Macular Edema
Bevacizumab Versus Ranibizumab for the Treatment of Diabetic Macular Edema
The purpose of this study is to compare the morphological and visual acuity outcomes associated with 1.5 mg bevacizumab versus 0.5 ranibizumab intravitreal injections for treatment of diabetic macular edema.
- Trial name
- IBERA-DME (NCT01487629)
- Testing
- Bevacizumab, Ranibizumab
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- University of Sao Paulo
Diabetic Retinopathy, Retinal Neovascularization
Krypton-Argon Regression of Neovascularization Study (KARNS)
To evaluate whether red krypton laser treatment is as effective at causing regression of diabetic disc neovascularization as treatment with the blue-green argon laser, when both lasers are used with identical panretinal…
- Conditions
- Diabetic Retinopathy, Retinal Neovascularization, Diabetes Mellitus
- Trial name
- NCT00000153
- Testing
- Blue-Green Argon Laser Treatment, Red Krypton Laser Treatment
- Sponsor
- National Eye Institute (NEI)
Diabetic Retinopathy
Coupling of Neural Activity and Retinal Blood Flow in Diabetes
The prevalence of diabetes is increasing and the management of the disease is nowadays considered a major challenge. Affected patients have increased mortality and morbidity as well as a significant drop in the quality of life.
- Trial name
- NCT01375166
- Where
- Austria
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Diabetic Retinopathy
Topical Application of Latanoprost in Diabetic Retinopathy
Randomized double-blinded two-year intervention study with topical application of latanoprost or placebo eye drops in patients with diabetic retinopathy.
- Trial name
- Latano-2 (NCT01225653)
- Testing
- Latanoprost
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- University of Aarhus
Diabetic Macular Edema, Neovascular (Wet) Age-Related Macular Degeneration
Effectiveness of Multidisciplinary Protocolised Interventions on IVT Non-adherence Rates
The purpose of this research study is to test whether a personalised care approach improves adherence compared to standard care.
- Conditions
- Diabetic Macular Edema, Neovascular (Wet) Age-Related Macular Degeneration, Intravitreal Injection
- Trial name
- ADHERE (NCT07567898)
- Testing
- multidisciplinary protocolized intervention (MPI), Routine medical care & monitoring
- Volunteers
- 200 people
- Sponsor
- Singapore Eye Research Institute
Diabetic Macular Edema
Safety and Efficacy Study of Topical Administration of FOV2304 (High Dose or Low Dose) for the Treatment of Center-involving Clinically Significant Macular Edema Associated With Diabetic Retinopathy
The purpose of the study is to determine whether concentrations of FOV2304 (high dose or low dose) administered in the eye are more effective than placebo in treating patients with diabetic macular edema, following 12 weeks of…
- Trial name
- NCT01319487
- Testing
- 2304 Eye Drops High Dose, 2304 Eye Drops Low Dose
- Where
- 65 sites in United States, Australia and 8 more
- Volunteers
- 267 people
- Sponsor
- Fovea Pharmaceuticals SA
Microalbuminuria, Endothelial Dysfunction
Microalbuminuria as a Cardiovascular Risk Factor (PRECISED Substudy)
Microalbuminuria (MA) is an independent cardiovascular risk factor in diabetic and non-diabetic subjects. However, in the setting of type 2 diabetes, microalbuminuria could be a marker of either early diabetic nephropathy or…
- Conditions
- Microalbuminuria, Endothelial Dysfunction, Diabetic Nephropathy, Diabetic Retinopathy
- Trial name
- NCT02409511
- Testing
- non intervention
- Where
- Spain
- Volunteers
- 75 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Cataract Diabetic
Safety of Trypan Blue on Endothelium of Diabetic Retinopathy Patients
This study examines the use of Trypan Blue staining of the corneal endothelium in patients undergoing phacoemulsification. It is a single-center prospective, randomized individual cohort study.
- Trial name
- NCT03755752
- Testing
- Phacoemulsification with and without Trypan Blue capsule staining
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Assiut University
Age-Related Macular Degeneration (AMD), Diabetic Retinopathy (DR)
Artificial Intelligence-Aided Screening for Patients With Diabetic Retinopathy and Age-related Macular Degeneration in Family Medicine and Geriatric Medicine Outpatient Clinics
Diabetic retinopathy (DR) and age-related macular degeneration (AMD) are leading causes of vision loss, with rising incidence due to aging populations and increasing diabetes prevalence.
- Trial name
- NCT07069647
- Testing
- VeriSee AI-assisted screening tools for diabetic retinopathy and age-related macular degeneration, Standard fundus photography with physician interpretation
- Where
- Taiwan
- Volunteers
- 4,300 people
- Sponsor
- National Taiwan University Hospital
Diabetic Retinopathy
Augmenting Referral Pathway to Improve Uptake of Retinal Services by Diabetic Patients
Reiyukai Eiko Masunaga Eye Hospital (REMEH) is a non-profitable organization. Retina services were resumed from October 2019. Until this retinal service started, it has been mostly cataract-focused.
- Trial name
- NCT04829084
- Testing
- Pre-post educational intervention
- Where
- Nepal
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Seva Foundation
Proliferative Diabetic Retinopathy
Study to Evaluate Effects of Emixustat Hydrochloride in Subjects With Proliferative Diabetic Retinopathy
To evaluate the effects of oral emixustat hydrochloride (emixustat) on aqueous humor biomarkers associated with proliferative diabetic retinopathy (PDR) from baseline to week 12.
- Trial name
- NCT02753400
- Testing
- emixustat hydrochloride
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Kubota Vision Inc.
High Risk Proliferative Diabetic Retinopathy
Prospective, Randomized, Multicentre, Open-label, Phase II / III Study to Assess Efficacy and Safety of Ranibizumab 0.5 mg Intravitreal Injections Plus Panretinal Photocoagulation (PRP) Versus PRP in Monotherapy in the Treatment of Subjects With High Risk Proliferative Diabetic Retinopathy.
This study is a prospective, randomized, multicentre, open label study that intents to compare the efficacy and safety of ranibizumab 0.5 mg Intravitreal (ITV) injections plus Panretinal Photocoagulation versus Panretinal…
- Trial name
- PROTEUS (NCT01941329)
- Testing
- Panretinal Photocoagulation (PRP), Intravitreous injection of ranibizumab
- Where
- 13 sites in France, Italy and 2 more
- Volunteers
- 94 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Diabetes Mellitus, Diabetic Retinopathy
CLEAR SIGHT: A Trial of Non-Mydriatic Ultra-Widefield Retinal Imaging to Screen for Diabetic Eye Disease
Diabetic eye disease causes major vision loss in many Canadians and is costly. There are effective preventions and treatments for diabetic eye disease but they strongly depend upon regular screening in asymptomatic patients.
- Trial name
- NCT02579837
- Testing
- Optos 200Tx, Zeiss Cirrus
- Where
- Canada
- Volunteers
- 742 people
- Sponsor
- Western University, Canada
Non Proliferative Diabetic Retinopathy, Proliferative Diabetic Retinopathy
Effect of Folic Acid, Vitamin B6 and Vitamin B12 in Diabetic Retinopathy
Homocysteine, a well-known inducer of vascular endothelial cell damage has been associated with extracellular matrix changes. Many studies demonstrated that high levels of this aminoacid in diabetic patients increases…
- Trial name
- NCT01921192
- Testing
- Folic Acid, vit B6 and B12
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Catania
Diabetic Retinopathy
A Study to Test Whether BI 764524 Helps People With an Eye Condition Called Diabetic Retinopathy
This study is open to adults with diabetic retinopathy. People who have non-proliferative diabetic retinopathy of moderate or high severity can join the study.
- Trial name
- NCT06321302
- Testing
- BI 764524, Aflibercept (Eylea®) - US only
- Where
- 90 sites in United States, Germany and 7 more
- Volunteers
- 175 people
- Sponsor
- Boehringer Ingelheim
Diabetic Retinopathy
Assessment of EyeArt Performance With Retinal Imaging Devices
The study evaluates the performance of the EyeArt system for detecting diabetic retinopathy from images captured using multiple retinal imaging devices and operators.
- Trial name
- NCT04302012
- Testing
- Color fundus photography, Mydriatic Agent
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Eyenuk, Inc.
Diabetes, Diabetic Retinopathy
Optimization and Evaluation of the Diagnosis and Treatment System for Diabetic Retinopathy in Type 2 Diabetes Mellitus
This study aims to integrate clinical indicators and features of fundus images, combined with metabolomics, to construct an early warning model for diabetic retinopathy (DR) in type 2 diabetes.
- Conditions
- Diabetes, Diabetic Retinopathy, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- NCT06821399
- Testing
- Fundus Examination, Metabolomics analysis
- Where
- 3 sites in China
- Volunteers
- 2,920 people
- Sponsor
- Yufan Wang
Macular Edema
Efficacy and Safety of Three Different Aflibercept Regimens in Subjects With Diabetic Macular Edema (DME)
To evaluate the efficacy of long-term treatment with 2 mg aflibercept via different intravitreal (IVT) treatment regimens to participants with DME pretreated with 2 mg aflibercept every 8 weeks after 5 initial monthly injections…
- Trial name
- VIOLET (NCT02818998)
- Testing
- Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
- Where
- 64 sites in Austria, Canada and 12 more
- Volunteers
- 463 people
- Sponsor
- Bayer
Age-related Macular Degeneration, Neovascular Age-related Macular Degeneration
A 3-month Study to Assess the Safety of ONS-5010 in Subjects With Visual Impairment Due to Retinal Disorders
The study will evaluate the safety of ophthalmic bevacizumab in subjects diagnosed with a retinal condition that would benefit from treatment with intravitreal injection of bevacizumab, including: exudative age-related macular…
- Conditions
- Age-related Macular Degeneration, Neovascular Age-related Macular Degeneration, Wet Macular Degeneration, BRVO - Branch Retinal Vein Occlusion
- Trial name
- NCT04516278
- Testing
- bevacizumab
- Where
- 20 sites in United States
- Volunteers
- 197 people
- Sponsor
- Outlook Therapeutics, Inc.
Choroidal Neovascularization, Macular Edema
An Open-label Extended Clinical Protocol of Ranibizumab to Evaluate Safety and Efficacy in Rare VEGF Driven Ocular Diseases.
The pupose of this study is to evaluate the safety and the efficacy of ranibizumab in rare VEGF driven ocular diseases.
- Conditions
- Choroidal Neovascularization, Macular Edema, Glaucoma, Neovascular, Diabetic Retinopathy
- Trial name
- ECLIPSE (NCT01908816)
- Testing
- ranibizumab
- Where
- 39 sites in France
- Volunteers
- 270 people
- Sponsor
- Novartis Pharmaceuticals
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