Clinical trials: Retinopathy of Prematurity
Retinopathy of Prematurity Both Eyes
Ranibizumab Vs Bevacizumab for Type 1 Retinopathy of Prematurity
Retinopathy of prematurity (ROP) with inadequate growth and development of retinal blood vessels in premature infants is one of the foremost reasons for childhood blindness.
- Trial name
- NCT05033106
- Testing
- Bevacizumab, Ranibizumab
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Zagazig University
Pre-Term
Optos Versus Indirect Ophthalmoscopy for ROP Screening Examination (Optos vs BIO Study)
ROP is a preventable cause of blindness in premature infants. It is routinely screened for by using an indirect ophthalmoscope, a scleral depressor, and a condensing lens.
- Trial name
- NCT04292015
- Testing
- Optos ultra-widefield retinal imaging (Optos California)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Premature Birth of Newborn, Retinopathy of Prematurity (ROP)
A Multicenter and Prospective Study of Screening Retinopathy of Prematurity in China
The purpose of the study is to explore the current incidence rate of retinopathy of prematurity (ROP) in China and to explore more appropriate screening criteria for ROP.
- Conditions
- Premature Birth of Newborn, Retinopathy of Prematurity (ROP), Low Birthweight Infant
- Trial name
- SChiROP (NCT06729333)
- Where
- China
- Volunteers
- 4,841 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Retinopathy
Anesthesia for Retinopathy of Prematurity
Premature infants experience more respiratory problems after surgical procedures. The investigators aimed to compare general anesthesia with sedation on the need for post-operative mechanical ventilation in infants undergoing…
- Trial name
- NCT01955135
- Testing
- Ketamine, Sevoflurane, propofol
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Retinopathy of Prematurity
The Efficacy of Paracetamol in Reducing Pain During Ophthalmological Examination for Retinopathy of Prematurity: a Prospective Randomised Trial
Retinopathy of prematurity (ROP) is one of the major morbidity among preterm infants. Although, local anesthetics reduce pain to some extent, eye examination still remains as a painful procedure.
- Trial name
- NCT01872871
- Testing
- Paracetamol
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Dr. Sami Ulus Children's Hospital
Retinopathy of Prematurity
A Scan Ultrasonography in the Evaluation of Retinopathy of Prematurity
The purpose of the investigators study is to determine the relationship between the length of the eye and the rate of change in eye length at each visit with progression of retinopathy of prematurity.
- Trial name
- NCT01335113
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stanford University
Retinopathy of Prematurity
VEGF Levels in Aqueous, Vitreous and Subretinal Fluid in ROP Stage IV and V
To determine the degree of VEGF in Aqueous, vitreous and SRF in patients with ROP in stage V. Verifying that it is greater to that found in healthy newborn patients with different ocular pathology.
- Trial name
- NCT00563121
- Testing
- Vitrectomy
- Where
- 2 sites in Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Retinopathy of Prematurity
Prospective Evaluation of iCam-OCT
This is a prospective, non-significant-risk clinical study sponsored by Siloam Vision, Inc. to evaluate whether ophthalmologists can assess retinopathy of prematurity (ROP) using images from the iCam-OCT device as effectively as…
- Trial name
- NCT07839923
- Testing
- imaged with i-Cam OCT
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Siloam Vision
Retinopathy of Prematurity
A Randomized Trial of Low-Dose Bevacizumab vs Laser for Type 1 ROP
This randomized clinical trial will compare retinal outcomes with low-dose intravitreous bevacizumab (0.063 mg) versus laser photocoagulation as treatment for infants with type 1 retinopathy of prematurity (ROP).
- Trial name
- ROP3 (NCT04634604)
- Testing
- Bevacizumab, Laser
- Where
- 35 sites in United States, Canada
- Volunteers
- 16 people
- Sponsor
- Jaeb Center for Health Research
Retinopathy of Prematurity, Pain
Acupuncture for Preterm Infants Requiring Eye-exam
The purpose is to investigate whether non-invasive acupuncture - NIA (i.e. acupuncture without needles) will help reduce pain for babies in the Neonatal Intensive Care Unit (NICU) during their routine weekly eye-exam for…
- Conditions
- Retinopathy of Prematurity, Pain, Acupuncture, Premature Infant
- Trial name
- MAGNIFIC-ROP (NCT03650621)
- Testing
- Magnetic acupuncture, stickers (magnets removed)
- Where
- 3 sites in Australia, Canada and 1 more
- Volunteers
- 100 people
- Sponsor
- University of Alberta
Retinopathy of Prematurity, Diabetic Retinopathy
Optical Coherence Tomography Angiography (OCT-A) in Children (≥ 6 <14 Years of Age)
Comparison of OCTA to conventional imaging modalities for the diagnosis of eye diseases in children
- Trial name
- OCTAC (NCT03399825)
- Testing
- OCT-A
- Volunteers
- healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Development of Side Effects From Betaxolol
Topical Betaxolol for the Prevention of Retinopathy of Prematurity
We hypothesize that topical betaxolol will reduce the development of severe retinopathy of prematurity.
- Trial name
- NCT01660620
- Testing
- Betaxolol, topical betaxolol
- Volunteers
- 23 people
- Sponsor
- Smith-Kettlewell Eye Research Institute
Retinopathy of Prematurity (ROP)
Efficacy and Safety of Low-dose Conbercept for Retinopathy of Prematurity Therapy
Evaluating the Optimal Effective Dose and Safety of Conbercept in Treating Retinopathy of Prematurity (ROP)
- Trial name
- NCT06717412
- Testing
- Conbercept
- Where
- 3 sites in China
- Volunteers
- 146 people
- Sponsor
- Wang Yusheng
Premature, Retinopathy of Prematurity
Comfort Level in Premature Infants Undergoing Retinopathy of Prematurity Screening
Retinopathy of prematurity (ROP) screening is a routine yet painful procedure for premature infants, often necessitating pharmacological mydriasis.
- Conditions
- Premature, Retinopathy of Prematurity, Pain
- Trial name
- NCT07016984
- Testing
- standard phototherapy eye patches
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Istanbul Nisantasi University
Retinopathy of Prematurity (ROP)
Intravitreal Ranibizumab for Aggressive Posterior Retinopathy of Prematurity: A Prospective Interventional Case Series
Aggressive posterior retinopathy of prematurity (AP-ROP) is a severe form of retinopathy of prematurity that can progress rapidly and lead to retinal detachment and permanent vision loss if not treated promptly.
- Trial name
- NCT07721298
- Testing
- Intravitreal Ranibizumab injection
- Where
- Egypt
- Volunteers
- 39 people
- Sponsor
- Ain Shams University
Retinopathy of Prematurity
Sucrose Analgesia for the Reduction of Pain During Retinopathy of Prematurity Screening
Retinopathy of Prematurity (ROP) screening is one of many potentially painful diagnostic and therapeutic procedures performed routinely on preterm infants in the Neonatal Intensive Care Unit.
- Trial name
- NCT00921544
- Testing
- Sucrose, Sterile water
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- Coombe Women and Infants University Hospital
Retinopathy of Prematurity
Bevacizumab Treatment For Type 1 ROP
Type 1 retinopathy of prematurity in zone I represents the most severe type of ROP and has the worst prognosis. It is unknown whether low-dose bevacizumab will be successful in these severe cases.
- Trial name
- ROP4 (NCT04634578)
- Testing
- Bevacizumab
- Where
- 26 sites in United States, Canada
- Volunteers
- 77 people
- Sponsor
- Jaeb Center for Health Research
Retinopathy of Prematurity, ROP
Automated Screening Device to Detect MTMROP
The purpose of the study is to evaluate the i-ROP DL system for autonomous ROP screening. To demonstrate the sensitivity and specificity of the i-ROP DL system on images obtained by healthcare providers in the neonatal intensive…
- Trial name
- NCT06517836
- Testing
- iROP DL
- Where
- United States
- Volunteers
- 1,284 people, healthy volunteers welcome
- Sponsor
- Siloam Vision
Retinopathy of Prematurity
Infant-parent Skin-to-skin Contact During Screening for Retinopathy
Retinopathy of prematurity (ROP) is a feared complication of premature birth. If discovered in time, the disease can be treated, and impaired vision or blindness can be reduced.
- Trial name
- NCT02780544
- Testing
- skin-to-skin contact, incubator, Sucrose
- Where
- Norway
- Volunteers
- 34 people
- Sponsor
- St. Olavs Hospital
ROP Examination
The Effect of Music on Pain, Comfort and Physiological Parameters During Prematurity Retinopathy Examination
It is planned to determine the effect of music during Retinopathy of Prematurity (ROP) examination on pain, comfort and physiological parameters in preterm infants.
- Trial name
- NCT05263973
- Testing
- Music
- Where
- Turkey (Türkiye)
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University