Clinical trials: Retrocochlear Pathology
Auditory Perceptual Disorders, Age-related Hearing Loss
Objective Measurement of Hearing Aid Benefit
Hearing loss is a critical health concern in the rapidly aging population, affecting approximately 22 million older individuals in the United States.
- Trial name
- NCT04431622
- Testing
- Hearing aid amplification algorithms
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Central Auditory Disease, Auditory Processing Disorder, Central
taVNS Effect on Central Auditory Processing
The behavioral effects of vagus nerve stimulation (VNS) and observed activation in the auditory cortex with transcutaneous auricular VNS (taVNS) raise questions about their potential impact on auditory processing.
- Conditions
- Central Auditory Disease, Auditory Processing Disorder, Central, Auditory Processing Disorders, Vagus Nerve Stimulation
- Trial name
- NCT06970444
- Testing
- transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Medipol University
Auditory Processing Disorders
Contribution of Functional MRI in Assessment of Auditory Processing Disorders
Auditory Processing Disorder (APD) affects 0.5-7% of the pediatric population. This disorder is responsible for a child's low hearing ability.
- Trial name
- IRMf-TTA (NCT03887182)
- Testing
- functional MRI, Automated Cortical Brainstem Auditory Evoked Potential, whole exome sequencing
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Leukemia, Adenomatous Polyposis
Familial Investigations of Childhood Cancer Predisposition
NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll.
- Conditions
- Acute Leukemia, Adenomatous Polyposis, Adrenocortical Carcinoma, AML
- Trial name
- SJFAMILY (NCT03050268)
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- St. Jude Children's Research Hospital
Auditory Processing Disorder
Hearing Aids for Veterans With Functional Hearing Difficulties
Every year, approximately 100,000 Veterans seek help at VA Audiology clinics for hearing and communication difficulties only to learn that they have normal hearing sensitivity.
- Trial name
- NCT06117254
- Testing
- Communication Counseling, Hearing Aids, Remote Microphones
- Where
- United States
- Volunteers
- 142 people
- Sponsor
- VA Office of Research and Development
Vestibular Schwannoma
Anti-VEGF Gene Therapy Trial for Vestibular Schwannoma
This trial will evaluate the safety and tolerability of a single unilateral administration of one of three dose levels of AAVAnc80-antiVEGF and will evaluate the Akouos delivery device to safely achieve the intended product…
- Trial name
- NCT06517888
- Testing
- AAVAnc80-antiVEGF via Akouos Delivery Device
- Where
- 4 sites in United States
- Volunteers
- 27 people
- Sponsor
- Akouos, Inc.
Benign Paroxysmal Positional Vertigo (BPPV), Vestibular Migraine
Metabolic Disorders and Vertigo
The purpose of investigation is to assess the levels of metabolic factors (hydroxyvitamin D, homocysteine) between patients with vestibular dysfunction of peripheral origin (BPPV) and central origin (vestibular migraine).
- Conditions
- Benign Paroxysmal Positional Vertigo (BPPV), Vestibular Migraine, Central Positional Vertigo, Vestibular Neuritis
- Trial name
- NCT04935970
- Testing
- diagnostic blood test, neuropsychological test
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Auditory Diseases, Central
Comparing Hearing Aid Fitting Methods in Blast-exposed Veterans
Since 2000, at least 250,000 U.S. Service members have experienced a blast-related mild traumatic brain injury. A retrospective analysis of over 100,000 post-9/11 Veterans shows that blast injury more than doubles the risk of a…
- Trial name
- SBA (NCT06309264)
- Testing
- Phonak Lumina P90
- Where
- 3 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Vestibular Schwannoma, Visual Impairment
Consequence of Unilateral Vestibular Loss on Visual Abilities
Unilateral vestibular lesions are frequent and disabling pathologies causing a set of oculomotor, postural and perceptual symptoms. These symptoms reduce over time according to a vestibular compensation.
- Conditions
- Vestibular Schwannoma, Visual Impairment, Vestibular Meniere Syndrome
- Trial name
- SVorthoptie (NCT03581331)
- Testing
- orthoptic balance
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Traumatic Brain Injury
Approaches to Auditory Rehabilitation for Mild Traumatic Brain Injury
Many soldiers returning from their recent service in Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) were exposed to blasts during combat.
- Trial name
- mTBI (NCT00930774)
- Testing
- FM system, Auditory training
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- US Department of Veterans Affairs
Vestibular Schwannoma, Hearing Loss
Intraoperative EABR for Decision Making
In this study patients undergoing simultaneous translabyrinthine vestibular schwannoma resection and cochlear implantation are included. The goal of the study is to correlate the eABR results with postoperative hearing results.
- Trial name
- NCT03745560
- Where
- Austria
- Volunteers
- 15 people
- Sponsor
- Christoph Arnoldner
Mild Concussion, Post Concussion Syndrome
Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool
The iDETECT (Integrated Display Enhanced Testing for Concussion and mild traumatic brain injury) system is a novel portable, open access platform that enables immediate and rapid assessment of multimodal neurologic function.
- Conditions
- Mild Concussion, Post Concussion Syndrome, Vestibular Neuritis
- Trial name
- NCT02171312
- Testing
- iDETECT Assessment, Routine Balance and Vestibular Testing
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Emory University
Auditory Processing Disorder
The Phonak EduLink-System in Students With Specific Performance Deficits in Speech-in-Noise Intelligibility
In the management and remediation of students with specific performance deficits in speech-in-noise intelligibility, most often, a "triad" approach for treatment is used, which includes direct therapy, compensatory strategies…
- Trial name
- NCT00167128
- Testing
- hearing aid, Phonak EduLink-FM System
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital Muenster
Vertigo, Vertigo, Peripheral
Effectiveness of Gaze Stability Exercises on Balance and Activities of Daily Living Among Patients Suffering Vertigo With Vestibular Neuritis in Saudi Arabia
Gaze stability exercise is a medical procedure for persons with unilateral vestibular disturbances such as vestibular neuritis or persons who have had tumors of their 8th nerve.
- Conditions
- Vertigo, Vertigo, Peripheral, Vertigo Labyrinthine, Migraine
- Trial name
- NCT04842474
- Testing
- Gaze stability exercises and balance exercises
- Where
- Saudi Arabia
- Volunteers
- 20 people
- Sponsor
- King Saud University
Progesterone, Estrogens
Neural Changes in the Aging Auditory System
The purpose of this study was to determine the effects of hormone replacement therapy (HRT) on hearing in post-menopausal women.
- Conditions
- Progesterone, Estrogens, Hearing, Psychoacoustics
- Trial name
- NCT00264407
- Testing
- Hormone Replacement Therapy - HRT
- Where
- 2 sites in United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Auditory Perceptual Disorders, Aging Problems
Auditory Temporal Processes in Aging
Older people experience great difficulty understanding speech, especially accented English, and this problem is expected to increase with the influx of immigrants who provide services to the elderly population.
- Trial name
- NCT03468660
- Testing
- Auditory training with feedback, Listening paradigm with no feedback
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Auditory Processing Disorder
Effects of Remote Microphone Hearing Aids on Children With Auditory Processing Disorder
Auditory Processing Disorder (APD) is a disorder where the functions of the ear are normal, but the person has difficulty identifying or discriminating sounds and experiences listening difficulties in noise.
- Trial name
- NCT02353091
- Testing
- Remote Microphone Hearing Aids
- Volunteers
- 26 people
- Sponsor
- University College, London
Neurofibromatosis 2
Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2
OBJECTIVES: I. Define the tonotopocity of multichannel brain stem stimulation and use this information to better program the auditory brain stem implant for an individual. II.
- Trial name
- NCT00004437
- Testing
- Multichannel Auditory Brain Stem Implant
- Sponsor
- FDA Office of Orphan Products Development
Auditory Processing Disorder
Auditory Processing in Spanish-English Bilinguals: Is Performance Better When Tested in Spanish or English?
The purpose of this study is to learn more about how bilingual individuals process sound in challenging listening environments and how testing language may impact results on auditory processing assessments.
- Trial name
- NCT05452486
- Testing
- English APD assessment, Spanish APD assessment
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Schizophrenia
Basic Auditory Processing and Auditory Hallucinations
Schizophrenia is a severe psychiatric disorder that affects approximately 1% of the population worldwide. Although pathophysiology of this disease remains unclear, a growing interest is emerging for low-level sensory function…
- Trial name
- AUDISCHIZ (NCT02887794)
- Testing
- Clinical and psychoacoustic measures
- Where
- France
- Volunteers
- 59 people
- Sponsor
- Hôpital le Vinatier