Clinical trials: Retroperitoneal Disease
Testis Cancer, Germ Cell Tumor
Role of Axumin PET Scan in Germ Cell Tumor
Investigators will use Axumin PET/CT to help with the imaging modalities to determine the presence of occult retroperitoneal disease.
- Conditions
- Testis Cancer, Germ Cell Tumor, Testicular Cancer, Germ Cell Tumor of Testis
- Trial name
- TESTPET (NCT03426865)
- Testing
- Axumin PET scan
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Texas Southwestern Medical Center
Renal Cell Carcinoma
Transperitoneal vs Retroperitoneal Laparoscopic or Robotic Partial Nephrectomy
Both laparoscopic partial nephrectomy (LPN) and robotic partial nephrectomy (RPN) can be performed through transperitoneal (TP) or retroperitoneal (RP) approach.
- Trial name
- NCT02849119
- Testing
- Laparoscopic or robotic partial nephrectomy
- Where
- South Korea
- Volunteers
- 106 people
- Sponsor
- Samsung Medical Center
Pancreatic Cancer, Retroperitoneal Pain Syndrome
Simulation-Free Celiac Plexus Pain Ablation Using Stereotactic Body Radiotherapy (SBRT) in Participants With Cancer-Related Celiac Pain
Participants who are experiencing abdominal pain due to having cancer in their pancreas may be eligible for this research study. For this type of pain, doctors often recommend radiation therapy to help with the pain.
- Trial name
- NCT07117032
- Testing
- Simulation-free workflow, Celiac plexus SBRT
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Case Comprehensive Cancer Center
Retroperitoneal Fibrosis, Autoimmune Pancreatitis
Rituximab in IgG4-RD: A Phase 1-2 Trial
The primary objective of this study is to evaluate the safety and effectiveness of rituximab in IgG4-RD.
- Conditions
- Retroperitoneal Fibrosis, Autoimmune Pancreatitis, Sialadenitis, Pseudotumor
- Trial name
- NCT01584388
- Testing
- Rituximab
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Gastric Cancer/Gastroesophageal Junction Adenocarcinoma
XELOX Combined With Fruquintinib and Sintilimab Regimen Conversion Therapy for Gastric Cancer/Gastroesophageal Junction Adenocarcinoma Only With Liver and/or Retroperitoneal Lymph Node Metastasis, a Prospective Single-arm, Multicenter Study
Gastric cancer is the third leading cause of morbidity and mortality among malignant tumors in China, and less than 30% of patients can be cured by surgery.
- Trial name
- NCT06091423
- Testing
- XELOX combined with Fruquintinib and Sintilimab
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Xiaofeng Chen
Gastric Adenocarcinoma, Stomach Neoplasms
Conversion Therapy Plus Surgery and Radiotherapy for Retroperitoneal Nodal Metastases in Gastric Cancer
This is a randomized, controlled, multicenter phase II clinical trial evaluating the efficacy and safety of conversion therapy combined with radical gastrectomy and adjuvant radiotherapy targeting para-aortic (station 16) lymph…
- Trial name
- NCT07007182
- Testing
- SOX regimen, CAPEOX regimen, PD-1 inhibitor
- Where
- China
- Volunteers
- 54 people
- Sponsor
- Jinbo Yue
Liposarcoma, Leiomyosarcoma
Efficacy Study on Trabectedin in Retroperitoneal Leiomyosarcoma and Well Differentiated/Dedifferentiated Liposarcoma
This is an Italian, multicentre, single arm, phase II study, with an intra-patient comparison end point. This study aims at confirming the activity of the drug trabectedin as second/further line treatment in retroperitoneal…
- Trial name
- TRAVELL (NCT02247544)
- Testing
- Trabectedin
- Where
- 21 sites in Italy
- Volunteers
- 105 people
- Sponsor
- Italian Sarcoma Group
Immunoglobulin G4 Related Sclerosing Disease
Leflunomide for Maintenance of Remission in IgG4 Related Disease
The study has been designed as a 12-month, open-label, randomized, controlled study comparing the use of prednisone mono-therapy and prednisone and leflunomide combination therapy in treating patients with IgG4-related disease.
- Trial name
- NCT02703194
- Testing
- Prednisone, Leflunomide
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Chinese PLA General Hospital
Retroperitoneal Sarcoma, Malnutrition
Nutritional Status in Retroperitoneal Sarcoma.
Prospective feasibility study of perioperative nutrition in patients affected by primary retroperitoneal sarcoma
- Trial name
- NOVA (NCT03877588)
- Testing
- Oral Nutritional Support
- Volunteers
- 35 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Endometrial Cancer Stage I, Sentinel Lymph Node
Sentinel Node Biopsy in Endometrial Cancer
Endometrial cancer (EC) is the most common gynaecological cancer. Current treatment of EC typically includes removal of the uterus and to determine the extent of the disease (removal of fallopian tubes, ovaries \& if required a…
- Conditions
- Endometrial Cancer Stage I, Sentinel Lymph Node, Surgery
- Trial name
- ENDO-3 (NCT04073706)
- Testing
- TH BSO with SNB Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted, TH BSO without retroperitoneal node dissection Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted
- Where
- 23 sites in United States, Argentina and 5 more
- Volunteers
- 760 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
Malignant Peritoneal Neoplasm, Malignant Retroperitoneal Neoplasm
Nivolumab With or Without Ipilimumab in Treating Patients With Recurrent or High Grade Gynecologic Cancer With Metastatic Peritoneal Carcinomatosis
This phase Ib trial studies the side effects and best dose of nivolumab with or without ipilimumab in treating patients with female reproductive cancer that has come back (recurrent) or is high grade and has spread extensively…
- Conditions
- Malignant Peritoneal Neoplasm, Malignant Retroperitoneal Neoplasm, Metastatic Cervical Carcinoma, Metastatic Endometrial Carcinoma
- Trial name
- NCT03508570
- Testing
- Ipilimumab, Laboratory Biomarker Analysis, Nivolumab
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- M.D. Anderson Cancer Center
Chronic Periaortitis, Tocilizumab Monotherapy
Pilot Study of Tocilizumab Monotherapy for Active Chronic Periaortitis
This is a prospective study to investigate the treatment response of Tocilizumab on patients with active chronic periaortitis (CP).
- Trial name
- NCT05133895
- Testing
- Tocilizumab monotherapy
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Peking Union Medical College Hospital
Colorectal Cancer, Retroperitoneal Lymph Node Metastasis
CRT Versus Surgery for Retroperitoneal or Paraaortic Lymph Node Recurrence of CRC
The study aims to compare the effects of chemoradiation versus radical surgery in treating retro-peritoneal or para-aortic lymph node metastasis in colorectal cancer.
- Conditions
- Colorectal Cancer, Retroperitoneal Lymph Node Metastasis, Para-aortic Lymph Node Metastasis
- Trial name
- NCT03725254
- Testing
- lymphadenectomy, chemoradiotherapy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Fudan University
Disorder of Upper Gastrointestinal Tract, Pancreatic Nodule
Tissue Characterisation by Endoscopic GI-elastography
In this single centre study we study the use of endoscopic ultrasonography (EUS) combined with elastography in order to separate malignant tissue from benign tissue in and adjacent to the upper gastrointestinal tract.
- Conditions
- Disorder of Upper Gastrointestinal Tract, Pancreatic Nodule, Secondary and Unspecified Malignant Neoplasm of Retroperitoneal Lymph Nodes, Secondary Malignant Neoplasm of Lymph Node
- Trial name
- NCT01360411
- Where
- Norway
- Volunteers
- 137 people
- Sponsor
- Haukeland University Hospital
Testicular Cancer
Intrathecal Morphine Versus Intravenous Methadone for Postoperative Analgesia Following Retroperitoneal Lymph Node Dissection.
This randomization study is to compare both intrathecal morphine and intravenous methadone, which are both standard of care, for pain management in patients undergoing retroperitoneal lymph node dissections for primary testicular…
- Trial name
- RPLND (NCT06593665)
- Testing
- Inrathecal Morphine, Intravenous Methadone
- Where
- 2 sites in United States
- Volunteers
- 142 people
- Sponsor
- Indiana University
Cancer of the Urinary Tract
Merits of Performing a Modified Template Retroperitoneal Lymph Node Dissection
The primary objective is to show that performing a lymph node dissection may detect occult nodal metastasis in this patient population whereby providing important diagnostic information, with potential therapeutic benefits in…
- Trial name
- NCT00751140
- Testing
- Lymph Node Dissection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Locally Advanced Soft Tissue Sarcoma, Recurrent Soft Tissue Sarcoma
First-in-man Clinical Trial of CEB-01 PLGA Membrane in Recurrent or Locally Advanced Retroperitoneal Soft Tissue Sarcoma
This is an open label, first-in-man clinical trial to assess safety and tolerability of CEB-01 PLGA membrane in patients with recurrent or locally advanced retroperitoneal soft tissue sarcoma after surgery.
- Trial name
- NCT04619056
- Testing
- CEB-01 membrane loaded with SN-38
- Where
- 5 sites in Spain
- Volunteers
- 21 people
- Sponsor
- CEBIOTEX
Gastric Cancer
Safety and Efficacy of Sintilimab in Combination With Chemoradiothrapy Followed by D2 Surgical Resection in Patients With Advanced Gastric Cancer With Retroperitoneal Lymph Node Metastasis
Gastric cancer with retroperitoneal lymph node metastasis was considered as unresectable, to improve these patients' prognosis, we designed systematic conversion therapy including immunotherapy and chemoradiotherapy.
- Trial name
- NCT05002686
- Testing
- Sintilimab, Albumin-Paclitaxel, Capecitabine
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Adult Soft Tissue Sarcoma, Bone Sarcoma
Real-Time Contrast-Enhanced Ultrasonography and Shear Wave Elastography in Predicting Treatment Response in Patients With Soft Tissue Sarcoma
This pilot clinical trial studies real-time contrast-enhanced ultrasonography and shear wave elastography in predicting treatment response in patients with soft tissue sarcomas.
- Conditions
- Adult Soft Tissue Sarcoma, Bone Sarcoma, Retroperitoneal Sarcoma
- Trial name
- NCT02384473
- Testing
- Real-Time CEUS, SWE, Definity Suspension for Injection
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Southern California
Leiomyosarcoma, Malignant Peripheral Nerve Sheath Tumor
Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma
This phase I trial studies the side effects of BO-112 when given together with nivolumab before surgery in treating patients with soft tissue sarcoma that can be removed by surgery (resectable).
- Conditions
- Leiomyosarcoma, Malignant Peripheral Nerve Sheath Tumor, Myxofibrosarcoma, Pleomorphic Rhabdomyosarcoma
- Trial name
- NCT04420975
- Testing
- Definitive Surgical Resection, Nanoplexed Poly I:C BO-112, Nivolumab
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Jonsson Comprehensive Cancer Center