Clinical trials: Reversal of Neuromuscular Blockade
Spine Surgery
Speed of Recovery of Reversal of Neuromuscular Blockade in Geriatric Patients Undergoing Spine Surgery
Spine surgery is one of the most common operative procedures in the United States. It is performed in the prone position (a patient laying on belly).
- Trial name
- NCT03112993
- Testing
- sugammadex, Neostigmine
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Missouri-Columbia
Vocal Cord Paralysis, Recurrent Laryngeal Nerve
Effect of IONM on Efficacy and Safety Using Sugammadex in Thyroid Surgery
Thyroidectomy is a frequently performed surgeon by the head and neck and endocrine surgeons. In recent years, surgical techniques and technological developments have resulted in a significant reduction in complication rates.
- Trial name
- NCT03634956
- Testing
- Group B. Sugammadex sodium-IONM
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people
- Sponsor
- Lütfiye Nuri Burat Government Hospital
Residual Neuromuscular Blockade
Incidence and Severity of Residual Neuromuscular Blockade
This prospective study will take place at Harborview Medical Center (HMC) and the University of Washington Medical Center (UWMC), and will enroll adult patients undergoing abdominal surgery.
- Trial name
- NCT02660398
- Testing
- Standardized NMBD Management
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- University of Washington
Posterior Cervical Decompression and Fusion
A Randomized Controlled Crossover Study Comparing Sugammadex and Placebo
Intraoperative monitoring of the motor evoked potentials has been shown to be both a sensitive and specific indicator for detecting intraoperative neurological injuries during spine surgery.(Fehlings, Brodke et al.
- Trial name
- NCT03087513
- Testing
- Sugammadex Injection [Bridion]
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Anesthesia Recovery Period, Neuromuscular Blockade
The Dose of Sugammadex for Rapid Reversal of Profound Neuromuscular Block in Young and Elderly Patients
To find out the dose of sugammadex for recovery of the TOF ratio to 0.9 within 2 minutes from profound rocuronium-induced neuromuscular block in young and elderly adult patients.
- Trial name
- NCT01890057
- Testing
- Sugammadex
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Severance Hospital
Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus
Neuromuscular Blocking Agents on Gastrointestinal Function Following Colorectal Surgery
This study is a clinical research project conducted at Xijing Hospital to compare the effects of two different neuromuscular blockade reversal strategies on the recovery of gastrointestinal (GI) function after colorectal surgery.
- Conditions
- Postoperative Gastrointestinal Dysfunction (POGD), Postoperative Ileus, Colorectal Surgery
- Trial name
- NCT07271875
- Testing
- Neostigmine + Atropine, Sugammadex
- Volunteers
- 560 people
- Sponsor
- Xijing Hospital
Anesthesia; Functional
Neuromuscular Blockade Reversal Agent Effect on Postoperative Cognitive Function and Behaviour in Children
The aim of this prospective randomized study is to investigate comparatively the effect of neostigmine-atropine versus sugammadex on speed and quality of recovery and on postoperative cognitive function \& behavior in children…
- Trial name
- NCT02455921
- Testing
- neostigmine - atropine, Sugammadex
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- Attikon Hospital
Residual Neuromuscular Blockade
Reversal of Neuromuscular Blockade in Thoracic Surgical Patients
The majority of patients undergoing surgery receive neuromuscular blocking agents (NMBAs) in the operating room. Reversal of neuromuscular blockade at the conclusion of a general anesthetic is accomplished with cholinesterase…
- Trial name
- NCT01837498
- Testing
- Neostigmine, Sugammadex
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Endeavor Health
Neuromuscular Blockade, Arthroplasty, Replacement, Hip
Reversal of Neuromuscular Blockade With Sugammadex or Usual Care in Hip Fracture Surgery or Joint (Hip/Knee) Replacement (P07038)
This study will assess the effect of reversal of neuromuscular blockade with sugammadex compared with reversal according to usual care (neostigmine or spontaneous reversal) on the incidence of post-surgical bleeding events and on…
- Conditions
- Neuromuscular Blockade, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Blood Coagulation
- Trial name
- NCT01422304
- Testing
- Sugammadex, neostigmine and glycopyrrolate or atropine
- Volunteers
- 1,198 people
- Sponsor
- Merck Sharp & Dohme LLC
Underdosing of Other General Anesthetics
Influence of Mild Hypothermia on Reversal of Rocuronium With Sugammadex
The primary efficacy endpoint is the time from the start of administration of sugammadex to recovery of the TOF ratio to 0.9 in deep neuromuscular block (1-2 twitches post-tetanic count) induced by rocuronium during mild…
- Trial name
- NCT01965067
- Testing
- sugammadex
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- MSD Korea Ltd.
Neuromuscular Block, Residual, Pain Management
Methylprednisolone vs Dexamethasone Interaction With Sugammadex in Pediatric Patients
This randomized controlled trial aims to compare the interaction of methylprednisolone and dexamethasone with sugammadex in pediatric patients undergoing adenoidectomy and/or tonsillectomy.
- Conditions
- Neuromuscular Block, Residual, Pain Management, Postoperative Nausea
- Trial name
- NCT07175623
- Testing
- Methyl Prednisolone (MP), Dexamethasone (0.2 mg/kg), Saline (0.9% NaCl)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Konya City Hospital
Prostate Hypertrophy, Renal Disease
Effect of Deep BLock on Intraoperative Surgical Conditions
Rationale: A deep neuromuscular block is often associated with improved surgical conditions especially in laparoscopic surgery. However, a deep block comes at the expense of a variety of items that may conflict with the use of a…
- Trial name
- BLISS (NCT01631149)
- Testing
- Surgical block (rocuronium; atracurium/mivacurium)
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Leiden University Medical Center
Anaesthesia
Sugammadex and Brain Waves
According to our experience, electroencephalogram-based indices of anaesthetic state show elevated numbers after administration of sugammadex (new reversal of neuromuscular blockade).
- Trial name
- NCT01142648
- Testing
- Sugammadex, Neostigmine and glycopyrrolate
- Where
- Finland
- Volunteers
- 30 people
- Sponsor
- Tampere University Hospital
Brain Cancer
Sugammadex Given for the Reversal of Rocuronium Induced Neuromuscular Blockade Under Sevoflurane Anesthesia in Infants
The objective of this study is to evaluate the efficacy and safety of sugammadex in reversing profound neuromuscular block induced by rocuronium in infant patients
- Trial name
- NCT02708056
- Testing
- Sugammadex
- Volunteers
- 26 people
- Sponsor
- Baskent University
Thyroid Diseases, Surgical Injury
Feasibility of Neostigmine for Intraoperative Neuromonitoring in Thyroid Surgery
For successful intraoperative neuromonitoring (IONM), adequate reversal of neuromuscular blocking agent is a prerequisite in thyroid surgery with .
- Conditions
- Thyroid Diseases, Surgical Injury, Nerve Monitoring
- Trial name
- NCT04873531
- Testing
- Neostigmine, Normal saline
- Where
- South Korea
- Volunteers
- 44 people
- Sponsor
- Seoul National University Hospital
Morbid Obesity
Sugammadex Dosage Based on Ideal Body Weight for Profound Rocuronium-induced Neuromuscular Blockade Reversal in Morbidly Obese Patients
This randomized double blind clinical trial focuses on patients with Body Masse Index ≥ 40 kg/m2, undergoing scheduled surgery. Neuromuscular transmission monitoring at the adductor is performed using.
- Trial name
- NCT02545595
- Testing
- Sugammadex 1 mg/kg, Sugammadex 2 mg/kg, Sugammadex 4 mg/kg
- Where
- France
- Sponsor
- Poitiers University Hospital
Neuromuscular Blockade
Impact of iv Dexamethasone on Reversal of Rocuronium-induced Neuromuscular Block by Sugammadex
Sugammadex is used as a reversal drug for rocuronium- or vecuronium-induced neuromuscular block during general anaesthesia. IV dexamethasone is injected as a prophylactic measure against postoperative nausea and vomiting.
- Trial name
- NCT02562417
- Testing
- Normal saline, IV dexamethasone
- Where
- Switzerland
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Observation of Neuromuscular Block
Appropriate Dose of Neostigmine for Reversal of Rocuronium and Cisatracurium
This study aims to find appropriate dose of neostigmine which is possible to reverse rocuronium or cisatracurium till train of four (TOF) 0.9 within 10 minutes.
- Trial name
- NCT01885715
- Testing
- Injection of neostigmine
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Seoul National University Hospital
Neuromuscular Blockade
Reversal of Residual Neuromuscular Blockade at Train-of-four Ratio 0.3 With Sugammadex and Neostigmine
The aim of this study is to estimate the optimal dose of sugammadex and neostigmine reversal of a vecuronium-induced residual neuromuscular block at train-of-four ratio 0.3.
- Trial name
- NCT03656614
- Testing
- Sugammadex, Neostigmine, Saline 0.9%
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Caesarean Section, Pregnancy
Modern Myorelaxation Procedure and Reversal of Neuromuscular Blockade With General Anesthesia for Caesarean Section
The project aims to introduce into clinical practice for Caesarean section conducted under general anesthesia with the rapid induction myorelaxation with rocuronium and the reversal of neuromuscular blockade by using sugammadex.
- Trial name
- RocSugIO (NCT01718236)
- Testing
- Rocuronium + sugammadex, Succinylcholine + Neostigmine
- Where
- 2 sites in Czechia
- Volunteers
- 500 people
- Sponsor
- Brno University Hospital