Clinical trials: Reward
Healthy
A Study To Examine Safety, Pharmacokinetics, And Pharmacodynamic Of Pf 06412562 In Healthy Males
This study is designed to investigate the safety, tolerability pharmacokinetics and pharmacodynamic effects of PF-06412562 following multiple dose administration as MR tablets in healthy adult males.
- Trial name
- NCT02306876
- Testing
- PF-06412562 3mg BID, PF-06412562 15mg BID
- Where
- 3 sites in United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Pfizer
Anhedonia, Depression
A Neurobiological Model of Anhedonia
The purpose of this research study is to better understand anhedonia in Major Depressive Disorder by investigating the reward-related neural and inflammatory correlates.
- Trial name
- NCT05629520
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Healthy
The Impact of Reward-induced Dopamine Release on Functional Connectivity: a Combined PET/fMRI Study
The present study would be the first to investigate the relationship between reward- and or social stimuli-induced dopamine (DA) release and neural function using a combined PET/fMRI approach.
- Trial name
- NCT02801643
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Reward, Tetrahydrocannabinol
Investigating the Acute Effects of THC on Functional Brain Systems
The purpose of this study is to determine whether THC, the main psychoactive ingredient in cannabis, affects functional brain systems underlying memory and reward.
- Conditions
- Reward, Tetrahydrocannabinol, Endocannabinoids, Memory
- Trial name
- FIX (NCT00628706)
- Testing
- Delta9-tetrahydrocannabinol (THC)
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Healthy
Effect of Reward on Learning in Motor Cortex
Background: Magnetic resonance imaging (MRI) uses a strong magnetic field and radio waves to take pictures of the brain. Some MRI studies suggest that this technique reveals brain differences in patients with a nervous system…
- Trial name
- NCT00885131
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Adiposity
Reward System Responses to Food Aromas
Food aromas are a part of foods' flavor, and can promote overeating. Alcohol consumption also stimulates appetite, and contributes to overeating while under alcohol's acute effects.
- Trial name
- NCT02041039
- Where
- United States
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- Robert Considine
Depression in Adolescence, Antidepressant Activity in Healthy Volunteers
Fluoxetine and Understanding Social Experiences
Adolescence is a critical developmental period marked by significant social, cognitive, and emotional changes. Unfortunately, it is also a time when the risk of depression and anxiety rises dramatically.
- Conditions
- Depression in Adolescence, Antidepressant Activity in Healthy Volunteers, Healthy Adult Participants
- Trial name
- FUSE (NCT07456501)
- Testing
- Fluoxetine
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Learning Disabilities
Effects of Oxytocin on Reinforcement Learning
The main aim of the study is to investigate whether intranasal oxytocin (24IU) influences reward sensitivity and performance monitoring during reinforcement learning.
- Trial name
- NCT03846271
- Testing
- intranasal oxytocin
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Stimulant Use Disorder
Repetitive Transcranial Magnetic Stimulation Treatment of Stimulant Use Disorder
The purpose of this study is to establish a new treatment (repetitive transcranial stimulation (rTMS)) for Veterans with stimulant use disorder (SUD).
- Trial name
- VA-StARTS (NCT07112105)
- Testing
- Repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- VA Office of Research and Development
Diabetes Mellitus
Hawaii Patient Reward And Incentives to Support Empowerment
The purpose of this randomized controlled trial (RCT) study is to examine the extent that financial incentives when combined with diabetes evidence-based practices, improve self-management and biometric measures for adult…
- Trial name
- HI-PRAISE (NCT02123251)
- Testing
- Financial Incentives
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- University of Hawaii
Chronic Low Back Pain, Posttraumatic Stress Disorder
Exercise Maintenance in Chronic Pain and PTSD
The primary purpose of the R21 is using an experimental medicine research approach to study whether a chronic, progressive-based exercise program will help Veterans suffering from chronic low back pain (cLBP) and PTSD achieve…
- Trial name
- NCT03644927
- Testing
- Progressive exercise training, Waitlist Control
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Boston University
Depression, Depressive Disorder
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information.
- Conditions
- Depression, Depressive Disorder, Major Depressive Disorder, Major Depressive Episode
- Trial name
- NCT06080646
- Testing
- cross-sectional MRI and EEG assessments (NO INTERVENTION)
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- San Francisco Veterans Affairs Medical Center
Cocaine Dependence
Study of the Effects of Risperdal Consta on Brain Reward Circuitry Function, Craving and Cocaine Use in Active Cocaine Dependence
The purpose of this study is to examine the effects of the administration of Risperidal-Consta on the brain's reward circuitry using Magnetic resonance Imaging (MRI), behavioral tests and measuring cocaine craving and use among…
- Trial name
- NCT00385801
- Testing
- Risperidone
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Disruptive Behavior, Aggression
Cognitive-Behavioral Therapy for Disruptive Behavior in Children and Adolescents
This is a randomized controlled study of cognitive-behavioral therapy (CBT) for disruptive behavior such as irritability, anger and aggression in children and adolescents.
- Conditions
- Disruptive Behavior, Aggression, Anger, Irritability
- Trial name
- RDoC-CBT (NCT01965184)
- Testing
- Cognitive-Behavioral Therapy for Anger and Aggression, Supportive Psychotherapy (SPT)
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Yale University
Impulsivity
Shaping Tolerance for Delayed Rewards
Deficits in self-control are of major public health relevance as they contribute to several negative outcomes for both individuals and society.
- Trial name
- DelTA (NCT03457402)
- Testing
- Shaping Delay Tolerance
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, Davis
Anhedonia
Serotonin-receptor Agonism in Reward Processing
There is growing animal and human evidence for role of 5HT1A receptor agonism in treating depression and reward deficits. The next step is to translate this evidence directly into humans by characterising the effects of…
- Trial name
- SARP (NCT05357547)
- Testing
- Buspirone 20mg
- Where
- United Kingdom
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Obesity
Investigation of the Effects of Bariatric Surgery on Taste Reward in Humans
The investigators hypothesize that some of these changes in the reduced appetite after surgery may be due to alterations in taste.
- Trial name
- NCT01531738
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Psychosis
Determining the Role of Social Reward Learning in Social Anhedonia
This is a clinical trial study that aims to evaluate the specificity of the relationship between reduced sensitivity to social reward and social anhedonia at both behavioral and neural levels.
- Trial name
- SAMI (NCT05617898)
- Testing
- Motivational Interviewing, Nutrition Didactic Training
- Where
- 2 sites in United States
- Volunteers
- 152 people
- Sponsor
- University of Alabama at Birmingham
Healthy
Does Oxytocin Modulate Rewarding Effects in Women and Fluctuating Across the Menstrual Cycle
The aim of the study is to explore how the rewarding effect of men's verbal compliment is modulated by oxytocin and gonadal hormone in a romantic context.
- Trial name
- NCT03144115
- Testing
- Oxytocin
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Vagus Nerve Stimulation in Reward Learning
Pulsed tVNS Protocol and Reinforcement Learning
The aim of this study is to investigate the potential of a phasic taVNS stimulation protocol for reinforcement learning. The investigators will disentangle its effects on learning actions and outcomes through the administration…
- Trial name
- NCT06205108
- Testing
- taVNS stimulation
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bonn