Clinical trials: RhA - Rheumatoid Arthritis
Rheumatoid Arthritis
A Study Comparing SB5 to Humira® in Subjects With Moderate to Severe Rheumatoid Arthritis Despite Methotrexate Therapy
This is a randomised, double-blind, parallel group, multicentre clinical study to evaluate the efficacy, safety, tolerability, pharmacokinetics and immunogenicity of SB5 compared to Humira® in subjects with moderate to severe RA…
- Trial name
- NCT02167139
- Testing
- Humira (adalimumab), SB5 (proposed biosimilar to adalimumab)
- Where
- 2 sites in Lithuania, Poland
- Volunteers
- 544 people
- Sponsor
- Samsung Bioepis Co., Ltd.
Rheumatoid Arthritis
Study Evaluating Multiple Ascending Doses Of ATN-103 In Japanese Subjects With Rheumatoid Arthritis
This primary purpose of this study is to evaluate the safety, tolerability, and pharmacokinetic properties of multiple ascending doses of ATN-103 administered subcutaneously (below the skin) to Japanese subjects with active…
- Trial name
- NCT01007175
- Testing
- ATN-103 10 mg q4wks, ATN-103 30 mg q4wks, ATN-103 80 mg q4wks
- Where
- 15 sites in Japan
- Volunteers
- 60 people
- Sponsor
- Ablynx, a Sanofi company
Arthritis, Rheumatoid, Inflammation
A Study To Look At The Safety Of SB-681323 In Healthy Adult Subjects After Intravenous Administration Of A Single Dose
SB-681323 inhibits the action of an enzyme which is known to contribute to the inflammation seen in such conditions as Chronic Obstructive Pulmonary Disease and Rheumatoid Arthritis.
- Trial name
- NCT00439881
- Testing
- SB-681323
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Rheumatoid Arthritis
An Extension Study to Demonstrate Long-Term Efficacy and Safety of CT-P13 When Co-administered With Methotrexate in Patient With Rheumatoid Arthritis Who Were Treated With Infliximab (Remicade or CT-P13) in Study CT-P13 3.1
CT-P13 (Infliximab) is a monoclonal antibody currently being developed by CELLTRION, Inc. This open-label, single-arm, multicenter, multiple single dose intravenous (IV) infusion, efficacy, and safety extension study of the Phase…
- Trial name
- NCT01571219
- Testing
- Infliximab
- Where
- South Korea
- Volunteers
- 302 people
- Sponsor
- Celltrion
Coxarthrosis; Primary, Coxarthrosis; Post-Traumatic
Cemented TrendHip® - Multicenter PMCF Study on Total Indications
This Post Market Clinical Follow-Up (PMCF) study to evaluate the performance and safety of the cemented TrendHip® stem in a prospective follow-up study with patients who underwent a hip arthroplasty with the investigational…
- Conditions
- Coxarthrosis; Primary, Coxarthrosis; Post-Traumatic, Necrosis, Femur Head, Rheumatoid Arthritis
- Trial name
- TRESTI (NCT04943328)
- Testing
- Total Hip Arthroplasty
- Where
- 4 sites in Germany
- Volunteers
- 119 people
- Sponsor
- Aesculap AG
Rheumatoid Arthritis
The Role of Tofacitinib in Steroid Withdrawal in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a systemic chronic arthritis characterized by systemic inflammation, persistent synovitis and final joint destruction Inflammatory diseases can lead to decreased productivity and impaired…
- Trial name
- NCT04927000
- Testing
- Tofacitinib
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Rheumatoid Arthritis
Efficacy and Safety Study of Mizoribine in Active Rheumatoid (AMOLED)
The purpose of this study is to access the efficacy and safety of Mizoribine 150mg qid and 50mg tid in active rheumatoid arthritis patients unsuccessfully treated with disease-modifying antirheumatic drug.
- Trial name
- AMOLED (NCT02005757)
- Testing
- Bredinin tablet 150mg, Bredinin tablet 50mg
- Where
- 7 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Rheumatoid Arthritis
Comparison of Three Different Treatment Regimes in Early Rheumatoid Arthritis: A Randomized Open-labelled Trial
Many studies have been conducted to evaluate the role of pulse steroids in early rheumatoid arthritis (RA) but no consensus exists. The aim of this study is to study the efficacy of various treatment regimens in early RA.
- Trial name
- NCT01870128
- Testing
- Combination Steroid, Methotrexate, Combination
- Where
- India
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Rheumatoid Arthritis
Success of Tocilizumab in RA Patients With Remission Induction and Sustained Efficacy After Discontinuation
The objective of this study is to investigate the efficacy and safety of the humanized anti-human IL-6 receptor monoclonal antibody tocilizumab (TCZ) either in monotherapy or in combination therapy with methotrexate (MTX) in…
- Trial name
- SURPRISE (NCT01120366)
- Testing
- Tocilizumab plus methotrexate, Tocilizumab
- Where
- 30 sites in Japan
- Volunteers
- 233 people
- Sponsor
- SURPRISE Study Group
Rheumatoid Arthritis, Ankylosing Spondylitis
Survey of Cannabis Use in Patients With Chronic Inflammatory Arthritis
Patients with inflammatory rheumatism very often have residual pain that is not easily relieved by conventional treatments. They can then use non-drug methods, such as physiotherapy, hypnosis or even cannabis.
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- CannabisRIC (NCT04402554)
- Testing
- Cannabis questionnaire
- Where
- France
- Volunteers
- 501 people
- Sponsor
- University Hospital, Clermont-Ferrand
Rheumatoid Arthritis
Bone Resorption, Osteoclastogenesis and Adalimumab
Osteoclastic bone resorption depends on both the capacity to generate osteoclasts (osteoclastogenesis) and on individual osteoclast activity.
- Trial name
- BROCA (NCT00814866)
- Testing
- Adalimumab
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- Université de Sherbrooke
Rheumatoid Arthritis
Biomarkers in Rheumatoid Arthritis Treated With Anti-interleukin-6 Therapy
The use of anti-interleukin (IL)-6 therapy, including tocilizumab, in rheumatoid arthritis or giant cell arteritis, led to the improvement or even control of disease in some patients for whom no further therapeutic options were…
- Trial name
- INTER-ACT (NCT04281602)
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Osteoarthritis, Rheumatoid Arthritis
6 Week Open-label Trial With Lumiracoxib 200mg o.d. in Primary Knee Osteoarthritis or Rheumatoid Arthritis
This study tested the safety, tolerability and efficacy of lumiracoxib - a COX-2 inhibitor- in patients with primary knee osteoarthritis or rheumatoid arthritis.
- Trial name
- NCT00170872
- Testing
- Lumiracoxib
- Volunteers
- 135 people
- Sponsor
- Novartis
Rheumatoid Arthritis (RA), Juvenile Idiopathic Arthritis (JIA)
Safety and Immunogenicity of the Live Attenuated Tetravalent Butantan-Dengue Vaccine in Autoimmune Rheumatic Diseases
The goal of this clinical trial is to evaluate whether the live attenuated tetravalent Butantan-Dengue vaccine (Butantan-DV) is safe and capable of inducing an immune response in patients aged 12 to 59 years with autoimmune…
- Conditions
- Rheumatoid Arthritis (RA), Juvenile Idiopathic Arthritis (JIA), Systemic Lupus Erythematosus (SLE), Juvenile Systemic Lupus Erythematosus
- Trial name
- BTNDV-ARD (NCT07087912)
- Testing
- Dengue 1,2,3,4 (attenuated) vaccine
- Where
- 2 sites in Brazil
- Volunteers
- 477 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Rheumatoid Arthritis
Open Label Extension for Patients Coming From the Dosing Flexibility Study in Patients With Rheumatoid Arthritis (RA)
The purpose of this study is to continue to assess the safety of certolizumab pegol in combination with methotrexate (MTX).
- Trial name
- Dose Flex II (NCT00753454)
- Testing
- Certolizumab pegol
- Where
- 40 sites in United States, Canada
- Volunteers
- 168 people
- Sponsor
- UCB Pharma
Dry Eye Syndromes
Dual-Polymer Hydroxypropyl Guar-and Hyaluronic Acid Lubricants in Rheumatoid Arthritis
The goal of this clinical trial is to evaluate the efficacy of hydroxypropyl guar-and hyaluronic acid containing lubricant eye drops in rheumatoid arthritis patients .
- Trial name
- NCT06209879
- Testing
- SYSTANE™ Hydration Lubricant Eye Drops
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Rheumatoid Arthritis
Factors Affecting Hand Dysfunction in Patient With Rheumatoid Arthritis and Its Correlation With Quality of Life
The aims of the research are: To predict factors affecting hand dysfunction in patient with rheumatoid arthritis To study the effect of hand dysfunction on quality of life in patient with rheumatoid arthritis
- Trial name
- NCT03274570
- Volunteers
- 100 people
- Sponsor
- Assiut University
Rheumatoid Arthritis
Efficacy and Safety of Adalimumab in Patients With Active Rheumatoid Arthritis Treated Concomitantly With Methotrexate.
The purpose of the study was to assess the safety, immunogenicity, and clinical efficacy of adalimumab compared with placebo (during double-blind phase) and to to evaluate the long-term safety and maintenance of efficacy…
- Trial name
- NCT00195702
- Testing
- Adalimumab
- Where
- 87 sites in United States, Canada
- Volunteers
- 619 people
- Sponsor
- Abbott
Arthritis, Rheumatoid
Efficacy and Safety of GSK3196165 Versus Placebo and Tofacitinib in Participants With Moderately to Severely Active Rheumatoid Arthritis Who Have an Inadequate Response to Conventional Synthetic (cs)/Biologic (b) Disease Modifying Anti-rheumatic Drugs (DMARDs)
This study [contRAst 2 (201791: NCT03970837)] is a phase 3, randomized, multicenter, double blind study to assess the safety and efficacy of GSK3196165 in combination with csDMARD(s), for the treatment of adult participants with…
- Trial name
- contRAst 2 (NCT03970837)
- Testing
- GSK3196165 (Otilimab), Tofacitinib
- Where
- 269 sites in United States, Argentina and 16 more
- Volunteers
- 1,764 people
- Sponsor
- GlaxoSmithKline
Rheumatoid Arthritis
VELVET, a Dose Range Finding Trial of Veltuzumab in Subjects With Moderate to Severe Rheumatoid Arthritis
This is a multi-national, multi-centre, placebo-controlled, double-blind, randomized, 4-arm parallel group trial, comparing three different dose levels (80 mg, 160 mg and 320 mg) of veltuzumab to placebo, administered weekly…
- Trial name
- VELVET (NCT01390545)
- Testing
- Veltuzumab
- Where
- 63 sites in United States, Argentina and 9 more
- Volunteers
- 300 people
- Sponsor
- Takeda
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