Clinical trials: RhA - Rheumatoid Arthritis
Rheumatoid Arthritis
Study to Evaluate Safety and Efficacy of CCX 354-C in Subjects With Rheumatoid Arthritis
The purpose of this study is to evaluate the safety and tolerability of multiple oral doses of CCX354-C at a number of dose levels in subjects with stable rheumatoid arthritis (RA).
- Trial name
- CARAT-1 (NCT01027728)
- Testing
- CCX 354-C
- Where
- 5 sites in Belgium, Romania
- Volunteers
- 24 people
- Sponsor
- Amgen
Rheumatoid Arthritis
A Prospective, Non-Interventional Study of RoActemra/Actemra (Tocilizumab) in Patients With Moderate to Severe Active Rheumatoid Arthritis
This prospective, observational study will evaluate the efficacy, safety and tolerability of RoActemra/Actemra (tocilizumab) in patients with moderate to severe active rheumatoid arthritis who have had an inadequate response or…
- Trial name
- NCT01770834
- Where
- 12 sites in Kuwait, Lebanon and 2 more
- Volunteers
- 100 people
- Sponsor
- Hoffmann-La Roche
Juvenile Chronic Arthritis
Juvenile Rheumatoid Arthritis
The purpose of this study is to determine the safety of anakinra in patients with Polyarticular-Course Juvenile Rheumatoid Arthritis, a form of rheumatoid arthritis affecting children.
- Trial name
- NCT00037648
- Testing
- Anakinra
- Volunteers
- 86 people
- Sponsor
- Amgen
Rheumatoid Arthritis, Cardiovascular Disease
Vitamin D and Cardiovascular Events in Rheumatoid Arthritis
The aim of the study is to evaluate cardiovascular events during long-term follow-up in Rheumatoid Arthritis. The primary outcome "any cardiovascular event" will be evaluated using systematic audits of patient records, and will…
- Trial name
- NCT02932644
- Testing
- Baseline serum vitamin D level below 50 nmol/l, Baseline serum vitamin D level at or above 50 nmol/l
- Volunteers
- 160 people
- Sponsor
- Odense University Hospital
Rheumatoid Arthritis
Study Evaluating the Long-Term Safety and Efficacy of ABX464 in Patients With Moderate to Severe Rheumatoid Arthritis
A phase 2a open-label study to evaluate the long-term safety and efficacy of ABX464 50mg as maintenance therapy in patients with moderate to severe rheumatoid arthritis.
- Trial name
- NCT04049448
- Testing
- ABX464
- Where
- 14 sites in Belgium, France and 2 more
- Volunteers
- 40 people
- Sponsor
- Abivax S.A.
Rheumatoid Arthritis
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Tofacitinib vs Abatacept
This study aims to evaluate the comparative risk of dementia/Alzheimer's disease onset between patients treated with medications that target specific metabolic pathways and patients treated with alternative medications for the…
- Trial name
- DREAM (NCT04529876)
- Testing
- Tofacitinib, Abatacept
- Where
- United States
- Volunteers
- 29,464 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Rheumatoid Arthritis
Biomarkers of Remission in Rheumatoid Arthritis (BioRRA)
Rheumatoid arthritis is a common condition affecting approximately 1% of the United Kingdom population; it is an autoimmune disease where the body's natural defences (the immune system) attack the body itself resulting, most…
- Trial name
- BioRRA (NCT02219347)
- Testing
- DMARD cessation
- Where
- United Kingdom
- Volunteers
- 74 people
- Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
Rheumatoid Arthritis
A Study of LNK01001 Capsule in Moderately to Severely Active Rheumatoid Arthritis
This study includes two periods. In Period 1, Participants who meet eligibility criteria will be randomized in a 1:1:1 ratio to receive a twice-daily oral LNK01001 Dose A or LNK01001 Dose B or a matching placebo for 12 weeks.
- Trial name
- NCT06099535
- Testing
- LNK01001 Dose A, LNK01001 Dose B
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Lynk Pharmaceuticals Co., Ltd
Rheumatoid Arthritis
Zr-89 Cimzia PET Imaging Rheumatoid Arthritis
This is a single center exploratory imaging study investigating the initial application of zirconium-89 Deferoxamine B Certolizumab pegol (89Zr-DFO-CZP) PET in patients with rheumatoid arthritis.
- Trial name
- NCT03546335
- Testing
- 89Zr-DFO-CZP
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Robert Flavell, MD, PhD
Rheumatoid Arthritis
More Added Value of Therapeutic Education in the Management of Patients With Rheumatoid Arthritis (ETP-PR)
Taking into account the recommendations of the Health Authority [1] and the application of patients' associations, we have structured a course of therapeutic education includes three stages for patients with rheumatoid arthritis…
- Trial name
- ETP-PR (NCT01564147)
- Testing
- immediate therapeutic education, therapeutic education delayed
- Where
- France
- Volunteers
- 62 people
- Sponsor
- Nantes University Hospital
Arthritis, Rheumatoid
Progression of Bone Erosions in Rheumatoid Arthritis Assessed by HR-pQCT and Conventional X-ray
Today, regular X-ray examination is not sufficiently sensitive for detecting progression of bone destruction in rheumatoid arthritis, but a new type of high-resolution CT scanner, the High-Resolution peripheral Quantitative…
- Trial name
- RACTX (NCT03429426)
- Where
- Denmark
- Volunteers
- 625 people
- Sponsor
- Aarhus University Hospital
Arthritis, Rheumatoid, Inflammatory Response
Postprandial Inflammation in Rheumatoid Arthritis
Patients with RA will be studied to see whether meals of different content will affect inflammation and metabolic variables in the postprandial state.
- Conditions
- Arthritis, Rheumatoid, Inflammatory Response, Dietary Exposure, Diet, Healthy
- Trial name
- PIRA (NCT04247009)
- Testing
- Meal based on red meat, fish products or vegan products, Meal based on red meat
- Where
- Sweden
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Lupus Erythematosus, Rheumatoid Arthritis
Dietary Phytoestrogens as Risk Factors for Systemic Lupus Erythematosus
The study aims at determining if dietary phytoestrogens can be risk factors for Systemic Lupus Erythematosus (SLE). Dietary enquiry and phytoestrogens measurements will be performed in blood and urine of patients with SLE in an…
- Conditions
- Lupus Erythematosus, Rheumatoid Arthritis, Autoimmune Thrombocytopenia
- Trial name
- ISOLED (NCT03421184)
- Testing
- blood sample, urine sample, food questionnaire
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Rheumatoid Arthritis
A Study of Tocilizumab in Combination With Disease-Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Moderate to Severe Active Rheumatoid Arthritis With an Inadequate Response to DMARDs
This open-label, single-arm study will evaluate the efficacy and safety of tocilizumab in combination with DMARDs in participants with moderate to severe active rheumatoid arthritis who have an inadequate response to DMARDs.
- Trial name
- NCT00996606
- Testing
- DMARDs, Tocilizumab
- Where
- 11 sites in Italy
- Volunteers
- 58 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Safety and Efficacy of Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disorder that can cause substantial pain and joint tenderness, significant joint damage, and serious disability.
- Trial name
- RA-1 (NCT00221000)
- Testing
- Methoxsalen, Extracorporeal Photopheresis
- Where
- 32 sites in United States, Australia and 9 more
- Volunteers
- 86 people
- Sponsor
- Mallinckrodt
Rheumatoid Arthritis
Safety and Efficacy of the Combination of Diacerein 100 mg Daily and MTX Versus MTX Alone in the Treatment of Early Rheumatoid Arthritis (RA)
To evaluate the efficacy of Diacerein 100 mg daily versus placebo in reducing rheumatoid arthritis symptoms, when added to stable oral MTX therapy in patients with active early RA.
- Trial name
- NCT01264211
- Testing
- Diacerein
- Where
- 2 sites in Thailand
- Volunteers
- 40 people
- Sponsor
- TRB Chemedica
Rheumatoid Arthritis
Anti-TNF Agents for the Treatment of Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic disease that leads to inflammation and progressive joint damage. RA is a systemic inflammatory autoimmune disorder affecting almost 1% of the United States population.
- Trial name
- NCT00837434
- Testing
- Etanercept, Adalimumab
- Where
- 7 sites in United States
- Volunteers
- 63 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Rheumatoid Arthritis
A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Failed on One Prior Anti-TNF Therapy (RESET)
This study will evaluate the safety and effectiveness of MabThera (rituximab) in patients with active rheumatoid arthritis who are receiving methotrexate, and who have a previous or current inadequate response to one prior…
- Trial name
- NCT01272908
- Testing
- rituximab
- Where
- 41 sites in Canada, Sweden
- Volunteers
- 120 people
- Sponsor
- Hoffmann-La Roche
Erosive Disease in Early Rheumatoid Arthritis
Prediction of Erosive Disease in Early Rheumatoid Arthritis (RA) by Ultrasound and Cartilage Biodegradation Markers
Multicenter, prospective, open-label, cohort study. Primary objective: Determination of the predictive value of US alone and in combination with cartilage biodegradation markers on radiographic progression (change in Ratingen…
- Trial name
- NCT02464384
- Testing
- Venipuncture, ultrasound, MRI, x-ray
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Osteoarthritis, Rheumatoid Arthritis
Anterior Advantage With KINCISE
This is a post-market prospective, 1:1 randomized, multicenter non-inferiority study to compare the femoral broaching time for THA with the Anterior Advantage approach with KINCISE vs. without KINCISE.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post Traumatic Arthritis
- Trial name
- NCT04191733
- Testing
- KINCISE(TM) Surgical Automated System
- Where
- 11 sites in United States
- Volunteers
- 250 people
- Sponsor
- DePuy Orthopaedics
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