Clinical trials: RhA - Rheumatoid Arthritis
Osteoarthritis Arthritis, Rheumatoid Arthritis
G7 Acetabular System vs. Exceed ABT Acetabular System in THA
Evaluate the safety and effectiveness of patients who received G7 Acetabular system in conjunction with Ceramic on Ceramic articulation and Taperloc Complete Microplasty stem compared to patients who received the Exceed ABT…
- Trial name
- G7 (NCT02340390)
- Testing
- G7, Exceed ABT
- Where
- 3 sites in South Korea
- Volunteers
- 160 people
- Sponsor
- Zimmer Biomet
Rheumatoid Arthritis
A Study of Tocilizumab Plus Non-biological DMARD in Patients With Moderate to Severe Rheumatoid Arthritis and an Inadequate Response to Non-biological DMARDs
This randomized, double-blind, placebo-controlled study will use Magnetic Resonance Imaging (MRI) to assess the efficacy of tocilizumab plus non-biological DMARD in patients with moderate to severe rheumatoid arthritis who have…
- Trial name
- NCT01034397
- Testing
- tocilizumab [RoActemra/Actemra], non-biological DMARDs
- Where
- 11 sites in Portugal
- Volunteers
- 54 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
A Study of the Effect of Tocilizumab on Markers of Atherogenic Risk in Patients With Moderate to Severe Rheumatoid Arthritis
This 2 arm study will investigate the effects of tocilizumab on lipids, arterial stiffness, and markers of atherogenic risk in patients with moderate to severe active rheumatoid arthritis.
- Trial name
- NCT00535782
- Testing
- Tocilizumab, Methotrexate
- Where
- 40 sites in United States, Canada and 2 more
- Volunteers
- 132 people
- Sponsor
- Hoffmann-La Roche
Myocardial Inflammation, Rheumatoid Arthritis
Myocardial Inflammation in Rheumatoid Arthritis: A Descriptive Study
Rheumatoid arthritis (RA) patients have a higher prevalence of subclinical atherosclerosis than the general population. In addition, RA patients experience higher rates of heart failure with preserved ejection fraction (HFpEF).
- Conditions
- Myocardial Inflammation, Rheumatoid Arthritis, Coronary Artery Disease, Myocardial Strain
- Trial name
- NCT03776682
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic
Systemic Juvenile Idiopathic Arthritis (SJIA)
ß-SPECIFIC 4 Patients: Study of Pediatric EffiCacy and Safety wIth FIrst-line Use of Canakinumab
The purpose of this study was to evaluate the efficacy observed with canakinumab dose reduction in a subgroup of patients in the extension study CACZ885G2301E1.
- Trial name
- ß-SPECIFIC 4 (NCT02296424)
- Testing
- ACZ885 150 mg (Canakinumab)
- Where
- 50 sites in United States, Austria and 14 more
- Volunteers
- 182 people
- Sponsor
- Novartis Pharmaceuticals
Rheumatoid Arthritis
Human Umbilical Cord-Mesenchymal Stem Cells for Rheumatoid Arthritis
The purpose of this study is to evaluate the safety and efficacy of human umbilical cord mesenchymal stem cell(hUC-MSC) for Rheumatoid Arthritis.
- Trial name
- NCT02643823
- Testing
- hUC-MSC + DMARDs, DMARDs
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shenzhen Hornetcorn Bio-technology Company, LTD
Osteo Arthritis Knee, Rheumatoid Arthritis of Knee
A Study on the Use of Tourniquet Use In Primary Total Knee Arthroplasty
A tourniquet is often used in total knee arthroplasty (TKA) to achieve better visualization, reduce intra-operative bleeding and facilitate cement interdigitation.
- Trial name
- NCT04502459
- Testing
- Tourniquet
- Volunteers
- 90 people
- Sponsor
- The University of Hong Kong
Rheumatoid Arthritis (RA), Systemic Sclerosis (SSc)
Correlation Between Circulating Fibroblast Activation Protein (FAP) and Fibrosis in Two Diseases (Rheumatoid Arthritis and Systemic Sclerosis)
This study aims to measure a blood protein called fibroblast activation protein (FAP), which is linked to tissue scarring and inflammation.
- Trial name
- FAP (NCT07393217)
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Sohag University
Rheumatoid Arthritis, Ankylosing Spondylitis
A Study to Evaluate the Safety of Remsima® SC in the Treatment of RA, AS, PsA and Ps
This is an observational, prospective cohort study to evaluate the safety of Remsima® SC in the treatment of RA, AS, PsA and Ps.
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis, Psoriasis
- Trial name
- NCT05866614
- Testing
- Remsima IV, Remsima SC
- Where
- France
- Volunteers
- 881 people
- Sponsor
- Celltrion
Knee Osteoarthritis, Rheumatoid Arthritis (RA)
Comparative Study on the Medium- and Long-term Benefits of Prosthesis Selection in Total Knee Arthroplasty
This retrospective real-world study aims to compare the medium- and long-term clinical outcomes, safety, and economic benefits of different knee prosthesis brands used in primary unilateral total knee arthroplasty (TKA) at our…
- Trial name
- NCT07553871
- Volunteers
- 3,500 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Rheumatoid Arthritis
Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During IL-6 vs. TNF Antibody Therapy
The present study will investigative the physiological effects of the cytokines interleukin-6 (IL-6) and tumor necrosis factor (TNF) on the adaptive changes to exercise in patients with rheumatoid arthritis.
- Trial name
- RABEX (NCT05215509)
- Testing
- Exercise, No exercise
- Where
- Denmark
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Rheumatoid Arthritis
A Long-Term Extension Study of WA22762 to Evaluate Safety and Efficacy of Subcutaneous Tocilizumab in Participants With Moderate to Severe Rheumatoid Arthritis (RA).
This multicenter, open-label, single arm, interventional, long-term extension (LTE) study will evaluate the safety and efficacy of tocilizumab (TCZ, RoActemra/Actemra) in French participants with moderate to severe RA who have…
- Trial name
- NCT01734993
- Testing
- Tocilizumab
- Where
- 6 sites in France
- Volunteers
- 11 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
RESTART C0168Z05 Rheumatoid Arthritis Study
The purpose of this study is to assess the effectiveness of treatment in patients with active rheumatoid arthritis who are having an inadequate response to at least 3 months of treatment with etanercept or adalimumab in addition…
- Trial name
- NCT00714493
- Testing
- Infliximab
- Where
- 76 sites in United States, Austria and 8 more
- Volunteers
- 203 people
- Sponsor
- Centocor Ortho Biotech Services, L.L.C.
Rheumatoid Arthritis, Pain
Effect of Antiinflammatory Treatment Versus Hand Training on Neuropsychiatric Comorbidity in RA-patients
The purpose of this study is to investigate how RA affect the brain structures in RA-patients and if anti-inflammatory treatment that target TNF-α or JAK OR physical training of hands has positive impact on neuropsychiatric…
- Conditions
- Rheumatoid Arthritis, Pain, Fatigue, Cognitive Decline
- Trial name
- NeuMRA (NCT04378621)
- Testing
- TNF-α inhibitor OR JAK inhibitor, Hand training
- Where
- Sweden
- Volunteers
- 212 people
- Sponsor
- Vastra Gotaland Region
Rheumatoid Arthritis
Tai Chi in Rheumatoid Arthritis (TaiChiRA)
The investigator's hypothesis is that tai chi sessions would increase physical activity of patients with Rheumatoid Arthritis. The main objective is to study the effect of tai chi sessions (16 vs.0) on total physical activity of…
- Trial name
- TaiChiRA (NCT03678363)
- Testing
- Tai chi chuan
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Clermont-Ferrand
Rheumatoid Arthritis
Comparative Study (Double-Blind) of MRA for Rheumatoid Arthritis (RA)
The purpose of this study is to investigate the clinical efficacy and safety of MRA in a double-blind, parallel-group, controlled study using MRA or methotrexate (MTX) in rheumatoid arthritis (RA) patients with MTX administered.
- Trial name
- NCT00144521
- Testing
- MRA(Tocilizumab), MTX
- Volunteers
- 127 people
- Sponsor
- Chugai Pharmaceutical
Rheumatoid Arthritis
Rebamipide in Patients With Active Rheumatoid Arthritis
Although the aetiology of RA remains to be fully elucidated, interleukin (IL)-17 are believed to play a critical role in the pathogenesis of RA.
- Trial name
- NCT05166304
- Testing
- Rebamipide
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- October 6 University
Osteoarthritis, Rheumatoid Arthritis
PS150 Total Knee Arthroplasty Outcomes Registry
This registry is intended to evaluate the clinical outcomes of the DePuy P.F.C. Sigma PS150 RP Total Knee System. 200 participants will be enrolled prospectively or retrospectively and the follow up period will be 5 years.
- Trial name
- NCT02319291
- Testing
- P.F.C. Sigma PS150 RP Total Knee System
- Where
- 4 sites in Australia, South Korea
- Volunteers
- 175 people
- Sponsor
- DePuy Orthopaedics
Rheumatoid Arthritis
Evaluation of Safety and Effectiveness of Fostamatinib Compared to Placebo in Patients in Asia With Rheumatoid Arthritis
The purpose of the study is to evaluate the effectiveness of four dosing regimens of fostamatinib compared to placebo, in patients with rheumatoid arthritis (RA) who are taking methotrexate but not responding.
- Trial name
- OSKIRA-Asia-1 (NCT01569074)
- Testing
- Fostamatinib
- Where
- 34 sites in Hong Kong, Japan and 4 more
- Volunteers
- 163 people
- Sponsor
- AstraZeneca
Rheumatoid Arthritis
Filling Bone Erosions: a Longitudinal Multicentric HR-pQCT Study of Subcutaneous Tocilizumab in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory disease mediated by the production of several cytokines, which leads to the destruction of bone and cartilage tissue in multiple joints and to bone loss.
- Trial name
- REPAIR (NCT02765074)
- Testing
- subcutaneous tocilizumab
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Régional d'Orléans