Clinical trials: RhA - Rheumatoid Arthritis
Rheumatoid Arthritis
Study of SHR0302 Tablets (SHR0302) as Monotherapy in Active Rheumatoid Arthritis (RA) Patients
To evaluate the safety and efficacy of SHR0302 tablets (SHR0302) in subjects with moderate to severe active rheumatoid arthritis.
- Trial name
- NCT03254966
- Testing
- SHR0302
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Rheumatoid Arthritis
First in Human Study of a Monoclonal Antibody (SOL-116) Targeting BSSL (Bile Salt-Stimulated Lipase), Single and Multiple Dose Parts
This is a randomized, double-blind, placebo-controlled, first-in-human phase I study. It consists of a single ascending dose part in healthy subjects (Part 1) and in patients with rheumatoid arthritis (Part 2) as well as a…
- Trial name
- NCT05576012
- Testing
- SOL-116
- Where
- 2 sites in Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Lipum AB
Rheumatoid Arthritis
A Study in Rheumatoid Arthritis
The purpose of this study is to evaluate the safety and tolerability of multiple doses of LY2439821 in Japanese patients with rheumatoid arthritis.
- Trial name
- NCT01253265
- Testing
- LY2439821
- Where
- 8 sites in Japan
- Volunteers
- 32 people
- Sponsor
- Eli Lilly and Company
Infertility, Rheumatoid Arthritis
Causes of Comorbid Infertility Among Women With Rheumatoid Arthritis
The purpose of this study is to increase our understanding of infertility in women with Rheumatoid Arthritis (RA). In this study the study team will compare the differences in ovarian reserve (the ability to provide egg cells…
- Trial name
- NCT02313129
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Duke University
Rheumatoid Arthritis
A Study of the Safety of Rituximab in Combination With Other Anti-Rheumatic Drugs in Subjects With Active Rheumatoid Arthritis
This is a Phase III, open-label study of a total of approximately 560 subjects with active rheumatoid arthritis (RA) who have had an inadequate response to one or more disease-modifying anti-rheumatic drugs (DMARDs).
- Trial name
- SUNDIAL (NCT00443651)
- Testing
- Rituximab, Anti-inflammatory drugs
- Volunteers
- 578 people
- Sponsor
- Genentech, Inc.
Pain, Anxiety
Humor Therapy and Rheumatoid Arthritis
The goal of this prospective, randomized controlled study was to inverstigate the effect of humor on pain and in patients with rheumatoid arthritis (RA) during IV treatment.
- Conditions
- Pain, Anxiety, Rheumatoid Arthritis, Nursing Caries
- Trial name
- NCT05877937
- Testing
- Supportive care (Watching a comedy movie)
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Eskisehir Osmangazi University
Knee Arthritis, Knee Osteoarthritis
Gold Factor on Knee Joint Health and Function
The purpose of this clinical study was to determine whether gold nanoparticles (AuNP) supplement holds clinical value in improving joint health, function, and quality of life for arthritis patients.
- Conditions
- Knee Arthritis, Knee Osteoarthritis, Knee Pain Chronic, Knee Discomfort
- Trial name
- NCT05347602
- Testing
- Gold Factor (Gold Nanoparticles, AuNPs)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- 4Life Research, LLC
Joint Disease
Post Market Clinical Follow-Up Study Protocol for PROFEMUR® Gladiator HA Coated Modular Femoral Stems
MicroPort Orthopedics (MPO) is conducting this post market clinical follow-up (PMCF) study to evaluate the safety and efficacy of its total hip arthroplasty (THA) and resurfacing components marketed in the European Union (EU).
- Trial name
- NCT02314611
- Testing
- PROFEMUR® Gladiator HA Coated Modular Femoral Stem
- Where
- Belgium
- Volunteers
- 154 people
- Sponsor
- MicroPort Orthopedics Inc.
Rheumatoid Arthritis
Evaluation of Tumour Necrosis Factor Alpha (TNFα) Blockers in Early Rheumatoid Arthritis in France
Aim: To describe 1) The use of TNF blockers in early arthritis in daily clinical practice in France 2) To evaluate symptomatic, structural efficacy, and retention rate over 5 years 3) To evaluate predictive factors for TNF…
- Trial name
- NCT02927509
- Testing
- TNF alpha blockers
- Volunteers
- 813 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Rheumatoid Arthritis
Serum Concentration of Adalimumab as a Predictive Factor of Clinical Outcomes in Rheumatoid Arthritis (AFORA)
Adalimumab is a fully human monoclonal antibody to tumor necrosis factor-alpha (TNF-α) approved in rheumatoid arthritis (RA) refractory to disease modifying anti rheumatic drugs (DMARDs) and for the treatment of severe, active…
- Trial name
- AFORA (NCT01382160)
- Testing
- adalimumab
- Where
- 7 sites in France
- Volunteers
- 69 people
- Sponsor
- University Hospital, Tours
Osteoarthritis, Hip, Rheumatoid Arthritis
A Clinical Investigation of the Balance® Microplasty™ Hip System
The purpose of this prospective clinical data-collection is to document the performance and clinical outcomes of the Balance® Microplasty™ Hip System.
- Conditions
- Osteoarthritis, Hip, Rheumatoid Arthritis, Avascular Necrosis
- Trial name
- NCT00699088
- Where
- 4 sites in United States
- Volunteers
- 70 people
- Sponsor
- Biomet Orthopedics, LLC
Inflammatory Disease, Rheumatoid Arthritis
Prospective Follow-up of Patients With Chronic Inflammatory Rheumatism
It is a prospective follow-up. The aim is to study the maintenance of therapeutic at 10 years and 20 years of inflammatory rheumatism (rheumatoid arthritis and spondyloarthritis)
- Conditions
- Inflammatory Disease, Rheumatoid Arthritis, Spondyloarthritis
- Trial name
- PPCRNice (NCT03076866)
- Testing
- observational follow-up:clinical, radiological et biological
- Where
- France
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Inflammatory Joint Diseases, Rheumatoid Arthritis (RA)
Oxidative Stress in Autoimmune Rheumatic Diseases
Rheumatic diseases constitute a group of non-communicable diseases characterized by chronic inflammation. The most common autoimmune rheumatic diseases (ARDs) are rheumatoid arthritis, psoriatic arthritis, systemic lupus…
- Conditions
- Inflammatory Joint Diseases, Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Ankylosing Spondylitis (AS)
- Trial name
- REDOX-ARD (NCT07536529)
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Thessaly
Rheumatoid Arthritis
BIIB057 in Subjects With Rheumatoid Arthritis and Inadequate Response to Disease-Modifying Antirheumatic Drugs
Phase II study designed to evaluate the safety and efficacy of BIIB057 in Subjects with Rheumatoid Arthritis who have experienced an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs).
- Trial name
- EMBRACE (NCT01652937)
- Testing
- BIIB057
- Where
- 3 sites in Canada
- Sponsor
- Biogen
Arthritis, Rheumatoid
Efficacy and Safety of Different Doses of BIRB 796 BS in Patients With Active Rheumatoid Arthritis
The objective was to determine the effects of BIRB 796 BS on CRP and clinical parameters in Rheumatoid Arthritis as measures of efficacy, and on population pharmacokinetics and safety parameters
- Trial name
- NCT02209779
- Testing
- BIBR 796 BS
- Volunteers
- 167 people
- Sponsor
- Boehringer Ingelheim
Rheumatoid Arthritis
A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Rheumatoid Arthritis (RENOIR)
RENOIR Study: This study will evaluate the safety, tolerability, and efficacy of Rosnilimab in subjects with moderate to severe Rheumatoid Arthritis (RA)
- Trial name
- NCT06041269
- Testing
- Rosnilimab
- Where
- 92 sites in United States, Belgium and 13 more
- Volunteers
- 420 people
- Sponsor
- AnaptysBio, Inc.
Rheumatoid Arthritis
Open-label, Extension Study of CDP870 in Patients With Rheumatoid Arthritis
This is a phase Ⅲ multicenter, open-label, follow-up study, to assess the safety and efficacy of certolizumab pegol (CZP) as additional medication to methotrexate (MTX), in patients with active rheumatoid arthritis (RA) who…
- Trial name
- NCT01197066
- Testing
- Certolizumab Pegol
- Volunteers
- 110 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Rheumatoid Arthritis, Osteoarthritis
A Single Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement
The purpose of this study is to monitor the performance of the Pinnacle™ Cup with a ceramic-on-ceramic bearing combination in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00872222
- Testing
- Pinnacle™ Acetabular System
- Where
- Czechia
- Volunteers
- 98 people
- Sponsor
- DePuy International
Rheumatoid Arthritis
The Use of Synovial Biopsies in Predicting Response to Biologic Therapy in Rheumatoid Arthritis Patients
SYBRA is an open-label, phase 3, randomized controlled clinical trial that aims to assess the use of synovial biopsies in predicting response to biologic therapy in patients with rheumatoid arthritis that have failed…
- Trial name
- SYBRA (NCT05379322)
- Testing
- Anti-TNF, JAK inhibitor
- Where
- United Arab Emirates
- Sponsor
- Abu Dhabi Stem Cells Center
Rheumatoid Arthritis
Clinically Important Changes in Rheumatoid Arthritis
This study will explore how patients with rheumatoid arthritis evaluate, or rate, symptom improvements. Physicians generally evaluate patients health and treatment benefits based on laboratory measures, such as the number of…
- Trial name
- NCT00056602
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
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