Clinical trials: Rheumatic Disease
Rheumatoid Arthritis
Oral CF101 Tablets and Methotrexate Treatment in Rheumatoid Arthritis Patients
This trial will test the hypothesis that the addition of CF101, a novel anti-inflammatory agent, will improve the clinical condition of patients with rheumatoid arthritis who still have active joint inflammation despite taking…
- Trial name
- NCT00556894
- Testing
- CF101
- Where
- 26 sites in Bulgaria, Czechia and 4 more
- Volunteers
- 253 people
- Sponsor
- Can-Fite BioPharma
Rheumatoid Arthritis
A Study of TJ003234 in Rheumatoid Arthritis Patients
Study Purpose and Design: A Multi-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single Ascending Dose and Multiple Ascending Doses of TJ003234 in…
- Trial name
- NCT04457856
- Testing
- TJ003234 injection
- Where
- 5 sites in China
- Volunteers
- 63 people
- Sponsor
- I-Mab Biopharma US Limited
Arthritis, Rheumatoid
A Study Of CP-195543 And Celecoxib Dual Therapy In Subjects With Rheumatoid Arthritis
To evaluate the efficacy, safety and tolerability of CP-195543 and celecoxib dual therapy in subjects with rheumatoid arthritis
- Trial name
- NCT00424294
- Testing
- CP-195,543, celecoxib, Methotrexate
- Where
- 39 sites in United States
- Volunteers
- 70 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
Enbrel Liquid Immunogenicity Protocol
The purpose of this study is to assess the antibody formation to Enbrel liquid in subjects with Rheumatoid Arthritis
- Trial name
- NCT00249041
- Testing
- 50 mg Etanercept, Enbrel liquid
- Volunteers
- 447 people
- Sponsor
- Amgen
Rheumatoid Arthritis
An Open Label Study for Participants With Rheumatoid Arthritis
The primary purpose of this study is to help answer if LY2127399 is safe and effective during long-term treatment in participants with Rheumatoid Arthritis.
- Trial name
- NCT01215942
- Testing
- LY2127399
- Where
- 327 sites in United States, Argentina and 25 more
- Volunteers
- 1,086 people
- Sponsor
- Eli Lilly and Company
Hypertrophic Scars, Keloids
Scar Gel Product Family Clinical Investigation
The purpose of this PMCF investigation is to determine whether there are differences between the two formulations (Dermatix and Dermatix Ultra) in improving keloid and hypertrophic scars clinical symptoms and in the overall scar…
- Trial name
- NCT07684573
- Testing
- Dermatix, Dermatix Ultra
- Volunteers
- 150 people
- Sponsor
- Hanson Medical, Inc.
Knee Pain Chronic, Osteoarthritis
Persona Ti-Nidium Post-Market Clinical Follow-up
The main objectives of this study are to evaluate overall clinical performance and safety of the Persona Ti-Nidium implant in total knee arthroplasty.
- Conditions
- Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- TKA (NCT04817969)
- Testing
- Zimmer Biomet Persona Ti-Nidium Total Knee System
- Where
- 7 sites in United States
- Volunteers
- 240 people
- Sponsor
- Zimmer Biomet
Osteoarthritis
A Trial of Mechanical Axis With Soft Tissue Release Balancing vs Functional Alignment With Bony Release Balancing in Total Knee Replacement Using Stryker's Mako Robot
This study is a prospective, randomized, longitudinal study of the clinical outcomes of osteoarthritis patients treated by two different alignment philosophies for total knee replacement.
- Trial name
- NCT04600583
- Testing
- Triathlon® Total Knee System (Stryker Orthopaedics, Mahwah, NJ USA)
- Where
- New Zealand
- Volunteers
- 278 people
- Sponsor
- Stryker South Pacific
Bicompartmental Osteoarthritis
Study of the ConforMIS iDuo(R) G2
To evaluate the ConforMIS iDuo G2 implant
- Trial name
- NCT01564641
- Testing
- iDuo G2
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Restor3D
Rheumatoid Arthritis, Degenerative Arthritis
Clinical Evaluation of Integra® Cadence™ Total Ankle System in Primary Ankle Joint Replacement (CADENCE)
A post market, prospective, non-randomized, multi-center, open-label,clinical study using survivorship as the reference performance goal to study the safety and efficacy of the Cadence Total Ankle System (TAS) when used for…
- Conditions
- Rheumatoid Arthritis, Degenerative Arthritis, Post Traumatic Arthritis
- Trial name
- Cadence (NCT03142958)
- Testing
- Integra Cadence Total Ankle System
- Where
- 11 sites in United States, Canada
- Volunteers
- 132 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Degenerative Joint Disease
Post Marketing Clinical Follow up Study to Evaluate the Performance and Safety of HYALEXO
This trial is a post marketing clinical follow up study, aiming to evaluate the performance and safety of Hyalexo for pain relief in patients suffering from osteoarthritis or degenerative joint diseases.
- Trial name
- NCT05229458
- Volunteers
- 54 people
- Sponsor
- Yooyoung Pharmaceutical Co., Ltd.
Rheumatoid Arthritis, Pharmacokinetics of ASP2409
A Dose Escalation Study to Assess Safety, Tolerability and Pharmacokinetics of ASP2409 Following a Single Intravenous Dose in Patients With Rheumatoid Arthritis on Methotrexate
The purpose of this study is to assess the safety, tolerability and pharmacokinetics (PK) of single, ascending, intravenous (IV) doses of ASP2409 in patients with Rheumatoid Arthritis (RA) on methotrexate (MTX) and to evaluate…
- Trial name
- NCT02171143
- Testing
- ASP2409
- Where
- 10 sites in United States
- Volunteers
- 58 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Knee Osteoarthritis
A Study to Compare Levels of Capsaicin After Intra-Articular Injection and Topical Application in Patients With Painful Knee Osteoarthritis
This is a Phase 1b, open-label, two-period, randomized crossover study in adult male and female participants with painful knee osteoarthritis.
- Trial name
- NCT03576508
- Testing
- CNTX-4975-05, Qutenza, Lidocaine (without epinephrine)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Centrexion Therapeutics
Osteoarthritis, Knee
A Phase Ib/II Clinical Trial to Evaluate the Safety and Efficacy of LG00034053 in Patients With Knee OA
This study is a multi-center, randomized, placebo-controlled, double-blind clinical study, consisting of Part 1 (Phase 1b) in a sequential, dose-escalating design and Part 2 (Phase 2) in a parallel design.
- Trial name
- NCT05237752
- Testing
- LG00034053
- Where
- 2 sites in Australia, South Korea
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- LG Chem
Rheumatoid Arthritis
A Study of Efficacy and Safety of Rosnilimab in Subjects with Moderate to Severe Rheumatoid Arthritis (RENOIR)
RENOIR Study: This study will evaluate the safety, tolerability, and efficacy of Rosnilimab in subjects with moderate to severe Rheumatoid Arthritis (RA)
- Trial name
- NCT06041269
- Testing
- Rosnilimab
- Where
- 92 sites in United States, Belgium and 13 more
- Volunteers
- 420 people
- Sponsor
- AnaptysBio, Inc.
Osteoarthritis of the Knee
Efficacy and Safety of the Lidoderm Patch Applied to Patients With Osteoarthritis of the Knee
Patients with knee pain due to Osteoarthritis (OA) experiencing sub-optimal pain relief from their current analgesic regimen will participate in a pilot clinical trial to evaluate the effectiveness and tolerability of the…
- Trial name
- NCT00589979
- Testing
- Lidoderm (Lidocaine 5% Patch)
- Where
- 20 sites in United States
- Volunteers
- 169 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Rheumatoid Arthritis
Ultrasound Treatment for Rheumatoid Arthritis Study [ULTRA Study]
The research objective is to assess efficacy of spleen ultrasound stimulation in the treatment of rheumatoid arthritis (RA) in a pilot study.
- Trial name
- ULTRA (NCT05417854)
- Testing
- Splenic Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- SecondWave Systems Inc.
Osteoarthritis
To Evaluate the Safety of 'Shinbaro Capsule'in Patients With Osteoarthritis
This study investigates if Shinbaro capsule has a lower incident of gastrointestinal events than celecoxib in subjects with osteoarthritis.
- Trial name
- NCT01604239
- Testing
- Shinbaro Capsule
- Where
- 18 sites in South Korea
- Volunteers
- 761 people
- Sponsor
- Green Cross Corporation
Osteoarthritis
Safety, Tolerability, Pharmacokinetics and -Dynamics of Multiple Rising Oral Doses of BI 113823 in Patients Patients With Osteoarthritis of the Knee
The objective of the study is to investigate the safety and tolerability of BI 113823 in male and female patients with osteoarthritis, following oral administration of BI 113823 with repeated rising doses.
- Trial name
- NCT01207973
- Testing
- BI 113823
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Boehringer Ingelheim
Fibromyalgia, Cannabis
Phase II Clinical Trial, Use of KL16-012 in Women With Fibromyalgia Refractary to Conventional Treatment.
A double blind randomized placebo controlled trial in 44 women with fibromyalgia and persistent symptoms in spite of use of conventional pharmacotherapy, will be performed in the city of Valparaiso.
- Trial name
- NCT04239469
- Testing
- KL16-012
- Volunteers
- 44 people
- Sponsor
- Knop Laboratorios