Clinical trials: Rheumatic Diseases
Systemic Lupus Erythematosus
Follow-up of the Systemic Lupus Erythematosus Cohort as Part of the Multidisciplinary Consultation at Brest CHRU
Systemic lupus erythematosus is a complex systemicautoimmune disease that can affect most organs of the human body. Although they are many recommendations on the diagnosis and managment of SLE, diagnosis and therapeutic managment…
- Trial name
- COLUPUS (NCT06551389)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Rheumatic Heart Disease
A Non-Inferiority Trial of Stopping Penicillin in Early Rheumatic Heart Disease: GOAL-Stop
GOAL-Stop is a randomized, controlled, non-inferiority trial designed to evaluate whether discontinuing secondary antibiotic prophylaxis (SAP) is non-inferior to continuing SAP in preventing progression of rheumatic heart disease…
- Trial name
- GOAL-Stop (NCT07146048)
- Testing
- Secondary Prophylaxis
- Where
- Uganda
- Volunteers
- 922 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Inflammatory Rheumatism, Polymyalgia Rheumatica
PRediction Of DIverse Glucocorticoids toxIcity OUtcomeS
To date, there is no available tool that allows, at individual level, determination of the probability to develop clinically relevant complications of prolonged glucocorticoid therapy.
- Conditions
- Inflammatory Rheumatism, Polymyalgia Rheumatica, Giant Cell Arteritis, Idiopathic Inflammatory Myopathies
- Trial name
- PRODIGIOUS (NCT04664465)
- Where
- 12 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Brest
Myocarditis, ANCA Associated Vasculitis
EACVI Study on Multimodality Cardiovascular Imaging of Inflammatory Cardiovascular Diseases
Inflammatory Cardiovascular Diseases and Autoimmune Rheumatic Diseases (ICARDs) encompass cardiovascular involvement in connective tissue diseases, vasculitis, and primary inflammatory cardiac processes affecting all layers of…
- Conditions
- Myocarditis, ANCA Associated Vasculitis, Pericarditis, Systemic Sclerosis
- Trial name
- EACVI-INFLAME (NCT07077304)
- Testing
- observational study
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatoid Arthritis, Psoriatic Arthritis
A Study of SPY072 in Rheumatic Disease
This is a multi-center, double-blind, placebo-controlled, Phase 2, proof-of-concept basket study with the goal of assessing the efficacy and safety of SPY072 compared to placebo in adults (aged ≥18 years) with rheumatic disease…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Axial Spondyloarthritis, Rheumatic Diseases
- Trial name
- SKYWAY-RD (NCT07148414)
- Testing
- SPY002-072
- Where
- 64 sites in United States, Bulgaria and 6 more
- Volunteers
- 285 people
- Sponsor
- Spyre Therapeutics, Inc.
Rheumatic Fever, Valvular Heart Diseases
Improving Management and Secondary Prevention Through Azithromycin Comparative Trial in Rheumatic Heart Disease in Nigeria)- IMPACT-RHD Nigeria
Background: Nigeria, among other Low and Middle-income countries, bears one of the highest burdens of RHD in Africa, affecting young to middle-aged adults within their productive years.
- Conditions
- Rheumatic Fever, Valvular Heart Diseases, Valvular Cardiomyopathy
- Trial name
- IMPACT-RHD (NCT07625228)
- Testing
- Benzathine Penicillin, Azithromycin (Azithro)
- Volunteers
- 474 people
- Sponsor
- Ladoke Akintola University of Technology, Ogbomoso, Nigeria
Physical Activity, Adolescent
Development of The Pediatric Physical Activity Tracking Platform (Pedi@Ctivity) and Smartwatch-based Big Data Analysis
Regular physical activity is extremely important for the protection and development of physical and psychosocial health. In addition, acquiring regular physical activity habits in the early years of life allows maintaining…
- Conditions
- Physical Activity, Adolescent, Childhood Rheumatic Disease
- Trial name
- NCT05509907
- Testing
- Pedi@ctivity Analysis and Tracking Mobile Applications and Web Platform
- Where
- Turkey (Türkiye)
- Volunteers
- 362 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Juvenile Idiopathic Arthritis, Childhood Rheumatic Disease
Dynamic Gait Index as a Functional Gait Assessment Measure in Children With JIA
Juvenile idiopathic arthritis (JIA) is one of the most common chronic rheumatic diseases seen in childhood. Pain, joint swelling and loss of function caused by inflammation significantly reduce the patients' quality of life and…
- Trial name
- NCT06870045
- Testing
- Physical examination, Dynamic Gait Index
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Asthma
Retrospective Analysis of Systemic Glucocorticoid Mediated Long-term Effects, Patient Pathways and Economic Burden Across Multiple Indications
Glucocorticoids are important in the treatment of many inflammatory, allergic, immunologic, and malignant disorders. However, the adverse effects of systemic corticosteroids are one of the most common causes of iatrogenic…
- Trial name
- NCT06488703
- Where
- Germany
- Volunteers
- 107,032 people
- Sponsor
- GlaxoSmithKline
Rheumatic Diseases, COVID-19 Vaccine
Vaccine Hesitancy in Black/African Americans With Rheumatic Diseases
To establish the efficacy of a community-based POL (Popular Opinion Leader) intervention with two different trainings designed to increase COVID-19 vaccine and booster uptake and reduce hesitancy among social networks of Black…
- Conditions
- Rheumatic Diseases, COVID-19 Vaccine, COVID-19, SLE
- Trial name
- NCT05822219
- Testing
- COVID-19 vaccine and booster training, and importance
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Rheumatic Heart Disease in Children, Heart Disease, Valvular
Identifying Essential Elements of SAP Supports
CAMPS Plus is a non-randomized extension cohort to assess the non-inferiority of a case manager only (CM) intervention when compared to case manager plus peer support group (CM+PG) to support secondary antibiotic prophylaxis…
- Trial name
- CAMPSPlus (NCT07603297)
- Testing
- Case Management Supports
- Where
- Uganda
- Volunteers
- 335 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Myocardial Ischemia, Rheumatic Diseases
Secondary Event Prevention Using Population Risk Management After PCI and for Anti-Rheumatic Medications
Ischemic heart disease (IHD) and its treatment carry profound public health and economic implications. Among Veterans, IHD represents one of the most common causes of death and disability, with over 500,000 affected individuals'…
- Trial name
- SEPPRMACI-ARM (NCT02694185)
- Testing
- Caplan IVR
- Where
- 5 sites in United States, Puerto Rico
- Volunteers
- 5,269 people
- Sponsor
- VA Office of Research and Development
Arthritis, Rheumatoid
Defining Stress REsilience And Mindfulness Effects in Rheumatoid Arthritis
This clinical trial will test a mindfulness program in individuals with rheumatoid arthritis (RA). The main goals of this pilot study are to: Assess patient satisfaction with a mindfulness course Identify barriers to…
- Trial name
- DREAMER (NCT06276387)
- Testing
- Mindfulness Program
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of California, San Francisco
Rheumatic Heart Disease
Accelerating Delivery of rheUmatic Heart Disease Preventive iNterventions in Northern Uganda
The goal of this prospective study is to evaluate the feasibility, sustainability, and public health impact of a district-based program for secondary prevention of Rheumatic Heart Disease (RHD) in Uganda.
- Trial name
- ADUNU (NCT05783375)
- Testing
- ADUNU program for delivery of RHD care services
- Where
- Uganda
- Volunteers
- 221 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Rheumatic Diseases, Pregnancy Related
Network to Understand Reproductive Rheumatology Registry
The purpose of the NURTURE Registry is to enroll those who are pregnant and/or potentially capable of pregnancy. Participants will complete patient-reported surveys at enrollment and periodically prior to conception, during…
- Conditions
- Rheumatic Diseases, Pregnancy Related, Pregnancy Interest, Reproductive Health
- Trial name
- NURTURE (NCT06940869)
- Testing
- NURTURE Registry
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Duke University
Osteolysis, Arthroplasty Complications
Plasmafit® Revision Structan® Hip Endoprosthesis Cup
The aim of this observational study is to collect clinical and radiological results of the new Plasmafit® Revision Structan® Hip Endoprosthesis Cup in a standard patient population and when used in routine clinical practice.
- Conditions
- Osteolysis, Arthroplasty Complications, Instability of Prosthetic Joint, Degenerative Osteoarthritis
- Trial name
- NCT04255966
- Testing
- Plasmafit® Revision Structan®
- Where
- 4 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Aesculap AG
Rheumatic Diseases, Inflammatory Arthritis
The RheumSafer Study: Improving Medication Appropriateness in People With Rheumatic Conditions
The goal of this prospective observational quality improvement study is to determine if a physician tool, MedSafer, combined with educational brochures for patients, can help to reduce the use of 'potentially inappropriate…
- Conditions
- Rheumatic Diseases, Inflammatory Arthritis, Systemic Lupus Erthematosus (SLE), Vasculitis
- Trial name
- NCT07278609
- Testing
- MedSafer deprescribing opportunity reports, EMPOWER brochures
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Knee Osteoarthritis
A Study to Evaluate the Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee
This study is being conducted to evaluate the efficacy and safety of ASA compared to placebo in the management of osteoarthritis (OA) symptoms of the knee.
- Trial name
- NCT06000410
- Testing
- Amniotic Suspension Allograft
- Where
- 41 sites in United States
- Volunteers
- 594 people
- Sponsor
- Organogenesis
Chronic Inflammatory Rheumatic Diseases of Childhood, Juvenile-Onset Chronic Inflammatory Rheumatic Diseases
Compassionate Care and Organization of Healthcare Services for a Successful Transition in Rheumatology
The transition from pediatric to adult care is a critical period for young people with chronic inflammatory rheumatic diseases (CIRD) and is associated with risks of poor self-management, loss to follow-up, and disease worsening.
- Conditions
- Chronic Inflammatory Rheumatic Diseases of Childhood, Juvenile-Onset Chronic Inflammatory Rheumatic Diseases, Transition of Care in Chronic Inflammatory Rheumatic Diseases
- Trial name
- BOOST-R (NCT07469787)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Inflammatory Rheumatic Diseases
Dysphagia Risk in Rheumatic Diseases
This study aims to evaluate the impact of dysphagia on eating and swallowing functions, gastrointestinal symptoms, and related clinical findings in individuals with inflammatory rheumatic diseases.
- Trial name
- NCT07504900
- Where
- Turkey (Türkiye)
- Volunteers
- 191 people
- Sponsor
- Pamukkale University