Clinical trials: Rheumatic Disorder
Rheumatoid Arthritis (RA), Systemic Sclerosis (SSc)
Correlation Between Circulating Fibroblast Activation Protein (FAP) and Fibrosis in Two Diseases (Rheumatoid Arthritis and Systemic Sclerosis)
This study aims to measure a blood protein called fibroblast activation protein (FAP), which is linked to tissue scarring and inflammation.
- Trial name
- FAP (NCT07393217)
- Where
- Egypt
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Sohag University
Periodontitis, Rheumatoid Arthritis
The Effect of Non-Surgical Periodontal Therapy on Rheumatoid Arthritis
Periodontitis is a common chronic inflammatory disease characterised by the destruction of the soft and hard tissues supporting the tooth, including alveolar bone, periodontal ligament and cementum.
- Trial name
- NCT06245265
- Testing
- ELISA (Enzyme-Linked ImmunoSorbent Assay)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Biruni University
Osteoarthritis
Pain Expectations in Subjects With Osteoarthritis
The purpose of this research study is to test whether or not researchers can alter or change expectations on pain. The researchers will test whether there is an effect on the size of the pupil and responses to thermal heat…
- Trial name
- NCT02155257
- Testing
- Modafinil, Gabapentin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Rheumatoid Arthritis, Endothelial Dysfunction
Atherosclerosis in Rheumatoid Arthritis
The purpose of this study is to investigate the link between rheumatoid arthritis and cardiovascular disease by studying inflammation, joint disease, cholesterol abnormalities, and endothelial function.
- Trial name
- NCT00990730
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy Subjects, Rheumatoid Arthritis
Biodistribution, Dosimetry and Performance of [68Ga]Ga-DOTA-Siglec-9 in Healthy and Patients With Rheumatoid Arthritis, Vasculitis or Pulmonary Sarcoidosis
This study evaluates safety, tolerability, biodistribution and performance of the [68Ga]Ga-DOTA-Siglec-9 following a single intravenous administration in patients with active rheumatoid arthritis, vasculitis or pulmonary…
- Conditions
- Healthy Subjects, Rheumatoid Arthritis, Vasculitis, Pulmonary Sarcoidosis
- Trial name
- SIGLEC (NCT03755245)
- Testing
- [68Ga]Ga-DOTA-Siglec-9
- Where
- Finland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Type 2 Diabetes Mellitus, Lung Diseases, Obstructive
Integration of Guidelines for Comorbidities
Introduction: in the course of the research, the investigators will develop a decision-support system (comorbidity-DSS) consisting (1) a knowledge base (KB) consisting of (a) computer-interpretable clinical guidelines for type 2…
- Conditions
- Type 2 Diabetes Mellitus, Lung Diseases, Obstructive, Osteoporosis, Hypertension
- Trial name
- NCT02928666
- Testing
- DSS for mitigating interactions between recommendations
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Physician-patient Relationship, Fibromyalgia
Brain Mechanisms of Psychosocial Aspects of Acupuncture Therapy
The overall aim of the present proposal is to investigate how patients' and clinicians' (Licensed acupuncturists, LAc) neural and autonomic processes during treatment interaction correlate to patient outcomes.
- Conditions
- Physician-patient Relationship, Fibromyalgia, Acupuncture Therapy
- Trial name
- NCT02908022
- Testing
- Electroacupuncture Analgesia, Hokanson Rapid Cuff Inflator
- Where
- 2 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Osteoarthritis, Knee
The Effect of Injection Site Cooling on Pain Experienced After the Administration of CNTX-4975-05 Into the Knee
A clinical study to measure the effects of injection-site cooling on pain experienced after knee injections of capsaicin in healthy subjects and in patients with knee osteoarthritis.
- Trial name
- NCT03472677
- Testing
- Ice Pack and Cooling Device, CNTX-4975-05 (trans-capsaicin), Capsaicin
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centrexion Therapeutics
Fibromyalgia, Heathy Volunteers
Traduction and Validation of the Central Sentitization Inventory Into French
The study will include a translation of the Central Sensisization Inventory into French and a cultural validation of the French version of the questionnaire (Reliability, discrimination and comparison with other questionnaires).
- Trial name
- NCT02270775
- Where
- Belgium
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Gout
RDEA3170 Bioavailability Study
This is a Phase 1, randomized, open-label, 4-way crossover pharmacokinetic (PK) and pharmacodynamic (PD) study in healthy adult male subjects designed to assess the relative bioavailability of RDEA3170 2.5 mg tablets administered…
- Trial name
- NCT02336594
- Testing
- RDEA3170 10 mg, RDEA3170 2.5 mg
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ardea Biosciences, Inc.
Arthrosis
Prospective Study Deltamotion - DAA THA Study
1. Introduction Few gait analytical data are available concerning the Direct Anterior Approach (DAA) in total hip arthroplasty (THA). All the studies have focused on immediate post-operative recovery.
- Trial name
- NCT01474031
- Testing
- Biomechanics
- Where
- Belgium
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Arthritis, Rheumatoid
Identification of Epigenetic Biomarkers for Early Detection of Rheumatic Disease
Given the cost and risk associated with biologic disease modifying anti-rheumatic drugs (bDMARDs), selection of the optimal medication is imperative.
- Trial name
- NCT02742337
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Arthritis Northwest PLLC
Rheumatoid Arthritis
Serum Anti-PCOLCE as Novel Diagnostic Biomarker in Rheumatoid Arthritis With Emphasis on Seronegative Patients.
Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects synovial joints, leading to pain, swelling, and progressive joint damage. Early diagnosis is critical to prevent irreversible disability.
- Trial name
- Anti-pcolce/RA (NCT07129837)
- Testing
- Clinical evaluation, disease activity and disability scoring, and laboratory testing including RF, anti-CCP, and serum anti-PCOLCE antibody measurement by ELISA.
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sedentary Lifestyle, Knee Osteoarthritis
NEAT!2 Sedentary Behavior Reduction for Individuals With Past or Present Knee Symptoms, Injuries, or Surgeries
This study will evaluate the effectiveness of an mHealth sedentary reduction program over a 6-month period of time in adults with past or present knee symptoms, injuries, or surgeries.
- Conditions
- Sedentary Lifestyle, Knee Osteoarthritis, Knee Injuries, Knee Pain Chronic
- Trial name
- NCT03987932
- Testing
- NEAT!2, NEAT!2+Calls, Delayed NEAT!2
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Arthritis, Rheumatoid
Evaluation of the Intestinal Microbiota and Bacterial Translocation in Patients With Rheumatoid Arthritis
The main objective of this study is to compare the intestinal microbiota in newly diagnosed rheumatoid arthritis (RA) with that from individuals without RA.
- Trial name
- MICROPOLY (NCT01961310)
- Testing
- Plasma analysis for bacterial translocation, Stool analysis
- Where
- 3 sites in France
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Osteoarthritis
Clinical Trial on the Articular Pain With a Cucumber Supplement in Patients Diagnosed With Arthrosis
Randomized, controlled, double-blind clinical trial of two parallel branches to analyze the efficacy of a supplement extracted from the cucumber on the joint pain of patients diagnosed with osteoarthritis.
- Trial name
- CUCART (NCT04607759)
- Testing
- nutraceutical
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Rheumatoid Arthritis
ACTHAR for Acute Treatment of Rheumatoid Arthritis Patients With Inadequate Response to Methotrexate
Adenocorticotrophic Hormone provides safe and effective treatment to induce disease remission in rheumatoid arthritis patients with active disease due to an inadequate response to methotrexate.
- Trial name
- NCT01984268
- Testing
- ACTHAR
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Rheumatoid Arthritis
A Study to Assess the Effect of BMS-986142 on Pharmacokinetics (PK) of Probe Substrates
The study is being conducted to assess the effect of BMS-986142 on the single-dose PK parameters of montelukast, flurbiprofen, omeprazole, midazolam, and digoxin, probe drugs for (cytochome P450) CYP2C8, CYP2C9, CYP2C19, CYP3A4…
- Trial name
- NCT02762123
- Testing
- BMS-986142 200mg, BMS Drug-drug interaction cocktail (montelukast, flurbiprofen, omeprazole, midazolam, and digoxin), BMS-986142 350mg
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Hip Osteoarthritis, Knee Osteoarthritis
Acceptance and Commitment Therapy Delivered by Automated Software Messaging
This study aims to 1) observe the course of pain, 2) mental status, and 3) possible effect of a behavioral intervention delivered via an automated mobile phone messaging robot in patients were indicated and/or scheduled to…
- Conditions
- Hip Osteoarthritis, Knee Osteoarthritis, Mental Stress, Coronavirus
- Trial name
- NCT04329897
- Testing
- Software Messaging
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Total Knee Arthroplasty, Osteoarthritis
Blood Flow Restriction Training Following Total Knee Arthroplasty
This study will evaluate blood flow restriction training as a rehabilitation modalities following total knee arthroplasty in order to determine if patient reported outcomes and objective functional outcomes can be improved…
- Trial name
- NCT02763488
- Testing
- DelfiPTS tourniquet system, Standard physical therapy
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- San Antonio Military Medical Center
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