Clinical trials: Rheumatic Disorder
Chronic Primary Pain, Musculoskeletal Pain
Facilitators and Barriers in Neuroscience-based Pain Education Programmes in Primary Care Physiotherapy
The new approach in pain neuroscience education (PNE) requires specific training for the physiotherapists in charge of applying it.
- Conditions
- Chronic Primary Pain, Musculoskeletal Pain, Fibromyalgia
- Trial name
- NCT05860816
- Testing
- Survey
- Where
- Spain
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- Castilla-León Health Service
Rheumatoid Arthritis, Cellular Immune Response
Effect of Tocilizumab to the Cellular Immune Response to Influenza Vaccine
Patients with rheumatoid arthritis (RA) are prone to respiratory infections and therefore recommmended to receive vaccination against seasonal influenza.
- Trial name
- NCT01980836
- Testing
- Seasonal influenza vaccine
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Knee Osteoarthritis, Knee Arthritis
Effectiveness of Reduced Frequency Physical Therapy in Total Knee Arthroplasty
Rehabilitation after Total Knee Arthroplasty surgery involves physical therapy services to address limitations in range of motion, strength, and participation in normal daily activities.
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Knee Arthropathy
- Trial name
- NCT03302832
- Testing
- Physical Therapy, In-home Exercise Equipment
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Campbell University, Incorporated
Healthy, Idiopathic Inflammatory Myopathies
A Phase 1 Open-label Study to Evaluate Safety in Healthy Participants and Participants With Autoimmune Diseases
The purpose of this study is to determine the safety and tolerability of XmAb657 in healthy participants and participants with autoimmune diseases.
- Conditions
- Healthy, Idiopathic Inflammatory Myopathies, Systemic Sclerosis, Sjögren's Disease
- Trial name
- NCT07284797
- Testing
- XmAb657
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xencor, Inc.
Rheumatoid Arthritis, Healthy Subjects
Effects of Administration of Fostamatinib on Blood Concentrations of Warfarin in Healthy Subjects
The purpose of this study is to determine whether fostamatinib influences the plasma concentration of warfarin and changes its blood thinning effect, and to investigate how safe and tolerable it is when administered with warfarin.
- Trial name
- NCT01311622
- Testing
- warfarin, fostamatinib
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Osteoarthritis
Clinical Outcome of Birmingham Hip Resurfacing (BHR) Using VISIONAIRE Femoral Alignment Guide
The primary objective of this study is to investigate the accuracy of the femoral implant placement utilizing the VISIONAIRE Femoral Alignment Guide in Birmingham Hip Resurfacing (BHR) surgery postoperatively after total hip…
- Trial name
- BHR (NCT01427361)
- Where
- 2 sites in Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Smith & Nephew, Inc.
Fibromyalgia Syndrome, Anxiety Disorders
The Relationship Between Fibromyalgia Syndrome Parameters With Disease-Pain Severity and the Quality Of Life
In this study, the investigators aim to evaluate the relationship between disease severity, quality of life, anxiety and pain level in patients diagnosed with Fibromyalgia Syndrome (FMS) with the parameters according to the…
- Conditions
- Fibromyalgia Syndrome, Anxiety Disorders, Depressive Disorder
- Trial name
- NCT05850442
- Testing
- Questionary
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Umraniye Education and Research Hospital
Sjögren's Syndrome
DNA Exome Sequencing TCM for Sjögren's Syndrome
To explore the association among gene, TCM pattern, TCM tongue diagnosis and TCM pulse diagnosis with the DNA Exome sequencing tools for Sjögren's syndrome
- Trial name
- NCT03935373
- Testing
- DNA Exome sequencing, Oral microbiome, Proteomics
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Fibromyalgia, Temporomandibular Disorder
An Algorithm for Approaching Temporomandibular Disorders With Osteopathic Manual Therapy in Patients With Fibromyalgia
Nowadays, fibromyalgia is the rheumatic disorder with the highest levels of deterioration in quality of life. Among the comorbidities it presents, one of the most frequent is temporomandibular disorders.
- Trial name
- NCT06365151
- Testing
- Osteopathic manual therapy
- Where
- Spain
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Universitat de Lleida
Rheumatoid Arthritis (RA)
The Effect of the Ideal Food Pyramid on Rheumatoid Arthritis
The aim of this study was to observe the effects of the Ideal Food Pyramid created for Rheumatoid Arthritis patients on disease activity, inflammatory markers, body composition and intestinal microbiota.
- Trial name
- NCT06621927
- Testing
- Diet, Control (Standard treatment)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Total Knee Arthroplasty (TKA)
Total Knee Arthroplasty Biomechanics
In total knee arthroplasty (TKA), the relationship between implant design, soft tissue balance, neuromuscular contributions, and rehabilitation strategies on patient satisfaction and functional outcomes is highly complex and…
- Trial name
- NCT03671954
- Testing
- Home Strengthening Exercises, Standard Physical Therapy, Preoperative Assessments
- Where
- 4 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Florida
Fibromyalgia
The Effect of Sympathetic Dysfunction on Muscle Spindle in Fibromyalgia
This study aims to reveal whether there is an impairment in the sympathetic regulation of muscle spindle sensitivity in patients with fibromyalgia syndrome (FMS).
- Trial name
- NCT05704374
- Testing
- sympathetic stimulation maneuver (mental arithmetic test, cold pressure test), Pregabalin 150mg
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Rheumatic Heart Disease
Effectiveness of Edutainment-Based Interventions in Increasing Knowledge of Rheumatic Fever and Rheumatic Heart Disease Among School-Going Children in Nepal: Study Protocol for Colors to Save Hearts Quasi-Experimental Pretest-Posttest Study
Background: Acute rheumatic fever (ARF) and its sequela, rheumatic heart disease (RHD), remain significant public health concerns in low- and middle-income countries, including Nepal.
- Trial name
- NCT07065474
- Testing
- education material
- Where
- Nepal
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Kathmandu Institute of Child Health
Healthy Volunteers
A Double-blind, Placebo-controlled, Single-dose Study to Evaluate the PK, IM, and Safety in Japanese Subjects
A phase 1 randomized, double blind single-dose study to evaluate the PK and immunogenicity of single SC 100 and 150 mg doses of mavrilimumab in healthy adult Japanese subjects.
- Trial name
- NCT02213315
- Testing
- 100mg Mavrilimumab, 150mg mavrilimumab
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Rheumatoid Arthritis
Safety, Tolerability and Relative Bioavailability Study of BMS-986195 in Healthy Subjects
The purpose of this study is to evaluate the safety profile, tolerability, pharmacokinetics, and pharmacodynamics following single and multiple ascending oral doses of BMS-986195 in healthy subjects, and to assess the relative…
- Trial name
- NCT02705989
- Testing
- BMS-986195
- Where
- Australia
- Volunteers
- 439 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Knee Osteoarthritis
Treatment of Knee Osteoarthritis (KOA) by Injection of Autologous Adipose-derived Vascular Matrix Components (SVF) Into Joint Cavity
The purpose of this study was to analyze and study the efficacy and safety of autologous adipose-derived vascular matrix components (SVF) in patients with knee osteoarthritis before and after treatment through clinical…
- Trial name
- NCT06109220
- Testing
- Stromal vascular fraction,SVF
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Rheumatoid Arthritis
Baricitinib, Methotrexate as Monotherapy or Combination in the Treatment of Rheumatoid Arthritis - an Open Label Randomized Clinical Trial
The goal of this open-label randomized clinical trial is to assess the efficacy of baricitinib 2 mg in comparison to methotrexate 25 mg as monotherapy followed by baricitinib 4 mg in comparison to methotrexate 10 mg and…
- Trial name
- NCT05827497
- Testing
- Baricitinib 2 MG, Methotrexate 25mg
- Where
- Bangladesh
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Pharmacokinetics, Safety
Study to Compare PK & Safety of Advixa With Humira in Healthy, Adult Subject Followed by Efficacy & Safety Study in RA Patients
Adalimumab is a recombinant monoclonal antibody (IgG1 subclass) against human TNF-α (Tumor Necrosis Factor-alpha). It is an immunosuppressive medication predominantly used to treat rheumatoid arthritis autoimmune disease.
- Conditions
- Pharmacokinetics, Safety, Efficacy, Rheumatoid Arthritis
- Trial name
- ACT (NCT05172817)
- Testing
- Advixa (Adalimumab)
- Where
- Bangladesh
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institute for Developing Science and Health Initiatives, Bangladesh
Arthritis, Rheumatoid, Syndrome, Metabolic
An Exploratory Clinical Study on Autophagy During Fasting
Autophagy is considered one of the key molecular mechanisms for the broad preventive and therapeutic effects of periodic fasting.
- Conditions
- Arthritis, Rheumatoid, Syndrome, Metabolic, Healthy
- Trial name
- NCT04739852
- Testing
- Fasting
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Fibromyalgia
Logistic Regression and Elastic Net Regularization for the Diagnosis of Fibromyalgia
This study will utilize ultrasound image texture variables to construct an elastic net regularized, logistic regression model to differentiate between healthy and Fibromyalgia patients.
- Trial name
- LEDF (NCT04088747)
- Testing
- Ultrasound Imaging
- Where
- Canada
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Toronto Rehabilitation Institute
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