Clinical trials: Rheumatic Disorder
Chronic Pain, Osteoarthritis
Acupuncture Approaches for Chronic Pain
Chronic pain is a major public health problem that places many burdens on individuals, including impairment of physical and psychological functioning, lost productivity, and side effects of medications used to treat pain.
- Conditions
- Chronic Pain, Osteoarthritis, Neck Pain, Back Pain
- Trial name
- AADDOPT-2 (NCT02456727)
- Testing
- Group/Community Acupuncture, Individual Acupuncture
- Where
- United States
- Volunteers
- 779 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Osteoarthritis, Knee
An Intervention Study Evaluating the Effects of a Raspberry Leaf Extract in an Osteoarthritic Population.
A double-blind, randomized, placebo-controlled clinical study to evaluate the efficacy of raspberry extract to alleviate symptoms of osteoarthritis in the knee.
- Trial name
- NCT03703024
- Testing
- Raspberry Leaf Extract
- Where
- Ireland
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Atlantia Food Clinical Trials
Chronic Pain, Acute Pain
Assessing Symptom and Mood Dynamics in Pain Using the Smartphone Application SOMA
This study relies on the use of a smartphone application (SOMA) that the investigators developed for tracking daily mood, pain, and activity status in acute pain, chronic pain, and healthy controls over four months.The primary…
- Conditions
- Chronic Pain, Acute Pain, Post Operative Pain, Fibromyalgia, Primary
- Trial name
- NCT05754190
- Testing
- SOMA pain manager smartphone application
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Brown University
Adult ALL, Healthy
Heel Wedges and Carbon Fiber Custom Dynamic Orthoses to Control Knee Biomechanics
The proposed study evaluates the effect of medial and lateral wedges and carbon fiber custom dynamic orthoses (CDOs) on lower limb forces and motion during walking.
- Trial name
- CDOKNEEpilot (NCT05209360)
- Testing
- Medial or Lateral Wedge, Carbon Fiber Custom Dynamic Orthosis
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Fibromyalgia
Fibromyalgia in Patient With Impaired Fasting Glucose
To assess the frequency of fibromyalgia among women with impaired fasting glucose.
- Trial name
- NCT03871946
- Testing
- oral glucose tolerance test (OGTT)
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Hitit University
Noninflammatory Degenerative Joint Disease, Avascular Necrosis
Signature Acetabular Posterior/Lateral Data Collection
The primary purpose of this pilot study is to evaluate the accuracy of cup placement between two instrumentation technologies: Cutting Guide and Conventional Instrumentation.
- Conditions
- Noninflammatory Degenerative Joint Disease, Avascular Necrosis, Rheumatoid Arthritis
- Trial name
- NCT02220478
- Testing
- Posterior Lateral Approach Total Hip Arthroplasty
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Gout
Effect of Aquatic Exercise and Traditional Physical Therapy on Gout in Hypertensive Menopausal Women With Hyperuricemia
Aquatic Exercise and traditional physical therapy are effective methods of treatment for gout and hypertension in menopausal women.
- Trial name
- NCT05454423
- Testing
- the Aquatic exercises +Traditional physical therapy programs +anti-hyperuricemia medication, traditional physical therapy + anti-hyperuricemia medication
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Merit University
Abatacept, Treatment Compliance
Efficacy and Safety of Abatacept Combined With JAK Inhibitor for Refractory Rheumatoid Arthritis
The aim of this study is to observe the clinical efficacy and safety of abatacept combined with JAK inhibitor in the treatment of D2TRA patients
- Conditions
- Abatacept, Treatment Compliance, Rheumatoid Arthritis
- Trial name
- NCT05451615
- Testing
- Janus Kinase Inhibitor, Abatacept
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zhejiang Provincial People's Hospital
Healthy
PK And Safety Study Of PF-04171327 In Healthy Japanese And Western Subjects In Fasting And Fed Conditions
This Phase 1 study is the first clinical trial in Japanese subjects. This study is designed to evaluate the single- and multiple-dose pharmacokinetics, safety and tolerability of PF-04171327 oral tablet in healthy adult Japanese…
- Trial name
- NCT01362673
- Testing
- PF-04171327
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Pfizer
Rheumatoid Arthritis
Mass Balance and Metabolic Profiling of [14C]AZD5672 in Healthy Male Volunteers
The purpose of this study is to determine how the body breaks down and excretes the investigational drug, AZD5672.
- Trial name
- NCT00711074
- Testing
- AZD5672
- Where
- United Kingdom
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Gout, Coronary Artery Disease
Uric Acid Study in Healthy Male Volunteers
This study is being conducted to examine the effect of AZD6140 on the levels of certain chemicals in subjects' blood and urine.
- Trial name
- NCT00738842
- Testing
- AZD6140
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Physical Activity
Effects of Hyaluronic Acid vs. Hyaluronic Acid on Knee Osteoarthritis
Using double blind, randomized controlled design to study the immediate, short-term and intermediate-term therapeutic effects of ultrasound guided hyaluronic acid injection and hyaluronic acid combined corticosteroid injection to…
- Trial name
- NCT02625727
- Testing
- hyaluronic acid, hyaluronic acid combined corticosteroid
- Where
- Taiwan
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Rheumatoid Arthritis
Clinical Study to Evaluate the Pharmacokinetic Profiles and Safety of CKD-374 5 mg in Healthy Volunteers
This study is a randomized, open-label, fasted, single dose, crossover study to evaluate the pharmacokinetic profiles and safety of CKD-374 5 mg in healthy volunteers.
- Trial name
- NCT03858725
- Testing
- D569 Tab., CKD-374 5mg Tab.
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Knee Osteoarthritis
Porous Baseplate in Total Knee Replacement
This is a multi-centre single cohort trial of patients undergoing cruciate-retaining total knee arthroplasty with the Advance Porous fixed bearing tibial baseplate and compatible femoral, patellar, and bearing components.
- Trial name
- NCT05226689
- Testing
- POROUS TIBIA BASEPLATE W/ JRNY LOCK
- Where
- 2 sites in Canada
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Canadian Radiostereometric Analysis Network
Psoriatic Arthritis, Arthritis
99mTc-anti-TNF-alpha Scintigraphy in the Evaluation of Inflammatory Processes Activity
Rheumatoid and psoriatic arthritis patients benefit from anti-TNF-α therapy, once it is effective in reducing joint and skin manifestations in 60-70% of patients with inflammatory articular joint and skin diseases.
- Trial name
- NCT02134613
- Testing
- 99mTc-anti-TNF-alpha Scintigraphy
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Rheumatoid Arthritis, Systemic Lupus
Combined Pneumococcal Conjugate and Polysaccharide Vaccination in Inflammatory Rheumatic Disease
The overall objective of this project is to study the influence of modern anti-inflammatory treatments in established inflammatory rheumatic diseases (IRD) on antibody response elicited by pneumococcal vaccination using 13-valent…
- Conditions
- Rheumatoid Arthritis, Systemic Lupus, Sjögren Syndrome, Systemic Vasculitis
- Trial name
- IPS-BOOSTER (NCT03762824)
- Testing
- 13-valent pneumococcal conjugate vaccine, 23-valent pneumococcal polysaccharide vaccine
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Region Skane
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Rheumatoid Arthritis
A Study to Assess the Effect of BMS-986142 on Pharmacokinetics (PK) of Probe Substrates
The study is being conducted to assess the effect of BMS-986142 on the single-dose PK parameters of montelukast, flurbiprofen, omeprazole, midazolam, and digoxin, probe drugs for (cytochome P450) CYP2C8, CYP2C9, CYP2C19, CYP3A4…
- Trial name
- NCT02762123
- Testing
- BMS-986142 200mg, BMS Drug-drug interaction cocktail (montelukast, flurbiprofen, omeprazole, midazolam, and digoxin), BMS-986142 350mg
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Juvenile Idiopathic Arthritis
Interleukin 33 in Juvenile Idiopathic Arthritis Patients
The aim of this study is to measure serum and synovial fluid levels of IL 33 and its relative mRNA expression in peripheral blood mononuclear cells in juvenile idiopathic arthritis (JIA) patients and to correlate it with the…
- Trial name
- NCT03835624
- Testing
- interleukin 33
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Benha University
Sjögren's Syndrome, Meibomian Gland Dysfunction
Is Sjögren's Syndrome Associated With Meibomian Gland Dysfunction ?
The investigators hypothesize that the dry eye caused by SS may include the evaporative type, resulting from the MGD. Furthermore, the investigators hypothesize that both pSS and sSS are associated with MGD.To test our…
- Trial name
- NCT03060005
- Testing
- Tears Naturale Forte, liposic
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tung Wah Hospital
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