Clinical trials: Rheumatoid Arthritis, completed
Rheumatoid Arthritis
Supporting Patient Care With Electronic Resources in the United States
This proof-of-concept randomized trial evaluates the effectiveness of using an online decision aid (US-ANSWER-2) in the decision-making to start or switch biologic therapy in US patients with rheumatoid arthritis.
- Trial name
- SuPER-US (NCT02787538)
- Testing
- US-ANSWER-2 decision aid, Control group (Online medication guide)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Rheumatoid Arthritis
Efficacy and Safety Study of CC-292 Versus Placebo as Co-therapy With Methotrexate in Active Rheumatoid Arthritis
CC-292 is an oral agent that is under clinical development for the treatment of rheumatoid arthritis an autoimmune inflammatory disorder.
- Trial name
- NCT01975610
- Testing
- CC-292
- Where
- 27 sites in United States
- Volunteers
- 47 people
- Sponsor
- Celgene
Gastric Ulcer
A 12-month, Phase 3, Open-label, Multi-center Study to Evaluate the Long-term Safety of PN400 (VIMOVO)
This study uses an open-label design and will be conducted in approximately 60 sites aiming to enroll a total number of 200 subjects to ensure that at least 100 subjects will have 12 months exposure to PN400 (VIMOVO).
- Trial name
- NCT00527904
- Testing
- PN400 (VIMOVO), PN 400 (VIMOVO)
- Where
- United States
- Volunteers
- 239 people
- Sponsor
- POZEN
Rheumatoid Arthritis
Impact of Subcutaneous Abatacept in Rheumatoid Arthritis Assessing Inhibition of Structural Damage
The hypothesis of this study is that subcutaneous Abatacept is effective in reducing synovial inflammation, osteitis, and erosions in Rheumatoid Arthritis as assessed by low field extremity MRI and X-ray.
- Trial name
- NCT01333878
- Testing
- Subcutaneous Abatacept
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Orrin M Troum, M.D. and Medical Associates
Rheumatoid Arthritis
Safety, Tolerability, and Pharmacokinetics of GS-5745 in Subjects With Rheumatoid Arthritis
This study is to assess the safety, tolerability, and pharmacokinetics (PK) of multiple infusions of GS-5745 in adults with rheumatoid arthritis (RA).
- Trial name
- NCT02176876
- Testing
- GS-5745
- Where
- 4 sites in Czechia, Hungary
- Volunteers
- 18 people
- Sponsor
- Gilead Sciences
Crohn Disease, Ulcerative Colitis
National Observational Study On The Use Of Inflectra™ An Infliximab Biosimilar In Real Life
National, prospective, multicentre observational study designed for eligible patients treated with Inflectra. Its objectives are to describe under real conditions of use, the profile of patients treated with Inflectra and the…
- Conditions
- Crohn Disease, Ulcerative Colitis, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- ReFLECT (NCT02925338)
- Testing
- QOL questionaire
- Where
- 67 sites in France
- Volunteers
- 1,431 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
A Study of the Effects of RoActemra/Actemra on Vaccination in Patients With Rheumatoid Arthritis on Background Methotrexate (VISARA)
This randomized, parallel-group, open-label study will evaluate the effect of Actemra (tocilizumab) on vaccination in patients with active rheumatoid arthritis who have an inadequate response to methotrexate and who have had an…
- Trial name
- NCT01163747
- Testing
- tocilizumab, methotrexate, 23-Valent Pneumococcal Polysaccharide Vaccine
- Where
- 47 sites in United States
- Volunteers
- 91 people
- Sponsor
- Genentech, Inc.
Arthritis, Rheumatoid
Golimumab for Adherence in Rheumatoid Arthritis
The purpose of this study is to determine if non-adherence to Rheumatoid Arthritis (RA) drugs in participants treated with biologic disease modifying anti-rheumatic drugs (DMARDs) is associated with a greater incidence of disease…
- Trial name
- GO FAR (NCT03729349)
- Testing
- Golimumab
- Where
- 32 sites in Canada
- Volunteers
- 222 people
- Sponsor
- Janssen Inc.
Rheumatoid Arthritis
A Retrospective, Observational Chart Review of Biologics in Monotherapy Versus the Combination Biologic Plus Methotrexate in Patients With Rheumatoid Arthritis
This cross-sectional, non-interventional, retrospective chart review will compare the efficacy and safety of biologic monotherapy and biologic and methotrexate combination therapy in patients with rheumatoid arthritis who have…
- Trial name
- NCT01866150
- Where
- 15 sites in United Kingdom
- Volunteers
- 476 people
- Sponsor
- Hoffmann-La Roche
Arthritis, Rheumatoid
Effects Of Prednisolone On Rheumatoid Arthritis Patients
This study will assess the Pharmacokinetic (PK) and Pharmacodynamic (PD) effects of Prednisolone on Rheumatoid Arthritis (RA) patients.
- Trial name
- NCT00330889
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 32 people
- Sponsor
- GlaxoSmithKline
Periodontitis, Rheumatoid Arthritis
The Effect of Non-Surgical Periodontal Therapy on Rheumatoid Arthritis
Periodontitis is a common chronic inflammatory disease characterised by the destruction of the soft and hard tissues supporting the tooth, including alveolar bone, periodontal ligament and cementum.
- Trial name
- NCT06245265
- Testing
- ELISA (Enzyme-Linked ImmunoSorbent Assay)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Biruni University
Rheumatoid Arthritis
A Study of the Safety and Pharmacokinetics of PRO283698 in Patients With Rheumatoid Arthritis
This is a Phase I multicenter study that will be conducted in the United States and Europe.
- Trial name
- NCT00888745
- Testing
- PRO283698
- Where
- 12 sites in United States, Hungary
- Volunteers
- 65 people
- Sponsor
- Genentech, Inc.
Autoimmune Disorder, Rheumatoid Arthritis
Study to Assess Safety and Effectiveness of Branebrutinib Treatment in Participants With Active Systemic Lupus Erythematosus or Primary Sjögren's Syndrome, or Branebrutinib Treatment Followed by Open-label Abatacept Treatment in Study Participants With Active Rheumatoid Arthritis
The purpose of this study is to evaluate the safety and effectiveness of treatment with branebrutinib treatment in participants with active systemic Lupus Erythematosus (SLE) or Primary Sjögren's Syndrome (pSS), or branebrutinib…
- Conditions
- Autoimmune Disorder, Rheumatoid Arthritis, Systemic Lupus Erythematosus, Primary Sjögren's Syndrome
- Trial name
- NCT04186871
- Testing
- branebrutinib, abatacept
- Where
- 81 sites in United States, Argentina and 8 more
- Volunteers
- 119 people
- Sponsor
- Bristol-Myers Squibb
Rheumatoid Arthritis
An Open Label Extension Study in Participants With Rheumatoid Arthritis
To evaluate the safety and tolerability of LY2127399 administered as subcutaneous injections for 48 weeks in participants with Rheumatoid Arthritis
- Trial name
- NCT00837811
- Testing
- LY2127399
- Where
- 62 sites in United States, Australia and 12 more
- Volunteers
- 182 people
- Sponsor
- Eli Lilly and Company
Rheumatoid Arthritis (RA)
A Study With Upadacitinib (ABT-494) in Subjects From China and Selected Countries With Moderately to Severely Active Rheumatoid Arthritis Who Have Had an Inadequate Response to Conventional Synthetic Disease-Modifying Anti-Rheumatic Drugs (csDMARDs)
The study objectives of Period 1 of this study were to compare the efficacy, safety, and tolerability of upadacitinib versus placebo for the treatment of signs and symptoms of subjects from China and selected countries including…
- Trial name
- NCT02955212
- Testing
- Upadacitinib
- Where
- 43 sites in Brazil, China and 1 more
- Volunteers
- 338 people
- Sponsor
- AbbVie
Rheumatoid Arthritis, Endothelial Dysfunction
Atherosclerosis in Rheumatoid Arthritis
The purpose of this study is to investigate the link between rheumatoid arthritis and cardiovascular disease by studying inflammation, joint disease, cholesterol abnormalities, and endothelial function.
- Trial name
- NCT00990730
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Rheumatoid Arthritis
A Study of a Novel Investigational Drug in Rheumatoid Arthritis Patients (MK-0873-012)(COMPLETED)
This study will look at whether this new drug is effective in the treatment of rheumatoid arthritis, and at whether it is safe and well-tolerated by participants with the disease.
- Trial name
- NCT00132769
- Testing
- MK-0873
- Volunteers
- 106 people
- Sponsor
- Merck Sharp & Dohme LLC
Rheumatoid Arthritis
The CORRONA Treat to Target Trial: Outcomes and Feasibility in a US Population
The Treat to Target Trial is a clinical trial available to new and existing CORRONA (Data Collection Program) sites. Subjects are recruited to participate in this 12 month trial examining outcomes and feasibility of implementing…
- Trial name
- NCT01407419
- Testing
- Treatment Acceleration, Monthly Assessment
- Where
- United States
- Volunteers
- 538 people
- Sponsor
- CorEvitas
Osteoarthritis, Hip, Arthroplasty, Replacement, Hip
Prevention of Ectopic Bone Related Pain and Disability After Hip Replacement Surgery With Peri-Operative Ibuprofen
The primary aim of this randomised trial is to determine the effects of a short peri-operative course of treatment with a non-steroidal anti-inflammatory drug (NSAID), ibuprofen, on the long-term consequences of ectopic bone…
- Conditions
- Osteoarthritis, Hip, Arthroplasty, Replacement, Hip, Arthritis, Rheumatoid
- Trial name
- NCT00145730
- Testing
- Ibuprofen
- Volunteers
- 1,000 people
- Sponsor
- The George Institute
Rheumatoid Arthritis
A Study of Filgotinib in Korean Participants With Rheumatoid Arthritis
The primary purpose of this study is to assess the percentage of participants achieving an American College of Rheumatology (ACR) 20 percent (%) Improvement (ACR20) response at Week 12 of the administration of the investigational…
- Trial name
- NCT06625242
- Testing
- Filgotinib Maleate
- Where
- 15 sites in South Korea
- Volunteers
- 118 people
- Sponsor
- Eisai Korea Inc.
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