Clinical trials: Rheumatoid Arthritis, completed
Rheumatoid Arthritis - Hand Joint, Osteoarthritis Hand
Effectiveness of an Exercise Program and Education Through a Mobile Application for the Management of Patients With Hand Osteoarthritis and Rheumatoid Arthritis
Strengthening and stretching exercise programs, and recommendations to protect the affected joint have shown to be effective both clinically and economically in conditions such as hand osteoarthritis and hand rheumatoid…
- Conditions
- Rheumatoid Arthritis - Hand Joint, Osteoarthritis Hand, Pain, Mobility Limitation
- Trial name
- NCT04263974
- Testing
- Smartphone Application, Conventional treatment
- Where
- Spain
- Volunteers
- 213 people
- Sponsor
- University of Seville
Rheumatoid Arthritis, Healthy Volunteers
A Study in Normal Healthy People, Testing Different Versions of a Pill That Will be Used to Treat Rheumatoid Arthritis.
The study will try, in 2 separate parts, each using 12 research subjects, to see how a new form of the pill CE 224,535 gets released into the bloodstream and whether that is affected by food.
- Trial name
- NCT00838058
- Testing
- CE-224,535, CE 224,535
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Pfizer
Rheumatoid Arthritis (RA)
The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of SHR-3045 in Healthy Subjects
The study is being conducted to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of a single-dose subcutaneous injection of SHR-3045 in healthy subjects.
- Trial name
- NCT07200596
- Testing
- SHR-3045 Injection
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Arthritis, Rheumatoid
Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of SKI-O-703 in Healthy Volunteers
This double-blind, placebo-controlled, multiple ascending dose study is designed to evaluate the safety, tolerability, and pharmacokinetics (PK) of SKI-O-703 in healthy volunteers.
- Trial name
- NCT03315494
- Testing
- SKI-O-703 capsule
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Oscotec Inc.
Rheumatoid Arthritis
Characterize Patients With Moderately Active Rheumatoid Arthritis (RA)
1. To assess the baseline (i.e. RA therapy initiation) characteristics in a real-world setting across two moderate RA cohorts: a Test Group of patients newly exposed to etanercept (Enbrel) therapy and a Control Group of patients…
- Trial name
- NCT01557322
- Testing
- etanercept, methotrexate (MTX)
- Volunteers
- 1,754 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
Study Of The Effects Of Atorvastatin On Cholesterol Levels In Rheumatoid Arthritis Patients Taking CP-690,550
All patients will be in instructed to eat a therapeutic lifestyle diet and will receive CP-690,550 throughout the 12 weeks of this study.
- Trial name
- NCT01059864
- Testing
- CP-690,550, Atorvastatin
- Where
- 15 sites in United States, South Korea
- Volunteers
- 111 people
- Sponsor
- Pfizer
Osteoarthritis, Arthritis, Rheumatoid
A Study of Rabeprazole for Prevention of Non Steroidal Anti-inflammatory Drug -Associated Gastroduodenal Injury
The aim of this study is to determine whether rabeprazole is superior to placebo in preventing dyspepsia and gastroduodenal injury in subjects with osteoarthritis (OA) and/or rheumatoid arthritis (RA) and/or bone pain.
- Conditions
- Osteoarthritis, Arthritis, Rheumatoid, Dyspepsia
- Trial name
- NCT01140828
- Testing
- Rabeprazole
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Chinese University of Hong Kong
Rheumatoid Arthritis
Long-term Follow-up Study of GLPG0634 in Active Rheumatoid Arthritis Participants
The primary objective of the study was to evaluate the long-term safety and tolerability of filgotinib (formerly GLPG0634) for the treatment of rheumatoid arthritis.
- Trial name
- DARWIN3 (NCT02065700)
- Testing
- Filgotinib
- Where
- 111 sites in United States, Argentina and 20 more
- Volunteers
- 739 people
- Sponsor
- Lakefront Biotherapeutics NV
Rheumatoid Arthritis
A Study Of PF-04171327 In The Treatment Of The Signs And Symptoms Of Rheumatoid Arthritis
This study will investigate the safety and efficacy of an investigational drug, PF-04171327 on the signs and symptoms of rheumatoid arthritis in patients that require glucocorticoids while on background methotrexate.
- Trial name
- NCT00938587
- Testing
- PF-04171327 10 mg, PF-04171327 25 mg, Prednisone 5 mg
- Where
- 41 sites in United States, Czechia and 11 more
- Volunteers
- 86 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to a Single Anti-TNF Inhibitor
This study will evaluate the efficacy and safety of MabThera in patients with active rheumatoid arthritis who have had an inadequate response to one prior anti-TNF alpha inhibitor.
- Trial name
- NCT02079532
- Testing
- rituximab [MabThera]
- Where
- 69 sites in Germany
- Volunteers
- 302 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Demonstrate the Equivalence of CT-P10 to MabThera With Respect to the Pharmacokinetic Profile in Patients With Rheumatoid Arthritis
This randomized,controlled, multicenter, 2-arm, parallel-group, double-blind, prospective, Phase 1 study is designed to demonstrate comparable pharmacokinetics in terms of AUC0-last and Cmax (after second infusion) between CT-P10…
- Trial name
- Triad RA (NCT01534884)
- Testing
- rituximab
- Where
- South Korea
- Volunteers
- 154 people
- Sponsor
- Celltrion
Arthritis, Rheumatoid
A Study to Evaluate the Long-term Safety and Efficacy of ASP015K in Subjects Previously Enrolled in a Phase 2 ASP015K Rheumatoid Arthritis Study
The purpose of this study is to evaluate the long-term safety and efficacy of ASP015K in subjects with Rheumatoid Arthritis (RA) who have completed a preceding Phase 2 ASP015K RA study.
- Trial name
- NCT01711814
- Testing
- peficitinib
- Where
- 51 sites in United States, Belgium and 6 more
- Volunteers
- 611 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Rheumatoid Arthritis, DMARD-naive and Early Disease Patients
A Study of the EP4 Antagonist CR6086 in Combination With Methotrexate, in DMARD-naïve Patients With Early Rheumatoid Arthritis
CR6086 is a new, potent and selective, orally available, small molecule prostaglandin EP4 receptor antagonist, endowed with immunomodulatory properties.
- Trial name
- NCT03163966
- Testing
- CR6086, Methotrexate
- Where
- Czechia
- Volunteers
- 248 people
- Sponsor
- Rottapharm Biotech
Chronic Disease, Rheumatic Diseases
Feasibility of a Mobile Application to Support Reflection and Dialog About Strengths in People With Chronic Illness
Self-management of chronic illness can be highly demanding and people need to mobilize their personal strengths in order to live well with their condition.
- Trial name
- NCT03437863
- Testing
- Mobile application
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Arthritis, Rheumatoid, Tocilizumab
Characterization of the Effect of Tocilizumab in Vivo and in Vitro on T Follicular Helper Cells in Rheumatoid Arthritis Patients and Consequence on B Cells Maturation
Naïve CD4+ helper T (Th) cells, upon encountering their cognate antigens presented on professional antigen-presenting cells, differentiate into different effector cells: Th1 cells produce Interferon-γ and regulate antigen…
- Conditions
- Arthritis, Rheumatoid, Tocilizumab, T-Lymphocytes, Helper-Inducer
- Trial name
- Tocihelper (NCT02569736)
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Association Aquitaine de Recherche Clinique en Rhumatologie
Rheumatoid Arthritis, Ankylosing Spondylitis
Quality of Life Outcomes of HUMIRA in Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Ankylosing Spondylitis (AS) After Unsustainable Response to Biologicals and Disease Modifying Antirheumatic Drugs
The aim of this post-marketing observational study is to obtain further data on the evaluation of quality of life outcomes of HUMIRA® in routine clinical use in patients with Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA)…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT01083693
- Where
- 20 sites in Austria
- Volunteers
- 162 people
- Sponsor
- Abbott
Rheumatoid Arthritis
A Study to Investigate Safety, Tolerability, and PK of Oral Doses of TCK-276 in Patients With Rheumatoid Arthritis
The study is to evaluate the safety, tolerability, and pharmacokinetic (PK) of multiple orally administered TCK-276 in both males and females with Rheumatoid Arthritis (RA).
- Trial name
- NCT05437419
- Testing
- TCK-276
- Where
- 8 sites in United States
- Volunteers
- 32 people
- Sponsor
- Teijin America, Inc.
Rheumatoid Arthritis
Evaluation of 2 Oral Doses of PG-760564 in Rheumatoid Arthritis (RA) Patients Receiving Methotrexate
This will be a 12-week, double-blind, randomized, placebo-controlled, parallel group, multicenter study to evaluate the safety, efficacy, and PK of oral administration of PG-760564 in adult patients with active RA receiving…
- Trial name
- NCT00369928
- Testing
- PG-760564
- Where
- 53 sites in United States, Czechia and 4 more
- Volunteers
- 254 people
- Sponsor
- Procter and Gamble
Rheumatoid Arthritis
Association Between Methotrexate Erythrocyte Polyglutamate Concentration and Clinical Response in Rheumatoid Arthritis Patients Treated With Subcutaneous Injectable Methotrexate
Methotrexate (MTX) is the first-line treatment of rheumatoid arthritis (RA). In case of MTX failure, it is discussed to start a Biologic Disease-modifying Antirheumatic Drug (bDMARDs) according to the latest European…
- Trial name
- POLYGLU (NCT03445871)
- Testing
- Blood sample, CRQ
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Arthritis, Rheumatoid, Arthritis, Psoriatic
A Study to Investigate the Use of Golimumab (Simponi®) in Participants With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis (P06554)
This is a study to assess the use of golimumab (Simponi®) in participants with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
- Conditions
- Arthritis, Rheumatoid, Arthritis, Psoriatic, Spondylitis, Ankylosing
- Trial name
- GO-NICE (NCT01313858)
- Testing
- Simponi®, Methotrexate
- Volunteers
- 1,613 people
- Sponsor
- Merck Sharp & Dohme LLC
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