Clinical trials: Rheumatoid Arthritis, completed
Rheumatoid Arthritis
Evaluation of Tumour Necrosis Factor Alpha (TNFα) Blockers in Early Rheumatoid Arthritis in France
Aim: To describe 1) The use of TNF blockers in early arthritis in daily clinical practice in France 2) To evaluate symptomatic, structural efficacy, and retention rate over 5 years 3) To evaluate predictive factors for TNF…
- Trial name
- NCT02927509
- Testing
- TNF alpha blockers
- Volunteers
- 813 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Rheumatoid Arthritis
Evaluation of 2 Oral Doses of PG-760564 in Rheumatoid Arthritis (RA) Patients Receiving Methotrexate
This will be a 12-week, double-blind, randomized, placebo-controlled, parallel group, multicenter study to evaluate the safety, efficacy, and PK of oral administration of PG-760564 in adult patients with active RA receiving…
- Trial name
- NCT00369928
- Testing
- PG-760564
- Where
- 53 sites in United States, Czechia and 4 more
- Volunteers
- 254 people
- Sponsor
- Procter and Gamble
Rheumatoid Arthritis
Study of MDX-1100 (Anti-CXCL10 Human Monoclonal Antibody) in Combination With Methotrexate in Subjects With Active Rheumatoid Arthritis (RA)
The purpose of this study is to: 1. determine the American College of Rheumatology (ACR) 20 response rate at Day 85 in subjects with active rheumatoid arthritis(RA) administered MDX 1100 with methotrexate (MTX); and 2.
- Trial name
- MDX1100-04 (NCT01017367)
- Testing
- MDX-1100
- Where
- 18 sites in Romania, Ukraine
- Volunteers
- 70 people
- Sponsor
- Bristol-Myers Squibb
Knee Osteoarthritis, Rheumatoid Arthritis
Computer Navigation vs Conventional Technique in Knee Arthroplasty
Project summary: Background: Computer navigation in knee replacement surgery is increasingly being used around the world, but the documentation of its usefulness is lacking.
- Trial name
- CAOS (NCT00782444)
- Testing
- Computer navigated knee replacement, Conventional knee replacement
- Where
- 4 sites in Norway
- Volunteers
- 192 people
- Sponsor
- Haukeland University Hospital
Rheumatoid Arthritis
Changes of Depression After First-year of Tofacitinib in RA Patients
12-month, single arm, prospective, non-interventional, multi-center study according to Czech legal definitions (Law 378/2007 Sb.).The primary objective of this study is to describe and evaluate the changes of depression level…
- Trial name
- NCT03992781
- Where
- 6 sites in Czechia
- Volunteers
- 73 people
- Sponsor
- Pfizer
Rheumatoid Arthritis (RA)
A Study to Compare Efficacy, Pharmacokinetics, Safety and Immunogenicity of MB04 [Proposed Etanercept Biosimilar] to Enbrel® [EU-sourced] in Rheumatoid Arthritis
A study to compare efficacy, pharmacokinetics, safety and immunogenicity of MB04 [proposed etanercept biosimilar] to Enbrel® [EU-sourced] in rheumatoid arthritis
- Trial name
- NCT06596772
- Testing
- MB04 (proposed biosimilar to etanercept), Enbrel (etanercept)
- Where
- 60 sites in Bulgaria, Georgia and 4 more
- Volunteers
- 501 people
- Sponsor
- mAbxience Research S.L.
Coccidioidomycosis, Rheumatoid Arthritis
Risk of Coccidioidomycosis in Patients Receiving Anti-TNF and Other Biologic Agents for an Inflammatory Arthritis
The goal of the project is to study the risk of coccidioidomycosis (valley fever) in patients receiving anti-TNF and other biologic agents for inflammatory arthritis in Tucson, Arizona.
- Trial name
- NCT00796809
- Where
- United States
- Volunteers
- 598 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Rheumatoid Arthritis
An Evaluation of the Optimal Dose of Tofacitinib Needed to Achieve Low Disease Activity (LDA) or Clinical Remission in Patients With Active Rheumatoid Arthritis (RA) as Measured From a Clinical and Structural Perspective
This study will evaluate the optimal dose of tofacitinib needed to achieve low disease activity (LDA) or clinical remission as measured by the CDAI score.
- Trial name
- NCT02566967
- Testing
- tofacitinib
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Norman B. Gaylis, MD
Rheumatoid Arthritis
Comorbidities and Outcomes in Early Rheumatoid Arthritis
Identify the burden of comorbidity at the time of diagnosis of rheumatoid arthritis. Identify the impact of comorbidity present at diagnosis on cardiovascular disease, death, rheumatoid arthritis disease progression and…
- Trial name
- NCT03675516
- Testing
- No specific intervention
- Where
- United Kingdom
- Volunteers
- 13,182 people
- Sponsor
- Momentum Data
Arthritis, Rheumatoid, Arthritis, Psoriatic
A Study to Investigate the Use of Golimumab (Simponi®) in Participants With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis (P06554)
This is a study to assess the use of golimumab (Simponi®) in participants with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis.
- Conditions
- Arthritis, Rheumatoid, Arthritis, Psoriatic, Spondylitis, Ankylosing
- Trial name
- GO-NICE (NCT01313858)
- Testing
- Simponi®, Methotrexate
- Volunteers
- 1,613 people
- Sponsor
- Merck Sharp & Dohme LLC
Rheumatoid Arthritis
A Pilot Proof of Concept Study of the Effects of Administration of SCFA in Rheumatoid Arthritis (EASi-RA)
This study is a pilot, proof of concept study to determine the effects of administering an oral short chain fatty acid (SCFA) supplement along with methotrexate as first line treatment of new onset rheumatoid arthritis (NORA)…
- Trial name
- NCT05152615
- Testing
- Short Chain Fatty Acids (SCFA) Dietary Supplement
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- NYU Langone Health
Xerostomia, Hyposalivation
Quality of Life and Sjögren Syndrome
The aims of this study are: To compare salivary pH changes and stimulation efficacy of two different Gustatory Stimulants of Salivation (GSSS) in patients with Primary Sjögren Syndrome (PSS); To evaluate Primary Sjögren syndrome…
- Conditions
- Xerostomia, Hyposalivation, Quality of Life, Sjogren's Syndrome
- Trial name
- NCT03578900
- Testing
- Xeros, Citric Acid based Mouthwash
- Volunteers
- 289 people
- Sponsor
- Grupo de Investigação em Bioquímica e Biologia Oral
Rheumatoid Arthritis
National Data Bank for Rheumatic Disease Registry Study of Safety in Patients With Rheumatoid Arthritis Treated With Cimzia® or Disease-modifying Antirheumatic Drugs (DMARDs)
Observational registry to assess the longer-term risk of serious infections and malignancies reported with TNFα-blocker therapy, as well as the longer-term risk of cardiovascular and thromboembolic events in adult Rheumatoid…
- Trial name
- NCT01095393
- Volunteers
- 12,500 people
- Sponsor
- UCB Pharma
Rheumatoid Arthritis
A Study Comparing SB4 to Enbrel® in Subjects With Moderate to Severe Rheumatoid Arthritis Despite Methotrexate Therapy
This is a randomized, double-blind, parallel group, multicentre clinical study to evaluate the efficacy, safety, pharmacokinetics and immunogenicity of SB4 compared to Enbrel in subjects with moderate to severe Rheumatoid…
- Trial name
- NCT01895309
- Testing
- Enbrel (etanercept), SB4 (proposed biosimilar to etanercept)
- Where
- 2 sites in Poland, United Kingdom
- Volunteers
- 596 people
- Sponsor
- Samsung Bioepis Co., Ltd.
Arthritis, Rheumatoid
Compare Diagnostic Performance of DIXON &CHESS Sequences Calculating RAMRIS Score in Early Rheumatoid Arthritis.
In a preliminary MRI study of healthy volunteers's hands investigators showed that the suppression of the fat signal obtained by the Dixon sequences is greater than that obtained by the "classic" CHESS sequences with a better…
- Trial name
- IDEAL PR (NCT03943563)
- Testing
- Dixon sequences acquisition
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Active Rheumatoid Arthritis
Study Evaluating The Efficacy And Safety Of SBI-087 In Seropositive Subjects With Active Rheumatoid Arthritis
This study is designed to evaluate the safety and efficacy of a dose and dosage regimen of SBI-087 in seropositive patients with active Rheumatoid Arthritis, who are on a stable dose of methotrexate.
- Trial name
- NCT01008852
- Testing
- SBI-087
- Where
- 55 sites in United States, Argentina and 8 more
- Volunteers
- 210 people
- Sponsor
- Pfizer
Diabetes Mellitus, Sarcoidosis
Salivary Proteins in Disease and Health
This study will examine saliva samples from healthy volunteers and patients with various diseases to learn more about how disease affects the mouth and salivary glands.
- Conditions
- Diabetes Mellitus, Sarcoidosis, Dental Caries, Sjorgren's Syndrome
- Trial name
- NCT00100204
- Where
- United States
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Rheumatoid Arthritis of Ankle, Ultrasound Therapy; Complications
Combined Effect of Underwater Ultrasound
This randomised controlled trial aims to investigate the effects of underwater ultrasound therapy and customised foot insoles in RA patients.
- Trial name
- NCT06753552
- Testing
- Underwater US, CFO
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Kirsehir Ahi Evran Universitesi
Rheumatoid Arthritis, Osteoarthritis
PReventive Efficacy and Safety of rEbamipide on Nsaid Induced Mucosal Toxicity
To prove that the efficacy and safety of Mucosta® (Rebamipide) is non-inferior to those of Cytotec® (Misoprostol), in terms of prevention of NSAID-induced gastric ulcer.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Ankylosing Spondylitis
- Trial name
- PRESENT (NCT00576706)
- Testing
- Rebamipide, Misoprostol
- Where
- 10 sites in South Korea
- Volunteers
- 396 people
- Sponsor
- Korea Otsuka Pharmaceutical Co., Ltd.
Rheumatoid Arthritis
Reconstitution of CD4+CD25highCD127low/-Tcell
Rheumatoid arthritis (RA) is a systemic disabling inflammatory disease, of autoimmune origin characterized by chronic synovial inflammation resulting in joint damage.
- Trial name
- NCT03736044
- Testing
- TNF-blockers suspension in patients with rheumatoid arthritis
- Volunteers
- 48 people
- Sponsor
- University Hospital of Ferrara
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