Clinical trials: Rheumatoid Arthritis (RA)
Rheumatoid Arthritis
Study to Assess the Management of Synthetic Disease-modifying Antirheumatic Drug (DMARD) at the Onset of Adverse Events, Intolerance or Lack of Efficacy in Rheumatoid Arthritis (RA)
The purpose of this study is to find patterns in the use of non-biological DMARDs as the initial treatment of RA and how adverse events (AEs), intolerance or lack of efficacy may impact therapeutic decisions in real life in the…
- Trial name
- SAR-FAME (NCT02094326)
- Where
- 11 sites in Spain
- Volunteers
- 301 people
- Sponsor
- Fundación Andaluza de Reumatología
Rheumatoid Arthritis
Relationship Between Grip Endurance, Disability of Upper Extremity and Quality of Life in Patients With RA
The aim of this study is to investigate the relationship between grip endurance, disability of upper extremity and quality of life in patients with rheumatoid arthritis.
- Trial name
- NCT04563455
- Where
- Turkey (Türkiye)
- Volunteers
- 23 people
- Sponsor
- Izmir Katip Celebi University
Rheumatoid Arthritis
Effect of Controlling Environmental Risk Factors in Established RA
The factors contributing to the development of rheumatoid arthritis are multiple, with a role of the environment and a predisposing genetic background.
- Trial name
- DISRUPT-estRA (NCT05198271)
- Testing
- Management of risk factors, Smoking cessation, weightloss
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis
PK, PD, Safety, and Efficacy of SAIT101 Versus MabThera® Versus Rituxan® in Patients With Rheumatoid Arthritis
A randomised, double blind, parallel group, multicentre study yo compare the pharmacokinetics, pharmacokinetics, safety and efficacy of SAIT101 versus MabThera® versus Rituxan® in patients with rheumatoid arthritis.
- Trial name
- NCT02819726
- Testing
- SAIT101, MabThera, Rituxan
- Where
- 75 sites in United States, Bosnia and Herzegovina and 9 more
- Volunteers
- 294 people
- Sponsor
- Archigen Biotech Limited
Early Rheumatoid Arthritis or Early Undiffentiated Arthritis
Study and Monitoring of Early Undifferentiated Arthritis
The French Society of Rheumatology initiated a large national multicenter, longitudinal and prospective cohort, ESPOIR, in order to set up databases to allow various investigations on diagnosis, prognostic markers, epidemiology…
- Trial name
- ESPOIR (NCT03666091)
- Volunteers
- 813 people
- Sponsor
- Societe Francaise de Rhumatologie
Rheumatoid Arthritis
Phase 1b Study of PLX5622 in Rheumatoid Arthritis Patients Who Are Receiving Methotrexate
PLX115-02 is a phase 1b study to assess how the study drug, PLX5622: 1. affects the body, 2. how the body affects PLX5622 3. the interaction of PLX5622 with Methotrexate and 4.
- Trial name
- NCT01329991
- Testing
- PLX5622
- Where
- 4 sites in United States
- Volunteers
- 26 people
- Sponsor
- Plexxikon
Rheumatoid Arthritis, Influenza
2-week dc of MTX and Influenza Vaccination in RA
To investigate whether a transient discontinuation of methotrexate MTX for 2 weeks improves the vaccination response to a seasonal influenza.
- Conditions
- Rheumatoid Arthritis, Influenza, Methotrexate
- Trial name
- 2 wk MTX (NCT02897011)
- Testing
- Methotrexate
- Where
- 3 sites in South Korea
- Volunteers
- 318 people
- Sponsor
- Seoul National University Hospital
Rheumatoid Arthritis, Tuberculosis
Comparison of the Tuberculin Skin Test (TST) and QuantiFERON ®-TB Gold Test (QFT-G) In Patients With Rheumatoid Arthritis Being Considered for Anti-TNF-Alpha Therapy
This research will help doctors interested in the usefulness of a new test to discover hidden tuberculosis infections in patients diagnosed with rheumatoid arthritis (RA). This new test is called Quantiferon-Gold (QFT-G).
- Trial name
- NCT00925249
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Rheumatoid Arthritis
Comparison of Disease Modifying Antirheumatic Drugs Therapy in Patients With RA Failing Methotrexate Monotherapy
RA (Rheuatoid arthritis) is a multisystem disease that mainly involves joints resulting in destructive arthritis if not treated rapidly.
- Trial name
- NCT02930343
- Testing
- Methotrexate, Leflunomide, Hydroxychloroquine
- Where
- India
- Volunteers
- 136 people
- Sponsor
- Jawaharlal Institute of Postgraduate Medical Education & Research
Rheumatoid Arthritis
Observational Study of Tocilizumab in Participants With Rheumatoid Arthritis in Australia
This multi-center, observational study will evaluate the treatment patterns in clinical practice, efficacy and safety of tocilizumab in participants with rheumatoid arthritis (RA) who have had an inadequate response (or were…
- Trial name
- NCT01683604
- Testing
- Observational study
- Where
- 7 sites in Australia
- Volunteers
- 37 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Extension Study to Assess the Efficacy and Safety of Repeat Treatment With Rituximab (MabThera) in Participants With Active Rheumatoid Arthritis (RA)
This study will assess the long-term safety and efficacy of repeat treatment courses of rituximab, in combination with methotrexate in a disease-modifying anti-rheumatic drug (DMARD) inadequate responder population of…
- Trial name
- NCT02093026
- Testing
- Rituximab, Methotrexate, Methylprednisolone
- Where
- 92 sites in United States, Australia and 14 more
- Volunteers
- 465 people
- Sponsor
- Hoffmann-La Roche
Systemic Lupus Erthematosus, Sjogren's Syndrome
Mass Spectrometry-based Immune Profiling in Autoimmune Diseases
Based on mass spectrometry flow method, this study analyzed the typing of new T, B, NK and DC cell subsets in peripheral blood of common autoimmune diseases and their correlation with disease activity, aiming at establishing an…
- Conditions
- Systemic Lupus Erthematosus, Sjogren's Syndrome, Inflammatory Myopathies, Systemic Sclerosis (SSc)
- Trial name
- NCT07188285
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Rheumatoid Arthritis
Study of Some Risk Factors for Developing RA
Introduction Rheumatoid arthritis (RA), a chronic autoimmune disease of unknown etiology, .If not managed early , RA can result in irreversible, painful, and disabling joint damage.
- Trial name
- NCT03624179
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Rheumatoid Arthritis
Phase 1b/2 Study of IV Sarilumab in Adult With RA
This is a Phase 1/Phase 2 study with: 5-arms design for Part A; and a single arm for Part B. The purpose of this study is to measure PK parameters and safety with sarilumab intravenous (IV) with or without concomitant oral…
- Trial name
- OPALS (NCT07704580)
- Testing
- Sarilumab, SAR153191 SC, Sarilumab, SAR153191 IV
- Where
- 12 sites in United States
- Volunteers
- 140 people
- Sponsor
- Sanofi
Rheumatoid Arthritis
The Chinese University of Hong Kong Early Arthritis Study
The purpose of this study is: 1. To ascertain whether the quantitative assessment of enhancing synovial volume and perfusion indices on serial Magnetic Resonance Imaging (MRI) examination are useful indicators of responsiveness…
- Trial name
- ERA (NCT00901550)
- Testing
- Methotrexate, Infliximab
- Where
- 3 sites in China
- Volunteers
- 40 people
- Sponsor
- Chinese University of Hong Kong
Rheumatoid Arthritis
Tocilizumab REMission in Early RA
The TREMERA study focuses on patients with newly diagnosed, untreated, rheumatoid arthritis (RA). Recent international treatment recommendations emphasise the need to diagnose RA early and start treatment immediately (this being…
- Trial name
- TREMERA (NCT04157010)
- Testing
- Tocilizumab, Methotrexate
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Leeds
Rheumatoid Arthritis
A Study to Assess the Effect of Tocilizumab + Methotrexate on Prevention of Structural Joint Damage in Patients With Moderate to Severe Active Rheumatoid Arthritis (RA)
This 3 arm study will compare the safety and efficacy, with respect to a reduction in signs and symptoms and prevention of joint damage, of tocilizumab versus placebo, both in combination with methotrexate (MTX) in patients with…
- Trial name
- NCT00106535
- Testing
- tocilizumab [RoActemra/Actemra], Methotrexate
- Where
- 152 sites in United States, Australia and 14 more
- Volunteers
- 1,196 people
- Sponsor
- Hoffmann-La Roche
Rheumatoid Arthritis
Efficacy, Safety and Tolerability of Secukinumab in Patients With Rheumatoid Arthritis Taking Methotrexate
The study compared the efficacy and assessed the safety of secukinumab given as 3 intravenous (i.v.) loading doses or weekly sub-cutaneous (s.c.) loading doses, compared to placebo, followed by monthly s.c.
- Trial name
- NCT01359943
- Testing
- secukinumab (AIN457)
- Where
- 39 sites in United States, Bulgaria and 6 more
- Volunteers
- 221 people
- Sponsor
- Novartis Pharmaceuticals
Rheumatoid Arthritis, Lymph Node Mass
Relationship Between the Activity of Rheumatoid Arthritis and Lymph Node Morphology and Lymphatics Drainage
To observe the relationship between the activity of rheumatoid arthritis and popliteal/epitrochlear lymph node morphology and the drainage of hand/foot superficial lymphatic vessels
- Conditions
- Rheumatoid Arthritis, Lymph Node Mass, Lymphatic Vessel; Dilatation
- Trial name
- NCT02876874
- Testing
- indocyanine green(ICG)
- Where
- 2 sites in China
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Rheumatoid Arthritis（RA）
Infliximab and Classic DMARDs in the Rheumatoid Arthritis Patients
A prospective, multi-centric, cohort study to observe the efficacy difference between intensive classic DMARDs and Infliximab(IFX) with methotrexate(MTX) treatment in sever rheumatoid arthritis(RA) 28 joints disease activity…
- Trial name
- INNOVATION (NCT01915537)
- Testing
- Infliximab group, Classic DMARDs treatment group
- Where
- 3 sites in China
- Volunteers
- 170 people
- Sponsor
- Zhang, Xiao, M.D.