Clinical trials: Rhinitis; Allergic, With Asthma
ASTHMA, ALLERGIC RHINITIS
Hair Cortisol in Asthma or Allergic Rhinitis Treated With Topical Corticosteroids
The purpose of this study is to prospectively examine the relation between topical corticosteroid use and hair cortisol concentration, among patients with moderate persistent asthma or allergic rhinitis.
- Trial name
- NCT01839851
- Testing
- Treatment with any inhaled corticosteroid, Treatment with any intranasal glucocorticoid
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Meir Medical Center
Asthma, Allergic Rhinitis
CysLT1-r Expression Following Allergen Exposure in Asthma and Allergic Rhinitis
Cysteinyl leukotrienes (CysLTs) play an important role in asthma. CysLTs exert most of their bronchoconstrictive and pro-inflammatory effects through activation of the CysLT1-r.
- Trial name
- NCT00631254
- Testing
- Allergen challenge
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Laval University
Perennial Allergic Rhinitis Accompanied by Asthma
Study to Evaluate the Efficacy and Safety of DW1807 in Perennial Allergic Rhinitis Patients With Asthma
This study aims to compare the efficacy and safety of DW1807 and DW1807-R2 in patients with perennial allergic rhinitis and comorbid asthma.
- Trial name
- NCT07168473
- Testing
- Experimental, Comparator
- Where
- South Korea
- Volunteers
- 274 people
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
Allergic Rhinitis/Rhinoconjunctivitis +-Intermittent Asthma, Sensitization Against Betula Alba (Birch) Pollen
Depigoid Birch 5000 Longterm Study in Adults and Adolescents
Specific immunotherapy for IgE mediated sensitization to birch pollen. Long-term study to assess safety and efficacy of Depigoid(R)Birch 5000 - a modified pollen extract of Betula alba (Birch) - versus placebo.
- Trial name
- NCT01694836
- Testing
- s.c. injection
- Where
- 2 sites in Germany
- Volunteers
- 634 people
- Sponsor
- Leti Pharma GmbH
Allergic Rhinitis With Asthma
Efficacy and Safety of Yiqi Wenyang Sanhan Formula Combined With Acupoint Application in Patients With Combined Allergic Rhinitis and Asthma Syndrome During Remission and Yang-Deficiency Syndrome
Allergic rhinitis-asthma syndrome is a clinical comorbid condition involving both upper and lower airway allergic inflammation, reflecting the concept of "one airway, one inflammatory response." Epidemiological studies have…
- Trial name
- NCT07540351
- Testing
- Yiqi Wenyang Sanhan Formula Combined with Acupoint Application
- Volunteers
- 188 people
- Sponsor
- Beijing Daxing District Hospital of Integrated Chinese and Western Medicine
Asthma, Bronchial, Rhinitis, Allergic, Perennial
Study of MK0476 (Montelukast Sodium) and Effects on Asthma and Nasal Symptoms Upon Exposure to Cats (0476-256)
The purpose of this study is to determine the protective effect of an approved medication on asthma and allergic rhinitis (inflammation of the mucous membrane of the nose) upon exposure to cats.
- Trial name
- NCT00092105
- Testing
- MK0476, montelukast sodium
- Volunteers
- 58 people
- Sponsor
- Organon and Co
Asthma and Rhinitis
A Study to Investigate the Safety and Pharmacodynamics of Repeat Intranasal Administration of the TLR7 Agonist GSK2245035 in Subjects With Respiratory Allergies
GSK2245035 is a highly selective Toll-like receptor 7 (TLR7) agonist that stimulates preferentially the induction of type I interferons.
- Trial name
- NCT01607372
- Testing
- GSK2245035, Type 1 amber glass bottle
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Rhinitis, Asthma
Airway Inflammation and Bronchial Hyperresponsiveness in Rhinitic Children With or Without Asthma
This is a prospective observational study , to clarity the characteristics of airway inflammation, airway reactivity and airway resistance in rhinitic children with or without asthma and to explore the possible predictors in the…
- Conditions
- Rhinitis, Asthma, Inflammation, Hypersensitivity
- Trial name
- NCT02360072
- Where
- China
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Rhinitis, Allergic, Rhinoconjunctivitis
Efficacy and Safety Evaluation of the Treatment of Allergy Against Cupressaceae and Grasses.
A Randomized, Double-Blinded, Placebo-Controlled, Prospective, Multicenter Clinical Trial to Evaluate the Efficacy and Safety of Subcutaneous Immunotherapy in Patients With Rhinitis/Rhinoconjunctivitis With or Without Mild to…
- Conditions
- Rhinitis, Allergic, Rhinoconjunctivitis, Asthma, Allergic
- Trial name
- NCT04898283
- Testing
- 10,000 MG01 +10,000 T521, 30,000 MG01 +10,000 T521
- Where
- 27 sites in Spain
- Volunteers
- 180 people
- Sponsor
- Inmunotek S.L.
Atopic Rhinitis, Atopic Asthma
Vibroacoustic Therapy With Oscillating Positive Expiratory Pressure in the Treatment of Nasal Congestion
This is a prospective study. It enrolls subjects with allergic rhinitis, with or without asthma, who have nasal congestion as the main symptom and meet the inclusion criteria, aiming to evaluate the efficacy and safety of…
- Trial name
- VAT (NCT07114107)
- Testing
- VPAT (Vibratory Positive Pressure Therapeutic Apparatus）, basic medications (antihistamines, mometasone furoate nasal spray, ICS-LABA, OPEP（Oscillating Positive Expiratory Pressure device）
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Allergic Rhinitis, Asthma
Safety and Efficacy of Small Extracellular Vesicles Nebulizer in Patients With Allergic Rhinitis Complicated With Asthma
This trial aims to evaluate the safety, tolerability and efficacy of hUC-MSC-sEV-002 nebulizer in patients with allergic rhinitis and asthma.
- Trial name
- NCT07453771
- Testing
- hUC-MSC-sEV-002 Nebulizer, hUC-MSC-sEV-002 Mimetic (Normal Saline)
- Where
- 5 sites in China
- Volunteers
- 18 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Severe Asthma, Allergy to House Dust Mites
Potency of HDM Sublingual AIT Tablets in Assuring the Persistency of Asthma Control in HDM Allergic Patients With Severe Asthma, Treated With Tezepelumab
The aim of this drug trial is to evaluate the annualized asthma exacerbation rate under treatment with Acarizax versus placebo. The trial is intended for adults aged 18 to 65 with severe uncontrolled asthma and a house dust mite…
- Trial name
- TEZEPAIT (NCT07013123)
- Testing
- Tezepelumab, Acarizax
- Volunteers
- 38 people
- Sponsor
- University Hospital, Montpellier
Allergic Rhinitis Due to Pollen, Allergic Rhinitis With Asthma
Interaction Between Air Pollution, Pollens and Allergic Rhinitis
Seasonal allergic rhinitis has multiple consequences: sleep disturbances, fatigue, depressed mood, impaired quality of life and productivity, and co-morbid conditions such as asthma, which affects one third of AR patients.
- Trial name
- MISTRAL (NCT05007327)
- Testing
- Exposure to pollen and air pollution
- Where
- France
- Volunteers
- 1,215 people
- Sponsor
- MASK-air SAS
Allergic Asthma, Atopic Dermatitis
A Phase 1, Randomized, Placebo-controlled, Dose-escalation Safety Study of MEDI4212 in Subjects With IgE >= 30 IU/mL
Phase 1 study to evaluate the safety of MEDI4212.
- Conditions
- Allergic Asthma, Atopic Dermatitis, Allergic Rhinitis, Healthy Volunteers
- Trial name
- NCT01544348
- Testing
- Omalizumab, MEDI4212 5 mg Subcutaneous, MEDI4212 15 mg Subcutaneous
- Where
- 7 sites in United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
Type I-Allergy
Dose-Response-Study With a Recombinant Cocktail of Phleum (rPhleum) Allergens
Dose-response trial with a cocktail of recombinant major allergens of Timothy Grass Pollen (Phleum pratense)
- Trial name
- NCT00666341
- Testing
- rPhleum
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Allergopharma GmbH & Co. KG
Mild Asthma and Allergic Rhinitis
To Investigate the Safety, Pharmacodynamics and Effect on Allergic Reactivity of the Toll-like Receptor 7 (TLR7) Agonist GSK2245035 in Subjects With Respiratory Allergies
The purpose of this study is to examine the safety and effects on the immune system of treatment with GSK2245035 in subjects who suffer from nasal symptoms caused by an allergy to pollen or perennial allergen, with or without…
- Trial name
- NCT01788813
- Testing
- GSK2245035
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- GlaxoSmithKline
Food Allergy, Asthma
Assessing Risk of Food Insecurity Within Households of Children With Food Allergy
Our central hypothesis is that dietary limitations introduced by food allergy will contribute to increased food insecurity in households with food allergic children when compared to food insecure households without food allergic…
- Conditions
- Food Allergy, Asthma, Allergic Rhinitis, Atopic Dermatitis
- Trial name
- NCT01897506
- Where
- United States
- Volunteers
- 650 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Allergic Rhinitis Due to House Dust Mite
The Efficacy of Specific Immunotherapy Guided by Component-Resolved Diagnosis for Dust Mite Allergens in Chinese Pediatric Patients With Rhinitis and/or Asthma
This study is a Study to Understand How to Better Match Allergy Shots to a Child's Unique Mite Allergy Profile 1. Why is this study being done? For many children, tiny house dust mites are a major cause of persistent allergies…
- Trial name
- NCT07452380
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Asthma, Allergic Rhinitis
A Study to Compare Effectiveness of Montelukast Sodium With Comparator in Mild to Moderate Persistent Asthmatics (0476-329)
Subjects have 8-week with montelukast sodium or comparator drug administration period, 2-week wash-out period and 8-week comparator drug or the drug administration period (with cross-over design) for assessment of the drug…
- Trial name
- NCT00157937
- Testing
- MK0476; montelukast sodium/Duration of Treatment: 16 weeks, Comparator: theophylline ER/Duration of Treatment: 16 weeks
- Volunteers
- 31 people
- Sponsor
- Organon and Co
Dental Caries, Periodontal Diseases
Biomimetic Hydroxyapatite in Pediatric Patients With Asthma and/or Allergic Rhinitis
The aim of the study is to compare the incidence of dental caries and the level of demineralization in pediatric patients with asthma and/or allergic rhinitis. Patients will conduct professional oral hygiene at the baseline.
- Trial name
- NCT05631197
- Testing
- Biorepair Total Protection Plus + desensitizing enamel-repair shock treatment, Sensodyne Repair & Protect
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia