Clinical trials: Rhythm
Healthy
Circadian Brown Adipose Tissue Metabolism
Brown adipose tissue is poorly understood fat that can metabolize glucose in order to generate heat. Since activated brown fat has a high metabolic rate, it is of great interest as a potential target to combat obesity.
- Trial name
- NCT02285270
- Testing
- FDG PET/CT
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Dementia, Alzheimer Disease
The Healthy Patterns Sleep Study
The Healthy Patterns Study intervention is a home-based activity intervention designed to improve symptoms of circadian rhythm disorders (CRD) and quality of life (QOL) in home-dwelling persons with dementia.
- Conditions
- Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder
- Trial name
- NCT03682185
- Testing
- Attention-Control Condition, Timed Activity Intervention
- Where
- United States
- Volunteers
- 421 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Shift-Work Related Sleep Disturbance, Sleep Deprivation
Light Intervention for Adaptation to Night Work
The project will contribute with new knowledge concerning how aspects of the physical work environment (lighting conditions) can be arranged to facilitate the workers' adaptation to night work.
- Conditions
- Shift-Work Related Sleep Disturbance, Sleep Deprivation, Sleep
- Trial name
- NCT03203538
- Testing
- LED-light, 1000 lux, LED-light, 100 lux, LED-light, 7000 K
- Where
- Norway
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Healthy
A Clinical Trial to Evaluate the Effect of Ulonivirine (MK-8507) on Heart Rhythm in Healthy Adults (MK-8507-012)
Researchers are looking for new treatments for HIV-1 (human immunodeficiency virus type 1) that are safe, well-tolerated, and can be taken less often.
- Trial name
- NCT07305831
- Testing
- Ulonivirine, Moxifloxacin
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Sleep Disturbance, Sleep Problems
Transdiagnostic Sleep Intervention to Improve Mental Health in Adolescents
This cluster randomized controlled trial will evaluate whether a brief, school-based group adaptation of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) improves sleep and mental health in…
- Conditions
- Sleep Disturbance, Sleep Problems, Substance Use (Drugs, Alcohol), Anxiety
- Trial name
- SLEEP-TEEN (NCT07865728)
- Testing
- Transdiagnostic Intervention for Sleep and Circadian Dysfunction, Healthy habits psychoeducation
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Universidad Pública de Navarra
Atrial Fibrillation (AF), Obesity & Overweight
Exercise and Dietary Lifestyle Intervention on Reducing Atrial Fibrillation Burden, Cardiac and Body Fat Mass.
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is strongly associated with obesity and excess body fat. Lifestyle interventions, including exercise and dietary modification, may reduce AF burden, but long-term…
- Trial name
- MOVE-AF (NCT07430007)
- Testing
- Tailored Exercise and Dietary Lifestyle Program, Usual Clinical Care
- Where
- 4 sites in Finland
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Chewing Problem, Mastication Disorder
Masticatory Side Change and Masticatory Function.
The primary objective of this study is to establish the effect of the frequency of masticatory side switches on masticatory performance.
- Trial name
- NCT04714437
- Testing
- F, R, L
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Barcelona
T1DM, Sleep Disorders, Circadian Rhythm
Influence of Circadian Clock on Hormonal, Metabolic, Neurocognitive Markers in Adolescents With and Without Diabetes
Type 1 diabetes mellitus (T1DM), makes its appearance during childhood and youth, but management implications last till late adulthood.
- Conditions
- T1DM, Sleep Disorders, Circadian Rhythm, ADHD, Memory Impairment
- Trial name
- NCT04054934
- Testing
- Reversed Circadian Rhythm, Normal Circadian Rhythm
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Musculoskeletal Diseases
Strength Training Effects on Musculoskeletal Health
The objective here is to assess the efficacy of variable resistance muscle training on bone, sleep parameters and quality of life in healthy populations of men and women age 30 or older.
- Trial name
- Muscle:Time (NCT04810975)
- Testing
- Muscle Strength Training
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Duquesne University
Circadian Rhythm, Energy Balance
Timing and Resistance Exercise: Impact on Eating and Metabolism
Exercise timing (morning or evening) for optimal weight control is a research topic urgently addressed by scholars in the relevant field.
- Conditions
- Circadian Rhythm, Energy Balance, Appetitive Behavior, Food Reward
- Trial name
- NCT06549322
- Testing
- The exercise in morning, The exercise in evening
- Where
- Taiwan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Electrocardiogram
iECG: Recording Chest Leads Using a Smartwatch With a Digital Image Processing Algorithm
The purpose of this study is to evaluate the feasibility of a new method for self-recordable ECGs using a smartwatch coupled with an image processing algorithm.
- Trial name
- iECG (NCT05425342)
- Testing
- Smartwatch ECG
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Unrecognized Condition
The Influence of Rhythm, Cognitive Task and Physical Activity on the Cardiac ANS in Chronic Stroke Patients
Autonomic dysfunction is a common complication of stroke that may lead to poor rehabilitation outcomes and to increase in mortality.
- Trial name
- NCT03016416
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Clalit Health Services
Metastatic Colorectal Cancer
"Cancersensor": Circadian Rhythms
Observational, non randomized study aimed at measuring the circadian rhythms in the urinary concentrations of physiological modified nucleosides in 30 patients with metastatic colorectal cancer and in 30 age and sex-matched…
- Trial name
- NCT01693835
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Cushing Syndrome, Adrenal Insufficiency
Clinical Study on Circadian Genes Dysregulation in Patients With Glucocorticoid Disorders
This is a multicentric, prospective, intervention study on circadian genes expression in peripheral blood mononuclear cells as biomarkers of circadian rhythm derangement in patients affected by alterations of endogenous…
- Conditions
- Cushing Syndrome, Adrenal Insufficiency, Cushing Disease, Addison Disease
- Trial name
- CHROnOS (NCT04374721)
- Testing
- circadian gene expression evaluation
- Where
- Italy
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Circadian Rhythm, Pupillometry
Relationships Among Pupil Responses to Light, Circadian Rhythms, and Sleep
The investigators are studying relationships among eye pathology, pupil responses to light, sleep, circadian rhythms, and hormones in healthy individuals and those with various medical disorders or illnesses.
- Conditions
- Circadian Rhythm, Pupillometry, Sleep
- Trial name
- SCOPE (NCT07753889)
- Testing
- Ocular light exposure from portable light box
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Elizabeth B Klerman MD PhD
Chronobiology Disorders, Circadian Rhythm Disorders
Light Sensitization Study
Circadian rhythm disorders are a class of sleep disorders characterized by misalignment between the timing of sleep and the timing of rhythms driven by the biological clock.
- Conditions
- Chronobiology Disorders, Circadian Rhythm Disorders, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT01327040
- Testing
- light exposure
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Diabetes Mellitus, Type 2, Insulin Resistance
Exercise to Restore 24h Rhythms in Metabolism
This study will investigate the effect of exercise training on 24h rhythms in substrate metabolism in overweight subjects with impaired glucose tolerance. Subjects will perform exercise training for 12 weeks.
- Trial name
- RESTORE (NCT04565418)
- Testing
- High-intensity interval training
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Continuous Glucose Monitoring, Diabetes, Gestational
Early Pregnancy Lifestyle and Glucose Patterns: A Substudy of TOFFFY
The goal of this clinical trial is to examine how daily behavioral patterns in early pregnancy, including sleep, physical activity, and meal timing, influence continuous glucose dynamics and subsequent risk of gestational…
- Conditions
- Continuous Glucose Monitoring, Diabetes, Gestational, Diet During Pregnancy, Meal Time
- Trial name
- NCT07534670
- Testing
- Continuous glucose monitor (CGM), Wrist actigraphy device, AI-based dietary and meal timing logging mobile application
- Where
- Singapore
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Sleep Disorder, Shift-Work
Examination of the Effectiveness of Suvorexant in Improving Daytime Sleep in Shift Workers
The purpose of this study is to test the hypothesis that ingestion of the wake-inhibiting drug suvorexant 30 minutes prior to daytime sleep initiation in individuals working overnight shifts will significantly improve both…
- Trial name
- NCT02491788
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
Narcolepsy, Obstructive Sleep Apnea
The Nuvigil and Provigil Pregnancy Registry
The primary objective of the Nuvigil/Provigil Pregnancy Registry is to characterize the pregnancy and fetal outcomes associated with Nuvigil and Provigil exposure during pregnancy.
- Conditions
- Narcolepsy, Obstructive Sleep Apnea, Shift Work Sleep Disorder
- Trial name
- NCT01792583
- Testing
- Modafinil/armodafinil
- Where
- United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Cephalon, Inc.