Clinical trials: Rhythm
Sleep, Circadian Rhythm
Impact of Sleep Disruption on the Menstrual Cycle
The purpose of this study is to investigate whether sleep disruption affects menstrual cycle timing
- Conditions
- Sleep, Circadian Rhythm, Menstrual Cycle
- Trial name
- NCT00456222
- Testing
- Disrupting or changing the timing or the duration of sleep
- Where
- 2 sites in United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Aspirin, Circadian Rhythm
Aspirin AM or PM: Effect on Circadian Rhythm of Platelet Reactivity
Low-dose aspirin is a cornerstone in the secondary prevention of cardiovascular disease (CVD) and is usually taken on awakening, although evidence regarding optimal time of intake is lacking.
- Conditions
- Aspirin, Circadian Rhythm, Platelet Activation, Cardiovascular Diseases
- Trial name
- NCT01900639
- Testing
- change time of intake of aspirin
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Judo, Recovery of Function (G11.427.698.620)
Recovery Strategies and Diurnal Variation in Adolescent Judokas
The purpose of this study is to compare the effects of three different recovery strategies-sports massage (SM), static stretching (SS), and passive rest (PR)-on physiological and neuromuscular recovery in adolescent male judokas.
- Conditions
- Judo, Recovery of Function (G11.427.698.620), Athletic Performance, Muscle Fatigue
- Trial name
- RECOV-JUDO (NCT07586007)
- Testing
- Sports Massage, Static Stretching, Passive Rest
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Inonu University
Sleep, Circadian Dysregulation
The Impact of Artificial Sunlight on Human Sleep and Circadian Rhythms
The purpose of this study is to examine, in healthy controls, whether LED lighting that has a color spectrum similar to that of sunlight is able to differentially impact mood, circadian rhythms, sleep, and behavior, as compared…
- Conditions
- Sleep, Circadian Dysregulation, Mood
- Trial name
- NCT03636360
- Testing
- Light
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
Circadian Rhythm Sleep Disorder, Jet Lag Type
Facilitating Adjustment to Simulated Jet Lag
The aims of this study are to compare 3 different treatments for circadian adjustment to a laboratory protocol which will mimic westward air travel across 8 time zones.
- Trial name
- NCT05382923
- Testing
- Bright Light, Bright Light + Exercise + Melatonin, Control
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Circadian Rhythm Disorders
Identification of Novel Circadian Biomarkers
Circadian clocks are not only found in discrete areas of the brain, but are found in virtually every organ in our bodies, including the heart, lungs and immune system.
- Trial name
- NCT02291003
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Shift-Work Sleep Disorder
Light Treatment to Shift-working Nurses
This project examines 1) the effects of appropriately timed bright light on adaptation (in terms of sleep and sleepiness) to three consecutive night shifts; and 2) the effects of such bright light on re-adaptation (in terms of…
- Trial name
- NCT02978053
- Testing
- Bright light, Red light
- Where
- Norway
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Overweight, Obesity
Timing of Meals for Weight Loss
While eating the majority of energy earlier in the day appears to have a positive effect on weight and cardiometabolic outcomes, it is not clear how eating earlier in the day influences other behaviors that have a circadian…
- Conditions
- Overweight, Obesity, Weight Loss
- Trial name
- TIME (NCT02204735)
- Testing
- Eat majority of calories in the morning, Eat the majority of calories in the evening
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Sleep, Burns
Circadian Rhythm of Melatonin in Burns
Evaluate markers and postulated effectors of the endogenous circadian pacemaker in children admitted to the burn intensive care unit.
- Trial name
- Sleep4 (NCT01596101)
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Gingivitis, Circadian Rhythm Disruption
Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption
This prospective cross-sectional clinical study aims to investigate the relationship between circadian rhythm disruption and periodontal inflammation by evaluating circadian clock protein levels, inflammatory (IL-1beta) and…
- Conditions
- Gingivitis, Circadian Rhythm Disruption, Periodontal Inflammation, Circadian Rhythm Sleep Disorder, Shift Work Type
- Trial name
- Nursma-CIRC-HG (NCT07592052)
- Testing
- Standard Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Inonu University
Healthy, Circadian Rhythm
Effects of Different Colors of Light on Human Physiology
This study will determine which color of light is most effective in stimulating a range of biological functions in humans including activation of sleep-wake regulatory system (alertness, performance, microsleeps, brain activity)…
- Trial name
- NCT00200863
- Testing
- Monochromatic visible light exposure
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Sleep Disorder, Shift Work, Fatigue
Effect of Night Float Call on Sleep and Activity Patterns Among Anesthesia Residents
With increasing awareness about physician fatigue and its effect on patient safety, residency programs are increasingly transitioning to a night float call system.
- Conditions
- Sleep Disorder, Shift Work, Fatigue, Sleep Disturbance
- Trial name
- NCT05043038
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Stanford University
Sleep, Circadian Rhythm
Dexmedetomidine Trial for Effects on Rhythms, Sleep Architecture, and Biomarker Dynamics in Older Adults
The DEXTER study is a cross-over, double-blind, placebo-controlled pilot research study led by Dr. Peng Li. The goal of this project is to evaluate the safety, feasibility, and biological effects of a single dose of sublingual…
- Trial name
- DEXTER (NCT07800910)
- Testing
- Dexmedetomidine sublingual film
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Glaucoma, Open-Angle, Circadian Rhythm
Circadian Variations in Ocular Blood Flow in Glaucomatous and Normal Eyes
After focusing many years only on intraocular pressure (IOP) as the primary risk factor, recently the impact of ocular blood flow is getting more consideration for the pathophysiology of glaucoma.
- Conditions
- Glaucoma, Open-Angle, Circadian Rhythm, Intraocular Pressure, Regional Blood Flow
- Trial name
- NCT00707226
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Healthy, Bipolar
Examining Lithium's Mechanism in Bipolar Disorder
The primary objective of the current study is to examine the acute effect of lithium on the visual and non-visual responses to light in a sample of healthy participants.
- Trial name
- HELIOS-BD 2 (NCT07750925)
- Testing
- Lithium carbonate (Priadel), Controlled light exposure
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Obesity Prevention
The i Heart Rhythm Project: Healthy Sleep and Behavioral Rhythms for Obesity Prevention
This pilot study will examine the feasibility, acceptability, and preliminary efficacy of the intervention. This will ensure that all aspects of the research protocol and procedures work as desired and are acceptable to families…
- Trial name
- NCT04445740
- Testing
- i♥rhythm project
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Hyperthermia, Chronic Primary Pain
Hyperthermia in Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System and Movement Evoked Pain
This study, in a quasi-experimental matched two-group pre-post design, investigates the effect of serial water-filtered whole-body hyperthermia on circadian core body temperature, the somatosensory system (nociception) and the…
- Conditions
- Hyperthermia, Chronic Primary Pain, Widespread Pain, Muscular Disease
- Trial name
- HYPPRI-1 (NCT07101978)
- Testing
- serial whole body hyperthermia
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bern University of Applied Sciences
Shift-Work Sleep Disorder
Biological Rhythms Impact of 12 Hours Shift Work
Nonstandard time-schedules work are widespread in the world of work. Shift and night work have been shown to be responsible for a desynchronization of biological rhythms, associated with melatonin secretion impairment and sleep…
- Trial name
- MELACTI-12 (NCT03153917)
- Testing
- melatonin and cortisol sampling
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Atrial Fibrillation
SmartWATCHes for Detection of Atrial Fibrillation
In this trial the Preventives Heartbeats algorithm will be tested in two wearable devices for its specificity and sensitivity to distinguish between AF and SR.
- Trial name
- WATCHAF (NCT02956343)
- Testing
- Five minutes pulse wave recording
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 651 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Major Depressive Disorder (MDD), Sleep Disorders
A Longitudinal Follow-Up Study on Predicting Major Depressive Disorder From Rest-Activity Rhythm Profiles
This proposed study will be a longitudinal follow-up study of a case-control study of 160 participants (CREC Ref: 2023.234). This study aims to follow up on the trajectory of depression and rest-activity rhythm (RAR) disruptions…
- Conditions
- Major Depressive Disorder (MDD), Sleep Disorders, Circadian Rhythm
- Trial name
- NCT07388849
- Where
- Hong Kong
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong