Clinical trials: Rhythm
Osteopenia, Osteoporosis
Time-specific Exercise in Circadian Context
The project aims to explore the mechanisms, by which physical activity can support healthy ageing and decrease the negative impact of ageing on the circadian system, musculoskeletal system and immunity.
- Conditions
- Osteopenia, Osteoporosis, Aging
- Trial name
- CAEx (NCT06746649)
- Testing
- Combined training
- Where
- Slovakia
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Comenius University
Healthy Volunteers
Language and Brain Rhythms
For humans and other animals, predicting the timing of sensory events is essential for their daily behavior. Importantly, natural sensory stimulation (such as movements, music, or speech) can present temporal regularities…
- Trial name
- LaBRhythms (NCT04457622)
- Testing
- Auditory perception tasks in healthy participants
- Where
- France
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Healthy
A Clinical Trial to Evaluate the Effect of Ulonivirine (MK-8507) on Heart Rhythm in Healthy Adults (MK-8507-012)
Researchers are looking for new treatments for HIV-1 (human immunodeficiency virus type 1) that are safe, well-tolerated, and can be taken less often.
- Trial name
- NCT07305831
- Testing
- Ulonivirine, Moxifloxacin
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Inflammation, Sleep Deprivation
Circadian Rhythm Disruption Effects on Smoke Inhalation
Particulate matter exposure during smoke inhalation provokes inflammatory immune responses in people exposed to burning biomass including fire fighters and civilians.
- Conditions
- Inflammation, Sleep Deprivation, Circadian Rhythm Sleep Disorder, Shift Work Type, Smoke Inhalation
- Trial name
- NCT04955431
- Testing
- Sleep Restriction, Normal Sleep
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Montana
Circadian Rhythm, Menstrual Cycle Phase
Investigating the Effects of Time-of-day and Menstrual Cycle Phase (Low and High Progesterone) on Female's Cognitive and Strength Performance
This study is designed to determine whether time-of-day and menstrual cycle phase influence athletic performance and is expected to contribute valuable insight into how both time-of-day, and hormonal factors can influence…
- Conditions
- Circadian Rhythm, Menstrual Cycle Phase, Female Athletes, Executive Function (Cognition)
- Trial name
- NCT07399847
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lancaster University
Circadian Dysrhythmia, Delirium
The Circadian Rhythm of ICU Patients With Acute Myocardial Infraction and the Effect of Light Therapy
By using subjective and objective measurements, the investigators monitor the change of circadian rhythm in Intensive Care Unit (ICU) patients with acute myocardial infarction and the effect of light therapy.
- Trial name
- NCT04953767
- Testing
- Blue light therapy, White light
- Where
- Taiwan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Healthy Subjects
Study Evaluating The Effect of Bosutinib (SKI-606) On Cardiac Repolarization (Rhythms Of The Heart)
The purpose of this study is to examine the effect of SKI-606 on rhythms of the heart (cardiac repolarization)
- Trial name
- NCT00914121
- Testing
- SKI-606, Moxifloxacin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Sleep Quality, Meal Timing
This Trial Examines How Last Meal Composition and Timing Affect Sleep Quality and Circadian Gene Expression Among Medical Residents. Recruitment Not Yet Started; Study Begins Dec 2025 and Ends Dec 2026.
This randomized controlled trial aims to evaluate the effects of last meal composition and timing on sleep quality and circadian gene expression among medical residents in Jordanian hospitals.
- Conditions
- Sleep Quality, Meal Timing, Circadian Rhythm, Medical Residents
- Trial name
- CHRONO-MED (NCT07339592)
- Testing
- High-Carbohydrate Last Meal, High-Protein Last Meal, Balanced Standard Dinner
- Where
- Jordan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Abnormality in Fetal Heart Rate or Rhythm, Ultrasound
Uterine, Fetal Cerebral Doppler and Oligohydramnios to Predict Abnormal Heart Rate Tracings in Postterm Pregnancies
Objective: To estimate the value of uterine, fetal cerebral Doppler and oligohydramnios to predict abnormal fetal heart rate tracings in pregnancies at or beyond 41 weeks
- Conditions
- Abnormality in Fetal Heart Rate or Rhythm, Ultrasound, Late Pregnancy
- Trial name
- NCT03703037
- Testing
- Ultrasound and Doppler ultrasound
- Where
- Mexico
- Volunteers
- 227 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Metabolic Disturbance, Obesity
The Effect of Irregular Meal Pattern Providing Hypo-energetic Diet on Energy Expenditure and Metabolism
In this study we will compare the effect of two different meal patterns. Firstly, participants will consume a diet providing their estimated energy requirement for a 7 day standardisation period (6 meals per day).
- Trial name
- NCT05569837
- Testing
- Regular meal pattern, Irregular meal pattern
- Where
- United Kingdom
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease
Countermeasures to Circadian Misalignment
Insufficient sleep and circadian misalignment are independent risk factors for the development of obesity and diabetes, yet few strategies exist to counter metabolic impairments when these behaviors are unavoidable.
- Conditions
- Circadian Rhythm Sleep Disorder of Shift Work Type, Metabolic Disease, Insulin Sensitivity
- Trial name
- C2CM (NCT04966351)
- Testing
- Time-restricted feeding, Circadian Misalignment
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Shift-Work Sleep Disorder
Assessments in Stress and Quality of Sleep/Life in Night-shift Nurses and Doctors
This study aims to evaluate the effects of aroma massage to sleep quality of the nurses and staff during night shift.
- Trial name
- NCT02541747
- Testing
- massage
- Where
- Taiwan
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Taichung Veterans General Hospital
Binge-Eating Disorder, Circadian Rhythm Disorders
The Role of the Circadian System in Binge Eating Disorder
Binge eating disorder (BED) shows prominent circadian features that suggest a delay in circadian phase, and preliminary evidence shows binge eating may be responsive to chronobiological interventions, implicating a circadian…
- Trial name
- CHRONO-BE (NCT04724668)
- Testing
- Melatonin (3hrs before DLMO), Morning light version 1, Morning light version 2
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Sleep Wake Disorders, Circadian Rhythm Disorders
Implementing and Sustaining a Sleep Treatment to Improve Community Mental Health Part 3: Sustainment
Research on the sustainment of implemented evidence-based psychological treatments in routine practice settings, such as community mental health centers, is limited.
- Trial name
- NCT05956678
- Testing
- Standard Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Adapted Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C)
- Where
- 10 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Healthy, Bipolar
Examining Lithium's Mechanism in Bipolar Disorder
The primary objective of the current study is to examine the acute effect of lithium on the visual and non-visual responses to light in a sample of healthy participants.
- Trial name
- HELIOS-BD 2 (NCT07750925)
- Testing
- Lithium carbonate (Priadel), Controlled light exposure
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Healty Volunteers
Acute Effects of Thoracolumbar Fascia Myofascial Release on Cortical Activity
This study will examine the immediate (acute) effects of a single myofascial release technique applied to the thoracolumbar fascia on brain activity in healthy young adults aged 18-25.
- Trial name
- MFR-EEG (NCT07728617)
- Testing
- Thoracolumbar Fascia Myofascial Release (Pilat MIF Crossed-Hands Technique)
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Hitit University
Delayed Sleep Phase Syndrome, Delayed Sleep Phase
Pathophysiology of Circadian Rhythm Delayed Sleep Wake Phase Disorder
The goal of this study is to understand factors that contribute to delayed sleep wake phase disorder (DSWPD). The investigators will examine whether patients with DSWPD exhibit alterations in circadian rhythms and sensitivity to…
- Trial name
- NCT06471374
- Testing
- Circadian rhythm assessment, Light sensitivity assessment
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Electrocardiogram
iECG: Recording Chest Leads Using a Smartwatch With a Digital Image Processing Algorithm
The purpose of this study is to evaluate the feasibility of a new method for self-recordable ECGs using a smartwatch coupled with an image processing algorithm.
- Trial name
- iECG (NCT05425342)
- Testing
- Smartwatch ECG
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Hamstring Tightness, Lumbar Lordosis
Hamstring Tightness and Lumbar Lordosis Angel Across Functional Sitting Posture.
The goal of this observational study is to learn about the relationship between hamstring tightness and the lumbar lordosis angle in sedentary adults across different sitting postures.
- Conditions
- Hamstring Tightness, Lumbar Lordosis, Sedentary Behavior, Posture Sitting Position
- Trial name
- LLA-HT (NCT07682142)
- Testing
- Hamstring tightness and lumbar lordosis assessment
- Where
- Egypt
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dementia, Alzheimer Disease
The Music, Sleep and Dementia Study
The specific aims of this studyare to examine the 1) feasibility; 2) acceptability; and 3) preliminary efficacy of a tailored music intervention in home-dwelling older adults with dementia suffering from sleep disruption.
- Conditions
- Dementia, Alzheimer Disease, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder
- Trial name
- NCT04157244
- Testing
- Tailored music listening intervention
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania