Clinical trials: Rhythm
Paroxysmal Atrial Fibrillation (PAF)
Real-world Safety and Effectiveness Registry of Catheter Ablation of Paroxysmal Atrial Fibrillation as Initial Control Therapy With the Thermocool SmartTouch SF Catheter (A Sub-study of REAL AF Registry)
To generate real-world evidence from the parent study, REAL AF registry, on the use of Thermocool SmartTouch SF (STSF) catheter in ablation for the treatment of paroxysmal atrial fibrillation (PAF).
- Trial name
- First Line (NCT07092774)
- Testing
- Ablation
- Where
- 12 sites in United States
- Volunteers
- 344 people
- Sponsor
- Heart Rhythm Clinical and Research Solutions, LLC
Infant Sleep Problem
The Role of Circadian Rhythm in the Effect of Sleep Intervention on Obesity Prevention in Early Childhood
Over the last 40 years, obesity has increased dramatically among all age groups, especially in infants and young children, and became an important global public health challenge, thus early prevention is the highest priority.
- Trial name
- NCT05159141
- Testing
- Behavioral sleep intervention
- Where
- China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Sleep Disorders, Circadian Rhythm
Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift
Anesthesiology residency requires extended and overnight shifts, which may negatively impact the quantity and quality of sleep. Previous studies have investigated the effect of night float shift work on anesthesiology resident…
- Trial name
- NCT05701969
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Sleep Circadian Rhythms, Chronodisruption
Assessing Sleep and Circadian Rhythms in Primary Brain Tumors Patients
Background: Sleep disturbances are among the most common and severe symptoms reported by people with primary brain tumors (PBT).
- Trial name
- NCT04669574
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- National Cancer Institute (NCI)
Acute Brain Injury Coma
Circadian Rhythmicity During Coma Awakening
Acute brain injury is a major cause of admission to intensive care units, as well as of mortality and morbidity, worldwide and for all age groups.
- Trial name
- COMARHYTHM (NCT06245434)
- Testing
- Repeated behavioural assessment, Act-Pass paradigm, Biological measures of circadian and monoamines biomarkers
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Hospices Civils de Lyon
Obesity (Disorder), Morbid Obesity
Chrono-ALIGN: A Chronotype-Based Chrono-Nutrition Intervention in Post-Bariatric Patients
This randomized controlled trial will evaluate the impact of chrono-nutrition, a dietary approach that aligns meal timing with the body's circadian rhythms, on weight change, metabolic outcomes, appetite, and gut microbiota in…
- Conditions
- Obesity (Disorder), Morbid Obesity, Bariatric Sleeve Gastrectomy, Meal Time
- Trial name
- Chrono-ALIGN (NCT07324044)
- Testing
- Standard Post-Bariatric Care (Control), Early Time-Restricted Eating (eTRE), Chronotype-Based Chrono-Nutrition (CB-CN)
- Where
- Saudi Arabia
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- King Saud University
Chronotypes and Health
Testing the Effectiveness of an Intervention That Aligns Circadian Rhythm With Daily Activities on Student Flourishing
Previous studies have examined whether circadian rhythm tracking improves well-being, with some evidence suggesting that aligning daily activities with one's natural chronotype (a person's natural preference for being alert and…
- Trial name
- Not Required (NCT07410585)
- Testing
- Use of Owaves App
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cushing Syndrome
The Circadian Rhythm in CusHing SyndrOme in Active Phase and dUring RemiSsion (TheHOURS)
This is an observational, open, prospective multi-centre study designed to evaluate melatonin and cortisol circadian rhythm, immunological profile and anthropometric parameters in Cushing Syndrome patients during active Remission…
- Trial name
- TheHOURS (NCT03343470)
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Roma La Sapienza
Arrhythmias, Cardiac, Atrial Fibrillation
Activation Timing and Atrial Fibrillation
This is a single center, non-randomized, unblinded study of patients who are followed at Essentia Health - St. Mary's Medical Center and who are referred for a clinically indicated diagnostic electrophysiology (EP) study with or…
- Conditions
- Arrhythmias, Cardiac, Atrial Fibrillation, Bundle Branch Block
- Trial name
- AF-Activate (NCT02063191)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Essentia Health
Prematurity, Mechanical Ventilation
Circadian Feeding and Reciprocal Scent Intervention in NICU
Objective: This study evaluated the effects of circadian-aligned feeding and reciprocal scent intervention on premature infants receiving mechanical ventilation and on postpartum depression levels in their mothers.
- Trial name
- NCT07622459
- Testing
- Reciprocal Scent Intervention, Circadian-Aligned Feeding, Standard Care (in control arm)
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Inonu University
Delayed Sleep Phase Syndrome
Lemborexant in Delayed Sleep Phase Syndrome
The purpose of the study is to evaluate whether Lemborexant is more effective than placebo in shortening sleep onset latency in patients with delayed sleep phase syndrome (both type 1 and type 2).
- Trial name
- NCT05463861
- Testing
- Lemborexant
- Where
- 2 sites in United States
- Volunteers
- 86 people
- Sponsor
- Stanford University
Obesity
A Research Study Looking at How Cagrilintide Works on the Heart Rhythm in Healthy Participants
The study tests if treatment with cagrilintide delays the transmission of electrical signals in the heart compared to treatment with placebo.
- Trial name
- NCT05804162
- Testing
- Cagrilintide, Moxifloxacin
- Where
- Germany
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Atrial Fibrillation
Rhythm Control of AF in Patients With Acute Stroke
Prospective randomized (rhythm control or rate control) Objective of study 1. To analyze long term outcome of patients with acute stroke with atrial fibrillation according to the rhythm control 2.
- Trial name
- NCT02285387
- Testing
- Rhythm control, Rate control
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Heart Failure, Cardiac Resynchronization Therapy
Safety and Performance Aspects of CRT-DX System in Patients With Sinus Rhythm
The conventional CRT-D system consists of 3 leads in patients with Heart Failure (HF). A part of HF patients have non-impaired sinus node function and will not be stimulated in the right atrium.
- Trial name
- BIO|REDUCE (NCT03839121)
- Testing
- Cardiac Resynchronization Therapy (CRT)
- Where
- 21 sites in Austria, Czechia and 2 more
- Volunteers
- 113 people
- Sponsor
- Biotronik SE & Co. KG
Cardiac Pacemaker, Cardiac Rhythm Disorder
LEAP 2 Chronic EFS
Prospective, single-arm, non-randomized, unblinded, chronic feasibility study designed to evaluate the safety and performance of the AVEIR™ Conduction System Pacing (CSP) Leadless Pacemaker system.
- Conditions
- Cardiac Pacemaker, Cardiac Rhythm Disorder, Bradycardia
- Trial name
- NCT07287423
- Testing
- AVEIR CSP Leadless Pacemaker System
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Abbott Medical Devices
Colonoscopy, Bowel Preparation Solutions
Electrolyte Beverage Combined With Polyethylene Glycol for Colonoscopy Bowel Preparation
This randomized controlled trial aims to evaluate the effects of different ratios of electrolyte beverage and water combined with polyethylene glycol (PEG) on bowel preparation quality before colonoscopy.
- Conditions
- Colonoscopy, Bowel Preparation Solutions, Colorectal Cancer Screening
- Trial name
- NCT07608120
- Testing
- PEG With Water, PEG With Low-dose Electrolyte Beverage, PEG With Medium-dose Electrolyte Beverage
- Where
- China
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Mild Autonomous Cortisol Secretion
Ketoconazole Effects on the Daily Cortisol Rhythm in Mild Autonomous Cortisol Secretion
Background: Cortisol is a hormone in the blood. Cortisol levels normally go down at night and up in the morning. Mild autonomous cortisol secretion (MACS) is a disease in which the body makes too much cortisol.
- Trial name
- NCT07649317
- Testing
- Ketoconazole
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Postcardiac Arrest, Pulseless Electrical Activity
Study of Survivors of Different Types of Cardiac Arrest and Their Neurological Recovery
After successful resuscitation from certain types of cardiac arrest, total body cooling is now a well established treatment that improves the chances of the brain recovering.
- Conditions
- Postcardiac Arrest, Pulseless Electrical Activity, Asystole
- Trial name
- NCT02033720
- Testing
- No treatment, Therapeutic hypothermia
- Where
- 2 sites in Canada
- Volunteers
- 400 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Shift Workers' Health, Time Restricted Eating
The Healthy Heroes Study
This is the first study of its kind to assess and test an intervention to improve biological rhythms and general health of shift workers, specifically first responders with San Diego Fire and Rescue.
- Conditions
- Shift Workers' Health, Time Restricted Eating, Fasting
- Trial name
- NCT03533023
- Testing
- Time Restricted Eating + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Cardiac Arrhythmia
Screening for Hearth Rhythm Disorders
This study aimed to analyze the usefulness of telecardiology in the primary health care level using an ECG personal sensor developed in Slovenia.Investigators also wanted to evaluate the satisfaction of patients and their…
- Trial name
- NCT04463524
- Testing
- Personal ECG digital sensor
- Where
- Slovenia
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Healthcare Center Murska Sobota
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