Clinical trials: Rhythm
Arrhythmia, Atrial Fibrillation
Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)
To compare two standard treatment strategies for atrial fibrillation: ventricular rate control and anticoagulation vs. rhythm control and anticoagulation.
- Conditions
- Arrhythmia, Atrial Fibrillation, Cardiovascular Diseases, Heart Diseases
- Trial name
- NCT00000556
- Testing
- amiodarone, sotalol, propafenone
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Insomnia
The Effects of Lactobacillus Plantarum PS128 in Self-Reported Insomniacs
To determine whether PS128 (1) reduces the severity of anxiety and depressive symptoms, (2) adjusts autonomic nervous system functioning, and (3) improves sleep quality.
- Trial name
- NCT04592276
- Testing
- PS128
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Yang Ming Chiao Tung University
Physiological Responses, Sleep Disorders, Circadian Rhythm
Effect of Owning a Service Dog on Military Veterans With PTSD
The study aims to investigate the effects of a service dog on military veterans with post traumatic stress syndrome (PTSD). The investigators will use non-invasive measures of the physiological responses, data obtained via dairy…
- Conditions
- Physiological Responses, Sleep Disorders, Circadian Rhythm, Stress, Emotional
- Trial name
- NCT05208008
- Testing
- With service dog
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- University of Aarhus
Non 24 Hour Sleep Wake Disorder
Safety Study of Tasimelteon for Treatment of Non-24-Hour-Sleep-Wake Disorder in Blind Individuals With No Light Perception
The purpose of this study is to evaluate the safety of a one year open-label treatment of tasimelteon in male and female subjects with Non-24-Hour Sleep-Wake Disorder.
- Trial name
- NCT01218789
- Testing
- tasimelteon
- Where
- 7 sites in France
- Volunteers
- 140 people
- Sponsor
- Vanda Pharmaceuticals
Chronobiology, Light
Teen Sleep and Light Study
Circadian clocks shift later (delay) with the progression of puberty; this shift contributes to late sleep onsets in older adolescents.
- Conditions
- Chronobiology, Light, Sleep, Circadian Rhythm
- Trial name
- NCT04921215
- Testing
- Morning bright light
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Cardiac Rhythm Disorders, Urological Disorders
Product Surveillance Registry
The purpose of the Registry is to provide continuing evaluation and periodic reporting of safety and effectiveness of Medtronic market-released products.
- Conditions
- Cardiac Rhythm Disorders, Urological Disorders, Neurological Disorders, Cardiovascular Disorders
- Trial name
- PSR (NCT01524276)
- Where
- 402 sites in United States, Argentina and 39 more
- Volunteers
- 100,000 people
- Sponsor
- Medtronic
Blood Pressure, Heart Rate and Rhythm Disorders
Acute Maternal and Fetal Effects of Exercise in Pregnancy
This will be an open randomized clinical trial involving pregnant women between 35 and 37 weeks randomized to two modalities of exercise: treadmill or stationary bike.
- Conditions
- Blood Pressure, Heart Rate and Rhythm Disorders, Hypoglycemia, Lactate
- Trial name
- EXPREG (NCT01383889)
- Testing
- Physical exercise
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Sleep Apnea, Insomnia
Adult Sleep Health in the Rural Appalachia and Mississippi Delta Region and Its Relationships With Cardiometabolic Health Disparities.
Rural communities in the southern U.S. suffer a disproportionate burden of morbidity and mortality from cardiometabolic disease, with traditional risk factors explaining only a modest proportion of the excess burden of disease.
- Conditions
- Sleep Apnea, Insomnia, Sleep Deprivation, Sleep Disorders, Circadian Rhythm
- Trial name
- NCT06336525
- Where
- United States
- Volunteers
- 3,680 people
- Sponsor
- Brigham and Women's Hospital
Aging, Sleep Deprivation
Effects of Chronic Sleep Restriction in Young and Older People
The purpose of this study is to examine the consequences of chronic sleep restriction on nighttime sleep, daytime alertness, performance and memory functions, and metabolic and cardiovascular function, and to determine if the…
- Conditions
- Aging, Sleep Deprivation, Metabolic Syndrome
- Trial name
- NCT00506428
- Testing
- chronic sleep restriction
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Cushing Syndrome
Cushing's Syndrome Before and After Treatment (CORRECT)
The purpose of this study is to prospectively study patients with Cushing's syndrome before and after treatment, with a special emphasis on physical function, quality of life, and circadian rhythms.
- Trial name
- CORRECT (NCT05521529)
- Testing
- no intervention, as this is an observational study
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Circadian Rhythm Sleep Disorders
Safety and Efficacy of VEC-162 on Circadian Rhythm in Healthy Adult Volunteers
The purpose of this study is to assess the safety and efficacy of VEC-162 compared to matching placebo on circadian phase shift and sleep parameters.
- Trial name
- NCT00490945
- Testing
- VEC-162
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Vanda Pharmaceuticals
Metabolic Disturbance, Obesity
The Effect of Irregular Meal Pattern Providing Hypo-energetic Diet on Energy Expenditure and Metabolism
In this study we will compare the effect of two different meal patterns. Firstly, participants will consume a diet providing their estimated energy requirement for a 7 day standardisation period (6 meals per day).
- Trial name
- NCT05569837
- Testing
- Regular meal pattern, Irregular meal pattern
- Where
- United Kingdom
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Atrial Fibrillation (AF), Atrial Fibrillation (Prevention of Stroke)
Responding to AF: Pill-in-Pocket Anticoagulation Guided by Automated Monitoring and Alerts
Atrial Fibrillation (AF) is the most common sustained cardiac arrhythmia, affecting 1-2 million people in the UK. AF is characterised by uncoordinated electrical activation and ineffective contraction of the upper cardiac…
- Trial name
- RESPOND-AF (NCT06922695)
- Testing
- Pill-in-pocket anticoagulation
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Oxford University Hospitals NHS Trust
Shift Work Type Circadian Rhythm Sleep Disorder, Imbalance of Constituents of Food Intake
Meal Distribution Across the Day in Female Nurses Working Shifts
This study assessed the meal distribution across the day (energy and macronutrient intake) and its relationship to the nutritional status of nursing professionals.
- Trial name
- NCT02522195
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
Embolic Stroke of Undetermined Source
Thirty Day Heart Monitoring for Detection of Atrial Fibrillation Among Cryptogenic Stroke Patients
The PROPhecy study aims to detect the presence of atrial fibrillation/flutter in patients who have suffered an embolic stroke of undetermined source (ESUS) using 30 day cardiac monitoring.
- Trial name
- PROPhecy (NCT03712865)
- Where
- Canada
- Volunteers
- 232 people
- Sponsor
- University of British Columbia
Ischemic Stroke, Left Atrial Strain
Left Atrial Strain Assessment in Ischemic Stroke Patients
This study is investigating a potential link between a novel measurement made on cardiac ultrasound and the risk of ischemic stroke in patients with a normal heart rhythm. The novel measurement is called left atrial strain.
- Conditions
- Ischemic Stroke, Left Atrial Strain, Sinus Rhythm
- Trial name
- ASSISTANT (NCT07102693)
- Where
- Ireland
- Volunteers
- 468 people
- Sponsor
- Connolly Hospital Blanchardstown
Loss of Consciousness of Unspecified Duration, Cerebral Laceration and Contusion
The Clinical Research on the Relationship Between Circadian Rhythm and Gut Microbiota in TBI Patients
Microbiome studies may be highlighted as crucial in the development of sleep disorder for TBI patients. The microbiota-gut-brain connection may further provide an opportunity for microbiota manipulation to treat the TBI patients…
- Conditions
- Loss of Consciousness of Unspecified Duration, Cerebral Laceration and Contusion, Traumatic Brain Injury
- Trial name
- NCT02849028
- Testing
- sleep disorder
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Atrial Fibrillation
Time-dependent Amiodarone Treatment in Atrial Fibrillation
Sixty consecutive emergency patients with newly diagnosed Atrial Fibrillation were randomized into two groups. The first received intravenous amiodarone infusions continuously for 24 hours; the second received Amiodarone until…
- Trial name
- NCT03432663
- Testing
- Intravenous amiodarone(1), Intravenous amiodarone(2)
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto de Cardiología y Medicina Vascular Hospital Zambrano-Hellion Tec Salud
Mobility Impairments
Brain Computer Interfaces (Mu Rhythm Learning)
Sensorimotor (also know as mu) rhythm based brain-computer interfaces (BCIs) are a tool for controlling electronic devices using only brain signals. The Mu rhythm is a naturally occuring wave produced by the brain.
- Trial name
- NCT02011399
- Testing
- Brain Computer Interface for Mu Rhythm
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Sleep Wake Disorders, Circadian Rhythm Disorders
Implementing and Sustaining a Sleep Treatment to Improve Community Mental Health Part 3: Sustainment
Research on the sustainment of implemented evidence-based psychological treatments in routine practice settings, such as community mental health centers, is limited.
- Trial name
- NCT05956678
- Testing
- Standard Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C), Adapted Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C)
- Where
- 10 sites in United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
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