Clinical trials: Right Heart Catheterization
Heart Failure, Diastolic, Echocardiography
Assessment of Left Ventricular Filling Pressure by Applying Artificial Intelligence Algorithms to Left Atrial Speckle-tracking Echocardiography
The goal of this single-center, prospective, observational study is to validate a software package based on an artificial intelligence algorithm for automated non-invasive estimation of LVFP against invasively measured ones by…
- Trial name
- LVEDP (NCT05768698)
- Testing
- Software algorithm
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Istituto Auxologico Italiano
Pulmonary Hypertension
Contrast Enhanced PA Pressure Measurements
Pulmonary hypertension (PH) is an abnormal increase of the pressure inside the lung circulation. This condition can be caused by many different diseases.
- Trial name
- NCT06240871
- Testing
- Pulmonary artery pressure measurements
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Northwestern University
Septic Shock
Comparison of Cardiac Index Measurement Using Right Ventricular Pressure Curve Analysis and Thermodilution Via a Swan-Ganz IQ™ Catheter.
The pulmonary artery catheter (Swan-Ganz) is a standard tool in intensive care for measuring and monitoring cardiac index by thermodilution.
- Trial name
- MICAP (NCT07628023)
- Testing
- Swan-Ganz
- Where
- 2 sites in France
- Volunteers
- 43 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Disease
Left vs. Right Radial Approach for Routine Catheterization of Heart Transplant Patients
Orthotopic heart transplantation is a well established therapeutic measure for end stage heart failure, leading to significant improvements in survival and quality of life.
- Trial name
- NCT02163031
- Testing
- devices used in the coronary angiography
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Clinic of Barcelona
Catheterization
Bedside Ultrasound for Fluid Estimation
The study aims to standardize patient positioning during bedside ultrasound assessment of internal jugular vein (IJV) and correlate the results with invasive hemodynamics obtained immediately after.
- Trial name
- NCT05159063
- Testing
- Ultrasound imaging
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Gaurang Vaidya
Right Ventricular Dysfunction
Incidence, Impact and Mechanisms of Perioperative Right VEntricular Dysfunction (IMPRoVE)
A study to see how common right heart failure (right ventricular dysfunction) after major surgery is, and to investigate if right ventricular dysfunction causes worse patient outcomes after surgery.
- Trial name
- IMPRoVE (NCT05827315)
- Testing
- Echocardiography, T1 Cardiovascular Magnetic Resonance, Right heart catheterisation and coronary sinus blood sampling
- Where
- 3 sites in United Kingdom
- Volunteers
- 175 people
- Sponsor
- NHS National Waiting Times Centre Board
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Multimodality RV Phenotyping for Risk Stratification and Short-Term Outcomes in Group 1 PAH
The MIRROR-PAH is a single-center, prospective, observational cohort study evaluating the incremental value of multimodality imaging-derived right ventricular characteristics for risk stratification in patients with Group 1…
- Conditions
- Pulmonary Hypertension, Pulmonary Arterial Hypertension, Right Ventricular Function
- Trial name
- MIRROR-PAH (NCT07667673)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Pulmonary Embolism (Diagnosis)
Inorganic Nitrates in Intermediate High-risk Pulmonary Embolism
Pulmonary embolism (PE) is a serious condition caused by blood clots blocking the blood vessels in the lungs. In some patients, PE leads to increased pressure in the lung circulation and strain on the right side of the heart.
- Trial name
- NITRATE-PE (NCT07431229)
- Where
- 2 sites in Sweden
- Volunteers
- 36 people
- Sponsor
- Karolinska Institutet
Pulmonary Hypertension
Investigation of H01 in Adults With Pulmonary Hypertension Including Interstitial Lung Disease (The SATURN Study).
This study is a prospective, randomized, double-blind, study of H01 (Hymecromone) in adults with pulmonary hypertension (PH). The primary objective of this study is to evaluate the safety and tolerability of oral H01 and the…
- Trial name
- SATURN (NCT05128929)
- Testing
- Hymecromone (H01)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Stanford University
Sarcoidosis, Precapillary Pulmonary Hypertension
Inhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension
This study aims to evaluate the efficacy and safety of inhaled treprostinil in subjects with sarcoidosis-associated interstitial lung disease and pulmonary hypertension.
- Conditions
- Sarcoidosis, Precapillary Pulmonary Hypertension, Interstitial Lung Disease
- Trial name
- SAPPHIRE (NCT03814317)
- Testing
- Inhaled Treprostinil
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Congestion, Heart Failure
Portal Vein Flow Variability to Quantify Right-Sided Hemodynamic Congestion (PORTAL)
This study evaluates the accuracy of a comprehensive venous Doppler echography including the portal vein pulsatility index (PVPI) to quantify invasively measured right-sided venous pressures.
- Conditions
- Congestion, Heart Failure, Right Heart Catheterisation, Central Venous Pressure
- Trial name
- PORTAL (NCT05411263)
- Testing
- Comprehensive transthoracic echocardiography, Doppler echography & Kino-cardiograph (Kino)
- Where
- Belgium
- Volunteers
- 61 people
- Sponsor
- Vrije Universiteit Brussel
Endomyocardial Fibrosis, Aortic Valve Stenosis
Assessment of Myocardial Fibrosis in Aortic STenosis
This observational cohort study studies the impact myocardial fibrosis has on patients with severe aortic stenosis undergoing aortic valve replacement.
- Trial name
- AMFAST (NCT02316587)
- Where
- Denmark
- Volunteers
- 112 people
- Sponsor
- Odense University Hospital
Heart Failure
Comparison of CorWatch With Right Heart Catheter Measurements in Heart Failure
This is an observational study to evaluate the agreement between the InCardia diagnostic technology CorWatch for the assessment of venous pressure in human subjects.
- Trial name
- NCT04928326
- Testing
- CorWatch
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- InCardia Inc.
Heart Failure
A Multi-site, Prospective, Non-interventional, Observational Data Collection Study in Patients Undergoing a Right Heart Catheterization
Acorai is developing a non-invasive monitoring system for the estimation of intracardiac hemodynamic parameters in patients with suspected or confirmed heart failure, and/or pulmonary hypertension, who require hemodynamic…
- Trial name
- NCT07010562
- Testing
- Data collection
- Where
- Sweden
- Volunteers
- 392 people
- Sponsor
- Acorai AB
Chronic Obstructive Pulmonary Disease (COPD), Pulmonary Hypertension
Clinical Registry for the Characterization of the 'Pulmonary Vascular Phenotype' in Patients With Chronic Obstructive Pulmonary Disease
Registry of COPD (Chronic Obstructive Pulmonary Disease) patients who underwent right heart catheterization (RHC) and full clinical evaluation for pulmonary hypertension
- Trial name
- COPD-PH (NCT07102823)
- Where
- 3 sites in Austria, Switzerland and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Medical University of Graz
Pulmonary Hypertension Secondary
Pulmonary Artery Pressure in COVID-19 Survivors
Post COVID-19 pulmonary hypertension can develop as a result of lung parenchymal damage and altered pulmonary circulation induced by COVID-19 infection.
- Trial name
- NCT05993338
- Testing
- right heart catheterization (RHC).
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Mansoura University Hospital
HIV
Sildenafil to Treat HIV-Associated Pulmonary Hypertension
This study will examine how blood pressure in the lungs is controlled in healthy people, people with HIV and people with HIV and pulmonary artery hypertension (high blood pressure in the lungs, also called PAH).
- Trial name
- NCT00327080
- Testing
- MRI, L-NMMA, Acetylcholine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Right Heart Catheterization
The Nanowear Wearable System SimpleSense Validation Trial for Cardiac Output
The Nanowear SimpleSense study is a single center, prospective, non-randomized, feasibility, non- significant risk study The study will be done in 2 phases.
- Trial name
- NCT05629533
- Testing
- SimpleSense
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Nanowear Inc.
Pulmonary Hypertension, Right Heart Failure Due to Pulmonary Hypertension
Postural Changes During Right Heart Catheterization
Hemodynamic measurements obtained during pulmonary artery catheterization are essential for the diagnosis and classification of pulmonary hypertension.
- Trial name
- NCT03089164
- Testing
- Right heart catheterization
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Pulmonary Hypertension, Precapillary Pulmonary Hypertension
Digital Assessment of Real-World Walking Activity in Pulmonary Hypertension: A Prospective Multicenter Trial
The goal of this observational study is to validate digital mobility outcomes for monitoring the treatment and disease progression in adult patients with pulmonary hypertension.
- Conditions
- Pulmonary Hypertension, Precapillary Pulmonary Hypertension, Right Heart Catheterisation, Digital Mobility Outcomes
- Trial name
- NCT07137260
- Testing
- Accelerometer (measurement of walking activity)
- Where
- 4 sites in Germany
- Volunteers
- 77 people
- Sponsor
- Simon Jäger